Skip to main content
PLOS One logoLink to PLOS One
. 2026 Mar 9;21(3):e0344420. doi: 10.1371/journal.pone.0344420

Prevalence and associated risk factors of tinnitus among Palestinian adolescents aged 15–18: A cross-sectional study

Saad Al-Lahhaam 1,*, Raghad Dweikat 2, Tala Nazzal 2, Aman Maraqa 2, Joud Khalil 2, Tala Albadawi 2, Raghad Doufish 2, Wa'd Amer 2, Mustafa Ghanim 1, Mohammad Abuawad 1, Amer Ghrouz 2, Samar Alkhaldi 2, Laith El-lahham 3, Majdi Dwikat 2, Maha Rabayaa 1, Malik Alqub 1,*
Editor: Paul H Delano4
PMCID: PMC12970918  PMID: 41802007

Abstract

Background

Tinnitus is a prevalent condition worldwide, particularly among adolescents, that has a substantial impact on quality of life, yet it remains an understudied issue.

Objectives

This study aims to determine the prevalence of tinnitus and its associated risk factors among Palestinian adolescents aged 15–18.

Methods

A cross-sectional study was conducted from January to March 2025. A convenience sample of participants was recruited. The study utilized the European School for the Interdisciplinary Tinnitus Research Screening Questionnaire.

Results

A total of 1,131 participants were enrolled in the study, with 64.5% being females. The prevalence of tinnitus among the study sample was 532, representing 47% of the population. Females had a higher prevalence of tinnitus, with 370 affected (50.7%) compared to males (40.4%). Significant associations were found between tinnitus and several factors: age, positive family history of tinnitus (threefold increased risk), sensitivity to external sounds (2.7 times higher likelihood), slight hearing difficulty in noisy environments (1.7 times higher risk), pain symptoms (double the risk), and difficulty falling asleep (1.8 times higher risk). Notably, the majority of affected participants (71.5%) had never sought professional care for their tinnitus.

Conclusion

Although Tinnitus is common among Palestinian adolescents aged 15–18 years, the majority of affected participants did not seek professional care for tinnitus. These findings highlight the importance of conducting further research to shed insight into this prevalent and neglected health priority.

Introduction

Tinnitus is described as the perception of sound in the absence of external auditory stimuli. Commonly, individuals with tinnitus report hearing sounds such as hissing, sizzling, or ringing. More complex auditory experiences, such as voices or music, have also been documented in some patients [1]. Tinnitus that coincides with the heartbeat may suggest a vascular origin [2,3]. When it does not, palatal muscles or myoclonus of the middle ear is more likely to be the cause, while a lack of such synchronization often points to other causes, such as palatal muscle spasms or myoclonus of the middle ear [2]. Tinnitus typically develops gradually, although it can sometimes have a rapid onset [4]. Many patients report that stress can exacerbate their symptoms, highlighting the potential influence of emotional and psychological factors in the experience of tinnitus [5].

Despite extensive research, the mechanisms behind tinnitus remain poorly understood. It is believed to arise from complex interactions between the auditory pathways, the central nervous system, and other systems. Several factors have been identified as potential risk factors for the development of tinnitus. These include otological (hearing-related), neurological, psychiatric, cardiovascular, traumatic, rheumatological, immune-mediated, endocrine, and metabolic factors. Lifestyle factors such as previous head injuries, alcohol consumption, arthritis, obesity, smoking, and hypertension have also been identified as contributing to the risk of tinnitus [69]. The challenges in tinnitus research stem from its multifactorial etiology, the diverse comorbidities associated with it, its wide clinical variability, and the subjective nature of its assessment [10,11].

Tinnitus is a widespread condition, affecting a significant proportion of the global population [12]. Significant variation in the prevalence of tinnitus was reported from numerous studies across Middle Eastern countries. Estimates of tinnitus prevalence in the general population have been reported at 30.6% in Palestine [7], 33% in Turkey [13], 5.2% in Egypt [14], and 4.6% in Iran [15]. The prevalence of tinnitus in children has been reported to range from 7.5% to 60% [12,16]. Tinnitus is believed to be more common in children with hearing impairment compared with children with normal hearing [17].

In Palestine, the prevalence of tinnitus has been estimated at 30.6% among adults [7] and 31% among university students [18]. Yet data on Palestinian adolescents remain scarce. This represents a critical gap, as tinnitus is increasingly recognized as a condition with significant psychosocial dimensions beyond its auditory characteristics [19]. In adolescents, tinnitus may be closely intertwined with psychological stress, anxiety, sleep disturbance, and daily functioning [20,21], particularly during a developmental stage characterized by academic pressure and heightened emotional sensitivity [22]. These impacts can substantially affect quality of life, emotional equilibrium, and social engagement [23,24]. Conceptualizing tinnitus within a biopsychosocial framework is therefore essential to understanding its mechanisms and risk factors in young populations, as well as for addressing its potential effects on their quality of life [25]. Therefore, the current study aims to examine the prevalence and risk factors of tinnitus among Palestinian children aged 15–18 years.

Methods

Study design and population

A cross-sectional questionnaire-based study was conducted from January to March 2025 to assess the prevalence of tinnitus and its associated risk factors.

The sample size was calculated using Cochran’s formula for prevalence studies:

𝐧=(𝐙2×𝐩×(1𝐩))/𝐞2

Assuming a 95% confidence level (Z = 1.96), an expected prevalence of 50% (p = 0.5; no prior regional data), and a 5% margin of error (e = 0.05), the initial sample size was determined to be 385 participants. Given the large target population (N ≈ 340,000), the finite population correction had a negligible impact, and the sample size remained unchanged. To account for potential non-response, the target was increased by 15%, resulting in a final sample size of 443 participants.

Study setting, sampling method, and data collection procedure

The study involved a population survey of Palestinians aged from 15 to 18 years. The population included individuals from all four governorates of the West Bank in Palestine. The participants in this study were recruited from different settings across the West Bank in Palestine to ensure a representative sample. Participants were recruited by selecting individuals from local community centers and social media platforms. The questionnaire was shared with people and friends, including researchers’ accounts, to reach a larger number of community participants, enabling a deeper understanding of the study’s findings.

Given the contextual limitations in Palestine, such as restricted institutional access, lack of centralized databases for adolescents, and logistical barriers due to political instability, probability-based sampling strategies were not feasible. Therefore, a large-scale convenience sampling approach was employed, which is a commonly used method in public health research in low-resource or conflict-affected settings. This approach allowed us to efficiently collect data from a broad and diverse sample and generate early epidemiological insights on tinnitus, a condition for which there is limited evidence in this population.

Study tools

The study’s questionnaire was based on the European School for Interdisciplinary Tinnitus Research-Screening Questionnaire (ESIT-SQ), a self-report tinnitus-relevant history questionnaire (supplementary file) [23]. Public health and speech disorders professionals examined and updated the questionnaire before distribution. The questionnaire comprised questions addressing the sociodemographic data, clinical characteristics of the participants, the characteristics of tinnitus, inciting triggers, treatment approaches, and responses to therapy among the tinnitus-affected participants. The questionnaire was an Arabic translation version of ESIT-SQ, which was used as a study tool in a recent Palestinian studies, the questionnaire underwent a forward-backward translation process to ensure language accuracy in prior research [7,18]. The study questionnaire was distributed digitally through email, institutional platforms, etc. Participation was entirely voluntary. A pilot study was executed before the comprehensive data collection to evaluate the clarity, relevance, and feasibility of the questionnaire. The pilot research data were excluded from the final analysis. The study was conducted using a digital questionnaire created via Google Forms. At the beginning of the form, an electronic informed consent statement was presented. Only participants who clicked “I agree” were able to proceed with the rest of the questionnaire. This ensured that informed consent was obtained digitally and voluntarily before any data were collected. To minimize respondent fatigue, the survey platform allowed participants to pause and resume, reducing the likelihood of inconsistent responses toward the end. A total of 1131 responses were received from participants who agreed and completed the questionnaire.

Data analysis

The statistical analyses were carried out using IBM Corp.‘s Statistical Package for the Social Sciences version 25 (SPSS 25) in Armonk, New York, USA. Data was analyzed descriptively, with categorical variables expressed as frequency and percentage. To examine associations between tinnitus and various socio-demographic and clinical variables, Chi-square tests or Fisher’s exact tests (as appropriate, based on cell counts) were performed for bivariate comparisons. A p-value of < 0.05 was considered statistically significant. Variables that showed significant associations in the bivariate analysis were subsequently entered into a binary multivariate logistic regression model to identify independent predictors of tinnitus. In addition, the association between the subtypes of tinnitus (objective vs. subjective tinnitus, continuous vs. intermittent tinnitus) and the characteristics of participants with tinnitus was evaluated using the chi-square and, followed by the binary logistic regression for significant variables to determine the predictive independent variables. The enter method was used for variable entry. Results were reported as adjusted odds ratios (ORs) with 95% confidence intervals (CIs).

Ethical consideration

The Institutional Review Board (IRB) of An-Najah University provided its approval for this study, which was conducted in accordance with ethical standards and was performed in compliance with the Helsinki Declaration for research in humans (Reference: BioMed. Dec.2024/23). Before inclusion, all participants provided written informed consent to take part in the study. All participants provided informed consent before proceeding to the online questionnaire questions, and those who did not sign the consent form were not allowed to participate. The permission form explained the study’s goal and guaranteed voluntary and anonymous participation, with no consequences for nonparticipation.

Results

The study population

The survey included 1131 participants. 35.5% were male, and 64.5% were female. The participants’ ages ranged from 15 to 18 years, with 30.2% being 15 years old, 32.2% being 16 years old, 28.2% being 17 years old, and 9.4% being 18 years old. The majority of the participants had a normal BMI (66%), with 16.5% underweight, 13.5% overweight, and 3.9% obese. Regarding city of residence, 37.3% were from Hebron, 25.2% from Nablus, 30.6% from Ramallah, and 6.9% from Bethlehem. 62% of participants reported high phone usage. The majority of participants (85.9%) were right-handed. Among the participants, 8.5% reported having a mother with tinnitus, 5% a father, 3.9% brothers, and 4% sisters with tinnitus. 46.7% of the participants didn’t know if they had first-degree relatives with tinnitus, while 40.4% reported having no relatives with tinnitus. Among those who reported having relatives with tinnitus, the mean number of affected relatives was 1.92 ± 1.292. Table 1 displays the participants’ characteristics.

Table 1. Background characteristics of the study participants, descriptive statistics of the sample characteristics (n = 1131).

