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PLOS One logoLink to PLOS One
. 2026 Feb 23;21(2):e0343015. doi: 10.1371/journal.pone.0343015

The influence of social support, physical activity, general psychological distress, and demographic characteristics on self-reported health status among women in Iran

Badriyeh Karami 1, Shahab Rezaeian 2,3, Ebrahim Shakiba 4,5, Amirhossien Naghibzadeh 6, Abbas Mohammad Karimi Mazhin 7, Masoumeh Malek 8, Hadi Darvishigilan 9,*
Editor: Zahra Lorigooini10
PMCID: PMC12928592  PMID: 41729986

Abstract

Background

Considering the impact of social support on women’s mental health and the importance of their mental health in improving the health of the society, this study aimed to investigate the influence of social support, physical activity, general psychological distress, and demographic characteristics on self-reported health status among women.

Methods

This cross-sectional study was conducted on 350 women aged 18–75 in 2024 in Iran. The Vaux social support, international physical activities, Depression- Anxiety- Stress Scale (DASS-21) questionnaires were administered. The Cluster random sampling method was used. The data were analyzed using STATA version 18. The significance level for examining the hypotheses was p ≥ 0.05.

Results

According to the results, there was a significant positive relationship between age, place of residence, history of chronic disease, evaluation of financial status and self-rated health in both crude and adjusted models. In addition, the positive significant relationship was observed between general psychological distress, and poor self- rated health in adjusted model. So that, the odds of poor self- rated health in women who achieved higher depression, anxiety, stress scale score was 1.04 times higher than others.

Conclusion

Considering the rising rates of psychological problems, particularly in recent years among women, as well as the influence of women’s health on societal well-being, it is imperative for policymakers in women’s health to pinpoint the underlying causes of mental disorders in women. They should take proactive measures to mitigate these causes, thereby decreasing the prevalence of anxiety, depression, and stress disorders through the implementation of effective interventions.

Introduction

Health is a fundamental human right and a key indicator of justice within society [1]. The right to health encompasses the ability to lead a healthy and productive life of good quality, characterized by an acceptable lifespan and freedom from illness and disability, with the responsibility for this right resting on governments [2]. Consequently, a primary objective of the health system in every nation is to ensure, sustain, and enhance the health and quality of life for all societal members [3]. In this context, the physical and mental well-being of women holds significant importance due to their professional and social contributions to society [4]. The health of women directly influences the health of their family members, particularly their children; thus, neglecting women’s health can adversely affect future generations [5].

In a 2023 study conducted by Armandpisheh et al., it was found that the rates of stress, depression, and anxiety were greater in women than in men [6]. This observation aligns with earlier research carried out in Iran, which indicated that women are more susceptible to psychiatric disorders [7]. Furthermore, such disorders are also found to be more common in women than in men in various other nations [5]. Factors such as socioeconomic disadvantages, sex hormones, cultural disparities, and violence contribute to the increased prevalence of psychiatric disorders among women [8].

Self-rated health (SRH) serves as a dependable and straightforward metric for assessing general health [9] and is an effective predictor of mortality and individual health status [10]. Research has demonstrated that individuals’ health perceptions largely correspond with evaluations made by healthcare professionals [11]. Numerous factors have been identified as influencing SRH, including demographic, socioeconomic, behavioral, psychological, and disease-related elements [12]. Significant socioeconomic disparities in SRH have been noted, with those of lower socioeconomic status reporting worse SRH outcomes [13].

SRH, also referred to as self-perceived health, is a singular health assessment tool where individuals evaluate their current health condition on a scale of four or five points, ranging from excellent to poor [14]. Prior research indicates that SRH serves as a reliable predictor of mortality associated with various illnesses [15]. Furthermore, numerous scholars have sought to investigate the factors linked to SRH, discovering a strong correlation between SRH and both morbidity [16] and disability [17]. Previous studies have revealed that individuals’ self-evaluation of their health across multiple physical, psychological, and social aspects is statistically significant in relation to social support; those with favorable overall social support tend to report better self-assessments of their health [18,19]. Additionally, physical activity is considered a crucial factor influencing health status, encompassing cardiovascular health, skeletal strength, and psychological wellness [20].

Health behaviors encompass actions or inactions that have a direct or indirect impact on health [21]. These behaviors include habits associated with a healthy lifestyle, such as sleep and exercise [22]. Additionally, certain studies indicate that economic or social factors play a significant role as determinants [23]. Consequently, gaining insight into the factors linked to self-rated health can assist professionals in prioritizing interventions for health promotion and disease prevention [24]. SRH serves as a subjective assessment of health status, often referred to as “perceived” or “subjective” health. This concept has been extensively examined in survey research [25]. Nevertheless, the majority of studies concerning SRH have concentrated on specific age groups, gender groups, or patient populations [26,27].

Currently, in light of evolving trends impacting health and disease, it is crucial to comprehend the elements influencing women’s health. Based on the results of our research, limited studies have examined self-rated health status among women in past years in Iran [28,29], but there has been no study that investigates the association between social support, physical activity, and psychological problems related to self- rated health among women in Iran. Therefore, given the significance of disease prevention among women, this study sought to assess the status of SRH and its correlation with social support, physical activity, and general psychological distress, considering various socio-demographic factors in women.

Methods

Study design and setting

This cross-sectional study was carried out in 2024 involving women aged 18–75 residing in Kermanshah city. Following the acquisition of the ethical code, and considering the socio-economic disparities across different areas of Kermanshah city, data collection was executed separately for the eight regions of the city. The method employed for sampling and selecting neighborhoods was cluster random sampling. Utilizing a random number table, two neighborhoods were randomly chosen from each of the eight regions of Kermanshah city, resulting in a total of 16 neighborhoods.

