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. 1989 Sep;82(9):539–541. doi: 10.1177/014107688908200911

Hypothesis: possible role for the melatonin receptor in vitiligo: discussion paper.

A Slominski 1, R Paus 1, A Bomirski 1
PMCID: PMC1292300  PMID: 2552111

Abstract

A new unifying hypothesis for the aetiology of vitiligo is proposed, in which we postulate that the final destruction of melanocytes in vitiligo results from a cascade of reactions initiated by a disregulation of melanogenesis, caused by activation of the melatonin receptor. These events result in the high and uncontrolled production of free radicals and toxic products of melanogenesis which sequentially damage or destroy melanocytes and keratinocytes, provoke an autoimmune response against exposed intracellular or altered cell surface antigens, and increase the propensity of melanocytes to undergo malignant transformation.

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Selected References

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