Variable Frequency Percentage (%)
Age
15 342 30.2%
16 364 32.2%
17 319 28.2%
18 106 9.4%
Gender
Male 401 35.5%
Female 730 64.5%
BMI
Underweight >18.5 187 16.5%
Normal weight 18.524.9 746 66%
Overweight 2529.9 153 13.5%
Obesity ≥ 30 44 3.9%
City
Hebron 422 37.3%
Nablus 285 25.2%
Ramallah 346 30.6%
Bethlehem 78 6.9%
High Phone Usage
Yes 701 62%
No 56 5%
Not much 374 33.1%
Dominant Writing Hand
Right 971 85.9%
Left 64 5.7%
Both 96 8.5%
First-Degree Relatives with Tinnitus
Mother 96 8.5%
Father 57 5%
Brothers 44 3.9%
Sisters 45 4%
I don’t know 528 46.7%
None 457 40.4%
Number of Affected Relatives
≤ 3 121 10.7%
4–6 21 1.9%
≥ 7 1 0.1%
Number of Affected Relatives (Mean ± SD) 1.92  ± 1.292

Clinical characteristics of the participant

Table 2 presents the clinical features of the study participants. Regarding dizziness, 42.7% reported experiencing it more than once a year, 26.1% less than once a year, and 31.2% reported no dizziness. Among ear-related conditions, acoustic trauma due to sudden loud noise affected 3.6%, and middle ear infection due to external pressure was present in 8.4%. Notably, age-related hearing loss, acoustic neuroma, otosclerosis, and sudden hearing loss were rare, each affecting less than 1% of participants. A significant majority, 82.6%, reported no ear-related conditions. In terms of prior medical procedures, 20.2% had undergone dental procedures, and 2.3% had ear surgery, while a substantial 74.8% reported no prior medical procedures. Sensitivity to external sounds in the past week was observed in 34.7% of participants. Regarding hearing difficulties, 42.4% reported slight difficulty hearing in noisy environments, and 2.9% reported complete hearing loss. The use of hearing assistive devices was uncommon, with only 0.7% using hearing aids and even smaller percentages using cochlear implants, sound generators, or combined devices. Headache was a prevalent symptom, affecting 41.9% of the participants. Psychological conditions were also common, with 37.7% experiencing anxiety or excessive stress. Sleep disturbances were present in 32.9% of participants who reported difficulty falling asleep. In contrast, several conditions demonstrated low prevalence within the participant group. For instance, within the cardiovascular conditions, myocardial infarction (heart attack) was reported by only 0.2% of participants. Among other conditions, Familial Mediterranean Fever, HSV (Herpes Simplex Virus), Helicobacter pylori, Iron Deficiency, Leukemia, OCD (obsessive-compulsive disorder), Schizophrenia, and Parkinson’s disease each affected a mere 0.1%. Detailed descriptions of these clinical characteristics are presented in Table 2.

Table 2. Clinical characteristics of the study participants (n = 1131).

Variable Frequency Percentage (%)
Dizziness
Yes, less than once a year 295 26.1%
Yes, more than once a year 483 42.7%
No 353 31.2%
Ear-related conditions:
Acoustic trauma due to sudden loud noise
Yes 41 3.6%
No 1090 96.4%
Middle ear infection due to external pressure
Yes 95 8.4%
No 1036 91.6%
Age-related hearing loss
Yes 1 0.1%
No 1130 99.9%
Sudden hearing loss
Yes 7 0.6%
No 1124 99.4%
Acoustic neuroma
Yes 1 0.1%
No 1130 99.9%
Chronic ear infection
Yes 27 2.4%
No 1104 97.6%
Otosclerosis
Yes 1 0.1%
No 1130 99.9%
Middle ear infection or Eustachian tube dysfunction
Yes 25 2.2%
No 1106 97.8%
Eardrum perforation
Yes 20 1.8%
No 1111 98.2%
Hearing loss due to other reasons
Yes 17 1.5%
No 1114 98.5%
None conditions
Yes 934 82.6%
No 197 17.4%
Prior medical procedures:
Ear surgery
Yes 26 2.3%
No 1105 97.7%
Dental procedure (filling removal, dental implants, prolonged dental surgery)
Yes 228 20.2%
No 903 79.8%
Neurosurgery
Yes 13 1.1%
No 1118 98.9%
Spinal tap (lumbar puncture)
Yes 10 0.9%
No 1121 99.1%
Chemotherapy
Yes 5 0.4%
No 1126 99.6%
Radiation therapy for the head and neck
Yes 11 1%
No 1120 99%
Electroconvulsive therapy
Yes 5 0.4%
No 1126 99.6%
Other; Nasal polypectomy
Yes 4 0.4%
No 1127 99.6%
Other; Tonsillectomy
Yes 17 1.5%
No 1114 98.5%
Other; Pulmonary Laceration
Yes 1 0.1%
No 1130 99.9%
Other; Hand Fracture
Yes 1 0.1%
No 1130 99.9%
Other: Sleeve Gastrectomy
Yes 1 0.1%
No 1130 99.9%
None procedures
Yes 846 74.8%
No 285 25.2%
Sensitivity to External Sounds during the past week
Yes 392 34.7%
No 739 65.3%
Difficulty Hearing in Noisy Environments
No 619 54.7%
Slight difficulty 479 42.4%
Yes, I cannot hear at all 33 2.9%
Hearing Assistive Device Usage:
Hearing aid
Yes 8 0.7%
No 1123 99.3%
Cochlear implant
Yes 1 0.1%
No 1130 99.9%
Sound generator
Yes 2 0.2%
No 1129 99.8%
Combined device (hearing aid and sound generator in one device)
Yes 3 0.3%
No 1128 99.7%
None devices
Yes 14 1.2%
No 1117 98.8%
Experience of Symptoms:
Headache
Yes 474 41.9%
No 657 58.1%
Neck pain
Yes 208 18.4%
No 923 81.6%
Ear pain
Yes 112 9.9%
No 1019 90.1%
Jaw joint pain
Yes 101 8.9%
No 1030 91.1%
Facial pain
Yes 41 3.6%
No 1090 96.4%
Other; Shoulder pain 5 0.4%
Yes 1126 99.6%
No
None Pain
Yes 573 50.7%
No 558 49.3%
Oral conditions:
Jaw joint pain
Yes 106 9.4%
No 1025 90.6%
Dental problems
Yes 357 31.6%
No 774 68.4%
Neurological conditions:
Meningitis
Yes 11 1%
No 1120 99%
Multiple sclerosis
Yes 8 0.7%
No 1123 99.3%
Epilepsy
Yes 24 2.1%
No 1107 97.9%
Stroke
Yes 3 0.3%
No 1128 99.7%
Other cerebrovascular diseases
Yes 9 0.8%
No 1122 99.2%
Psychological conditions:
Anxiety, excessive stress
Yes 426 37.7%
No 705 62.3%
Depression
Yes 141 12.5%
No 990 87.5%
Emotional trauma
Yes 82 7.3%
No 1049 92.7%
Sleep disorders:
Difficulty falling asleep
Yes 372 32.9%
No 759 67.1%
Difficulty staying asleep
Yes 180 15.9%
No 951 84.1%
Cardiovascular conditions:
Low blood pressure
Yes 54 4.8%
No 1077 95.2%
High blood pressure
Yes 35 3.1%
No 1096 96.9%
Myocardial infarction (heart attack)
Yes 2 0.2%
No 1129 99.8%
Endocrine and metabolic conditions:
Thyroid dysfunction
Yes 24 2.1%
No 1107 97.9%
Diabetes
Yes 10 0.9%
No 1121 99.1%
High cholesterol
Yes 11 1%
No 1120 99%
Rheumatic and autoimmune disorders:
Rheumatoid arthritis
Yes 22 1.9%
No 1109 98.1%
Lupus (facial rash)
Yes 9 0.8%
No 1122 99.2%
Ear, nose, and throat conditions:
Chronic sinusitis 117 10.3%
Yes 1014 89.7%
No
Deviated nasal septum 46 4.1%
Yes 1085 95.9%
No
Other conditions:
Anemia
Yes 80 7.1%
No 1051 92.9%
Balance disorder
Yes 79 7%
No 1052 93%
Gastroesophageal reflux disease (GERD)
Yes 27 2.4%
No 1104 97.6%
Adenoid
Yes 2 0.2%
No 1129 99.8%
Asthma
Yes 3 0.3%
No 1128 99.7%
Epistaxis
Yes 2 0.2%
No 1129 99.8%
Familial Mediterranean Fever
Yes 1 0.1%
No 1130 99.9%
HSV
Yes 1 0.1%
No 1130 99.9%
Helicobacter pylori
Yes 1 0.1%
No 1130 99.9%
Iron Deficiency
Yes 1 0.1%
No 1130 99.9%
Leukemia
Yes 1 0.1%
No 1130 99.9%
Migraine
Yes 5 0.4%
No 1126 99.6%
OCD
Yes 1 0.1%
No 1130 99.9%
Schizophrenia
Yes 1 0.1%
No 1130 99.9%
Parkinson’s disease
Yes 1 0.1%
No 1130 99.9%

Prevalence of tinnitus and its characteristics

Of the participants affected by tinnitus (n = 532), 12.6%, 17.9%, and 13.5% experienced it daily or almost daily, weekly, and monthly, respectively. The majority of participants (28.2%) experienced tinnitus every few months, with 27.8% experiencing it yearly. 32.7% of those affected reported constant tinnitus, while 67.3% reported intermittent tinnitus. Tinnitus sounded like a cricket in 34.8% of the affected participants, and 27.6% perceived it as tonal. Tinnitus was perceived inside the head by 25.6% of the participants. The majority of tinnitus cases (74.1%) had no rhythm. At least 6% of individuals reported tinnitus audible to the clinician. The results are presented in Table 3.

Table 3. Characteristics of tinnitus among the affected participants (n = 532).

Variable Frequency Percentage (%)
Experience of tinnitus in one or both ears lasting more than 5 minutes at a time over the past year
Yes, most or all of the time 26 2.3%
Yes, frequently 66 5.8%
Yes, occasionally 214 18.9%
No, not in the past year 49 4.3%
Never 550 48.6%
I don’t know 226 20%
Frequency of tinnitus (n  =  532)
Daily or almost daily 67 12.6%
About weekly 95 17.9%
About monthly 72 13.5%
Every few months 150 28.2%
Yearly 148 27.8%
Description of tinnitus
Constant 174 32.7%
Intermittent 358 67.3%
Tinnitus sound like
Tonal (continuous sound with varying frequencies) 147 27.6%
Noise-like 142 26.7%
Music-like 31 5.8%
Sounds like a cricket 185 34.8%
Buzzing 20 3.8%
Other; I don’t know 2 0.4%
Other; None 5 0.9%
Tinnitus rhythm
Yes, it follows my heartbeat (it may be checked by feeling the pulse at the same time as the tinnitus) 45 8.5%
Yes, it follows my breathing 34 6.4%
Yes, it follows head, neck, jaw, or facial muscle movements 53 10%
Other; I don’t know 6 1.1%
Other; None 394 74.1%
Tinnitus perceived
Right ear 67 12.6%
Left ear 47 8.8%
Both ears, worse in the right 60 11.3%
Both ears, worse in the left ear 22 4.1%
Both ears equally 136 25.6%
Inside the head 73 13.7%
Other; None 4 0.8%
I don’t know 123 23.1%
Audible by the clinician
Yes 32 6%
No 500 94%

As presented in Table 4, for many, tinnitus onset was unclear, with 57.7% not knowing when it began. In a small number of cases, tinnitus occurred before (2.6%), after (4.3%), or around the same time (1.1%) as other related conditions. Prominent conditions associated with tinnitus onset included exposure to loud sounds (28.2%), flu, common cold, or other infections (21.6%), and anxiety (20.9%). Concerning drug intake among respondents, 16.7% reported using pain relievers, while smaller percentages reported using antibiotics (9.2%), aspirin (1.9%), or quinine (1.9%). In terms of management, Table 5 shows that the majority of participants didn’t seek professional help, with 71.5% reporting they had never seen a healthcare professional for their tinnitus.