After obtaining the ethics code from the ethical committee of KUMS (ethics code: IR.KUMS.REC.1403.078), the data collection process began. Data collection was conducted from May 30 to October 15, 2024. Data were gathered in each neighborhood by visiting households and completing questionnaires by women aged 18–75. Households were included in the study based on the sample size calculated for each region in relation to the population. The inclusion criteria for participation in the study encompassed individuals aged 18–75 years, possessing adequate memory and capability to respond to the questionnaire items, while the exclusion criteria comprised a documented history of mental illnesses such as depression as diagnosed by a physician, a history of acute illnesses including cancer, stroke, cardiovascular diseases, etc., significant physical impairments that restricted physical activity, being pregnant, and a lack of willingness to participate in the study after receiving a comprehensive explanation of the research and its objectives, along with assurances regarding the confidentiality of the information provided. For participants which was unable to complete the questionnaire for any reason, trained interviewers were employed and asked the questions and then recorded their answers, confidentially.

Participants

To determine the sample size, the correlation coefficient of 0.24, which reflects the relationship between social support and SRH as reported in the study by Movahed et al., [30] was employed. Utilizing the sample size formula, it was projected that 290 women would be necessary. Considering a 20% non-response rate for the study, the final estimated sample size was determined to be at least 348 individuals. In the Sahebi et al.‘s study [31], the eight districts of Kermanshah city were classified into three categories: poor districts [2,3,9], medium districts [1,5,6], and good districts [4,8] based on the livability index, which encompasses three dimensions: socio-cultural, economic, and environmental. Consequently, participants were chosen utilizing the cluster random sampling technique. Each district comprises multiple neighborhoods that differ greatly in terms of socio economic status. Therefore, according to the research team’s decision, two neighborhoods were randomly chosen from each district (totally 16 neighborhoods. The requirements for participating in the study included women aged 18–75 years, willing to participate in the study, not having sensory perception disorders or mental retardation, and the ability to speak and understand Persian or Kurdish.

Variables

The primary instrument for data collection in this research was a questionnaire that comprised five distinct sections. The initial section gathered demographic details about the participants, which included relevant past behaviors such as their history of professional physical activity, involvement in sports classes, and the duration of time spent watching television and playing computer games. Additionally, personal factors were assessed, including age, gender, marital status, body mass index, educational level, occupation, place of residence, region of residence, income, previous medical history, and a self-comparison with others regarding education level, occupation, and income level.

The second section featured the International Physical Activity Questionnaire (IPAQ), designed to evaluate physical activity over the preceding 7 days through a self-reported format consisting of 6 questions. This section categorized individuals into three groups: inactive, minimally active, and highly active. The questionnaire further classified activities into three types: intense (questions 1 and 2), moderate (questions 3 and 4), and walking (questions 5 and 6). For intense activities, a coefficient of 8 was assigned, while moderate activities received a coefficient of 4, and moderate walking was assigned a coefficient of 3.3. After establishing these coefficients, the daily time spent on each activity type and the number of days per week dedicated to that activity were calculated and multiplied [32,33]. Ultimately, the resulting figures were input into STATA in a similar manner.

The third section was the Depression, Anxiety, and Stress Scale (DASS-21) for measuring general psychological distress and symptoms related to depression, anxiety, and stress. This scale was created by Lovibond in 1995, and its validity and reliability have been previously assessed by Moradipanah et al., in Iran [34]. The questionnaire consists of 21 items, which include 8 items pertaining to depression (D), 7 items concerning anxiety (A), and 6 items related to stress (S). In this assessment, individuals were instructed to indicate their moods over the past week based on the statements provided in the questionnaire, categorized into four groups. The response options were organized into four categories: (0; not at all), (1; little), (2; much), and (3; very much). The correlation of this scale with the Beck Depression Inventory (BDI) and the Eysenck Anxiety Inventory was found to be significant. The alpha values in a sample of 400 were reported as 70% for depression, 66% for anxiety, and 76% for stress, with the correlation of the depression subscale with the Beck Depression Inventory (BDI) being 0.70, the anxiety subscale with the Eysenck Anxiety Inventory at 0.75, and the stress subscale with the Perceived Stress Inventory at 0.49 [35].

The fourth section pertains to the Vaux Social Support Questionnaire. This questionnaire was created by Vaux et al., [36] utilizing Cobb’s definition of social support. Its validity was assessed in Iran during the research conducted by Ebrahimi Ghavam et al., [37] involving 100 and 200 students. The reliability of the test within the student sample was determined to be 0.90 for the overall scale, 0.7 for the student sample, and 0.81 in a retest conducted six weeks later. In the research carried out by Karimi et al., [38] and colleagues, the alpha coefficient calculated for this questionnaire was found to be 0.74. This questionnaire is composed of three dimensions and includes 23 questions. Each dimension concerning social support from friends and family was evaluated with 8 questions, while the dimension related to other sources of social support was assessed with 7 questions. The scoring for the questions is as follows: strongly disagree [1], disagree [2], no opinion [3], agree [4], and strongly agree [5]. A higher score signifies greater social support.

The fifth section was a survey question created by the World Health Organization (WHO) for measuring Self-rated health (SRH) [39]. This survey question serving as a tool for predicting mortality rates in populations both with and without cardiovascular disease [39,40]. In numerous countries, surveys that prompt participants to evaluate their overall health on a five-point scale (ranging from excellent to poor) have gained popularity as a health indicator [41,42]. Participants were inquired, “how do you feel about your health?”, and their health status was classified according to the five-point Likert scale: “very good”, “good”, “fair”, “poor”, or “very poor”. Utilizing this scale, SRH is categorized into poor SRH and good SRH [39].

Statistical analysis

Descriptive statistics, including frequency, percentage, mean, and standard deviation, were calculated to summarize participants’ demographic and study variables. The dependent variable, self-rated health (SRH), originally measured on a 5-point Likert scale (from very poor to very good), was dichotomized into two categories: poor SRH (very poor/poor/fair) and good SRH (good/very good). This dichotomization was performed to facilitate binary logistic regression analysis and is consistent with prior studies using SRH as a global health indicator. To examine the association between demographic characteristics, social support, physical activity, and psychological problems with SRH, binary logistic regression analysis was performed. Initially, univariable (crude) logistic regression models were fitted to assess the unadjusted associations between each independent variable and SRH. Variables with a p-value < 0.20 in the crude analysis were entered into the multivariable (adjusted) model to control for potential confounding effects. Before running the final model, multicollinearity among independent variables was examined using the variance inflation factor (VIF) and tolerance statistics, with VIF values < 2.5 indicating acceptable collinearity. The overall model fit was evaluated using the Hosmer–Lemeshow goodness-of-fit test and Nagelkerke R² to assess the explanatory power of the model. Results of the logistic regression are reported as odds ratios (ORs) with 95% confidence intervals (CIs). A two-tailed p-value < 0.05 was considered statistically significant. All analyses were performed using STATA version 18.

