Skip to main content
PMC home page
Journal of the Royal Society of Medicine logoLink to Journal of the Royal Society of Medicine
. 1990 Jun;83(6):383–386. doi: 10.1177/014107689008300616

Prospects for new drug treatment in epilepsy: a review.

D Chadwick 1
PMCID: PMC1292691  PMID: 1974307

Full text

PDF
383

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Annegers J. F., Hauser W. A., Elveback L. R. Remission of seizures and relapse in patients with epilepsy. Epilepsia. 1979 Dec;20(6):729–737. doi: 10.1111/j.1528-1157.1979.tb04857.x. [DOI] [PubMed] [Google Scholar]
  2. Butler W. H., Ford G. P., Newberne J. W. A study of the effects of vigabatrin on the central nervous system and retina of Sprague Dawley and Lister-Hooded rats. Toxicol Pathol. 1987;15(2):143–148. doi: 10.1177/019262338701500203. [DOI] [PubMed] [Google Scholar]
  3. Chadwick D. Comparison of monotherapy with valproate and other antiepileptic drugs in the treatment of seizure disorders. Am J Med. 1988 Jan 25;84(1A):3–6. doi: 10.1016/0002-9343(88)90049-6. [DOI] [PubMed] [Google Scholar]
  4. Chadwick D., Reynolds E. H. When do epileptic patients need treatment? Starting and stopping medication. Br Med J (Clin Res Ed) 1985 Jun 22;290(6485):1885–1888. doi: 10.1136/bmj.290.6485.1885. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Chapman A., Keane P. E., Meldrum B. S., Simiand J., Vernieres J. C. Mechanism of anticonvulsant action of valproate. Prog Neurobiol. 1982;19(4):315–359. doi: 10.1016/0301-0082(82)90010-7. [DOI] [PubMed] [Google Scholar]
  6. Crawford P., Chadwick D. A comparative study of progabide, valproate, and placebo as add-on therapy in patients with refractory epilepsy. J Neurol Neurosurg Psychiatry. 1986 Nov;49(11):1251–1257. doi: 10.1136/jnnp.49.11.1251. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Crawford P., Ghadiali E., Lane R., Blumhardt L., Chadwick D. Gabapentin as an antiepileptic drug in man. J Neurol Neurosurg Psychiatry. 1987 Jun;50(6):682–686. doi: 10.1136/jnnp.50.6.682. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Davies J., Evans R. H., Jones A. W., Smith D. A., Watkins J. C. Differential activation and blockade of excitatory amino acid receptors in the mammalian and amphibian central nervous systems. Comp Biochem Physiol C. 1982;72(2):211–224. doi: 10.1016/0306-4492(82)90086-7. [DOI] [PubMed] [Google Scholar]
  9. Goodridge D. M., Shorvon S. D. Epileptic seizures in a population of 6000. II: Treatment and prognosis. Br Med J (Clin Res Ed) 1983 Sep 3;287(6393):645–647. doi: 10.1136/bmj.287.6393.645. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Grove J., Schechter P. J., Tell G., Koch-Weser J., Sjoerdsma A., Warter J. M., Marescaux C., Rumbach L. Increased gamma-aminobutyric acid (GABA), homocarnosine and beta-alanine in cerebrospinal fluid of patients treated with gamma-vinyl GABA (4-amino-hex-5-enoic acid). Life Sci. 1981 May 21;28(21):2431–2439. doi: 10.1016/0024-3205(81)90511-7. [DOI] [PubMed] [Google Scholar]
  11. Hauw J. J., Trottier S., Boutry J. M., Sun P., Sazdovitch V., Duyckaerts C. The neuropathology of vigabatrin. Br J Clin Pract Suppl. 1988 Mar;61:10–13. [PubMed] [Google Scholar]
  12. Herrling P. L., Morris R., Salt T. E. Effects of excitatory amino acids and their antagonists on membrane and action potentials of cat caudate neurones. J Physiol. 1983 Jun;339:207–222. doi: 10.1113/jphysiol.1983.sp014712. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Jawad S., Richens A., Goodwin G., Yuen W. C. Controlled trial of lamotrigine (Lamictal) for refractory partial seizures. Epilepsia. 1989 May-Jun;30(3):356–363. doi: 10.1111/j.1528-1157.1989.tb05309.x. [DOI] [PubMed] [Google Scholar]
  14. John R. A., Rimmer E. M., Williams J., Cole G., Fowler L. J., Richens A. Micro-vacuolation in rat brains after long term administration of GABA-transaminase inhibitors. Comparison of effects of ethanolamine-O-sulphate and vigabatrin. Biochem Pharmacol. 1987 May 1;36(9):1467–1473. doi: 10.1016/0006-2952(87)90112-2. [DOI] [PubMed] [Google Scholar]
  15. Jung M. J., Lippert B., Metcalf B. W., Böhlen P., Schechter P. J. gamma-Vinyl GABA (4-amino-hex-5-enoic acid), a new selective irreversible inhibitor of GABA-T: effects on brain GABA metabolism in mice. J Neurochem. 1977 Nov;29(5):797–802. doi: 10.1111/j.1471-4159.1977.tb10721.x. [DOI] [PubMed] [Google Scholar]
  16. Leppik I. E., Dreifuss F. E., Porter R., Bowman T., Santilli N., Jacobs M., Crosby C., Cloyd J., Stackman J., Graves N. A controlled study of progabide in partial seizures: methodology and results. Neurology. 1987 Jun;37(6):963–968. doi: 10.1212/wnl.37.6.963. [DOI] [PubMed] [Google Scholar]
  17. Meldrum B. S. Epilepsy and gamma-aminobutyric acid-mediated inhibition. Int Rev Neurobiol. 1975;17:1–36. doi: 10.1016/s0074-7742(08)60205-6. [DOI] [PubMed] [Google Scholar]
  18. Olsen R. W. The GABA postsynaptic membrane receptor-ionophore complex. Site of action of convulsant and anticonvulsant drugs. Mol Cell Biochem. 1981 Sep 25;39:261–279. doi: 10.1007/BF00232579. [DOI] [PubMed] [Google Scholar]
  19. Reynolds E. H., Shorvon S. D. Monotherapy or polytherapy for epilepsy? Epilepsia. 1981 Feb;22(1):1–10. doi: 10.1111/j.1528-1157.1981.tb04327.x. [DOI] [PubMed] [Google Scholar]
  20. Watkins J. C., Evans R. H. Excitatory amino acid transmitters. Annu Rev Pharmacol Toxicol. 1981;21:165–204. doi: 10.1146/annurev.pa.21.040181.001121. [DOI] [PubMed] [Google Scholar]
  21. Wong R. K., Prince D. A. Participation of calcium spikes during intrinsic burst firing in hippocampal neurons. Brain Res. 1978 Dec 29;159(2):385–390. doi: 10.1016/0006-8993(78)90544-9. [DOI] [PubMed] [Google Scholar]
  22. Worms P., Depoortere H., Durand A., Morselli P. L., Lloyd K. G., Bartholini G. gamma-Aminobutyric acid (GABA) receptor stimulation. I. Neuropharmacological profiles of progabide (SL 76002) and SL 75102, with emphasis on their anticonvulsant spectra. J Pharmacol Exp Ther. 1982 Mar;220(3):660–671. [PubMed] [Google Scholar]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press

RESOURCES