Table 4. Onset of tinnitus-associated conditions and respondent drug intake (n = 532).

Variable Frequency Percentage (%)
Onset of Tinnitus
1–12 months 98 18.4%
13–24 months 72 13.5%
25–36 months 31 5.9%
> 36 months 14 2.6%
I don’t know 307 57.7%
Timing of previously mentioned conditions or procedures relative to tinnitus
Before tinnitus started 14 2.6%
After tinnitus started 23 4.3%
Around the same time, tinnitus started 6 1.1%
I don’t know 17 3.2%
The onset of tinnitus is related to
Exposure to loud sounds 150 28.2%
Change in hearing 27 5.1%
Exposure to changes in surrounding pressure (such as flying or driving) 54 10.2%
Flu, common cold, or other infections 115 21.6%
Feeling of fullness or pressure in the ears 53 10%
Anxiety 109 20.9%
Head injury 28 5.3%
Neck injury 9 1.7%
Other; Ear infection 2 0.4%
Other; I don’t know 4 0.8%
None circumstances 200 37.6%
Respondent drug intake
Aspirin 10 1.9%
Pain relievers 89 16.7%
Antibiotics 49 9.2%
Quinine 10 1.9%
Diuretics 3 0.6%
Antidepressants 7 1.3%
None 315 59.2
I don’t know 88 16.5

Table 5. Management of tinnitus (n = 532).

Variable Frequency Percentage(%)
Over the past year, have you seen your family doctor or seen a healthcare professional at a clinic or hospital about your tinnitus?
Yes, 5 or more visits 8 1.5%
Yes, 2–4 visits 18 3.4%
Yes, only one visit 34 6.4%
No, never 379 71.5%
I don’t know 93 17.5%
Tinnitus treatment
Psychological therapy 5 0.9%
Audiological therapy 5 0.9%
Physical therapy 2 0.4%
Self-management 16 3%
None 504 94.7

Tinnitus-associated factors

Table 6 presents the factors potentially associated with tinnitus. The Chi-square and Fisher’s exact tests revealed that several factors were significantly associated with tinnitus (p-value < 0.05). These factors included demographic variables such as age and gender, as well as a family history of tinnitus, specifically in the mother, brothers, or participants who reported “I don’t know” or “None.” Significant associations were also found with symptoms like dizziness and various ear-related conditions, including acoustic trauma from sudden loud noise, middle ear infections due to external pressure, sudden hearing loss, middle ear infections or Eustachian tube dysfunction, and even the absence of any ear-related conditions. Medical history, such as previous dental procedures or the absence of any procedures, was also significant. Other associated variables included sensitivity to external sounds, difficulty hearing in noisy environments, and a range of symptoms such as headache, neck pain, ear pain, jaw pain, facial pain, or the absence of pain. Additionally, oral health issues like Jaw joint pain and dental problems, neurological conditions such as epilepsy and multiple sclerosis, and psychological conditions including anxiety or excessive stress, depression, and emotional trauma were all significantly linked to tinnitus. Sleep problems, particularly difficulty falling asleep and staying asleep, were also associated. Further medical conditions, such as high blood pressure, thyroid dysfunction, high cholesterol, rheumatoid arthritis, chronic sinusitis, deviated nasal septum, anemia, balance disorders, and gastroesophageal reflux disease (GERD), showed significant relationships with tinnitus as well.

Table 6. Association between the presence of tinnitus with socio-demographic and clinical characteristics.

Characteristics Tinnitus yes (n  =  532) Tinnitus no (n  =  599) p-Value (*Chi-Square Test/^ Fisher’s Exact Test)
Age .028*
15 161 (14.2%) 181 (16%)
16 151 (13.4%) 213 (18.8%)
17 169 (14.9%) 150 (13.3%)
18 51 (4.5%) 55 (4.9%)
Gender <.001*
Male 162 (40.4%) 239 (59.6%)
Female 370 (50.7%) 360 (49.3%)
BMI .244*
Underweight >18.5 80 (7.1%) 107 (9.5%)
Normal weight 18.524.9 356 (31.5%) 390 (34.55)
Overweight 2529.9 70 (6.2%) 83 (7.3%)
Obesity ≥ 30 26 (2.3%) 18 (1.6%)
City .080*
Hebron 205 (18.1%) 217 (19.2%)
Nablus 119 (10.5%) 166 (14.7%)
Ramallah 176 (15.6%) 170 (15%)
Bethlehem 32 (2.8%) 46 (4.1%)
High Phone Usage .172*
Yes 345 (30.5%) 356 (31.5%)
No 24 (2.1%) 32 (2.8%)
Not much 163 (14.4%) 211 (18.7%)
Dominant Writing Hand .154*
Right 450 (39.8%) 521 (46.1%)
Left 28 (2.5%) 36 (3.2%)
Both 54 (4.8%) 42 (3.7%)
First-Degree Relatives with Tinnitus
Mother 57 (5%) 39 (3.4%) .011*
Father 33 (2.9%) 24 (2.1%) .092*
Brothers 31 (2.7%) 13 (1.1%) .002*
Sisters 26 (2.3%) 19 (1.7%) .141*
I don’t know 286 (25.3%) 242 (21.4%) <.001*
None 154 (13.6%) 303 (26.8%) <.001*
Number of Affected Relatives
≤ 3 78 (54.5%) 43 (30.1%)
4–6 12 (8.4%) 9 (6.3%) .761^
≥ 7 1 (0.7%) 0 (0%)
Dizziness <.001*
Yes, less than once a year 142 (12.6%) 153 (13.5%)
Yes, more than once a year 288 (25.5%) 195 (17.3%)
No 102 (9%) 251 (22.2%)
Ear-related conditions:
Acoustic trauma due to sudden loud noise <.001*
Yes 31 (2.7%) 10 (0.9%)
No 501 (44.3%) 589 (52.1%)
Middle ear infection due to external pressure <.001*
Yes 67 (5.9%) 28 (2.5%)
No 465 (41.1%) 571 (50.5%)
Age-related hearing loss .470^
Yes 1 (0.1%) 0 (0%)
No 531 (46.9%) 599 (53%)
Sudden hearing loss .005^
Yes 7 (0.6%) 0 (0%)
No 525 (46.4%) 599 (53%)
Acoustic neuroma .470^
Yes 1 (0.1%) 0 (0%)
No 531 (46.9%) 599 (53%)
Chronic ear infection .093*
Yes 17 (1.5%) 10 (0.9%)
No 515 (45.5%) 589 (52.1%)
Otosclerosis 1.000^
Yes 0 (0%) 1 (0.1%)
No 532 (47%) 598 (52.9%)
Middle ear infection or Eustachian tube dysfunction .003*
Yes 19 (1.7%) 6 (0.5%)
No 513 (45.5%) 593 (52.4%)
Eardrum perforation .854*
Yes 9 (0.85%) 11 (1.0%)
No 523 (46.2%) 588 (52%)
Hearing loss due to other reasons .327*
Yes 10 (0.9%) 7 (0.6%)
No 522 (46.2%) 592 (52.3%)
None conditions <.001*
Yes 398 (35.2%) 536 (47.4%)
No 134 (11.8%) 63 (5.6%)
Prior medical procedures:
Ear surgery .271*
Yes 15 (1.3%) 11 (1%)
No 517 (45.7%) 588 (52%)
Dental procedure (filling removal, dental implants, prolonged dental surgery)
Yes 132 (11.7%) 96 (8.5%) <.001*
No 400 (35.4%) 503 (44.5%)
Neurosurgery .292*
Yes 8 (0.7%) 5 (0.4%)
No 524 (46.3%) 594 (52.5%)
Spinal tap (lumbar puncture) .204^
Yes 7 (0.6%) 3 (0.3%)
No 525 (46.4%) 596 (52.7%)
Chemotherapy 1.000^
Yes 2 (0.2%) 3 (0.3%)
No 530 (46.9%) 596 (52.7%)
Radiation therapy for the head and neck .916*
Yes 5 (0.4%) 6 (0.5%)
No 527 (46.6%) 593 (52.4%)
Electroconvulsive therapy .671^
Yes 3 (0.3%) 2 (0.2%)
No 529 (46.8%) 597 (52.8%)
Nasal polypectomy 1.000^
Yes 2 (0.2%) 2 (0.2%)
No 530 (46.9%) 597 (52.8%)
Tonsillectomy .999*
Yes 8 (0.7%) 9 (0.8%)
No 524 (46.3%) 590 (52.2%)
Pulmonary Laceration 1.000^
Yes 0 (0%) 1 (0.1%)
No 532 (47%) 598 (52.9%)
Hand Fracture .470^
Yes 1 (0.1%) 0 (0%)
No 531 (46.9%) 599 (53%)
Sleeve Gastrectomy .470^
Yes 1 (0.1%) 0 (0%)
No 531 (46.9%) 599 (53%)
None procedures <.001*
Yes 368 (32.5%) 478 (42.3%)
No 164 (14.5%) 121 (10.7%)
Sensitivity to External Sounds during the past week <.001*
Yes 285 (25.2%) 107 (9.5%)
No 247 (21.8%) 492 (43.5%)
Difficulty Hearing in Noisy Environments <.001*
No 207 (18.3%) 412 (36.4%)
Slight difficulty 300 (24.5%) 179 (15.8%)
Yes, I cannot hear at all 25 (2.2%) 8 (0.7%)
Hearing Assistive Device Usage:
Hearing aid .486^
Yes 5 (0.4%) 3 (0.3%)
No 527 (46.6%) 596 (52.7%)
Cochlear implant 1.000^
Yes 0 (0%) 1 (0.1%)
No 532 (47%) 598 (52.9%)
Sound generator .221^
Yes 2 (0.2%) 0 (0%)
No 530 (46.9%) 599 (53%)
Combined device (hearing aid and sound generator in one device) .604^
Yes 2 (0.2%) 1 (0.1%)
No 530 (46.9%) 598 (52.9%)
None devices .193*
Yes 523 (46.2%) 594 (52.5%)
No 9 (0.8%) 5 (0.4%)
Experience of Symptoms:
Headache <.001*
Yes 301 (26.6%) 173 (15.3%)
No 231 (20.4%) 426 (37.7%)
Neck pain <.001*
Yes 153 (13.5%) 55 (4.9%)
No 379 (33.5%) 544 (48.1%)
Ear pain <.001*
Yes 88 (7.8%) 24 (2.1%)
No 444 (39.3%) 575 (50.8%)
Jaw pain <.001*
Yes 74 (6.5%) 27 (2.4%)
No 458 (40.5%) 572 (50.6%)
Facial pain <.001*
Yes 31 (2.7%) 10 (0.9%)
No 501 (44.3%) 589 (52.1%)
Shoulder pain .193^
Yes 4 (0.4%) 1 (0.1%)
No 528 (46.7%) 598 (52.9%)
None Pain <.001*
Yes 173 (15.3%) 400 (35.4%)
No 359 (31.7%) 199 (17.6%)
Oral conditions:
Jaw joint pain <.001*
Yes 73 (6.5%) 33 (2.9%)
No 459 (40.6%) 566 (50%)
Dental problems
<.001*
Yes 211 (18.7%) 146 (12.9%)
No 321 (28.4%) 453 (40.1%)
Neurological conditions:
Meningitis .268*
Yes 7 (0.6%) 4 (0.4%)
No 525(46.4%) 595 (52.6%)
Multiple sclerosis 0.030^
Yes 7 (0.6%) 1 (0.1%)
No 525 (46.4%) 598 (52.9%)
Epilepsy .018*
Yes 17 (1.5%) 7 (0.6%)
No 515 (45.5%) 592 (52.3%)
Stroke .604^
Yes 2 (0.2%) 1 (0.1%)
No 530 (46.9%) 598 (52.9%)
Other cerebrovascular diseases .092^
Yes 7 (0.6%) 2 (0.2%)
No 525 (46.4%) 597 (52.8%)
Psychological conditions:
Anxiety, excessive stress <.001*
Yes 264 (23.3%) 162 (14.3%)
No 268 (23.7%) 437 (38.6%)
Depression <.001*
Yes 98 (8.7%) 43 (3.8%)
No 434 (38.4%) 556 (49.2%)
Emotional trauma <.001*
Yes 59 (5.2%) 23 (2%)
No 473 (41.8%) 576 (50.9%)
Sleep disorders:
Difficulty falling asleep <.001*
Yes 246 (21.8%) 126 (11.1%)
No 286 (25.3%) 473 (41.8%)
Difficulty staying asleep <.001*
Yes 122 (10.8%) 58 (5.1%)
No 410 (36.6%) 541 (47.8%)
Cardiovascular conditions:
Low blood pressure .199*
Yes 30 (2.7%) 24 (2.1%)
No 502 (44.4%) 575 (50.8%)
High blood pressure <.001*
Yes 29 (2.6%) 6 (0.5%)
No 503 (44.5%) 593 (52.4%)
Myocardial infarction (heart attack) 1.000^
Yes 1 (0.1%) 1 (0.1%)
No 531 (46.9%) 598 (52.9%)
Endocrine and metabolic conditions:
Thyroid dysfunction 0.018*
Yes 17 (1.5%) 7 (0.6%)
No 515 (45.5%) 592 (52.3%)
Diabetes .529^
Yes 6 (0.5%) 4 (0.4%)
No 526 (46.5%) 595 (52.6%)
High cholesterol .020*
Yes 9 (0.8%) 2 (0.2%)
No 523 (46.2%) 597 (52.85)
Rheumatic and autoimmune disorders:
Rheumatoid arthritis <.001*
Yes 18 (1.6%) 4 (0.4%)
No 514 (45.4%) 595 (52.6%)
Lupus (facial rash) .092^
Yes 7 (0.6%) 2 (0.2%)
No 525 (46.4%) 597 (52.8%)
Ear, nose, and throat conditions:
Chronic sinusitis <.001*
Yes 77 (6.8%) 40 (3.5%)
No 455 (40.2%) 559 (49.4%)
Deviated nasal septum .012*
Yes 30 (2.7%) 16 (1.4%)
No 502 (44.4%) 583 (51.5%)
Other conditions:
Anemia .029*
Yes 47 (4.2%) 33 (2.9%)
No 485 (42.9%) 566 (50%)
Balance disorder <.001*
Yes 55 (4.9%) 24 (2.1%)
No 477 (42.2%) 575 (50.8%)
Gastroesophageal reflux disease (GERD) .039*
Yes 18 (1.6%) 9 (0.8%)
No 514 (45.4%) 590 (52.2%)
Adenoid .501^
Yes 0 (0%) 2 (0.2%)
No 532 (47%) 597 (52.8%)
Asthma 1.000^
Yes 1 (0.1%) 2 (0.2%)
No 531 (46.9%) 597 (52.8%)
Epistaxis 1.000^
Yes 1 (0.1%) 1 (0.1%)
No 531 (46.9%) 598 (52.9%)
Familial Mediterranean Fever .470^
Yes 1 (0.1%) 0 (0%)
No 531 (46.9%) 599 (53%)
HSV 1.000^
Yes 0 (0%) 1 (0.1%)
No 532 (47%) 598 (52.9%)
Helicobacter pylori 1.000^
Yes 0 (0%) 1 (0.1%)
No 532 (47%) 598 (52.9%)
Iron Deficiency .470^
Yes 1 (0.1%) 0 (0%)
No 531 (46.9%) 599 (53%)
Leukemia 1.000^
Yes 0 (0%) 1 (0.1%)
No 532 (47%) 598 (52.9%)
Migraine .671^
Yes 3 (0.3%) 2 (0.2%)
No 529 (46.8%) 597 (52.8%)
OCD 1.000^
Yes 0 (0%) 1 (0.1%)
No 532 (47%) 598 (52.9%)
Schizophrenia 1.000^
Yes 0 (0%) 1 (0.1%)
No 532 (47%) 598 (52.9%)
Parkinson’s disease .470^
Yes 1 (0.1%) 0 (0%)
No 531 (46.9%) 599 (53%)