Results

Participants

According to the results of Table 1, most of the participants were under 30 years (46%), married (55.71%), urban (91.42%). 67.14% had an academic degree. In addition, 41.42% received health information by social networks. 67.14% had history of chronic disease. 41.42% didn’t do any social activities, typically. 69.14% of participants were evaluated their self-rated health status as good.

Table 1. Demographic characteristics of the respondents by self- rated health status.

Demographic characteristics Self- rated health status
Good, N (%) Poor, N (%)
Self-rated health status 242 (69.14) 108 (30.86)
Age <24 71(29.34) 8 (7.41)
25-29 63 (26.03) 19 (17.59)
30-34 22 (9.09) 10 (9.26)
35-39 30 (12.4) 25 (23.15)
40-45 27 (11.16) 21(19.44)
46-51 13 (5.37) 5 (4.63)
>52 16 (6.61) 20 (18.52)
Education Preliminary 10 (4.13) 16 (14.81)
Secondary (guidance) 11(4.55) 7 (6.48)
High school 48 (19.83) 23 (21.3)
Academic 173 (71.49) 62 (57.41)
Marital status Single 128 (52.89) 27 (25)
Married 114 (47.11) 81(75)
Job status Retired 16 (6.61) 15 (13.89)
Unemployed 8 (3.31) 7 (6.48)
Employed 63 (26.03) 27 (25)
Other 155 (64.04) 69 (35.96)
Place of residence Urban 227 (93.8) 93 (86.11)
Rural 15 (6.2) 15 (13.89)
Home ownership Private 185 (76.45) 76 (70.37)
Rental 44 (18.18) 24 (22.22)
Other 13 (5.37) 8 (7.41)
Child numbers 0 158 (65.29) 36 (33.33)
1 33 (13.64) 29 (26.85)
2 33 (13.64) 22 (20.37)
3 18 (7.44) 21(19.44)
Supplementary insurance Yes 85 (35.12) 52 (48.15)
No 157 (64.88) 56 (51.85)
Source of received health information Public Media 45 (18.6) 29 (26.85)
Physician 80 (33.06) 36 (33.33)
Social Networks 106 (43.8) 39 (36.11)
Other 11 (4.55) 4 (3.7)
History of chronic disease Yes 52 (21.49) 63 (58.33)
No 190 (78.51) 45 (41.67)
Evaluation of your financial status Very good 13 (5.37) 3 (2.78)
Good 61 (25.21) 6 (5.56)
Not good, not bad 115 (47.52) 60 (55.56)
Poor 35 (14.46) 30 (27.78)
Very poor 18 (7.44) 9 (8.33)
People who support you Family 171 (70.66) 82 (75.93)
Closed relatives 13 (5.37) 8 (7.41)
Friend 58 (23.97) 18 (16.67)
Social activities you do typically Charitable Activities 12 (4.96) 6 (5.56)
Non-profit Activities 29 (11.98) 14 (12.96)
Religious Activities 15 (6.2) 14 (12.96)
Public Sports Activities 17 (7.02) 3 (2.78)
No Activities 139 (57.44) 56 (51.85)
Mixed activities 30 (12.4) 15 (13.89)

Main results

As shown in Table 2, there were a significant positive relationship between age, place of residence, history of chronic disease, evaluation of your financial status and self-rated health in both crude and adjusted models. So that, the odds of poor SRH in older women was 1.28 times higher than others (OR=1.28, CI: [1.04, 1.57], p < 0.001) and odds of poor SRH in those with higher education status was 1.27 times higher than others women (OR=1.27, CI: [0.89, 1.82], p < 0.001). In addition, the odds of poor SRH in women who live in rural region was 1.27 times higher than women who live in urban region (OR=1.27, CI: [1.06, 6.83], p < 0.03) and the odds of poor SRH in women who evaluate your financial status at very good status was 0.11 times more than others (OR=0.11, CI: [0.46, 0.94], p < 0.02).

Table 2. Logistic regression analysis the relationship between characteristics of the respondents, social support, and physical activity, depression, anxiety, stress, and poor self-rated health (SRH).

Variables Poor Self-Rated Health (SRH)
Crude model Adjusted model
OR SE P > |z| [95% CI] OR SE P > |z| [95% CI]
Age 1.38 0.08 0.00 1.23, 1.56 1.28 0.13 0.01 1.04, 1.57
Education 0.64 0.08 0.00 0.5, 0.82 1.27 0.23 0.17 0.89, 1.82
Marital status Single Ref.
Married 3.36 0.86 0.00 2.03, 5.57 1.81 0.7 0.12 0.85, 3.89
Place of residence Urban Ref.
Rural 2.44 0.94 0.02 1.14, 5.19 2.69 1.27 0.03 1.06, 6.83
Home ownership Private Ref.
Rental 1.32 0.38 0.32 0.75, 2.33
Other 1.49 0.7 0.38 0.59, 3.76
Child numbers 1.71 0.18 0.00 1.38, 2.12 1.04 0.19 0.81 0.72, 1.51
Supplementary insurance No Ref.
Yes 1.71 0.4 0.02 1.08, 2.71 1.54 0.45 0.13 0.87, 2.74
Source of received health information Public Media Ref.
Physician 1.43 0.44 0.24 0.77, 2.63
Social Networks 0.81 0.22 0.46 0.47, 1.4
Other 0.8 0.49 0.73 0.24, 2.71
History of chronic disease No Ref.
Yes 5.11 1.27 0.00 3.13, 8.35 2.95 0.89 0.00 1.63, 5.36
Evaluation of your financial status 0.62 0.08 0.00 0.48, 0.8 0.66 0.11 0.02 0.46, 0.94
People who support you Family Ref.
Closed relatives 1.28 0.6 0.59 0.51, 3.21 0.54 0.31 0.3 0.17, 1.71
Friends 0.64 0.19 0.14 0.35, 1.16 0.6 0.21 0.16 0.29, 1.23
Social activities you do typically No Activities Ref.
Charitable Activities 1.24 0.65 0.68 0.44, 3.46
Non-profit Activities 1.19 0.43 0.61 0.58, 2.43
Religious Activities 2.31 0.93 0.03 1.04, 5.11
Public Sports Activities 0.43 0.28 0.2 0.12, 1.55
Mixed activities 1.24 0.43 0.54 0.62, 2.48
Social Support 1.04 0.00 0.00 1.02, 1.06 1.01 0.01 0.18 0.99, 1.04
Physical Activity 0.93 0.21 0.77 0.59, 1.47 0.59 0.17 0.07 0.33, 1.06
Depression, Anxiety, Stress 1.05 0.01 0.00 1.03, 1.07 1.04 0.01 0.001 1.02, 1.07

