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. 1989 May;82(5):268–271. doi: 10.1177/014107688908200508

Acupuncture prophylaxis of cancer chemotherapy-induced sickness.

J W Dundee 1, R G Ghaly 1, K T Fitzpatrick 1, W P Abram 1, G A Lynch 1
PMCID: PMC1292129  PMID: 2666662

Abstract

In a multi-facet study we evaluated the efficacy of P6 electroacupuncture (10 Hz applied for 5 min) as an antiemetic in patients receiving a variety of cancer chemotherapy drugs. The study involved 130 (15 in an open pilot study, 10 in a randomized placebo controlled crossover study and 105 in a definitive study) patients who had a history of distressing sickness after previous treatment, and who, on the basis of a previous survey, would be expected to have a 96% chance of this with subsequent therapy. Sickness was either completely absent or reduced considerably in 97% of patients and no side effects were encountered. The limited crossover study, using a 'dummy' acupuncture (ACP) point showed that the beneficial effects were limited to the P6 point. Logistic and ethical considerations excluded the possibility of carrying out a larger placebo-controlled study. While in our hands P6 ACP was an effective antiemetic in patients having cancer chemotherapy, because of the time involved and the brevity of the action (8 h) an alternative approach to electro-ACP is required before this technique is adopted clinically.

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Selected References

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  1. Allan S. G., Cornbleet M. A., Warrington P. S., Golland I. M., Leonard R. C., Smyth J. N. Dexamethasone and high dose metoclopramide: efficacy in controlling cisplatin induced nausea and vomiting. Br Med J (Clin Res Ed) 1984 Oct 6;289(6449):878–879. doi: 10.1136/bmj.289.6449.878-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BEECHER H. K. The powerful placebo. J Am Med Assoc. 1955 Dec 24;159(17):1602–1606. doi: 10.1001/jama.1955.02960340022006. [DOI] [PubMed] [Google Scholar]
  3. Brinkley D. Quality of life in cancer trials. Br Med J (Clin Res Ed) 1985 Sep 14;291(6497):685–686. doi: 10.1136/bmj.291.6497.685. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bruera E. D., Roca E., Cedaro L., Chacón R., Estévez R. Improved control of chemotherapy-induced emesis by the addition of dexamethasone to metoclopramide in patients resistant to metoclopramide. Cancer Treat Rep. 1983 Apr;67(4):381–383. [PubMed] [Google Scholar]
  5. D'Olimpio J. T., Camacho F., Chandra P., Lesser M., Maldonado M., Wollner D., Wiernik P. H. Antiemetic efficacy of high-dose dexamethasone versus placebo in patients receiving cisplatin-based chemotherapy: a randomized double-blind controlled clinical trial. J Clin Oncol. 1985 Aug;3(8):1133–1135. doi: 10.1200/JCO.1985.3.8.1133. [DOI] [PubMed] [Google Scholar]
  6. Dodds L. J. The control of cancer chemotherapy-induced nausea and vomiting. J Clin Hosp Pharm. 1985 Jun;10(2):143–166. doi: 10.1111/j.1365-2710.1985.tb01129.x. [DOI] [PubMed] [Google Scholar]
  7. Dundee J. W., Ghaly R. G., Fitzpatrick K. T., Lynch G. A., Abram W. P. Acupuncture to prevent cisplatin-associated vomiting. Lancet. 1987 May 9;1(8541):1083–1083. doi: 10.1016/s0140-6736(87)90501-0. [DOI] [PubMed] [Google Scholar]
  8. Dundee J. W., Milligan K. R. Acupuncture as an antiemetic. Br Med J (Clin Res Ed) 1988 Jan 9;296(6615):135–135. doi: 10.1136/bmj.296.6615.135-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Dundee J. W., Sourial F. B., Ghaly R. G., Bell P. F. P6 acupressure reduces morning sickness. J R Soc Med. 1988 Aug;81(8):456–457. doi: 10.1177/014107688808100813. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Forrow L., Wartman S. A., Brock D. W. Science, ethics, and the making of clinical decisions. Implications for risk factor intervention. JAMA. 1988 Jun 3;259(21):3161–3167. [PubMed] [Google Scholar]
  11. Frytak S., Moertel C. G. Management of nausea and vomiting in the cancer patient. JAMA. 1981 Jan 23;245(4):393–396. [PubMed] [Google Scholar]