Binary logistic regression analysis of the associations between tinnitus and influencing factors

Predictors of tinnitus were determined by entering significant variables from the Chi-square and Fisher’s exact analysis into a binary logistic regression model. The analysis revealed that individuals aged 17 were significantly more likely to have tinnitus by 1.5 times compared to those aged 15 (p = 0.038, 95% CI: 1.023–2.157). Additionally, reporting first-degree relatives had tinnitus was significantly associated with an approximately threefold increased risk of tinnitus (p = 0.010, 95% CI: 1.277–6.044). Moreover, higher sensitivity to external sounds during the past week was significantly associated with tinnitus, with a 2.7 times increased likelihood compared to those who didn’t report such sensitivity (p < 0.001, 95% CI: 1.971–3.711). Slight difficulty hearing in noisy environments was also significantly associated with tinnitus, increasing the likelihood by 1.7 times compared to those without such difficulty (p < 0.001, 95% CI: 1.261–2.314). Reporting pain symptoms was significantly associated with tinnitus, doubling the risk compared to those who didn’t report experiencing pain (p = 0.033, 95% CI: 1.057–3.805). Lastly, difficulty falling asleep was associated with a 1.8-fold higher risk of tinnitus compared to those who didn’t report such difficulty (p < 0.001, 95% CI: 1.270–2.462). Results are shown in Table 7.

Table 7. Logistic regression analysis of the associations between tinnitus and influencing factors.

Variable (reference) B p-Value OR 95% CI
Lower Upper
Age: 16 (15) .019 .917 1.019 .709 1.465
Age: 17 (15) .396 .038 1.486 1.023 2.157
Age: 18 (15) .101 .711 1.107 .647 1.894
Gender: Female (Male) .188 .249 1.206 .877 1.660
First-Degree Relatives with Tinnitus: Mother (no) −.664 .128 .515 .219 1.210
First-Degree Relatives with Tinnitus: Brothers (no) .575 .215 1.778 .717 4.411
First-Degree Relatives with Tinnitus: I don’t know (yes) .353 .369 1.424 .658 3.079
First-Degree Relatives with Tinnitus: None (yes) 1.022 .010 2.778 1.277 6.044
Dizziness: Yes, less than once a year (no) .082 .680 1.086 .733 1.608
Dizziness: Yes, more than once a year (no) .091 .647 1.096 .742 1.619
Ear-related conditions: Acoustic trauma due to sudden loud noise (no) .779 .120 2.180 .816 5.824
Ear-related conditions: Middle ear infection due to external pressure (no) .676 .097 1.966 .884 4.370
Ear-related conditions: Sudden hearing loss (no) 19.779 .999 389085857.96 .000
Ear-related conditions: Middle ear infection or Eustachian tube dysfunction (no) .560 .359 1.751 .529 5.796
Ear-related conditions: None conditions (yes) −.133 .704 .875 .440 1.741
Prior medical procedures: Dental procedure (filling removal, dental implants, prolonged dental surgery) (no) .020 .957 1.020 .497 2.095
Prior medical procedures: None procedures (Yes) .162 .632 1.176 .606 2.282
Sensitivity to External Sounds during the past week (no) .995 <.001 2.704 1.971 3.711
Difficulty Hearing in Noisy Environments: Slight difficulty (no) .536 <.001 1.708 1.261 2.314
Difficulty Hearing in Noisy Environments: Yes, I cannot hear at all (no) .706 .144 2.025 .786 5.219
Symptoms: Headache (no) −.144 .633 .866 .478 1.567
Symptoms: Neck pain (no) .369 .113 1.447 .916 2.286
Symptoms: Ear pain (no) .292 .322 1.340 .751 2.388
Symptoms: Jaw pain (no) .049 .884 1.050 .544 2.027
Symptoms: Facial pain (no) −.478 .298 .620 .252 1.527
Symptoms: None Pain (yes) .696 .033 2.006 1.057 3.805
Oral conditions: Jaw joint pain (no) −.104 .741 .902 .488 1.665
Oral conditions: Dental problems (no) .082 .623 1.086 .782 1.507
Neurological conditions: Multiple sclerosis (no) .645 .609 1.906 .161 22.566
Neurological conditions: Epilepsy (no) .169 .771 1.185 .378 3.714
Psychological conditions: Anxiety, excessive stress (no) .126 .439 1.134 .824 1.561
Psychological conditions: Depression (no) .073 .765 1.076 .665 1.742
Psychological conditions: Emotional trauma (no) .310 .326 1.363 .735 2.528
Sleep disorders: Difficulty falling asleep (no) .570 <.001 1.768 1.270 2.462
Sleep disorders: Difficulty staying asleep (no) .209 .327 1.233 .812 1.873
Cardiovascular conditions: High blood pressure (no) .834 .141 2.301 .758 6.984
Endocrine and metabolic conditions: Thyroid dysfunction (no) .151 .795 1.163 .372 3.632
Endocrine and metabolic conditions: High cholesterol (no) .806 .459 2.239 .265 18.931
Rheumatic and autoimmune disorders: Rheumatoid arthritis (no) .813 .228 2.255 .601 8.459
Ear, nose, and throat conditions: Chronic sinusitis (no) -.073 .785 .930 .551 1.568
Ear, nose, and throat conditions: Deviated nasal septum (no) -.283 .495 .754 .334 1.698
Other conditions: Anemia (no) -.257 .387 .773 .432 1.384
Other conditions: Balance disorder -.067 .831 .935 .506 1.729
Other conditions: Gastroesophageal reflux disease (GERD) (no) -.240 .637 .787 .290 2.132

Binary logistic regression analysis of the associations between tinnitus subtypes and influencing factors

Within the group of participants with tinnitus (n = 532), the predictor variables were evaluated. The variables that were significant in the chi-square analysis (results not included) were introduced into the logistic regression analysis to determine the predictors for having objective tinnitus compared with the subjective subtype and intermittent tinnitus compared with the continuous subtype. Table 8 shows the variables that were significantly associated with having objective or subjective tinnitus in the first column; however, the variables that were significant predictors of having objective tinnitus based on the logistic regression were just having epilepsy and migraine. Participants with tinnitus who have epilepsy are more likely to have objective tinnitus by around 9 times (p = 0.001, 95% CI: 2.59–37.579). Additionally, participants with tinnitus who have migraine are more likely to have objective tinnitus by around 16 times (p = 0.032, 95% CI: 1.268–208.176). Table 9 shows the variables that were significantly associated with having intermittent or continuous tinnitus in the first column; however, the variables that were significant predictors for continuous tinnitus were prior tonsillectomy and sensitivity to external sounds. Participants with tinnitus who have had tonsillectomy are less likely to have continuous tinnitus (OR: 0.164), (p = 0.03, 95% CI: 0.032–0.836). Additionally, participants with tinnitus who were sensitive to external sounds are also less likely to have continuous tinnitus (OR: 0.0619), (p = 0.013, 95% CI: 0.424–0.903).

