Abstract
Preoperative treatment with controlled-release ketoprofen or diclofenac was compared in 56 out-patients, for control of postoperative dental pain, following unilateral or bilateral surgical removal of lower third molars. Six patients were excluded due to non-compliance, leaving 50 evaluable patients. Patients were assessed by the dental surgeon, on the day of the operation and one week later, prior to removal of sutures. Additionally, patients completed a daily diary during the postoperative week. Following surgery, scores for graded dental pain, consumption of paracetamol, incidence of dental bleeding, dysphagia, sleep disturbance and trismus were similar for the two treatment groups. However, median pain scores were consistently elevated in the diclofenac group over those seen with the ketoprofen group. The four adverse events reported were all minor and posed no problem to patient management.
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Selected References
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- Dionne R. A., Wirdzek P. R., Fox P. C., Dubner R. Suppression of postoperative pain by the combination of a nonsteroidal anti-inflammatory drug, flurbiprofen, and a long-acting local anesthetic, etidocaine. J Am Dent Assoc. 1984 Apr;108(4):598–601. doi: 10.14219/jada.archive.1984.0385. [DOI] [PubMed] [Google Scholar]
- Fowler P. D., Dawes P. T., John V. A., Shotton P. A. Plasma and synovial fluid concentrations of diclofenac sodium and its hydroxylated metabolites during once-daily administration of a 100 mg slow-release formulation. Eur J Clin Pharmacol. 1986;31(4):469–472. doi: 10.1007/BF00613526. [DOI] [PubMed] [Google Scholar]
- Frame J. W., Evans C. R., Flaum G. R., Langford R., Rout P. G. A comparison of ibuprofen and dihydrocodeine in relieving pain following wisdom teeth removal. Br Dent J. 1989 Feb 25;166(4):121–124. doi: 10.1038/sj.bdj.4806746. [DOI] [PubMed] [Google Scholar]
- Houghton G. W., Dennis M. J., Rigler E. D., Parsons R. L. Comparative pharmacokinetics of ketoprofen derived from single oral doses of ketoprofen capsules or a novel sustained-release pellet formulation. Biopharm Drug Dispos. 1984 Jul-Sep;5(3):203–209. doi: 10.1002/bdd.2510050302. [DOI] [PubMed] [Google Scholar]
- Lindgren U., Djupsjö H. Diclofenac for pain after hip surgery. Acta Orthop Scand. 1985 Feb;56(1):28–31. doi: 10.3109/17453678508992974. [DOI] [PubMed] [Google Scholar]
- Matthews R. W., Scully C. M., Levers B. G. The efficacy of diclofenac sodium (Voltarol) with and without paracetamol in the control of post-surgical dental pain. Br Dent J. 1984 Nov 24;157(10):357–359. doi: 10.1038/sj.bdj.4805486. [DOI] [PubMed] [Google Scholar]
- McCrea J. D., Telford A. M., Kaye C. M., Boyd M. W. A comparison of plasma and synovial fluid profiles of standard and controlled-release formulations of ketoprofen in patients with rheumatoid arthritis. Curr Med Res Opin. 1986;10(2):73–81. doi: 10.1185/03007998609110422. [DOI] [PubMed] [Google Scholar]
- Mehlisch D., Frakes L., Cavaliere M. B., Gelman M. Double-blind parallel comparison of single oral doses of ketoprofen, codeine, and placebo in patients with moderate to severe dental pain. J Clin Pharmacol. 1984 Nov-Dec;24(11-12):486–492. doi: 10.1002/j.1552-4604.1984.tb02757.x. [DOI] [PubMed] [Google Scholar]
- Mitchell D. A., Ward-Booth P., Seymour R. A. A comparative study of the efficacy of aspirin and an ibuprofen/codeine combination in patients treated pre-operatively with methylprednisolone acetate. Br Dent J. 1985 Aug 10;159(3):78–81. doi: 10.1038/sj.bdj.4805649. [DOI] [PubMed] [Google Scholar]
- Seymour R. A., Rawlins M. D., Clothier A. The efficacy and pharmacokinetics of sodium salicylate in post-operative dental pain. Br J Clin Pharmacol. 1984 Feb;17(2):161–163. doi: 10.1111/j.1365-2125.1984.tb02331.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Seymour R. A., Rawlins M. D. Pharmacokinetics of parenteral paracetamol and its analgesic effects in post-operative dental pain. Eur J Clin Pharmacol. 1981;20(3):215–218. doi: 10.1007/BF00544600. [DOI] [PubMed] [Google Scholar]
- Seymour R. A. Use of analgesics in postoperative dental pain: a review. J R Soc Med. 1984 Nov;77(11):949–954. doi: 10.1177/014107688407701111. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Watters C. H., Patterson C. C., Mathews H. M., Campbell W. Diclofenac sodium for post-tonsillectomy pain in children. Anaesthesia. 1988 Aug;43(8):641–643. doi: 10.1111/j.1365-2044.1988.tb04147.x. [DOI] [PubMed] [Google Scholar]