Furthermore, the positive significant relationship was observed between physical activity, DASS and poor SRH in adjusted model. So that, the odds of poor SRH in women who had more physical activity was 0.59 times higher than others. Also, the odds of poor SRH in women who achieved higher DASS score was 1.04 times higher than others.

Discussion

This study aimed to investigate the role of social support, physical activity, psychological disorders, and demographic characteristics in SRH among women. Most participants rated their health as “good” (69.14%). The findings indicated several results that illuminate the significance of social support, depression, anxiety, stress, and demographic factors in influencing self-rated health. Following the adjustment for possible confounding variables, the research discovered that the depression, anxiety, stress score, and demographic factors such as age, place of residence, history of chronic disease, and favorable financial status were linked to poor SRH.

In crude model SRH were significantly associated with social support. This is consistent with the results of a study by Matud et al., which states that women and men who had higher social support had better self-rated health [43]. In addition, in this study, the relationship between general psychological distress and SRH was statistically significant and in the research conducted by Zhang et al., [44] psychosomatic ailments emerged as the predominant factors in establishing a rating framework for self-rated health status. The results from the research conducted by Barkhordari-Sharifabad et al., indicated that social support is inversely related to symptoms of anxiety and depression [45]. Gutiérrez-Sánchez et al., [46] and Tadayon et al., [47] demonstrated in their study that receiving sufficient social support correlates with an improved quality of life and reduced levels of depression when compared to those who receive less social support. Social support can be regarded as a significant factor in mitigating the risk of developing mental health disorders. It is noted that social support is inversely related to symptoms of depression and anxiety in individuals [45], and those who have social support tend to experience greater efficacy along with reduced anxiety and depression [48].

Particularly, in circumstances where social support is minimal, symptoms of premenstrual syndrome can become exacerbated [49]. This suggests that women lacking social support may exert less effort in addressing their issues, resulting in diminished success in their endeavors. In essence, the absence of understanding and social support from their surroundings adversely affects women’s performance and diminishes their sense of worth and self-esteem. This chain of events can lead to depression and the experience of stress and pressure [50], ultimately influencing their SRH.

Furthermore, findings from additional studies indicated that an increase in the variety of social support received by women correlates with a rise in their engagement in leisure-time physical activities. This outcome aligns with the majority of domestic [5153] and international [5456] research, while contrasting with study conducted by Soto et al., [57]. The discrepancies observed may stem from regional differences where the studies were conducted, as well as variations in cultural contexts and participant characteristics. In the current research, the majority of participants possessed a university degree. Previous research indicates that higher education can enhance problem-solving capabilities and skills, improve individuals’ understanding and analytical abilities, and boost self-confidence levels. Individuals with higher education experience increased social freedom and garner more respect and support [58]. Conversely, educated women tend to participate more in recreational sports activities than their less-educated counterparts. Although individuals with varying educational backgrounds encounter obstacles, the participation rate in sports among those with education levels exceeding a bachelor’s degree is significantly higher than that of others [59]. This increased propensity for physical activity can positively influence individuals’ physical and mental well-being and, as a result, their self-perception of health.

According to the results, SRH were significantly associated with age. Which is in line with the results of the study by Movahed Majd et al., [60]. In such a way that in the aforementioned study, the individual’s self-rated health decreases with increasing age. Generally, health tends to decline as we grow older. This occurs due to physiological changes in the body and a gradual decrease in organ function over time [61]. The velocity and magnitude of these transformations are not uniform across various individuals, and additional determinants such as lifestyle choices, genetic predispositions, and environmental influences also contribute to the overall health of each person [62]. In our study, most participants were under 40 years of age, they received social support from family and friends, did not report a history of chronic disease, so they reported good self-rated health.

In addition, there was a significant relationship between place of residence and SRH. The presence of this noteworthy correlation between social support and self-rated health has been substantiated in the research conducted by Movahed Majd et al., [60] and as social support intensifies, the individual’s self-perceived health assessment has concurrently risen.

SRH were significantly associated with good financial status. In the results of a study conducted among women by Azmand et al., [28] the adequacy of income for living expenses was stated as an influential factor on SRH. In additional research, health was also found to have a substantial correlation with the financial status of individuals [63]. Insufficient income subjects individuals to a greater array of stressors, including inadequate living conditions and economic strain, thereby increasing their vulnerability to mental health disorders [64].

Limitations

One of the limitations of this cross-sectional study is the inability to establish causality. This type of research merely indicates the correlation between variables rather than a definitive cause-and-effect relationship, making it impossible to assert with certainty that one factor led to a change in another. Additionally, another limitation of this study arises from the fact that the variables were gathered via a questionnaire, and the data were obtained through self-reported measures, which introduces the potential for response bias. We acknowledge that the wide interval may introduce heterogeneity. Stratifying participants into narrower age groups could provide more precise insights into age-specific determinants of self-rated health. We will consider this recommendation in future studies and have noted it as a limitation of the current work.