Table 8. Logistic regression analysis of the associations between tinnitus form (subjective vs. objective) and the patients’ characteristics.

Variable (reference) B p-Value OR 95% CI
Lower Upper
First-Degree Relatives with Tinnitus: Mother (no) .397 .559 1.487 .392 5.637
.492 .526 1.636 .358 7.472
First-Degree Relatives with Tinnitus: Sister (no) .002 .999 1.002 .179 5.604
−.293 .554 .746 .283 1.970
Ear-related conditions: Acoustic trauma due to sudden loud noise (no) .405 .577 1.500 .361 6.237
Ear-related conditions: Sudden hearing loss (no) 1.217 .273 3.378 .383 29.786
Ear-related conditions: Eardrum perforation (no) −.034 .975 .966 .113 8.243
Ear-related conditions: None conditions (yes) −.963 .062 .382 .139 1.051
Prior medical procedures: Radiation therapy for the head and neck (no) 1.557 .211 4.743 .413 54.440
Sensitivity to External Sounds during the past week (No) −.094 .834 .910 .379 2.184
Hearing Assistive Device Usage: Sound Generator (no) 2.390 .254 10.911 .179 664.963
Hearing Assistive Device Usage: None (yes) −.662 .605 .516 .042 6.345
Neurological conditions: Meningitis (no) 1.426 .183 4.162 .511 33.918
Neurological conditions: Epilepsy (no) 2.289 0.001 9.865 2.590 37.579
Cardiovascular conditions: High BP (no) .308 .696 1.360 .291 6.366
Endocrine and metabolic conditions: Thyroid Dysfunction (no) .702 .422 2.017 .364 11.181
Endocrine and metabolic conditions: Diabetes (no) .760 .562 2.138 .164 27.932
Other conditions: Epistaxis (no) 22.499 1.000 5907292947.117 0.000
Other conditions: Migraine (no) 2.788 0.032 16.249 1.268 208.176

Table 9. Logistic regression analysis of the associations between tinnitus form (intermittent vs. continuous) and the patients’ characteristics.


Variable (reference)
B p-value OR 95% CI
Lower Upper
Prior medical procedures: Tonsillectomy (no) −1.808 0.030 .164 .032 .836
Sensitivity to External Sounds during the past week (No) −.480 0.013 .619 .424 .903
Hearing Assistive Device Usage: Combined Device(no) −21.759 0.999 .000 0.000

Discussion

The reported tinnitus prevalence in the current study is 47% among Palestinian young people aged 15–18 years old, which is notably high. The significant association between age and tinnitus in the current study, with older teenager (17-year-olds) exhibiting a 1.5-fold increased risk compared to younger studied group (15-year-olds). This is supported by previous studies that showed the prevalence of tinnitus increases with age [1,26,27] and among adolescents, those in their mid-teens have the highest incidence of tinnitus [26]. The single-year ages of 15 and 17 years examined in the present study both fall unequivocally within middle adolescence from a developmental perspective [20]. Their comparison should not be viewed as representing discrete developmental stages. The use of age ranges in adolescent research is theoretically based on the understanding that development during this life stage is continuous, non-linear, and not limited by rigid chronological limits, acknowledging contemporary perspectives that emphasize the fluidity and extended upper boundary of adolescence [28]. Adolescence is still a relatively understudied and developing life stage, with growing understanding that its upper boundary goes beyond traditional bounds.

Gender differences, more prevalent among females, align with prior research findings [2931]. This may be due to the greater tendency of girls to describe symptoms [32] and their more frequent generation of spontaneous otoacoustic emissions [33]. Our results revealed that tinnitus was more prevalent in females (50.7%) than in males (40.4%). Increased prevalence of tinnitus and tinnitus annoyance in females was also shown in a survey on the population of South Korea by Park et al. Those authors attributed their findings to the more stressful cultural situation of South Korean women, which demands female obedience and more roles for women within the family [34]. Palestinian females suffer similar cultural stressors in addition to political violence arising from the military occupation [35], which may have contributed to the increased perception of tinnitus in girls in our study. On the other hand, the decreased prevalence of tinnitus in Palestinian males may arise from the tendency of males to not declare their health problems [36].

Notably, the current study indicated that a positive family history of tinnitus increases the risk of developing tinnitus. This finding is in line with a previous study on tinnitus among Palestinian university students [18]. These notes support recent hypotheses about the possible genetic component in the etiology of tinnitus [37]. A recent genome-wide association study highlighted several significant pathways implicated in tinnitus [38]. Another study on tinnitus found a higher concordance rate in monozygotic twins compared to dizygotic twins [39]. Nevertheless, other large-scale studies have reported low heritability estimates for tinnitus and concluded that a strong association with any specific genetic locus is lacking [40]. It is frequently challenging to distinguish whether familial aggregation is caused by common genes or shared environmental factors, even though it has been demonstrated for many, if not all, disorders [41]. The existence of a familial impact for tinnitus allows for targeted research to ascertain if genetic factors or a shared familial environment are responsible for this effect [42]. Families are frequently exposed to the same environmental risks, eat comparable meals, and reside in the same geographic area. These common exposures may raise the chance of contracting specific illnesses, which could result in familial aggregation [43]. Because families live near one another and share living quarters, infectious diseases can spread readily within them. This may cause several family members to contract the same virus, giving the impression that there is a hereditary connection when in fact it is the result of transmission [44]. Family dynamics, stress levels, and learned coping mechanisms can also play a role. For example, a family with high levels of chronic stress might experience a higher prevalence of stress-related illnesses, even without a genetic predisposition [43]. Further collaborative attempts are necessary to provide biological insight into the potential genetic etiology of tinnitus.

Tinnitus in our sample frequently co-occurred with symptoms such as dizziness, sound sensitivity, headaches, and sleep disturbances, reflecting the multifaceted nature of the condition. These findings are consistent with previous research indicating that tinnitus often co-occurs with other auditory and non-auditory symptoms, including hyperacusis and psychological distress [45]. This study found a substantial association between disturbances in sleeping, especially difficulty in initiating sleep, and tinnitus. This corresponds with meta-analyses indicating that more than fifty percent of tinnitus sufferers suffer from sleep disturbances. The reciprocal association between tinnitus and sleep disruptions indicates that therapies aimed at improving sleep quality may positively impact tinnitus severity and vice versa [46].

According to the data, those affected experienced varying frequencies of tinnitus. Participants had tinnitus on a monthly, weekly, and daily basis with 13.5%, 17.9%, and 12.6% respectively, while a major proportion of participants experienced tinnitus every few months (28.2%) and yearly (27.8%). The frequency of tinnitus differs among individuals, suggesting it is a symptom rather than a disease, with multiple potential etiologies contributing to its onset. The figures indicate that a significant percentage of individuals experience tinnitus monthly, weekly, or daily. This data aligns with the evolving characteristics of tinnitus, emphasizing the necessity for a more profound understanding of its impact on individuals’ lives [47]. The other characteristics of tinnitus in our study sample confirm the disorder’s variability, with 32.7% reporting constant tinnitus and 67.3% experiencing intermittent tinnitus. The most prevalent tinnitus noises are crickets at 34.8%, noise at 25.7%, and tone sounds at 27.6%. Greater variation exists in the tinnitus rhythm, the affected ear, and whether it is subjective or objective. Notably, tinnitus is reported bilaterally in approximately 41% of our study population, indicating a potential association with systemic rather than localized disorders, such as Ménière’s disease, vestibular schwannoma, atmospheric inner ear barotrauma, vertebrobasilar ischemic stroke, and otosclerosis [48,49]. Although the precise etiology of tinnitus remains unclear, numerous risk factors have been identified. Multiple environmental and health-related factors were identified as associated with tinnitus. Older age, female, history of smoking, sleep disturbances, stress, exposure to noise, and a history of various medical conditions such as arthritis, asthma, and thyroid disorders have been identified as risk factors for tinnitus [9,31].

A significant proportion of respondents (57.7%) reported uncertainty about the onset of their tinnitus, indicating a potential lack of awareness or difficulty in pinpointing the exact timing of symptoms. The high proportion of uncertain responses regarding tinnitus onset reflects findings from Rosing et al. (2016), who noted similar challenges in pediatric tinnitus case histories. Among those who could recall, the majority (18.4%) experienced tinnitus within the past 1–12 months, followed by 13.5% reporting onset within 13–24 months. This suggests that tinnitus may often develop relatively recently in this population, though a subset (2.6%) reported symptoms persisting for over 36 months. The high percentage of uncertain responses underscores the need for improved education and awareness about tinnitus in adolescents [29]. The timing of tinnitus-associated conditions relative to tinnitus onset revealed that only a small fraction of respondents (2.6%) experienced these before tinnitus began, while 4.3% reported conditions arising after tinnitus started. A negligible proportion (1.1%) noted coincident timing. The low percentages suggest that while some conditions may be linked to tinnitus, the majority of cases (92.8%) either had no clear association or were unknown. This highlights the complexity of identifying direct causative factors and the need for further research into underlying mechanisms.

Regarding medication use, the majority of respondents (59.2%) reported no drug intake, which contrasts with adult populations [50], suggesting different risk profiles in adolescents. The pain relievers use (16.7%) could imply a potential association with over-the-counter medications [51]. Antibiotics were reported by 9.2% of respondents, raising questions about ototoxic effects in some cases. However, the high percentage of “I don’t know” responses (16.5%) indicates a need for better documentation and awareness of medication histories in this population. These findings emphasize the multifactorial nature of tinnitus in adolescents, with noise exposure, infections, and anxiety emerging as prominent risk factors [6]. The high prevalence of uncertainty regarding onset and associated conditions highlights the challenges in diagnosing and managing tinnitus in this age group. Public health efforts should focus on preventive measures, such as hearing protection and awareness campaigns, while clinicians should consider comprehensive evaluations that include mental health and medication histories [52].

The finding that 71.5% of participants had never sought professional help for tinnitus underscores a widespread reluctance or barrier to care. A recent scoping review reported that across diverse populations, fewer than one-third of individuals with tinnitus pursue medical evaluation, often due to beliefs that nothing can be done or low perceived severity [53]. Likewise, in Saudi Arabia, despite a prevalence of 37.6%, only a minority sought medical support, mirroring our finding of low help-seeking behavior [54].

