Abstract
The investigation of commercial diving accidents has indicated that the danger of anoxia, from the inhalation of gases not containing oxygen, is not fully recognized. The problem is more common in a variety of general industrial situations and is an occasional cause of death in anaesthesia. It is a particular hazard with inert gases, which, because they are recognized to be non-toxic, give a false sense of security. The pathological findings consist of pulmonary oedema and petechial haemorrhages, mainly in the brain, lungs and myocardium. Whenever possible, a minimum oxygen content should be included in all gases liable to be respired, but where this is not possible, oxygen analysers and alarms should be provided. Where a general hazard exists, personnel must be warned of the danger.
Full text
PDFImages in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Ames A., 3rd, Wright R. L., Kowada M., Thurston J. M., Majno G. Cerebral ischemia. II. The no-reflow phenomenon. Am J Pathol. 1968 Feb;52(2):437–453. [PMC free article] [PubMed] [Google Scholar]
- Burger P. C., Vogel F. S. Hemorrhagic white matter infarction in three critically ill patients. Hum Pathol. 1977 Mar;8(2):121–132. doi: 10.1016/s0046-8177(77)80075-0. [DOI] [PubMed] [Google Scholar]
- Feldman K. W., Herndon S. P. Positive expiratory pressure for the treatment of high-altitude pulmonary oedema. Lancet. 1977 May 14;1(8020):1036–1037. doi: 10.1016/s0140-6736(77)91263-6. [DOI] [PubMed] [Google Scholar]
- Goldbaum L. R., Ramirez R. G., Absalon K. B. What is the mechanism of carbon monoxide toxicity? Aviat Space Environ Med. 1975 Oct;46(10):1289–1291. [PubMed] [Google Scholar]
- JACOBSON I., HARPER A. M., MCDOWALL D. G. THE EFFECTS OF OXYGEN UNDER PRESSURE ON CEREBRAL BLOOD-FLOW AND CEREBRAL VENOUS OXYGEN TENSION. Lancet. 1963 Sep 14;2(7307):549–549. doi: 10.1016/s0140-6736(63)92644-8. [DOI] [PubMed] [Google Scholar]
- Kogure K., Scheinberg P., Reinmuth O. M., Fujishima M., Busto R. Mechanisms of cerebral vasodilatation in hypoxia. J Appl Physiol. 1970 Aug;29(2):223–229. doi: 10.1152/jappl.1970.29.2.223. [DOI] [PubMed] [Google Scholar]
- Oelz O. High altitude cerebral oedema after positive airway pressure breathing at high altitude. Lancet. 1983 Nov 12;2(8359):1148–1148. doi: 10.1016/s0140-6736(83)90666-9. [DOI] [PubMed] [Google Scholar]
- Olesen S. P. Rapid increase in blood-brain barrier permeability during severe hypoxia and metabolic inhibition. Brain Res. 1986 Mar 12;368(1):24–29. doi: 10.1016/0006-8993(86)91038-3. [DOI] [PubMed] [Google Scholar]
- Singh I., Khanna P. K., Srivastava M. C., Lal M., Roy S. B., Subramanyam C. S. Acute mountain sickness. N Engl J Med. 1969 Jan 23;280(4):175–184. doi: 10.1056/NEJM196901232800402. [DOI] [PubMed] [Google Scholar]
- Sukoff M. H., Ragatz R. E. Hyperbaric oxygenation for the treatment of acute cerebral edema. Neurosurgery. 1982 Jan;10(1):29–38. [PubMed] [Google Scholar]
- Troiano R., Hafstein M., Ruderman M., Dowling P., Cook S. Effect of high-dose intravenous steroid administration on contrast-enhancing computed tomographic scan lesions in multiple sclerosis. Ann Neurol. 1984 Mar;15(3):257–263. doi: 10.1002/ana.410150309. [DOI] [PubMed] [Google Scholar]
- Vaagenes P., Kjekshus J., Torvik A. The relationship between cerebrospinal fluid creatine kinase and morphologic changes in the brain after transient cardiac arrest. Circulation. 1980 Jun;61(6):1194–1199. doi: 10.1161/01.cir.61.6.1194. [DOI] [PubMed] [Google Scholar]