Abstract
Eleven patients with lipodermatosclerosis (LDS) and 14 patients without venous or arterial disease underwent measurement of xenon-133 (133Xe) half-clearance times from the gaiter region of the leg. Xenon has similar diffusion characteristics to oxygen, and the investigation reflects the ability of the isotope to diffuse from the skin surface into capillary blood. Median skin half-clearance time for skin in the LDS group was 2.2 min and in the control group 2.1 min. From the subcutaneous tissues, the respective times were 14.1 and 17.4 minutes. These differences are not statistically significant. The study fails to yield evidence suggesting that an oxygen diffusion barrier exists in lipodermatosclerosis.
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- Browse N. L., Burnand K. G. The cause of venous ulceration. Lancet. 1982 Jul 31;2(8292):243–245. doi: 10.1016/s0140-6736(82)90325-7. [DOI] [PubMed] [Google Scholar]
- Burnand K. G., Whimster I., Naidoo A., Browse N. L. Pericapillary fibrin in the ulcer-bearing skin of the leg: the cause of lipodermatosclerosis and venous ulceration. Br Med J (Clin Res Ed) 1982 Oct 16;285(6348):1071–1072. doi: 10.1136/bmj.285.6348.1071. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Clyne C. A., Ramsden W. H., Chant A. D., Webster J. H. Oxygen tension on the skin of the gaiter area of limbs with venous disease. Br J Surg. 1985 Aug;72(8):644–647. doi: 10.1002/bjs.1800720820. [DOI] [PubMed] [Google Scholar]
- Coleridge Smith P. D., Thomas P., Scurr J. H., Dormandy J. A. Causes of venous ulceration: a new hypothesis. Br Med J (Clin Res Ed) 1988 Jun 18;296(6638):1726–1727. doi: 10.1136/bmj.296.6638.1726. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hopkins N. F., Spinks T. J., Rhodes C. G., Ranicar A. S., Jamieson C. W. Positron emission tomography in venous ulceration and liposclerosis: study of regional tissue function. Br Med J (Clin Res Ed) 1983 Jan 29;286(6362):333–336. doi: 10.1136/bmj.286.6362.333. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LASSEN N. A., LINDBJERG J., MUNCK O. MEASUREMENT OF BLOOD-FLOW THROUGH SKELETAL MUSCLE BY INTRAMUSCULAR INJECTION OF XENON-133. Lancet. 1964 Mar 28;1(7335):686–689. doi: 10.1016/s0140-6736(64)91518-1. [DOI] [PubMed] [Google Scholar]
- Sejrsen P. Blood flow in cutaneous tissue in man studied by washout of radioactive xenon. Circ Res. 1969 Aug;25(2):215–229. doi: 10.1161/01.res.25.2.215. [DOI] [PubMed] [Google Scholar]