Conclusion

Overall, the results of this research suggest that women’s self- rated health is notably affected by a mix of demographic, socioeconomic, and health-related factors. In addition, psychological problems remained a significant determinant in the adjusted model, such that higher levels of depression, anxiety, and stress were associated with increased odds of poor self-rated health. These findings highlight the essential importance of mental health in conjunction with socioeconomic and clinical elements in influencing individuals’ views on their overall health, stressing the necessity for a holistic approach to both physical and psychological well-being. Considering the rising rates of anxiety, depression, and stress-related disorders, particularly in recent years among women, as well as the influence of women’s health on societal well-being, it is imperative for policymakers in women’s health to pinpoint the underlying causes of mental disorders in women. They should take proactive measures to mitigate these causes, thereby decreasing the prevalence of anxiety, depression, and stress disorders through the implementation of effective interventions. Conducting impactful educational workshops focused on women’s mental health, enhancing and providing access to sports facilities in community settings, offering social support from pertinent organizations, and establishing active non-governmental organizations dedicated to women’s issues are among the effective strategies that can be pursued.

Supporting information

S1 File. Results.

(RAR)

pone.0343015.s001.rar (365.8KB, rar)

Data Availability

All relevant data are within the paper and its Supporting Information file.

Funding Statement

The author(s) received no specific funding for this work.

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Decision Letter 0

Zahra Lorigooini

9 Oct 2025

Dear Dr. Darvishigilan,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

==============================

ACADEMIC EDITOR:

  • After reviewing the editorial, I found that the study topic is relevant; however, several important issues need to be addressed before further consideration.

    Foremost, although an ethics code (IR.KUMS.REC.1403.078) is provided, there is no IRCT registration number. Please clarify it.

    Next, the statistical analysis needs to be revised and clarified. The logistic regression model lacks information on variable selection, control for confounders, assumption testing (normality, multiple collinearity), and goodness-of-fit assessment. Confidence intervals for several odds ratios are missing, and the SRH duality needs to be justified.

    3rd, please confirm obviously that the study population and dataset are completely independent of the population used in your previously published article in Scientific Reports (2025; DOI: 10.1038/s41598-024-79835-9)

    Lastly, the manuscript requires significant improvements in language and formatting, including the correction of grammatical errors, consistent verb tense usage, and proper reference formatting.

    Please review the manuscript in its entirety and provide a detailed and point-by-point response. The revised version will be reevaluated for compliance with PLOS ONE's guidelines to be processed by reviewers.

Please submit your revised manuscript by Nov 23 2025 11:59PM. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at plosone@plos.org . When you're ready to submit your revision, log on to https://www.editorialmanager.com/pone/ and select the 'Submissions Needing Revision' folder to locate your manuscript file.

  • A rebuttal letter that responds to each point raised by the academic editor and reviewer(s). You should upload this letter as a separate file labeled 'Response to Reviewers'.

  • A marked-up copy of your manuscript that highlights changes made to the original version. You should upload this as a separate file labeled 'Revised Manuscript with Track Changes'.

  • An unmarked version of your revised paper without tracked changes. You should upload this as a separate file labeled 'Manuscript'.

If you would like to make changes to your financial disclosure, please include your updated statement in your cover letter. Guidelines for resubmitting your figure files are available below the reviewer comments at the end of this letter.

If applicable, we recommend that you deposit your laboratory protocols in protocols.io to enhance the reproducibility of your results. Protocols.io assigns your protocol its own identifier (DOI) so that it can be cited independently in the future. For instructions see: https://journals.plos.org/plosone/s/submission-guidelines#loc-laboratory-protocols . Additionally, PLOS ONE offers an option for publishing peer-reviewed Lab Protocol articles, which describe protocols hosted on protocols.io. Read more information on sharing protocols at https://plos.org/protocols?utm_medium=editorial-email&utm_source=authorletters&utm_campaign=protocols .

We look forward to receiving your revised manuscript.

Kind regards,

Zahra Lorigooini

Academic Editor

PLOS ONE

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[Note: HTML markup is below. Please do not edit.]

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PLoS One. 2026 Feb 23;21(2):e0343015. doi: 10.1371/journal.pone.0343015.r002

Author response to Decision Letter 1


15 Oct 2025

Dear editorial board of Journal of Plos One

Thanks for providing the comments of the respectful reviewer to us. We tried to revise the manuscript, titled “The Influence of Social Support, Physical Activity, psychological problems, and Demographic Characteristics on Self-Reported Health Status among Women” based on the comments and respond it in the following table. Revisions has been shown as highlight in the manuscript. Hope the revisions are satisfactory now. However, we welcome any further constructive comments if required.

Dr. Hadi Darvishigilan

Corresponding author

Comments Response

1. Foremost, although an ethics code (IR.KUMS.REC.1403.078) is provided, there is no IRCT registration number. Please clarify it. Thank you for your comments. This study is not a clinical trial study, so it does not have an IRCT code.

This study is the result of a research project conducted with code 4030146 from Kermanshah University of Medical Sciences.

2. The statistical analysis needs to be revised and clarified. The logistic regression model lacks information on variable selection, control for confounders, assumption testing (normality, multiple collinearity), and goodness-of-fit assessment. Confidence intervals for several odds ratios are missing, and the SRH duality needs to be justified. We appreciate your valuable comments. The section on Statistical analysis has been thoroughly revised to provide greater clarity and methodological transparency.

3. Please confirm obviously that the study population and dataset are completely independent of the population used in your previously published article in Scientific Reports (2025; DOI: 10.1038/s41598-024-79835-9) The mentioned study (DOI: 10.1038/s41598-024-79835-9) is the result of a research project with the code 4020003, which was conducted in early 2023 with the participation of 495 people aged 18 to 75 (men and women). This is while the submitted manuscript is the result of another research project with the code 4030146, which was conducted in 2024. The participants were 350 women aged 18 to 75, and the data from this study is completely independent of the study published in the journal Scientific Reports.

4. Lastly, the manuscript requires significant improvements in language and formatting, including the correction of grammatical errors, consistent verb tense usage, and proper reference formatting. The manuscript was improved in language and formatting.

Attachment

Submitted filename: Editors Comments Response..docx

pone.0343015.s003.docx (23.4KB, docx)

Decision Letter 1

Zahra Lorigooini

5 Dec 2025

Dear Dr. Darvishigilan,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

Please submit your revised manuscript by Jan 19 2026 11:59PM. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at plosone@plos.org . When you're ready to submit your revision, log on to https://www.editorialmanager.com/pone/ and select the 'Submissions Needing Revision' folder to locate your manuscript file.

