Skip to main content
NCBI home page
Journal of the Royal Society of Medicine logoLink to Journal of the Royal Society of Medicine
. 1996 Dec;89(12):694–698. doi: 10.1177/014107689608901210

Anogenital lichen sclerosus in women.

R H Thomas 1, C M Ridley 1, D H McGibbon 1, M M Black 1
PMCID: PMC1296033  PMID: 9014881

Abstract

A study of 350 women with lichen sclerosus, originally made to elucidate the relationship between lichen sclerosus and autoimmunity, led to the amassing of a considerable amount of clinical material. Our review is confined to those with anogenital lesions (342), supplemented by some new cases (15), giving a total of 357 women with biopsy proven lichen sclerosus. It demonstrates the wide age range of the condition, the association with morphoea and lichen planus and the occurrence of squamous cell carcinoma in some cases. It also shows that inappropriate surgery has continued to be carried out for benign disease.

Full text

PDF
694

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Connelly M. G., Winkelmann R. K. Coexistence of lichen sclerosus, morphea, and lichen planus. Report of four cases and review of the literature. J Am Acad Dermatol. 1985 May;12(5 Pt 1):844–851. doi: 10.1016/s0190-9622(85)70106-5. [DOI] [PubMed] [Google Scholar]
  2. Crum C. P. Carcinoma of the vulva: epidemiology and pathogenesis. Obstet Gynecol. 1992 Mar;79(3):448–454. doi: 10.1097/00006250-199203000-00025. [DOI] [PubMed] [Google Scholar]
  3. Haefner H. K., Tate J. E., McLachlin C. M., Crum C. P. Vulvar intraepithelial neoplasia: age, morphological phenotype, papillomavirus DNA, and coexisting invasive carcinoma. Hum Pathol. 1995 Feb;26(2):147–154. doi: 10.1016/0046-8177(95)90030-6. [DOI] [PubMed] [Google Scholar]
  4. Leibowitch M., Neill S., Pelisse M., Moyal-Baracco M. The epithelial changes associated with squamous cell carcinoma of the vulva: a review of the clinical, histological and viral findings in 78 women. Br J Obstet Gynaecol. 1990 Dec;97(12):1135–1139. doi: 10.1111/j.1471-0528.1990.tb02502.x. [DOI] [PubMed] [Google Scholar]
  5. Marren P., Millard P., Chia Y., Wojnarowska F. Mucosal lichen sclerosus/lichen planus overlap syndromes. Br J Dermatol. 1994 Jul;131(1):118–123. doi: 10.1111/j.1365-2133.1994.tb08468.x. [DOI] [PubMed] [Google Scholar]
  6. Marren P., Yell J., Charnock F. M., Bunce M., Welsh K., Wojnarowska F. The association between lichen sclerosus and antigens of the HLA system. Br J Dermatol. 1995 Feb;132(2):197–203. doi: 10.1111/j.1365-2133.1995.tb05013.x. [DOI] [PubMed] [Google Scholar]
  7. Meffert J. J., Davis B. M., Grimwood R. E. Lichen sclerosus. J Am Acad Dermatol. 1995 Mar;32(3):393–418. doi: 10.1016/0190-9622(95)90060-8. [DOI] [PubMed] [Google Scholar]
  8. Meyrick Thomas R. H., Kennedy C. T. The development of lichen sclerosus et atrophicus in monozygotic twin girls. Br J Dermatol. 1986 Mar;114(3):377–379. doi: 10.1111/j.1365-2133.1986.tb02831.x. [DOI] [PubMed] [Google Scholar]
  9. Meyrick Thomas R. H., Ridley C. M., McGibbon D. H., Black M. M. Lichen sclerosus et atrophicus and autoimmunity--a study of 350 women. Br J Dermatol. 1988 Jan;118(1):41–46. doi: 10.1111/j.1365-2133.1988.tb01748.x. [DOI] [PubMed] [Google Scholar]
  10. Newton J. A., Camplejohn R. S., McGibbon D. H. A flow cytometric study of the significance of DNA aneuploidy in cutaneous lesions. Br J Dermatol. 1987 Aug;117(2):169–174. doi: 10.1111/j.1365-2133.1987.tb04113.x. [DOI] [PubMed] [Google Scholar]
  11. Patterson J. A., Ackerman A. B. Lichen sclerosus et atrophicus is not related to morphea. A clinical and histologic study of 24 patients in whom both conditions were reputed to be present simultaneously. Am J Dermatopathol. 1984 Aug;6(4):323–335. doi: 10.1097/00000372-198408000-00007. [DOI] [PubMed] [Google Scholar]
  12. Ridley C. M. Genital lichen sclerosus (lichen sclerosus et atrophicus) in childhood and adolescence. J R Soc Med. 1993 Feb;86(2):69–75. [PMC free article] [PubMed] [Google Scholar]
  13. Ridley C. M. The aetiology of vulval neoplasia. Br J Obstet Gynaecol. 1994 Aug;101(8):655–657. doi: 10.1111/j.1471-0528.1994.tb13178.x. [DOI] [PubMed] [Google Scholar]
  14. Stiller M., Klein W., Dorman R., Albom M. Bilateral vulvar basal cell carcinomata. J Am Acad Dermatol. 1993 May;28(5 Pt 2):836–838. doi: 10.1016/0190-9622(93)70112-7. [DOI] [PubMed] [Google Scholar]
  15. Tan S. H., Derrick E., McKee P. H., Hobbs C., Ridley M., Neill S. Altered p53 expression and epidermal cell proliferation is seen in vulval lichen sclerosus. J Cutan Pathol. 1994 Aug;21(4):316–323. doi: 10.1111/j.1600-0560.1994.tb00706.x. [DOI] [PubMed] [Google Scholar]
  16. Thomas R. H., McGibbon D. H., Munro D. D. Basal cell carcinoma of the vulva in association with vulval lichen sclerosus et atrophicus. J R Soc Med. 1985;78 (Suppl 11):16–18. [PMC free article] [PubMed] [Google Scholar]
  17. Wallace H. J. Lichen sclerosus et atrophicus. Trans St Johns Hosp Dermatol Soc. 1971;57(1):9–30. [PubMed] [Google Scholar]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press

RESOURCES