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Journal of the Royal Society of Medicine logoLink to Journal of the Royal Society of Medicine
. 1995 Jun;88(6):356P–357P.

Long-term sequelae of Palmar-Plantar erythrodysaesthesia syndrome secondary to 5-fluorouracil therapy.

G K Banfield 1, I D Crate 1, C L Griffiths 1
PMCID: PMC1295248  PMID: 7629773

Abstract

Palmar-Plantar erythrodyasesthesia syndrome has been reported as a temporary complication of 5-fluorouracil therapy consisting of a debilitating erythema and tenderness of the skin of hands and feet. The syndrome has previously been observed to respond rapidly to either temporary cessation of chemotherapy or pyridoxine with little residual disability. We report a case which was characterized by persistent morbidity necessitating prolonged discontinuation of treatment.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Atkins J. N. Fluorouracil and the palmar-plantar erythrodysesthesia syndrome. Ann Intern Med. 1985 Mar;102(3):419–419. doi: 10.7326/0003-4819-102-3-419_1. [DOI] [PubMed] [Google Scholar]
  2. Curran C. F., Luce J. K. Fluorouracil and palmar-plantar erythrodysesthesia. Ann Intern Med. 1989 Nov 15;111(10):858–858. doi: 10.7326/0003-4819-111-10-858_1. [DOI] [PubMed] [Google Scholar]
  3. Feldman L. D., Ajani J. A. Fluorouracil-associated dermatitis of the hands and feet. JAMA. 1985 Dec 27;254(24):3479–3479. [PubMed] [Google Scholar]
  4. Lokich J. J., Moore C. Chemotherapy-associated palmar-plantar erythrodysesthesia syndrome. Ann Intern Med. 1984 Dec;101(6):798–799. doi: 10.7326/0003-4819-101-6-798. [DOI] [PubMed] [Google Scholar]
  5. Vukelja S. J., Lombardo F. A., James W. D., Weiss R. B. Pyridoxine for the palmar-plantar erythrodysesthesia syndrome. Ann Intern Med. 1989 Oct 15;111(8):688–689. doi: 10.7326/0003-4819-111-8-688. [DOI] [PubMed] [Google Scholar]

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