  12. Ghaly R. G., Fitzpatrick K. T., Dundee J. W. Antiemetic studies with traditional Chinese acupuncture. A comparison of manual needling with electrical stimulation and commonly used antiemetics. Anaesthesia. 1987 Oct;42(10):1108–1110. doi: 10.1111/j.1365-2044.1987.tb05180.x. [DOI] [PubMed] [Google Scholar]
  13. Gralla R. J., Itri L. M., Pisko S. E., Squillante A. E., Kelsen D. P., Braun D. W., Jr, Bordin L. A., Braun T. J., Young C. W. Antiemetic efficacy of high-dose metoclopramide: randomized trials with placebo and prochlorperazine in patients with chemotherapy-induced nausea and vomiting. N Engl J Med. 1981 Oct 15;305(16):905–909. doi: 10.1056/NEJM198110153051601. [DOI] [PubMed] [Google Scholar]
  14. Hughson A. V., Cooper A. F., McArdle C. S., Smith D. C. Psychological impact of adjuvant chemotherapy in the first two years after mastectomy. Br Med J (Clin Res Ed) 1986 Nov 15;293(6557):1268–1271. doi: 10.1136/bmj.293.6557.1268. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Huys J., Troch M., Bourguignon R. P., Smets P. High-dose alizapride versus high-dose domperidone: a double-blind comparative study in the management of cis-platinum-induced emesis. Curr Med Res Opin. 1985;9(6):400–406. doi: 10.1185/03007998509109611. [DOI] [PubMed] [Google Scholar]
  16. Jobst K., Chen J. H., McPherson K., Arrowsmith J., Brown V., Efthimiou J., Fletcher H. J., Maciocia G., Mole P., Shifrin K. Controlled trial of acupuncture for disabling breathlessness. Lancet. 1986 Dec 20;2(8521-22):1416–1419. doi: 10.1016/s0140-6736(86)92732-7. [DOI] [PubMed] [Google Scholar]
  17. Kessler J. F., Alberts D. S., Plezia P. M., Wilson V., Chase J., Aapro M., Surwit E. A. An effective five-drug antiemetic combination for prevention of chemotherapy-related nausea and vomiting. Experience in eighty-four patients. Cancer Chemother Pharmacol. 1986;16(3):282–286. doi: 10.1007/BF00293993. [DOI] [PubMed] [Google Scholar]
  18. Kris M. G., Gralla R. J., Tyson L. B., Clark R. A., Kelsen D. P., Reilly L. K., Groshen S., Bosl G. J., Kalman L. A. Improved control of cisplatin-induced emesis with high-dose metoclopramide and with combinations of metoclopramide, dexamethasone, and diphenhydramine. Results of consecutive trials in 255 patients. Cancer. 1985 Feb 1;55(3):527–534. doi: 10.1002/1097-0142(19850201)55:3<527::aid-cncr2820550310>3.0.co;2-2. [DOI] [PubMed] [Google Scholar]
  19. Lewith G. T. Can we assess the effects of acupuncture? Br Med J (Clin Res Ed) 1984 May 19;288(6429):1475–1476. doi: 10.1136/bmj.288.6429.1475. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Lewith G. T., Machin D. On the evaluation of the clinical effects of acupuncture. Pain. 1983 Jun;16(2):111–127. doi: 10.1016/0304-3959(83)90202-6. [DOI] [PubMed] [Google Scholar]
  21. Olver I. N., Simon R. M., Aisner J. Antiemetic studies: a methodological discussion. Cancer Treat Rep. 1986 May;70(5):555–563. [PubMed] [Google Scholar]
  22. Penta J. S., Poster D. S., Bruno S., Macdonald J. S. Clinical trials with antiemetic agents in cancer patients receiving chemotherapy. J Clin Pharmacol. 1981 Aug-Sep;21(8-9):11S–22S. doi: 10.1002/j.1552-4604.1981.tb02568.x. [DOI] [PubMed] [Google Scholar]
  23. Plezia P. M., Alberts D. S., Kessler J., Aapro M. S., Graham V., Surwit E. A. Immediate termination of intractable vomiting induced by cisplatin combination chemotherapy using an intensive five-drug antiemetic regimen. Cancer Treat Rep. 1984 Dec;68(12):1493–1495. [PubMed] [Google Scholar]
  24. Weightman W. M., Zacharias M., Herbison P. Traditional Chinese acupuncture as an antiemetic. Br Med J (Clin Res Ed) 1987 Nov 28;295(6610):1379–1380. doi: 10.1136/bmj.295.6610.1379. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Wilcox P. M., Fetting J. H., Nettesheim K. M., Abeloff M. D. Anticipatory vomiting in women receiving cyclophosphamide, methotrexate, and 5-FU (CMF) adjuvant chemotherapy for breast carcinoma. Cancer Treat Rep. 1982 Aug;66(8):1601–1604. [PubMed] [Google Scholar]
  26. Zelen M. A new design for randomized clinical trials. N Engl J Med. 1979 May 31;300(22):1242–1245. doi: 10.1056/NEJM197905313002203. [DOI] [PubMed] [Google Scholar]

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