  • A rebuttal letter that responds to each point raised by the academic editor and reviewer(s). You should upload this letter as a separate file labeled 'Response to Reviewers'.

  • A marked-up copy of your manuscript that highlights changes made to the original version. You should upload this as a separate file labeled 'Revised Manuscript with Track Changes'.

  • An unmarked version of your revised paper without tracked changes. You should upload this as a separate file labeled 'Manuscript'.

If you would like to make changes to your financial disclosure, please include your updated statement in your cover letter. Guidelines for resubmitting your figure files are available below the reviewer comments at the end of this letter.

If applicable, we recommend that you deposit your laboratory protocols in protocols.io to enhance the reproducibility of your results. Protocols.io assigns your protocol its own identifier (DOI) so that it can be cited independently in the future. For instructions see: https://journals.plos.org/plosone/s/submission-guidelines#loc-laboratory-protocols . Additionally, PLOS ONE offers an option for publishing peer-reviewed Lab Protocol articles, which describe protocols hosted on protocols.io. Read more information on sharing protocols at https://plos.org/protocols?utm_medium=editorial-email&utm_source=authorletters&utm_campaign=protocols .

We look forward to receiving your revised manuscript.

Kind regards,

Zahra Lorigooini

Academic Editor

PLOS One

Journal Requirements:

1. If the reviewer comments include a recommendation to cite specific previously published works, please review and evaluate these publications to determine whether they are relevant and should be cited. There is no requirement to cite these works unless the editor has indicated otherwise.

[Note: HTML markup is below. Please do not edit.]

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

Reviewer #1: All comments have been addressed

Reviewer #2: (No Response)

Reviewer #3: (No Response)

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2. Is the manuscript technically sound, and do the data support the conclusions??>

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Partly

**********

3. Has the statistical analysis been performed appropriately and rigorously? -->?>

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: I Don't Know

**********

4. Have the authors made all data underlying the findings in their manuscript fully available??>

The PLOS Data policy

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: No

**********

5. Is the manuscript presented in an intelligible fashion and written in standard English??>

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

**********

Reviewer #1:

To the Editor

PLOS ONE

Dear Editor,

Thank you very much for inviting me to read the paper titled, " The Influence of Social Support, Physical Activity, psychological problems, and Demographic Characteristics on Self-Reported Health Status among Women".

Overall, as a reader of the paper, I felt that the paper is very well written and have important content for professionals in the relevant fields.

Congratulations to the authors for their wonderful work.

Reviewer #2: General Comments:

- The topic is very interesting and relevant to contemporary women’s health issues. The authors aimed to assess how social support, physical activity, mental health, and sociodemographic characteristics among women affect their self-perceived health status. For this goal, the authors used appropriate tools.

- Self-reported health is a crucial data source for healthcare providers, researchers, and decision-makers.

- We suggest specifying the context of the study in the title and abstract (in Iran).

- We recommend using the STROBE checklist for observational studies to report the study.

Specific comments:

Introduction

Overall, the introduction is well written and clear. The authors described the relevance of the topic. However, the existence of 5 concepts (4 exposures and 1 outcome) in the study may make things hard to assimilate. Therefore, please specify why the authors chose to assess these four exposures in relation to self-reported health.

Line 99-101: The idea expression is complex to understand. Please avoid using too many linking adverbs consecutively (additionally, consequently, etc.)

Line 109: Provide a reference to research conducted that reveals that studies concerning the factors associated with SRH in Iran are quite scarce.

Methods

I don't agree with the methods’ section structure. We recommend using the STROBE checklist for observational studies to report on the study, especially the methods section.

Line 116: The research should have one design, descriptive or analytic. In this case, the study is an analytic cross-sectional. The authors could simply write “cross-sectional study”.

Line 129: The authors should report the minimal sample size is 348, and report 350 in the results section.

Line 145: women included in this were aged 18 to 75 years. I can see a huge difference in age in this population, and I wonder if a 75-year-old woman can recall her daily life habits for physical activity, or if she can do physical activity. I think that this age interval is so large that it can affect the study result because of the difference in age characteristics.

-Are pregnant women included in the study? Pregnant women have a specific need for social support and adaptive physical activity. This should be specified in the inclusion and exclusion criteria.

Line 152: Using two different data collection strategies (questionnaire for participants and interview for others) in the study creates information bias. How did the authors manage this?

Line 174: DASS is a measurement tool for mental health status. “Mental health” is more appropriate than “psychological disorders.”

Line 211-213: I do not agree with the authors to perform binary logistic regression should be performed because OR is applicable for case-control studies. However, linear logistic regression is correct and suitable for this study. We recommend performing a multivariable linear regression analysis or at least providing a reliable argumentation regarding the choice of logistic regression.

Results

As mentioned above, I think that the age interval (18 to 75 years) is too large, which can affect the study results due to the difference in age characteristics (developmental patterns are different in each age category). The authors would rather present the data according to age groups (young and adult women (18 to 40 years, middle adulthood women 41 to 65 years, and old women aged more than 65 years).

Discussion

Discussion is missing limitations of the study and its implications for practice

Reviewer #3: References used in the manuscript are outdated. I recommend updating the literature with more recent studies(3-5 years)

**********

what does this mean? ). If published, this will include your full peer review and any attached files.

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Reviewer #1: No

Reviewer #2: Yes: Dr Maha Dardouri

Reviewer #3: Yes: mobin ebrahimain

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PLoS One. 2026 Feb 23;21(2):e0343015. doi: 10.1371/journal.pone.0343015.r004

Author response to Decision Letter 2


23 Dec 2025

Dear editorial board of Journal of Plos One

Thanks for providing the comments of the respectful reviewer to us. We tried to revise the manuscript, titled “The Influence of Social Support, Physical Activity, General Psychological Distress, and Demographic Characteristics on Self-Reported Health Status among Women in Iran” based on the comments and respond it in the following table. Revisions has been shown as highlight in the manuscript. Hope the revisions are satisfactory now. However, we welcome any further constructive comments if required.

