Abstract
Data collected over the past 6 years suggest that Coxsackie B viruses (CBV) play an important role in myalgic encephalomyelitis (ME). Since psychological upset is a feature of this illness, 247 patients, recently admitted to a psychiatric hospital, were tested for neutralizing antibodies to CBV. A total of 12.5% had significantly raised CBV titres compared with 4-5% of 'well' control groups; the percentage positive was greatest (21%) in those aged 30-39 years. During 1985 and 1986 sera from 290 adults with ME were tested using the newly developed CBV IgM ELISA test; 37% were CBV IgM positive compared with 9% of 500 'well' adult controls. Forty-seven children, with ME were similarly tested during this period; 38% were positive, implying recent or active CBV infection. The combined use of this ELISA test and the virus probe techniques now available should further help to elucidate the exact role of CBV in this disabling illness.
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Selected References
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- Behan P. O., Behan W. M., Bell E. J. The postviral fatigue syndrome--an analysis of the findings in 50 cases. J Infect. 1985 May;10(3):211–222. doi: 10.1016/s0163-4453(85)92488-0. [DOI] [PubMed] [Google Scholar]
- Behan P. O. Epidemic myalgic encephalomyelitis. Practitioner. 1980 Aug;224(1346):805–807. [PubMed] [Google Scholar]
- Bell E. J., McCartney R. A. A study of Coxsackie B virus infections, 1972-1983. J Hyg (Lond) 1984 Oct;93(2):197–203. doi: 10.1017/s0022172400064718. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bowles N. E., Richardson P. J., Olsen E. G., Archard L. C. Detection of Coxsackie-B-virus-specific RNA sequences in myocardial biopsy samples from patients with myocarditis and dilated cardiomyopathy. Lancet. 1986 May 17;1(8490):1120–1123. doi: 10.1016/s0140-6736(86)91837-4. [DOI] [PubMed] [Google Scholar]
- Fegan K. G., Behan P. O., Bell E. J. Myalgic encephalomyelitis--report of an epidemic. J R Coll Gen Pract. 1983 Jun;33(251):335–337. [PMC free article] [PubMed] [Google Scholar]
- Hallam N. F., Eglin R. P., Holland P., Bell E. J., Squier M. V. Fatal Coxsackie B meningoencephalitis diagnosed by serology and in-situ nucleic acid hybridisation. Lancet. 1986 Nov 22;2(8517):1213–1214. doi: 10.1016/s0140-6736(86)92216-6. [DOI] [PubMed] [Google Scholar]
- Keighley B. D., Bell E. J. Sporadic myalgic encephalomyelitis in a rural practice. J R Coll Gen Pract. 1983 Jun;33(251):339–341. [PMC free article] [PubMed] [Google Scholar]
- King M. L., Shaikh A., Bidwell D., Voller A., Banatvala J. E. Coxsackie-B-virus-specific IgM responses in children with insulin-dependent (juvenile-onset; type I) diabetes mellitus. Lancet. 1983 Jun 25;1(8339):1397–1399. doi: 10.1016/s0140-6736(83)92353-x. [DOI] [PubMed] [Google Scholar]
- McCartney R. A., Banatvala J. E., Bell E. J. Routine use of mu-antibody-capture ELISA for the serological diagnosis of Coxsackie B virus infections. J Med Virol. 1986 Jul;19(3):205–212. doi: 10.1002/jmv.1890190302. [DOI] [PubMed] [Google Scholar]
- O'Neill D., McArthur J. D., Kennedy J. A., Clements G. Coxsackie B virus infection in coronary care unit patients. J Clin Pathol. 1983 Jun;36(6):658–661. doi: 10.1136/jcp.36.6.658. [DOI] [PMC free article] [PubMed] [Google Scholar]