Skip to main content
Journal of the Royal Society of Medicine logoLink to Journal of the Royal Society of Medicine
. 1990 Nov;83(11):724–730. doi: 10.1177/014107689008301116

Epidemiology of mouth cancer in 1989: a review.

P Boyle 1, G J Macfarlane 1, P Maisonneuve 1, T Zheng 1, C Scully 1, B Tedesco 1
PMCID: PMC1292923  PMID: 2250273

Abstract

The oral cavity and pharynx combined is the sixth commonest site of cancer in both sexes. In many countries the mortality rate is increasing among younger men born since approximately 1910-1920. A causal role in the aetiology of mouth cancer has been established for tobacco use, both smoking and chewing, separately and in conjunction with betel-quid chewing; with alcohol consumption and, less certainly, with other factors such as poor oral hygiene, nutritional factors and certain occupational exposures. In Western countries, there is convincing evidence that a large attributable risk can be ascribed to the joint habits of cigarette smoking and alcohol consumption. In Asian societies, a high attributable risk can be ascribed to cigarette smoking and betel chewing. Mouth cancer is at the same time an important form of cancer, and one for which practical prospects for prevention already exist. Against this background of a continually increasing trend among younger persons, it seems essential to engage upon programmes of prevention, including increasing awareness for early detection, against mouth cancer at the present time.