Inner-ear pathologies such as acoustic trauma, middle-ear infections, and sudden hearing loss were significantly linked to tinnitus in our cohort, consistent with reports that cochlear injury and Eustachian tube dysfunction predispose to aberrant neural firing underlying phantom sound perception. Dizziness and balance disorders often coexist with tinnitus, reflecting shared vestibular–auditory pathophysiology [55]. Tinnitus frequently co-occurs with psychiatric conditions: anxiety, depression, and post-traumatic stress have been shown to exacerbate tinnitus distress and may influence its onset [56]. Sleep disturbances, particularly insomnia, both worsen symptom perception and are a consequence of tinnitus-related arousal. Pain syndromes—including headache, neck pain, and temporomandibular disorders—share convergent neural circuits with tinnitus, potentially explaining the association we observed [57]. Importantly, these findings highlight the necessity of adopting a biopsychosocial framework when interpreting tinnitus in adolescents [19]. In our Palestinian sample, the high prevalence of anxiety, stress, and sleep disturbances may reflect not only individual predisposition but also broader contextual stressors, including ongoing political conflict [58], academic pressures [22], and restricted access to healthcare [58], that can amplify tinnitus perception and distress. This underscores that tinnitus in this population cannot be understood through biological pathways alone but must account for the psychosocial environment in which these adolescents develop. Moreover, while tinnitus emerged as a reported symptom, it should be understood within the broader context of trauma-related conditions such as PTSD, particularly in conflict-affected areas such as Palestine, where the population, including all age groups, is frequently experiencing collective violence and adverse childhood experiences (ACEs) [59].

In our multivariate model, six factors emerged as independent predictors of tinnitus: adolescents aged 17 showed a 1.5-fold higher risk compared to those aged 15 (p = 0.038, 95% CI: 1.023–2.157), consistent with documented increases in tinnitus prevalence during late adolescence and early adulthood [60]; having a first-degree family history of tinnitus conferred approximately a threefold elevated risk (p = 0.010, 95% CI: 1.277–6.044), underscoring genetic predisposition evidenced by familial aggregation and heritability studies [61,62]; recent sensitivity to external sounds—hyperacusis—was associated with a 2.7-times greater likelihood of tinnitus (p < 0.001, 95% CI: 1.971–3.711), in line with the tight comorbidity observed between these conditions [63]; slight difficulty hearing in noisy environments increased the odds by 1.7 times (p < 0.001, 95% CI: 1.261–2.314), reflecting early sensorineural deficits as precursors to tinnitus [64]; reporting pain symptoms doubled the risk of tinnitus (p = 0.033, 95% CI: 1.057–3.805), corroborating population-based associations between chronic pain and tinnitus [65]; and difficulty falling asleep was linked to a 1.8-fold increased risk (p < 0.001, 95% CI: 1.270–2.462), consistent with evidence that insomnia both predisposes to and exacerbates tinnitus distress [66].

Conclusions

This study demonstrates a remarkably high prevalence of tinnitus among young Palestinians aged 15–18. The findings suggest that tinnitus onset and severity are influenced by a number of risk factors, particularly age, family history, sleep disturbances, and comorbid symptoms such as hyperacusis and pain. A significant association between tinnitus and positive family history of tinnitus was noted, supporting the hypothesis of a genetic role. These findings underscore the need for targeted public health initiatives to raise awareness, promote early identification, and encourage appropriate management of tinnitus among adolescents.

Recommendations

Future research should aim to clarify causal relationships and further explore the genetic, environmental, and psychosocial contributors to tinnitus in young populations. In particular, subtype-specific risk analysis, distinguishing between continuous vs. intermittent, subjective vs. objective tinnitus, and tinnitus with or without ear-related comorbidities, will be crucial for advancing knowledge and clinical practice. Such analyses will require larger or clinically enriched samples to enable sufficient statistical power and more targeted prevention and intervention strategies. Additionally, future studies should collect medication use data from all participants, regardless of tinnitus status, to enable a more robust assessment of the potential role of analgesics in the onset and severity of tinnitus. Future studies should incorporate comprehensive audiological and otologic evaluations to improve diagnostic accuracy and allow for clearer differentiation of tinnitus subtypes. Collaboration with audiologists and otolaryngologists is recommended to provide a more clinically grounded understanding of tinnitus and its underlying risk factors.

Limitations

This study has several limitations to be considered when interpreting the results. First, its cross-sectional design limits our ability to establish causal relationships, as data were collected at a single point in time. Second, the reliance on self-reported measures may introduce information bias due to recall inaccuracies or subjective interpretations. Third, while the study included a large sample of Palestinian adolescents, the use of convenience sampling, necessitated by Ministry of Education restrictions and mobility barriers during the ongoing conflict, may introduce selection bias that could affect prevalence estimates. The non-probability sampling design does not allow formal estimation of the magnitude or direction of this bias; therefore, the findings should be interpreted with caution and cannot be generalized to the broader Palestinian population. Additionally, the absence of objective audiological assessments and otologic evaluations limits the ability to clinically verify tinnitus and differentiate between tinnitus subtypes. The prevalence of tinnitus might be overestimated in the current study, as individuals with pre-existing auditory problems may have been more motivated to participate. Individuals with access to digital platforms were able to participate, which represents an additional bias in participation. Since identity confirmation was not applicable in our study setting, the precision of age-specific findings requires future studies with stricter verification protocols.

Supporting information

S1 File. Questionnaire.

(DOCX)

pone.0344420.s001.docx (33KB, docx)
S2 File. SPSS Data Modified.

(PDF)

pone.0344420.s002.pdf (477.7KB, pdf)

Acknowledgments

We thank everyone who contributed their time to make this project a reality. Likewise, we are grateful to the faculty of medicine and health sciences of An-Najah National University for their affordable collaboration.

Data Availability

All relevant data are within the manuscript and its Supporting Information files.

Funding Statement

The author(s) received no specific funding for this work.