Dr. Hadi Darvishigilan

Corresponding author

Comments Response

Reviewer 1

1. Overall, as a reader of the paper, I felt that the paper is very well written and have important content for professionals in the relevant fields.

Congratulations to the authors for their wonderful work. Many thanks for your attention and times.

Reviewer 2

1. We suggest specifying the context of the study in the title and abstract (in Iran). Many thanks for your comments. It was conducted.

Page 1, line 2 and Page 2, line 41.

Introduction

1. Overall, the introduction is well written and clear. The authors described the relevance of the topic. However, the existence of 5 concepts (4 exposures and 1 outcome) in the study may make things hard to assimilate. Therefore, please specify why the authors chose to assess these four exposures in relation to self-reported health. Many thanks for your comments. Explanations for the reason for choosing four exposures in relation to self-reported health were added to the end of the introduction.

Page 4, lines 106-109 and Page 5, lines 110-112.

2. Line 99-101: The idea expression is complex to understand. Please avoid using too many linking adverbs consecutively (additionally, consequently, etc.) Many thanks for your comments. It was revised. Page 4, lines 96-101.

3. Line 109: Provide a reference to research conducted that reveals that studies concerning the factors associated with SRH in Iran are quite scarce. Many thanks for your comments. It was conducted.

Page 4, lines 106-107.

Methods

1. I don't agree with the methods’ section structure. We recommend using the STROBE checklist for observational studies to report on the study, especially the methods section. Many thanks for your comments. The method's section structure was revised based on the STROBE checklist.

2. Line 116: The research should have one design, descriptive or analytic. In this case, the study is an analytic cross-sectional. The authors could simply write “cross-sectional study”. Many thanks for your comments. It was revised. Page 1, line 2. Page 2 , line 41.

3. Line 129: The authors should report the minimal sample size is 348, and report 350 in the results section. Many thanks for your comments. It was revised. Page 1, line 41 and Page 5, line 116.

4. Line 145: women included in this were aged 18 to 75 years. I can see a huge difference in age in this population, and I wonder if a 75-year-old woman can recall her daily life habits for physical activity, or if she can do physical activity. I think that this age interval is so large that it can affect the study result because of the difference in age characteristics. The fact that the reviewer noted the good variety of age (18-75 years) of participants and the possibility of the differences between the memories of daily habits and physical activity among older women is insightful. The wide age bracket was chosen deliberately to get a rosy image of self-rated health in women within the community. Age was a covariate in crude and adjusted models of logistic regression, and its strong correlation with self-rated health was controlled. We acknowledge that this broad range can bring about heterogeneity and thus the future research can be stratified by organizing participants into smaller age groups in order to offer age specific information.

This limitation was added to the limitations section.

Page 13, lines 326-330.

5. Are pregnant women included in the study? Pregnant women have a specific need for social support and adaptive physical activity. This should be specified in the inclusion and exclusion criteria. Many thanks for your comments. Pregnant women were not included in this study and were an exclusion criterion. Being pregnant was added to the exclusion criteria in the Methods section.

Page 5, line 131.

6. Line 152: Using two different data collection strategies (questionnaire for participants and interview for others) in the study creates information bias. How did the authors manage this? Many thanks for your comments. The data collection method was not very different, and only in cases where participants were unable to complete the questionnaire for any reason, questions were asked by interviewers and then their responses were recorded confidentially. Hence, there is no possibility of bias.

More explanation added to the method section.

Page 6, lines 134-135.

7. Line 174: DASS is a measurement tool for mental health status. “Mental health” is more appropriate than “psychological disorders.” Many thanks for your comments. Based on the original version of the Depression Anxiety Stress Scales– 21 (DASS-21), this scale is 21-item self-report measure designed to assess the severity of general psychological distress and symptoms related to depression, anxiety, and stress in adults older adolescents (17 years +). So the phrase of “psychological disorders” in the title and other sections was edited.

Page 1, lines 1 and page 2, line 39 and page 7, line 173.

8. Line 211-213: I do not agree with the authors to perform binary logistic regression should be performed because OR is applicable for case-control studies. However, linear logistic regression is correct and suitable for this study. We recommend performing a multivariable linear regression analysis or at least providing a reliable argumentation regarding the choice of logistic regression. We sincerely thank the reviewer for this valuable comment regarding the choice of regression model. In our study, the dependent variable (self-rated health) was dichotomized into two categories (poor vs good SRH). For binary outcomes, logistic regression is widely recommended as the appropriate statistical method, since it estimates odds ratios to quantify the association between predictors and the likelihood of poor SRH. This approach is consistent with established statistical guidelines (Hosmer & Lemeshow, Applied Logistic Regression, 3rd edition).

Page 19, line 217.

Results

1. As mentioned above, I think that the age interval (18 to 75 years) is too large, which can affect the study results due to the difference in age characteristics (developmental patterns are different in each age category). The authors would rather present the data according to age groups (young and adult women (18 to 40 years, middle adulthood women 41 to 65 years, and old women aged more than 65 years). We thank the reviewer for raising this point again. As noted in our response to the previous comment regarding the age variable, all analyses were performed accordingly to control for the confounding effect of age. We added this point as a limitation in our study. Please kindly refer to our earlier response for details.

Page 13, lines 326-330.

Discussion

1. Discussion is missing limitations of the study and its implications for practice. Many thanks for your comments. The limitation section was added to the end of discussion.

Page 13, lines 326-330.

Reviewer 3

1. References used in the manuscript are outdated. I recommend updating the literature with more recent studies (3-5 years). Many thanks for your comments. All references were revised and updated as much as possible.

Attachment

Submitted filename: Reviewers Comments Response..docx

pone.0343015.s004.docx (28.7KB, docx)

Decision Letter 2

Zahra Lorigooini

5 Jan 2026

Dear Dr. Darvishigilan,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

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Zahra Lorigooini

Academic Editor

PLOS One

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

Reviewer #2: All comments have been addressed

Reviewer #3: All comments have been addressed

**********

2. Is the manuscript technically sound, and do the data support the conclusions??>

Reviewer #2: Yes

Reviewer #3: Partly

**********

3. Has the statistical analysis been performed appropriately and rigorously? -->?>

Reviewer #2: Yes

Reviewer #3: I Don't Know

**********

4. Have the authors made all data underlying the findings in their manuscript fully available??>

The PLOS Data policy

Reviewer #2: Yes

Reviewer #3: No

**********

5. Is the manuscript presented in an intelligible fashion and written in standard English??>

Reviewer #2: Yes

Reviewer #3: Yes

**********

Reviewer #2: We would like to thank the authors for addressing all comments. The manuscript now is more relevant and suitable for publication.

