Abstract
Drugs with anti-emetic properties can exert their actions at more than one receptor site, histamine H1, muscarinic cholinergic or dopaminergic D2 receptors. This study was designed to test the hypothesis that a combination of drugs acting at different receptor sites in lower than standard doses would be at least as effective as a standard therapeutic dose of a single anti-emetic agent. A combination of droperidol, hyoscine and metoclopramide in subtherapeutic doses has been shown to be at least as effective as droperidol (1.25 mg) alone. In both groups there was a low incidence of emetic sequelae in the first 3 hours postoperatively.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BELLVILLE J. W., BROSS I. D., HOWLAND W. S. Postoperative nausea and vomiting. IV. Factors related to postoperative nausea and vomiting. Anesthesiology. 1960 Mar-Apr;21:186–193. doi: 10.1097/00000542-196003000-00009. [DOI] [PubMed] [Google Scholar]
- BURTLES R., PECKETT B. W. Postoperative vomiting; some factors affecting its incidence. Br J Anaesth. 1957 Mar;29(3):114–123. doi: 10.1093/bja/29.3.114. [DOI] [PubMed] [Google Scholar]
- Clarke R. S. Nausea and vomiting. Br J Anaesth. 1984 Jan;56(1):19–27. doi: 10.1093/bja/56.1.19. [DOI] [PubMed] [Google Scholar]
- Cohen S. E., Woods W. A., Wyner J. Antiemetic efficacy of droperidol and metoclopramide. Anesthesiology. 1984 Jan;60(1):67–69. doi: 10.1097/00000542-198401000-00015. [DOI] [PubMed] [Google Scholar]
- Gold M. I. Postanesthetic vomiting in the recovery room. Br J Anaesth. 1969 Feb;41(2):143–149. doi: 10.1093/bja/41.2.143. [DOI] [PubMed] [Google Scholar]
- Kauste A., Tuominen M., Heikkinen H., Gordin A., Korttila K. Droperidol, alizapride and metoclopramide in the prevention and treatment of post-operative emetic sequelae. Eur J Anaesthesiol. 1986 Jan;3(1):1–9. [PubMed] [Google Scholar]
- Korttila K., Kauste A., Auvinen J. Comparison of domperidone, droperidol, and metoclopramide in the prevention and treatment of nausea and vomiting after balanced general anesthesia. Anesth Analg. 1979 Sep-Oct;58(5):396–400. doi: 10.1213/00000539-197909000-00010. [DOI] [PubMed] [Google Scholar]
- Madej T. H., Simpson K. H. Comparison of the use of domperidone, droperidol and metoclopramide in the prevention of nausea and vomiting following gynaecological surgery in day cases. Br J Anaesth. 1986 Aug;58(8):879–883. doi: 10.1093/bja/58.8.879. [DOI] [PubMed] [Google Scholar]
- McKenzie R., Wadhwa R. K., Uy N. T., Phitayakorn P., Tantisira B., Sinchioco C., Taylor F. H. Antiemetic effectiveness of intramuscular hydroxyzine compared with intramuscular droperidol. Anesth Analg. 1981 Nov;60(11):783–788. [PubMed] [Google Scholar]
- Mortensen P. T. Droperidol (Dehydrobenzperidol): postoperative anti-emetic effect when given intravenously to gynaecological patients. Acta Anaesthesiol Scand. 1982 Feb;26(1):48–52. doi: 10.1111/j.1399-6576.1982.tb01724.x. [DOI] [PubMed] [Google Scholar]
- Palazzo M. G., Strunin L. Anaesthesia and emesis. II: Prevention and management. Can Anaesth Soc J. 1984 Jul;31(4):407–415. doi: 10.1007/BF03015417. [DOI] [PubMed] [Google Scholar]