Abstract
After inoculation of herpes simplex virus (HSV) on the snout of the mouse, spread to the eye occurs via neural pathways. The keratitis which ensued was clinically atypical for a pure herpetic keratitis, leading to a search for other causative agents. Preliminary data suggests that bacteriological super-infection of the viral keratitis occurs frequently, producing a unique experimental model.
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- Anderson J. R., Field H. J. An animal model of ocular herpes. Keratitis, retinitis and cataract in the mouse. Br J Exp Pathol. 1984 Jun;65(3):283–297. [PMC free article] [PubMed] [Google Scholar]
- Blyth W. A., Harbour D. A., Hill T. J. Pathogenesis of zosteriform spread of herpes simplex virus in the mouse. J Gen Virol. 1984 Sep;65(Pt 9):1477–1486. doi: 10.1099/0022-1317-65-9-1477. [DOI] [PubMed] [Google Scholar]
- Boisjoly H. M., Pavan-Langston D., Kenyon K. R., Baker A. S. Superinfections in herpes simplex keratitis. Am J Ophthalmol. 1983 Sep;96(3):354–361. doi: 10.1016/s0002-9394(14)77827-4. [DOI] [PubMed] [Google Scholar]
- Claoue C., Hill T., Blyth W., Easty D. Clinical findings after zosteriform spread of herpes simplex virus to the eye of the mouse. Curr Eye Res. 1987 Jan;6(1):281–286. doi: 10.3109/02713688709020106. [DOI] [PubMed] [Google Scholar]
- Claoue C., Hodges T., Hill T., Blyth W., Easty D. The histology of the eye after zosteriform spread of herpes simplex virus in the mouse. Br J Exp Pathol. 1987 Aug;68(4):585–593. [PMC free article] [PubMed] [Google Scholar]
- DOHLMAN C. H., ZUCKER B. B. LONG-TERM TREATMENT WITH IDOXURIDINE AND STEROIDS: A COMPLICATION IN HERPETIC KERATITIS. Arch Ophthalmol. 1965 Aug;74:172–174. doi: 10.1001/archopht.1965.00970040174009. [DOI] [PubMed] [Google Scholar]
- Hill T. J., Field H. J., Blyth W. A. Acute and recurrent infection with herpes simplex virus in the mouse: a model for studying latency and recurrent disease. J Gen Virol. 1975 Sep;28(3):341–353. doi: 10.1099/0022-1317-28-3-341. [DOI] [PubMed] [Google Scholar]
- JONES B. The management of ocular herpes. Trans Ophthalmol Soc U K. 1959;79:425–437. [PubMed] [Google Scholar]
- Maudgal P. C., De Clercq K., Descamps J., Missotten L. Topical treatment of experimental herpes simplex keratouveitis with 2'-O-glycylacyclovir. A water-soluble ester of acyclovir. Arch Ophthalmol. 1984 Jan;102(1):140–142. doi: 10.1001/archopht.1984.01040030118049. [DOI] [PubMed] [Google Scholar]
- Metcalf J. F., Michaelis B. A. Herpetic keratitis in inbred mice. Invest Ophthalmol Vis Sci. 1984 Oct;25(10):1222–1225. [PubMed] [Google Scholar]
- Meyers R. L., Pettit T. H. The pathogenesis of corneal inflammation due to Herpes simplex virus. I. Corneal hypersensitivity in the rabbit. J Immunol. 1973 Oct;111(4):1031–1042. [PubMed] [Google Scholar]
- Russell R. G., Nasisse M. P., Larsen H. S., Rouse B. T. Role of T-lymphocytes in the pathogenesis of herpetic stromal keratitis. Invest Ophthalmol Vis Sci. 1984 Aug;25(8):938–944. [PubMed] [Google Scholar]
- Shimeld C., Dyson H., Lewkowicz-Moss S., Hill T. J., Blyth W. A., Easty D. L. Spread of HSV-1 to the mouse eye after inoculation in the skin of the snout requires an intact nerve supply to the inoculation site. Curr Eye Res. 1987 Jan;6(1):9–12. doi: 10.3109/02713688709020061. [DOI] [PubMed] [Google Scholar]
- Shimeld C., Lewkowicz-Moss S. J., Lipworth K. M., Hill T. J., Blyth W. A., Easty D. L. Antigens of herpes simplex virus in whole corneal epithelial sheets from mice. Arch Ophthalmol. 1986 Dec;104(12):1830–1834. doi: 10.1001/archopht.1986.01050240104049. [DOI] [PubMed] [Google Scholar]
- Tashiro M., Ciborowski P., Klenk H. D., Pulverer G., Rott R. Role of Staphylococcus protease in the development of influenza pneumonia. Nature. 1987 Feb 5;325(6104):536–537. doi: 10.1038/325536a0. [DOI] [PubMed] [Google Scholar]
- WILLIAMS L. E., NESBURN A. B., KAUFMAN H. E. EXPERIMENTAL INDUCTION OF DISCIFORM KERATITIS. Arch Ophthalmol. 1965 Jan;73:112–114. doi: 10.1001/archopht.1965.00970030114023. [DOI] [PubMed] [Google Scholar]
- Wilhelmus K. R., Falcon M. G., Jones B. R. Bilateral herpetic keratitis. Br J Ophthalmol. 1981 Jun;65(6):385–387. doi: 10.1136/bjo.65.6.385. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wilhelmus K. R. Suppurative corneal ulceration following herpetic keratitis. Doc Ophthalmol. 1982 May 14;53(1):17–36. doi: 10.1007/BF00143807. [DOI] [PubMed] [Google Scholar]