Abstract
A retrospective survey was conducted of 720 research protocols, approved by the Central Oxford Research Ethics Committee between 1984 and 1987, to determine the fate of research studies from inception. Forty-five per cent were clinical trials, 23% were observational studies and 32% were laboratory-based experimental studies. Further information was obtained on 487 studies, of which 287 (59%) had been completed, 100 (21%) had never started, 58 (12%) had been abandoned or were in abeyance and 42 (9%) were still ongoing, as of May 1990. Forty-three per cent of the original 487 studies were subsequently published or presented. The most frequent reason for not starting a study was failure to obtain funding (40%). The main reason for abandoning a study was difficulty in recruiting study participants (28%). Departure of one of the investigators from the institution and a variety of logistical problems were also common reasons for either not starting or abandoning a study. A thorough review of the pragmatic as well as the scientific aspects of a planned research project is important to minimize the initiation of studies that are unlikely to succeed.
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Selected References
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- Allen P. A., Waters W. E. Development of an ethical committee and its effect on research design. Lancet. 1982 May 29;1(8283):1233–1236. doi: 10.1016/s0140-6736(82)92349-2. [DOI] [PubMed] [Google Scholar]
- Altman D. G. Statistics and ethics in medical research: III How large a sample? Br Med J. 1980 Nov 15;281(6251):1336–1338. doi: 10.1136/bmj.281.6251.1336. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Anderson J., Evered D. C. Why do research on research? Lancet. 1986 Oct 4;2(8510):799–802. doi: 10.1016/s0140-6736(86)90312-0. [DOI] [PubMed] [Google Scholar]
- Arcand M., Williamson J. An evaluation of home visiting of patients by physicians in geriatric medicine. Br Med J (Clin Res Ed) 1981 Sep 12;283(6293):718–720. doi: 10.1136/bmj.283.6293.718. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Blackwell B., Shepherd M. Early evaluation of psychotropic drugs in man. A trial that failed. Lancet. 1967 Oct 14;2(7520):819–822. doi: 10.1016/s0140-6736(67)92250-7. [DOI] [PubMed] [Google Scholar]
- Cook C. C., Scannell T. D., Lipsedge M. S. Another trial that failed. Lancet. 1988 Mar 5;1(8584):524–525. doi: 10.1016/s0140-6736(88)91309-8. [DOI] [PubMed] [Google Scholar]
- Cooper L. S., Chalmers T. C., McCally M., Berrier J., Sacks H. S. The poor quality of early evaluations of magnetic resonance imaging. JAMA. 1988 Jun 10;259(22):3277–3280. [PubMed] [Google Scholar]
- Denham M. J., Foster A., Tyrrell D. A. Work of a district ethical committee. Br Med J. 1979 Oct 27;2(6197):1042–1045. doi: 10.1136/bmj.2.6197.1042. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Easterbrook P. J., Berlin J. A., Gopalan R., Matthews D. R. Publication bias in clinical research. Lancet. 1991 Apr 13;337(8746):867–872. doi: 10.1016/0140-6736(91)90201-y. [DOI] [PubMed] [Google Scholar]
- Fletcher R. H., Fletcher S. W. Clinical research in general medical journals: a 30-year perspective. N Engl J Med. 1979 Jul 26;301(4):180–183. doi: 10.1056/NEJM197907263010403. [DOI] [PubMed] [Google Scholar]
- Juhl E., Christensen E., Tygstrup N. The epidemiology of the gastrointestinal randomized clinical trial. N Engl J Med. 1977 Jan 6;296(1):20–22. doi: 10.1056/NEJM197701062960105. [DOI] [PubMed] [Google Scholar]
- Smith R. The funding of medical research: going up or coming down? Br Med J (Clin Res Ed) 1988 Jan 23;296(6617):267–270. doi: 10.1136/bmj.296.6617.267. [DOI] [PMC free article] [PubMed] [Google Scholar]