Full text

PDF
724

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blot W. J., Winn D. M., Fraumeni J. F., Jr Oral cancer and mouthwash. J Natl Cancer Inst. 1983 Feb;70(2):251–253. [PubMed] [Google Scholar]
  2. Boyle P., Zheng T., Macfarlane G. J., McGinn R., Maisonneuve P., LaVecchia C., Scully C. Recent advances in the etiology and epidemiology of head and neck cancer. Curr Opin Oncol. 1990 Jun;2(3):539–545. [PubMed] [Google Scholar]
  3. Brugere J., Guenel P., Leclerc A., Rodriguez J. Differential effects of tobacco and alcohol in cancer of the larynx, pharynx, and mouth. Cancer. 1986 Jan 15;57(2):391–395. doi: 10.1002/1097-0142(19860115)57:2<391::aid-cncr2820570235>3.0.co;2-q. [DOI] [PubMed] [Google Scholar]
  4. Burton-Bradley B. G. Is "betel chewing" carcinogenic? Lancet. 1979 Oct 27;2(8148):903–903. doi: 10.1016/s0140-6736(79)92716-8. [DOI] [PubMed] [Google Scholar]
  5. Dean G., MacLennan R., McLoughlin H., Shelley E. Causes of death of blue-collar workers at a Dublin brewery, 1954--73. Br J Cancer. 1979 Oct;40(4):581–589. doi: 10.1038/bjc.1979.223. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Easson E. C., Palmer M. K. Prognostic factors in oral cancer. Clin Oncol. 1976 Sep;2(3):191–202. [PubMed] [Google Scholar]
  7. Graham S., Dayal H., Rohrer T., Swanson M., Sultz H., Shedd D., Fischman S. Dentition, diet, tobacco, and alcohol in the epidemiology of oral cancer. J Natl Cancer Inst. 1977 Dec;59(6):1611–1618. doi: 10.1093/jnci/59.6.1611. [DOI] [PubMed] [Google Scholar]
  8. Greene M. H., Hoover R. N., Eck R. L., Fraumeni J. F., Jr Cancer mortality among printing plant workers. Environ Res. 1979 Oct;20(1):66–73. doi: 10.1016/0013-9351(79)90085-9. [DOI] [PubMed] [Google Scholar]
  9. Hakulinen T., Andersen A., Malker B., Pukkala E., Schou G., Tulinius H. Trends in cancer incidence in the Nordic countries. A collaborative study of the five Nordic Cancer Registries. Acta Pathol Microbiol Immunol Scand Suppl. 1986;288:1–151. [PubMed] [Google Scholar]
  10. Jussawalla D. J., Deshpande V. A. Evaluation of cancer risk in tobacco chewers and smokers: an epidemiologic assessment. Cancer. 1971 Jul;28(1):244–252. doi: 10.1002/1097-0142(197107)28:1<244::aid-cncr2820280150>3.0.co;2-h. [DOI] [PubMed] [Google Scholar]
  11. Keller A. Z., Terris M. The association of alcohol and tobacco with cancer of the mouth and pharynx. Am J Public Health Nations Health. 1965 Oct;55(10):1578–1585. doi: 10.2105/ajph.55.10.1578. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Klatsky A. L., Friedman G. D., Siegelaub A. B. Alcohol and mortality. A ten-year Kaiser-Permanente experience. Ann Intern Med. 1981 Aug;95(2):139–145. doi: 10.7326/0003-4819-95-2-139. [DOI] [PubMed] [Google Scholar]
  13. Kono S., Ikeda M., Tokudome S., Nishizumi M., Kuratsune M. Alcohol and mortality: a cohort study of male Japanese physicians. Int J Epidemiol. 1986 Dec;15(4):527–532. doi: 10.1093/ije/15.4.527. [DOI] [PubMed] [Google Scholar]
  14. Krolls S. O., Hoffman S. Squamous cell carcinoma of the oral soft tissues: a statistical analysis of 14,253 cases by age, sex, and race of patients. J Am Dent Assoc. 1976 Mar;92(3):571–574. doi: 10.14219/jada.archive.1976.0556. [DOI] [PubMed] [Google Scholar]
  15. Larsson L. G., Sandström A., Westling P. Relationship of Plummer-Vinson disease to cancer of the upper alimentary tract in Sweden. Cancer Res. 1975 Nov;35(11 Pt 2):3308–3316. [PubMed] [Google Scholar]
  16. Lloyd J. W., Decoufle P., Salvin L. G. Unusual mortality experience of printing pressmen. J Occup Med. 1977 Aug;19(8):543–550. [PubMed] [Google Scholar]
  17. MILLS C. A., PORTER M. M. Tobacco smoking habits and cancer of the mouth and respiratory system. Cancer Res. 1950 Sep;10(9):539–542. [PubMed] [Google Scholar]
  18. Marshall J., Graham S., Mettlin C., Shedd D., Swanson M. Diet in the epidemiology of oral cancer. Nutr Cancer. 1982;3(3):145–149. doi: 10.1080/01635588109513716. [DOI] [PubMed] [Google Scholar]
  19. McLaughlin J. K., Gridley G., Block G., Winn D. M., Preston-Martin S., Schoenberg J. B., Greenberg R. S., Stemhagen A., Austin D. F., Ershow A. G. Dietary factors in oral and pharyngeal cancer. J Natl Cancer Inst. 1988 Oct 5;80(15):1237–1243. doi: 10.1093/jnci/80.15.1237. [DOI] [PubMed] [Google Scholar]
