Positive association between vascular endothelial growth factor (VEGF) -2578 C/A variant and prostate cancer

Abstract

Background:

Vascular endothelial growth factor (VEGF) gene is an important angiogenesis regulator related to cancer development and progression. We evaluated the association between -2578 C/A (rs699947) VEGF polymorphism and PCa in Mexican subjects, to contribute to knowledge of VEGF role in genetic epidemiology of prostate cancer (PCa).

Objective:

The aim of this study was to evaluate the association between -2578 C/A VEGF variant and PCa in Mexican population.

Methods:

A total of 249 men (77 PCa cases and 172 controls) from the Northwestern region of Mexico were screened for the -2578 C/A VEGF variant. The polymorphism was determined by polymerase chain reaction-based restriction analysis.

Results:

Genotype frequencies for C/C, C/A, and A/A, were 0.48, 0.49, 0.03 for cases and 0.41, 0.45, 0.14 for controls respectively. Genotype A/A of -2578 VEGF variant reduces the risk of PCa in an 84% among studied population (Odds Ratio 0.16; 95% CI: 0.04–0.71, P=0.007). C/C carriers showed an increased PCa risk of 6.1 times among the study population.

Conclusions:

Inheritance of -2578 A/A genotype of VEGF gene may modify PCa susceptibility risk in Mexican population.

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