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Journal of the Royal Society of Medicine logoLink to Journal of the Royal Society of Medicine
. 1990 Dec;83(12):765–767. doi: 10.1177/014107689008301205

Failure of perception of hypocapnia: physiological and clinical implications.

J C King 1, S D Rosen 1, P G Nixon 1
PMCID: PMC1292948  PMID: 2125316

Abstract

Hyperventilation causes hypocapnia and respiratory alkalosis and thereby predisposes to coronary vasoconstriction and cardiac arrhythmia. Diagnostic methods for use between episodes have not been established. In this study of 100 patients and 25 control subjects the resting end-tidal PCO2 (Pet CO2) levels and the results of a forced hyperventilation test did not show a significant difference between the groups. However the patients hyperventilated more profoundly in response to emotional stimulation, and were less aware of inappropriate breathing and hypocapnia. It is suggested that these differences should be accommodated in cardiac rehabilitation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ayres S. M., Grace W. J. Inappropriate ventilation and hypoxemia as causes of cardiac arrhythmias. The control of arrhythmias without antiarrhythmic drugs. Am J Med. 1969 Apr;46(4):495–505. doi: 10.1016/0002-9343(69)90069-2. [DOI] [PubMed] [Google Scholar]
  2. Freeman L. J., Nixon P. G. Chest pain and the hyperventilation syndrome--some aetiological considerations. Postgrad Med J. 1985 Nov;61(721):957–961. doi: 10.1136/pgmj.61.721.957. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Freeman L. J., Nixon P. G. Dynamic causes of angina pectoris. Am Heart J. 1985 Nov;110(5):1087–1092. doi: 10.1016/0002-8703(85)90221-2. [DOI] [PubMed] [Google Scholar]
  4. King J. C. Hyperventilation--a therapist's point of view: discussion paper. J R Soc Med. 1988 Sep;81(9):532–536. doi: 10.1177/014107688808100913. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. LEWIS B. I. Hyperventilation syndrome: a clinical and physiological evaluation. Calif Med. 1959 Sep;91:121–126. [PMC free article] [PubMed] [Google Scholar]
  6. Ley R. Panic attacks during sleep: a hyperventilation-probability model. J Behav Ther Exp Psychiatry. 1988 Sep;19(3):181–192. doi: 10.1016/0005-7916(88)90039-0. [DOI] [PubMed] [Google Scholar]
  7. Magarian G. J. Hyperventilation syndromes: infrequently recognized common expressions of anxiety and stress. Medicine (Baltimore) 1982 Jul;61(4):219–236. [PubMed] [Google Scholar]
  8. Nixon P. G., Freeman L. J. The 'think test': a further technique to elicit hyperventilation. J R Soc Med. 1988 May;81(5):277–279. doi: 10.1177/014107688808100514. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Nixon P. G., Freeman L. J. What is the meaning of angina pectoris today? Am Heart J. 1987 Dec;114(6):1542–1546. doi: 10.1016/0002-8703(87)90583-7. [DOI] [PubMed] [Google Scholar]
  10. Rozanski A., Bairey C. N., Krantz D. S., Friedman J., Resser K. J., Morell M., Hilton-Chalfen S., Hestrin L., Bietendorf J., Berman D. S. Mental stress and the induction of silent myocardial ischemia in patients with coronary artery disease. N Engl J Med. 1988 Apr 21;318(16):1005–1012. doi: 10.1056/NEJM198804213181601. [DOI] [PubMed] [Google Scholar]
  11. SCHAEFER K. E. Respiratory pattern and respiratory response to CO2. J Appl Physiol. 1958 Jul;13(1):1–14. doi: 10.1152/jappl.1958.13.1.1. [DOI] [PubMed] [Google Scholar]

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