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. Author manuscript; available in PMC: 2026 Mar 5.
Published in final edited form as: Reprod Toxicol. 2025 Dec 13;140:109140. doi: 10.1016/j.reprotox.2025.109140

Table 2.

Weight gain statistics for animals on study (summarized from Hunter et al., 2025). Baseline weights (top) and final weights (middle) analyzed by 2-Way ANOVA, reported as Mean (Standard Error). Cumulative Weight gain (bottom) reported as repeated measures ANOVA.

6 Weeks  
 Filtered Air
 Nano-TiO2
 P Value
 Summary
  
  
 Filtered Air
 Nano-TiO2
 P Value
 Summary
Male 137 (3.272) 106.4 (1.482) < 0.0001 **** Female 116.1 (1.839) 94 (2.962) < 0.0001 ****
Male Filtered Air Nano-TiO2 P Value Summary Female Filtered Air Nano-TiO2 P Value Summary
24 Weeks GBD 506.7 (16.06) 492.6 (7.978) 0.7462 ns GBD 294.8 (3.238) 268.0 (3.590) 0.1306 ns
HFD 645.0 (18.97) 544.2 (10.18) < 0.0001 **** HFD 342.3 (7.269) 338.2 (8.182) 0.9903 ns
P Value < 0.0001 0.0002 P Value 0.0063 < 0.0001
Summary **** *** Summary ** ****
Male Filtered Air Nano-TiO2 P Value Summary Female Filtered Air Nano-TiO2 P Value Summary
Cumulative Weight Gain GBD 371.5 (12.53) 389.1 (7.393) 0.6372 ns GBD 180.8 (2.988) 178.6 (4.870) 0.9799 ns
HFD 505.8 (16.45) 435.3 (9.805) 0.031 * HFD 222.7 (4.856) 240.5 (5.033) 0.0948 ns
P Value 0.0009 0.0064 P Value 0.0002 < 0.0001
Summary *** ** Summary *** ****