References

  • 1.Al-Swiahb J, Park SN. Characterization of tinnitus in different age groups: a retrospective review. Noise Health. 2016;18(83):214–9. doi: 10.4103/1463-1741.189240 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 2.Bhimrao SK, Masterson L, Baguley D. Systematic review of management strategies for middle ear myoclonus. Otolaryngol Head Neck Surg. 2012;146(5):698–706. doi: 10.1177/0194599811434504 [DOI] [PubMed] [Google Scholar]
  • 3.Ramly NA, Roslenda AR, Suraya A, Asma A. Vascular loop in the cerebellopontine angle causing pulsatile tinnitus and headache: a case report. EXCLI J. 2014;13:192–6. [PMC free article] [PubMed] [Google Scholar]
  • 4.Sedley W. Tinnitus: does gain explain?. Neuroscience. 2019;407:213–28. [DOI] [PubMed] [Google Scholar]
  • 5.Patil JD, Alrashid MA, Eltabbakh A, Fredericks S. The association between stress, emotional states, and tinnitus: a mini-review. Front Aging Neurosci. 2023;15:1131979. doi: 10.3389/fnagi.2023.1131979 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 6.Baguley D, McFerran D, Hall D. Tinnitus. The Lancet. 2013;382(9904):1600–7. [DOI] [PubMed] [Google Scholar]
  • 7.Al-Lahham S, Nazzal Z, Massarweh A, Saymeh D, Al-Abed S, Muhammad D, et al. Prevalence and associated risk factors of tinnitus among adult Palestinians: a cross-sectional study. Sci Rep. 2022;12(1):20617. doi: 10.1038/s41598-022-24015-w [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 8.Boecking B, Klasing S, Walter M. Vascular-metabolic risk factors and psychological stress in patients with chronic tinnitus. 2022;14(11). [DOI] [PMC free article] [PubMed]
  • 9.Kim H-J, Lee H-J, An S-Y, Sim S, Park B, Kim SW, et al. Analysis of the prevalence and associated risk factors of tinnitus in adults. PLoS One. 2015;10(5):e0127578. doi: 10.1371/journal.pone.0127578 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 10.Cianfrone G, Mazzei F, Salviati M, Turchetta R, Orlando MP, Testugini V, et al. Tinnitus holistic simplified classification (thosc): a new assessment for subjective tinnitus, with diagnostic and therapeutic implications. Ann Otol Rhinol Laryngol. 2015;124(7):550–60. doi: 10.1177/0003489415570931 [DOI] [PubMed] [Google Scholar]
  • 11.Gallus S, Lugo A, Garavello W, Bosetti C, Santoro E, Colombo P, et al. Prevalence and determinants of Tinnitus in the Italian adult population. Neuroepidemiology. 2015;45(1):12–9. doi: 10.1159/000431376 [DOI] [PubMed] [Google Scholar]
  • 12.Møller AR, Langguth B, DeRidder D, Kleinjung T. Textbook of tinnitus. Springer Science & Business Media. 2010. [Google Scholar]
  • 13.Günay O, Borlu A, Horoz D, Günay İ. Tinnitus prevalence among the primary care patients in Kayseri, Turkiye. Erciyes Medical Journal. 2011;33(1):39–46. [Google Scholar]
  • 14.Khedr EM, Ahmed MA, Shawky OA, Mohamed ES, El Attar GS, Mohammad KA. Epidemiological study of chronic tinnitus in Assiut, Egypt. Neuroepidemiology. 2010;35(1):45–52. doi: 10.1159/000306630 [DOI] [PubMed] [Google Scholar]
  • 15.Jalessi M, Farhadi M, Asghari A, Kamrava SK, Amintehran E, Ghalehbaghi S, et al. Tinnitus: an epidemiologic study in Iranian population. Acta Med Iran. 2013;51(12):886–91. [PubMed] [Google Scholar]
  • 16.Esmaili AA, Renton J. A review of tinnitus. Aust J Gen Pract. 2018;47(4):205–8. doi: 10.31128/AJGP-12-17-4420 [DOI] [PubMed] [Google Scholar]
  • 17.Kentish R. Managing tinnitus in childhood. In: Baguley D, Fagelson M, editors. Tinnitus: clinical and research perspectives. Plural Publishing. 2016. [Google Scholar]
  • 18.Alqub M, Tourman N, Mousa J, Humead N, Abd Alrazeq A, Khatatbh A, et al. Tinnitus prevalence and associated risk factors among university students: A cross-sectional study. SAGE Open Med. 2024;12:20503121241283344. doi: 10.1177/20503121241283344 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 19.Cima RFF, Mazurek B, Haider H, Kikidis D, Lapira A, Noreña A, et al. A multidisciplinary European guideline for tinnitus: diagnostics, assessment, and treatment. Hno. 2019;67(Suppl 1):10–42. [DOI] [PubMed]
  • 20.Kim SY, Jeon YJ, Lee J-Y, Kim YH. Characteristics of tinnitus in adolescents and association with psychoemotional factors. Laryngoscope. 2017;127(9):2113–9. doi: 10.1002/lary.26334 [DOI] [PubMed] [Google Scholar]
  • 21.Tegg-Quinn S, Bennett RJ, Brennan-Jones CG, Barabash S, Mulders WH, Eikelboom RH. Reflections and perceptions of chronic tinnitus during childhood and adolescence. Int J Pediatr Otorhinolaryngol. 2020;138:110258. doi: 10.1016/j.ijporl.2020.110258 [DOI] [PubMed] [Google Scholar]
  • 22.Wang J, Wang Z, Yang Y, Wang T, Lin H, Zhang W, et al. Academic Burden and Emotional Problems Among Adolescents: A Longitudinal Mediation Analysis. J Adolesc. 2025;97(4):989–1001. doi: 10.1002/jad.12471 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 23.Genitsaridi E, Partyka M, Gallus S, Lopez-Escamez JA, Schecklmann M, Mielczarek M, et al. Standardised profiling for tinnitus research: the European school for interdisciplinary tinnitus research screening questionnaire (ESIT-SQ). Hear Res. 2019;377:353–9. doi: 10.1016/j.heares.2019.02.017 [DOI] [PubMed] [Google Scholar]
  • 24.Kennedy V, Wilson C, Stephens D. Quality of life and tinnitus. Audiological Medicine. 2004;2(1):29–40. doi: 10.1080/16513860410027349 [DOI] [Google Scholar]
  • 25.Shetye A, Kennedy V. Tinnitus in children: an uncommon symptom?. Arch Dis Child. 2010;95(8):645–8. doi: 10.1136/adc.2009.168252 [DOI] [PubMed] [Google Scholar]
  • 26.Rhee J, Lee D, Suh MW, Lee JH, Hong Y-C, Oh SH, et al. Prevalence, associated factors, and comorbidities of tinnitus in adolescents. PLoS One. 2020;15(7):e0236723. doi: 10.1371/journal.pone.0236723 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 27.Martinez C, Wallenhorst C, McFerran D, Hall DA. Incidence rates of clinically significant tinnitus: 10-year trend from a cohort study in England. Ear Hear. 2015;36(3):e69-75. doi: 10.1097/AUD.0000000000000121 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 28.Baird S, Choonara S, Azzopardi PS, Banati P, Bessant J, Biermann O, et al. A call to action: the second Lancet Commission on adolescent health and wellbeing. Lancet. 2025;405(10493):1945–2022. doi: 10.1016/S0140-6736(25)00503-3 [DOI] [PubMed] [Google Scholar]
  • 29.Rosing SN, Schmidt JH, Wedderkopp N, Baguley DM. Prevalence of tinnitus and hyperacusis in children and adolescents: a systematic review. BMJ Open. 2016;6(6):e010596. doi: 10.1136/bmjopen-2015-010596 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 30.Mahboubi H, Oliaei S, Kiumehr S, Dwabe S, Djalilian HR. The prevalence and characteristics of tinnitus in the youth population of the United States. Laryngoscope. 2013;123(8):2001–8. doi: 10.1002/lary.24015 [DOI] [PubMed] [Google Scholar]
  • 31.Bhatt IS. Prevalence of and risk factors for Tinnitus and Tinnitus-Related Handicap in a college-aged population. Ear Hear. 2018;39(3):517–26. doi: 10.1097/AUD.0000000000000503 [DOI] [PubMed] [Google Scholar]
  • 32.Eley TC, Lichtenstein P, Stevenson J. Sex differences in the etiology of aggressive and nonaggressive antisocial behavior: results from two twin studies. Child Dev. 1999;70(1):155–68. doi: 10.1111/1467-8624.00012 [DOI] [PubMed] [Google Scholar]
  • 33.Penner MJ. Linking spontaneous otoacoustic emissions and tinnitus. Br J Audiol. 1992;26(2):115–23. doi: 10.3109/03005369209077879 [DOI] [PubMed] [Google Scholar]
  • 34.Park KH, Lee SH, Koo J-W, Park HY, Lee KY, Choi YS, et al. Prevalence and associated factors of tinnitus: data from the Korean National Health and Nutrition Examination Survey 2009-2011. J Epidemiol. 2014;24(5):417–26. doi: 10.2188/jea.je20140024 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 35.Sousa CA, Kemp S, El-Zuhairi M. Dwelling within political violence: palestinian women’s narratives of home, mental health, and resilience. Health Place. 2014;30:205–14. doi: 10.1016/j.healthplace.2014.09.005 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 36.Tudiver F, Talbot Y. Why don’t men seek help? Family physicians’ perspectives on help-seeking behavior in men. J Fam Pract. 1999;48(1):47–52. [PubMed] [Google Scholar]
  • 37.Vona B, Nanda I, Shehata-Dieler W, Haaf T. Genetics of Tinnitus: still in its infancy. Front Neurosci. 2017;11:236. doi: 10.3389/fnins.2017.00236 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 38.Bhatt IS, Wilson N, Dias R, Torkamani A. A genome-wide association study of tinnitus reveals shared genetic links to neuropsychiatric disorders. Sci Rep. 2022;12(1):22511. doi: 10.1038/s41598-022-26413-6 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 39.Lopez-Escamez JA, Amanat S. Heritability and genetics contribution to tinnitus. Otolaryngologic Clinics of North America. 2020;53(4):501–13. [DOI] [PubMed] [Google Scholar]
  • 40.Kvestad E, Czajkowski N, Engdahl B, Hoffman HJ, Tambs K. Low heritability of tinnitus: results from the second Nord-Trøndelag health study. Arch Otolaryngol Head Neck Surg. 2010;136(2):178–82. doi: 10.1001/archoto.2009.220 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 41.Khoury MJ, Beaty TH, Liang KY. Can familial aggregation of disease be explained by familial aggregation of environmental risk factors?. Am J Epidemiol. 1988;127(3):674–83. doi: 10.1093/oxfordjournals.aje.a114842 [DOI] [PubMed] [Google Scholar]
  • 42.Hendrickx JJ, Huyghe JR, Demeester K, Topsakal V, Van Eyken E, Fransen E. Familial aggregation of tinnitus: a European multicentre study. B-ENT. 2007;3(Suppl 7):51–60. [PubMed] [Google Scholar]
  • 43.Institute of Medicine Committee on Assessing Interactions Among Social B, Genetic Factors in H. Genes, behavior, and the social environment: Moving beyond the nature/nurture debate. In: Hernandez LM, Blazer DG, editors. The National Academies Collection: Reports funded by National Institutes of Health. Washington (DC): National Academies Press (US). 2006. [PubMed] [Google Scholar]
  • 44.Matthews AG, Finkelstein DM, Betensky RA. Analysis of familial aggregation studies with complex ascertainment schemes. Stat Med. 2008;27(24):5076–92. doi: 10.1002/sim.3327 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 45.Fioretti AB, Fusetti M, Eibenstein A. Association between sleep disorders, hyperacusis and tinnitus: evaluation with tinnitus questionnaires. Noise Health. 2013;15(63):91–5. doi: 10.4103/1463-1741.110287 [DOI] [PubMed] [Google Scholar]
  • 46.Gu H, Kong W, Yin H, Zheng Y. Prevalence of sleep impairment in patients with tinnitus: a systematic review and single-arm meta-analysis. Eur Arch Otorhinolaryngol. 2022;279(5):2211–21. doi: 10.1007/s00405-021-07092-x [DOI] [PubMed] [Google Scholar]
  • 47.Langguth B, Kreuzer PM, Kleinjung T, De Ridder D. Tinnitus: causes and clinical management. Lancet Neurol. 2013;12(9):920–30. doi: 10.1016/S1474-4422(13)70160-1 [DOI] [PubMed] [Google Scholar]
  • 48.Thompson TL, Amedee R. Vertigo: a review of common peripheral and central vestibular disorders. Ochsner J. 2009;9(1):20–6. [PMC free article] [PubMed] [Google Scholar]
  • 49.Newman-Toker DE, Della Santina CC, Blitz AM. Vertigo and hearing loss. Handb Clin Neurol. 2016;136:905–21. doi: 10.1016/B978-0-444-53486-6.00046-6 [DOI] [PubMed] [Google Scholar]
  • 50.Cianfrone G, Pentangelo D, Cianfrone F, Mazzei F, Turchetta R, Orlando MP, et al. Pharmacological drugs inducing ototoxicity, vestibular symptoms and tinnitus: a reasoned and updated guide. Eur Rev Med Pharmacol Sci. 2011;15(6):601–36. [PubMed] [Google Scholar]
  • 51.Sheppard A, Hayes SH, Chen GD, Ralli M, Salvi R. Review of salicylate-induced hearing loss, neurotoxicity, tinnitus and neuropathophysiology. Acta Otorhinolaryngol Ital. 2014;34(2):79–93. [PMC free article] [PubMed] [Google Scholar]
  • 52.Tunkel DE, Bauer CA, Sun GH, Rosenfeld RM, Chandrasekhar SS, Cunningham ER Jr, et al. Clinical practice guideline: tinnitus. Otolaryngol Head Neck Surg. 2014;151(2 Suppl):S1–40. doi: 10.1177/0194599814545325 [DOI] [PubMed] [Google Scholar]
  • 53.Carmody N, Eikelboom RH, Tegg-Quinn S. Seeking Help for Tinnitus and Satisfaction With Healthcare Providers Including Diagnosis, Clinical Services, and Treatment: A Scoping Review. Eval Health Prof. 2023;46(2):170–93. doi: 10.1177/01632787231158402 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 54.Alkahtani R, Alkhalaf A, Aljabr A, Alharbi D, Almulafikh N, Almotairi S. Tinnitus Prevalence, Impact on Quality of Life, and Health-care-seeking Behavior among Adults: A Cross-sectional Study. Indian Journal of Otology. 2024;30(3):192–8. doi: 10.4103/indianjotol.indianjotol_56_24 [DOI] [Google Scholar]
  • 55.Batts S, Stankovic KM. Tinnitus prevalence, associated characteristics, and related healthcare use in the United States: a population-level analysis. Lancet Reg Health Am. 2024;29:100659. doi: 10.1016/j.lana.2023.100659 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 56.Beukes EW, Onozuka J, Brazell TP, Manchaiah V. Coping With Tinnitus During the COVID-19 Pandemic. Am J Audiol. 2021;30(2):385–93. doi: 10.1044/2021_AJA-20-00188 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 57.McFerran DJ, Stockdale D, Holme R, Large CH, Baguley DM. Why Is There No Cure for Tinnitus?. Front Neurosci. 2019;13:802. doi: 10.3389/fnins.2019.00802 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 58.Marie M, SaadAdeen S, Battat M. Anxiety disorders and PTSD in Palestine: a literature review. BMC Psychiatry. 2020;20(1):509. doi: 10.1186/s12888-020-02911-7 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 59.Butchart A, Villaveces A, Check P, Phinney A. Preventing violence: a guide to implementing the recommendations of the World report on violence and health. World Health Organisation. 2004. [Google Scholar]
  • 60.Meijers SM, de Ruijter JHJ, Stokroos RJ, Smit AL, Stegeman I. The Lifelines Cohort Study: Prevalence of Tinnitus Associated Suffering and Behavioral Outcomes in Children and Adolescents. Ear and Hearing. 2024;45(6). [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 61.T. J M, T Y, A D, O. A O, P. A O, A. A A, et al. The impact of occurrence of tinnitus in first degree relatives on the severity of disease among subjects. Int J Otorhinolaryngol Head Neck Surg. 2021;7(2):243. doi: 10.18203/issn.2454-5929.ijohns20210154 [DOI] [Google Scholar]
  • 62.Biswas R, Genitsaridi E, Trpchevska N, Lugo A, Schlee W, Cederroth CR, et al. Low Evidence for Tinnitus Risk Factors: A Systematic Review and Meta-analysis. J Assoc Res Otolaryngol. 2023;24(1):81–94. doi: 10.1007/s10162-022-00874-y [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 63.Cederroth CR, Lugo A, Edvall NK, Lazar A, Lopez-Escamez JA. Association between hyperacusis and tinnitus. 2020;9(8). [DOI] [PMC free article] [PubMed]
  • 64.Weilnhammer V, Gerstner D, Huß J, Schreiber F, Alvarez C, Steffens T, et al. Exposure to leisure noise and intermittent tinnitus among young adults in Bavaria: longitudinal data from a prospective cohort study. Int J Audiol. 2022;61(2):89–96. doi: 10.1080/14992027.2021.1899312 [DOI] [PubMed] [Google Scholar]
  • 65.Wang C, Li S, Shi M, Qin Z, Wang D, Li W, et al. Association between sleep and tinnitus in US adults: Data from the NHANES (2007–2012). Medicine. 2024;103(43). [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 66.Jiang Y, Liu Q, Ding Y, Sun Y. Systematic review and meta-analysis of the correlation between tinnitus and mental health. Am J Otolaryngol. 2025;46(3):104611. doi: 10.1016/j.amjoto.2025.104611 [DOI] [PubMed] [Google Scholar]

Decision Letter 0

Paul H Delano

3 Dec 2025

Dear Dr. ALQUB,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

Please submit your revised manuscript by Jan 17 2026 11:59PM. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at plosone@plos.org . When you're ready to submit your revision, log on to https://www.editorialmanager.com/pone/ and select the 'Submissions Needing Revision' folder to locate your manuscript file.