  20. Monson R. R., Lyon J. L. Proportional mortality among alcoholics. Cancer. 1975 Sep;36(3):1077–1079. doi: 10.1002/1097-0142(197509)36:3<1077::aid-cncr2820360335>3.0.co;2-e. [DOI] [PubMed] [Google Scholar]
  21. Moss E., Lee W. R. Occurrence of oral and pharyngeal cancers in textile workers. Br J Ind Med. 1974 Jul;31(3):224–232. doi: 10.1136/oem.31.3.224. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Parkin D. M., Lärä E., Muir C. S. Estimates of the worldwide frequency of sixteen major cancers in 1980. Int J Cancer. 1988 Feb 15;41(2):184–197. doi: 10.1002/ijc.2910410205. [DOI] [PubMed] [Google Scholar]
  23. Phillips R. L., Garfinkel L., Kuzma J. W., Beeson W. L., Lotz T., Brin B. Mortality among California Seventh-Day Adventists for selected cancer sites. J Natl Cancer Inst. 1980 Nov;65(5):1097–1107. [PubMed] [Google Scholar]
  24. Robinette C. D., Hrubec Z., Fraumeni J. F., Jr Chronic alcoholism and subsequent mortality in World War II veterans. Am J Epidemiol. 1979 Jun;109(6):687–700. doi: 10.1093/oxfordjournals.aje.a112732. [DOI] [PubMed] [Google Scholar]
  25. Rothman K., Keller A. The effect of joint exposure to alcohol and tobacco on risk of cancer of the mouth and pharynx. J Chronic Dis. 1972 Dec;25(12):711–716. doi: 10.1016/0021-9681(72)90006-9. [DOI] [PubMed] [Google Scholar]
  26. SHANTA V., KRISHNAMURTHI S. A study of aetiological factors in oral squamous cell carcinoma. Br J Cancer. 1959 Sep;13:381–388. doi: 10.1038/bjc.1959.43. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Schmidt W., Popham R. E. The role of drinking and smoking in mortality from cancer and other causes in male alcoholics. Cancer. 1981 Mar 1;47(5):1031–1041. doi: 10.1002/1097-0142(19810301)47:5<1031::aid-cncr2820470534>3.0.co;2-c. [DOI] [PubMed] [Google Scholar]
  28. Svejda J., Kosut V. Epidemiology of malignant tumours with special regards to the orofacial region. Neoplasma. 1971;18(2):193–196. [PubMed] [Google Scholar]
  29. Szpak C. A., Stone M. J., Frenkel E. P. Some observations concerning the demographic and geographic incidence of carcinoma of the lip and buccal cavity. Cancer. 1977 Jul;40(1):343–348. doi: 10.1002/1097-0142(197707)40:1<343::aid-cncr2820400148>3.0.co;2-w. [DOI] [PubMed] [Google Scholar]
  30. Tan K. N. Oral cancer in Australia. Aust Dent J. 1969 Feb;14(1):50–56. doi: 10.1111/j.1834-7819.1969.tb03332.x. [DOI] [PubMed] [Google Scholar]
  31. VOGLER W. R., LLOYD J. W., MILMORE B. K. A retrospective study of etiological factors in cancer of the mouth, pharynx, and larynx. Cancer. 1962 Mar-Apr;15:246–258. doi: 10.1002/1097-0142(196203/04)15:2<246::aid-cncr2820150206>3.0.co;2-5. [DOI] [PubMed] [Google Scholar]
  32. WYNDER E. L., BROSS I. J., FELDMAN R. M. A study of the etiological factors in cancer of the mouth. Cancer. 1957 Nov-Dec;10(6):1300–1323. doi: 10.1002/1097-0142(195711/12)10:6<1300::aid-cncr2820100628>3.0.co;2-2. [DOI] [PubMed] [Google Scholar]
  33. WYNDER E. L., FRYER J. H. Etiologic considerations of Plummer-Vinson (Patterson-Kelly) syndrome. Ann Intern Med. 1958 Nov;49(5):1106–1128. doi: 10.7326/0003-4819-49-5-1106. [DOI] [PubMed] [Google Scholar]
  34. Weaver A., Fleming S. M., Smith D. B. Mouthwash and oral cancer: carcinogen or coincidence? J Oral Surg. 1979 Apr;37(4):250–253. [PubMed] [Google Scholar]
  35. Winn D. M., Blot W. J., Shy C. M., Pickle L. W., Toledo A., Fraumeni J. F., Jr Snuff dipping and oral cancer among women in the southern United States. N Engl J Med. 1981 Mar 26;304(13):745–749. doi: 10.1056/NEJM198103263041301. [DOI] [PubMed] [Google Scholar]
  36. Winn D. M., Ziegler R. G., Pickle L. W., Gridley G., Blot W. J., Hoover R. N. Diet in the etiology of oral and pharyngeal cancer among women from the southern United States. Cancer Res. 1984 Mar;44(3):1216–1222. [PubMed] [Google Scholar]
  37. Wynder E. L., Stellman S. D. Comparative epidemiology of tobacco-related cancers. Cancer Res. 1977 Dec;37(12):4608–4622. [PubMed] [Google Scholar]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press

RESOURCES