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. 1996 Jul;89(7):396–400. doi: 10.1177/014107689608900711

The D2 dopamine receptor gene as a determinant of reward deficiency syndrome.

K Blum 1, P J Sheridan 1, R C Wood 1, E R Braverman 1, T J Chen 1, J G Cull 1, D E Comings 1
PMCID: PMC1295855  PMID: 8774539

Abstract

The dopaminergic system, and in particular the dopamine D2 receptor, has been profoundly implicated in reward mechanisms in the brain. Dysfunction of the D2 dopamine receptors leads to aberrant substance seeking behaviour (alcohol, drug, tobacco, and food) and other related behaviours (pathological gambling, Tourette's syndrome, and attention deficit hyperactivity disorder). We propose that variants of the D2 dopamine receptor gene are important common genetic determinants of the 'reward deficiency syndrome'.

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Selected References

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