Reviewer #3: As previously noted, it is recommended that the references in this section be updated to primarily include sources published within the last 3–5 years, in order to better reflect the current state of knowledge.

**********

what does this mean? ). If published, this will include your full peer review and any attached files.

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Reviewer #2: Yes: Dr Maha Dardouri

Reviewer #3: Yes: Mobin Ebrahimian

**********

[NOTE: If reviewer comments were submitted as an attachment file, they will be attached to this email and accessible via the submission site. Please log into your account, locate the manuscript record, and check for the action link "View Attachments". If this link does not appear, there are no attachment files.]

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NAAS will assess whether your figures meet our technical requirements by comparing each figure against our figure specifications.

PLoS One. 2026 Feb 23;21(2):e0343015. doi: 10.1371/journal.pone.0343015.r006

Author response to Decision Letter 3


7 Jan 2026

Dear editorial board of Journal of Plos One

Thanks for providing the comments of the respectful reviewer to us. We tried to revise the manuscript, titled “The Influence of Social Support, Physical Activity, General Psychological Distress, and Demographic Characteristics on Self-Reported Health Status among Women in Iran” based on the comments and respond it in the following table. Revisions has been shown as highlight in the manuscript. Hope the revisions are satisfactory now. However, we welcome any further constructive comments if required.

Dr. Hadi Darvishigilan

Corresponding author

Comments to the Author Response

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer 1:

All comments have been addressed Many thanks for your attention and time.

Reviewer 2:

All comments have been addressed Many thanks for your attention and time.

2. Is the manuscript technically sound, and do the data support the conclusions?

Reviewer 1:

Yes. Many thanks for your attention and time.

Reviewer 2:

Partly. Many thanks for your comment. The conclusion section was revised.

3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer 1:

Yes. Many thanks for your attention and time.

Reviewer 2:

I Don't Know. Many thanks for your comment. Considering that Dr. Shahab Rezaian (PhD in Epidemiology) has served as a statistical consultant and one of the study authors in various studies and has sufficient skills and expertise in this field, all statistical analysis of the study were performed and rechecked by him. Also, the other authors have sufficient skills and expertise in interpreting and analyzing the results, so there is no concern about the accuracy and precision of the statistical analysis.

4. Have the authors made all data underlying the findings in their manuscript fully available?

Reviewer 1:

Yes. Many thanks for your attention and time.

Reviewer 2:

No. Many thanks for your comment. As stated in the manuscript and in the submission system, all underlying study findings are available in the manuscript, and in the event of any ambiguity, the raw data of the study that has been analyzed and analyzed can be provided upon request.

5. Is the manuscript presented in an intelligible fashion and written in Standard English?

Reviewer 1:

Yes. Many thanks for your attention and time.

Reviewer 2:

Yes. Many thanks for your attention and time.

6. Review Comments to the Author

Reviewer 1: Yes.

We would like to thank the authors for addressing all comments. The manuscript now is more relevant and suitable for publication. Many thanks for your attention and time.

Reviewer 2: Yes.

As previously noted, it is recommended that the references in this section be updated to primarily include sources published within the last 3–5 years, in order to better reflect the current state of knowledge. Thanks for the comment from the respected referee. Older references have been updated. Currently, after updating the references, only references 29 and 31-41 are older, and given that these studies describe the initial design of the questionnaires used in this study in other contexts and their validity and reliability in Iran, it is not possible to update them.

Attachment

Submitted filename: Reviewers Comments Response.2ndR.docx

pone.0343015.s005.docx (26.4KB, docx)

Decision Letter 3

Zahra Lorigooini

1 Feb 2026

The Influence of Social Support, Physical Activity, General Psychological Distress, and Demographic Characteristics on Self-Reported Health Status among Women in Iran

PONE-D-25-48364R3

Dear Dr. Darvishigilan,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

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Kind regards,

Zahra Lorigooini

Academic Editor

PLOS One

Additional Editor Comments (optional):

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

Reviewer #2: All comments have been addressed

Reviewer #3: All comments have been addressed

**********

2. Is the manuscript technically sound, and do the data support the conclusions??>

Reviewer #2: Yes

Reviewer #3: Partly

**********

3. Has the statistical analysis been performed appropriately and rigorously? -->?>

Reviewer #2: Yes

Reviewer #3: I Don't Know

**********

4. Have the authors made all data underlying the findings in their manuscript fully available??>

The PLOS Data policy

Reviewer #2: Yes

Reviewer #3: Yes

**********

5. Is the manuscript presented in an intelligible fashion and written in standard English??>

Reviewer #2: Yes

Reviewer #3: Yes

**********

Reviewer #2: All comments have been addressed. We have no other suggestions for the author to address.

The manuscript now is suitable for publication.

Reviewer #3: The authors have satisfactorily addressed all previous comments. The manuscript is clear, compliant with PLOS policies, and suitable for publication. I recommend acceptance.

**********

what does this mean? ). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy

Reviewer #2: Yes: Maha Dardouri

Reviewer #3: Yes: Mobin Ebrahimian

**********

Acceptance letter

Zahra Lorigooini

PONE-D-25-48364R3

PLOS One

Dear Dr. Darvishigilan,

I'm pleased to inform you that your manuscript has been deemed suitable for publication in PLOS One. Congratulations! Your manuscript is now being handed over to our production team.

At this stage, our production department will prepare your paper for publication. This includes ensuring the following:

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PLOS ONE Editorial Office Staff

on behalf of

Prof. Zahra Lorigooini

Academic Editor

PLOS One

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    pone.0343015.s004.docx (28.7KB, docx)
    Attachment

    Submitted filename: Reviewers Comments Response.2ndR.docx

    pone.0343015.s005.docx (26.4KB, docx)

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