  • A rebuttal letter that responds to each point raised by the academic editor and reviewer(s). You should upload this letter as a separate file labeled 'Response to Reviewers'.

  • A marked-up copy of your manuscript that highlights changes made to the original version. You should upload this as a separate file labeled 'Revised Manuscript with Track Changes'.

  • An unmarked version of your revised paper without tracked changes. You should upload this as a separate file labeled 'Manuscript'.

If applicable, we recommend that you deposit your laboratory protocols in protocols.io to enhance the reproducibility of your results. Protocols.io assigns your protocol its own identifier (DOI) so that it can be cited independently in the future. For instructions see: https://journals.plos.org/plosone/s/submission-guidelines#loc-laboratory-protocols . Additionally, PLOS ONE offers an option for publishing peer-reviewed Lab Protocol articles, which describe protocols hosted on protocols.io. Read more information on sharing protocols at https://plos.org/protocols?utm_medium=editorial-email&utm_source=authorletters&utm_campaign=protocols .

We look forward to receiving your revised manuscript.

Kind regards,

Paul H Delano, Ph.D.

Academic Editor

PLOS ONE

Journal requirements:

When submitting your revision, we need you to address these additional requirements.

1. Please ensure that your manuscript meets PLOS ONE's style requirements, including those for file naming. The PLOS ONE style templates can be found at

https://journals.plos.org/plosone/s/file?id=wjVg/PLOSOne_formatting_sample_main_body.pdf and

https://journals.plos.org/plosone/s/file?id=ba62/PLOSOne_formatting_sample_title_authors_affiliations.pdf

If the reviewer comments include a recommendation to cite specific previously published works, please review and evaluate these publications to determine whether they are relevant and should be cited. There is no requirement to cite these works unless the editor has indicated otherwise.

Please review your reference list to ensure that it is complete and correct. If you have cited papers that have been retracted, please include the rationale for doing so in the manuscript text, or remove these references and replace them with relevant current references. Any changes to the reference list should be mentioned in the rebuttal letter that accompanies your revised manuscript. If you need to cite a retracted article, indicate the article’s retracted status in the References list and also include a citation and full reference for the retraction notice.

Additional Editor Comments:

Please add some discussion about the actual context of Palestine and how it might increase anxiety, insomnia and tinnitus

[Note: HTML markup is below. Please do not edit.]

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

Reviewer #1: Yes

Reviewer #2: Partly

Reviewer #3: Yes

**********

2. Has the statistical analysis been performed appropriately and rigorously? -->?>

Reviewer #1: Yes

Reviewer #2: No

Reviewer #3: Yes

**********

3. Have the authors made all data underlying the findings in their manuscript fully available??>

The PLOS Data policy

Reviewer #1: Yes

Reviewer #2: No

Reviewer #3: Yes

**********

4. Is the manuscript presented in an intelligible fashion and written in standard English??>

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

**********

Reviewer #1: Thank you very much for the opportunity to review this article. I find it highly interesting, and its findings undoubtedly warrant attention from public health policymakers.

The assumption of a 50% prevalence for the sample size calculation (which is striking because the prevalence in adults is 30%) is well justified because there were no previous regional data for the specific target population. It is understood that they assumed that tinnitus may have more pronounced risk factors in young people (e.g., exposure to loud music, academic stress levels, etc.). Without specific data for this age group, the researchers took the most rigorous and conservative route from a statistical point of view.

The only significant methodological weakness of this study is the use of convenience sampling, which introduces a possible selection bias and prevents the results from being generalised to the entire adolescent population of Palestine. However, this limitation is perfectly managed. The authors justify it due to the difficult conditions for research in the region, openly declare it, and explain its consequences.

The ‘Discussion’ section is particularly robust. The authors not only report their findings, but also contextualise them within the global scientific literature, discussing both the evidence that supports them and that which contradicts them.

The study is a very good example of rigorous and ethical research in an environment with logistical constraints.

Reviewer #2: Thank you for the opportunity to review this manuscript. It represents a commendable effort, and the article is generally well written and clearly communicated. I found it an engaging read. I do, however, have several important observations that I believe the authors should address to further strengthen the work.

Most of the concerns regarding this article stem from the limited information provided to evaluate the extent of bias introduced, particularly given the impossibility of randomization in the sample selection. This last consideration is a common issue in some attempts to establish population metrics, and it is well justified in this case in the text.

Although the final sample size is more than double the initially estimated target, the risk of substantial bias remains considerable. The authors acknowledge several potential sources of bias in their limitations section; however, they do not provide sufficient data to assess the magnitude of these issues, among others.

• Participation bias. The sampling strategy appears to favor individuals with auditory problems, which could significantly distort the representativeness of the findings. This potential bias is not discussed when comparing the results with other studies that may have relied on more representative sampling strategies.

• Access-related participation bias. A greater likelihood of participation among individuals with easier access to digital platforms introduces another layer of bias, potentially confounding, in an epidemiological fashion, the reported associations and limiting the external validity of the findings.

• Lack of quality control. No procedures are described to verify the identity or characteristics of respondents. While this is a recognized challenge in open surveys, it should be explicitly addressed, particularly given that the study population is narrowly defined in terms of age.

• Reflection about the instrument. Although I was not previously familiar with this instrument, it appears to have been widely applied across different settings. However, several methodological aspects require clarification. Was the instrument reverse-translated to ensure linguistic accuracy? Was a pilot study conducted prior to full implementation? In addition, given the length of the questionnaire, how did the authors account for the potential bias arising from respondent fatigue, whereby answers toward the end may be less accurate or consistent?

• Survey outreach. An estimation of the total population reached through different recruitment strategies would be valuable for evaluating coverage and representativeness.

• Attrition and completion rates. The manuscript does not report the number of participants who completed the survey relative to the number of attempts. It is implausible that all individuals who began the survey completed it. Similarly, it is unclear whether all data fields were fully completed, or whether the survey platform required mandatory responses to proceed. Clarifying this aspect would be essential, as attrition rates and missing data patterns are key indicators of data quality and potential bias.

In summary, while the sample size achieved is commendable, the absence of detailed information on recruitment, response validation, and attrition undermines confidence in the robustness and representativeness of the findings.

The presentation of results is excessively detailed, which diminishes the reader’s ability to discern the specific contributions of the article. Given that the topic is described as multifactorial and that the supporting evidence for associations with diverse risk factors remains generally weak, the simultaneous testing of a large number of variables is problematic. Moreover, some analyses based on the absence of associations within the dataset are presented but not adequately developed in the discussion. I recommend that the authors streamline their results by emphasizing those factors that appear most compelling or most closely aligned with the evidence introduced in the background, thereby strengthening the coherence and contribution of the manuscript.

Related to the previous point and regarding to the limited robustness of the sample, the use of modeling strategies may be problematic. The article would benefit from adopting a more explicitly exploratory tone, consistently avoiding the implication that the findings are representative of the entire population. For example, the results should be systematically framed as applying in “this sample of young Palestinians”, or something similar, rather than presented as generalizable estimates. In this light, the modeling exercises can still be considered valuable, but their contribution should be interpreted as illustrative and exploratory, rather than as evidence of definitive or population-level veracity.

There appears to be a systematic error in how prevalence percentages are calculated and communicated. For example, the second paragraph of the Discussion states that girls have a higher prevalence than boys, yet the percentages reported (32.7% and 14.3%) are inconsistent with the tabulated data. Using the authors’ own figures—730 girls in total (Table 1), of whom 370 have tinnitus (Table 6)—the prevalence among girls should be 370/730 ≈ 50.7%, not 32.7%. This suggests the denominator used was the total sample rather than the sex-specific subgroup. Please carefully review all other variables to ensure this error is not repeated, and re-evaluate whether comparisons with external studies remain valid in light of the corrected estimates.

Reviewer #3: The partial consideration of tinnitus as a psychosocial symptom is striking, given the context, both in the introduction and the discussion. The allusion to the healthcare costs of the problem is taken out of context and is not revisited in the discussion; it might be better to remove it.

**********

what does this mean? ). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy

Reviewer #1: Yes: Lorena Rodríguez-Osiac

Reviewer #2: No

Reviewer #3: No

**********

[NOTE: If reviewer comments were submitted as an attachment file, they will be attached to this email and accessible via the submission site. Please log into your account, locate the manuscript record, and check for the action link "View Attachments". If this link does not appear, there are no attachment files.]

To ensure your figures meet our technical requirements, please review our figure guidelines: https://journals.plos.org/plosone/s/figures

You may also use PLOS’s free figure tool, NAAS, to help you prepare publication quality figures: https://journals.plos.org/plosone/s/figures#loc-tools-for-figure-preparation.

NAAS will assess whether your figures meet our technical requirements by comparing each figure against our figure specifications.

PLoS One. 2026 Mar 9;21(3):e0344420. doi: 10.1371/journal.pone.0344420.r002

Author response to Decision Letter 1


21 Jan 2026

Dear editor,

Thank you for your time and we are grateful to the respected reviewers for their valuable comments which we believe they enhanced the manuscript. Kindly find below our responses. We highlighted the responses in the revised manuscript in red color.

Kind regards,

Malil Alqub, corresponding author, on behalf of all authors

Reviewer #1: Thank you very much for the opportunity to review this article. I find it highly interesting, and its findings undoubtedly warrant attention from public health policymakers.

We sincerely thank the reviewer for this positive assessment of the study’s relevance.

The assumption of a 50% prevalence for the sample size calculation (which is striking because the prevalence in adults is 30%) is well justified because there were no previous regional data for the specific target population. It is understood that they assumed that tinnitus may have more pronounced risk factors in young people (e.g., exposure to loud music, academic stress levels, etc.). Without specific data for this age group, the researchers took the most rigorous and conservative route from a statistical point of view.

We thank the reviewer for acknowledging and clearly articulating the rationale behind our sample size calculation. As noted, in the absence of prior regional data for Palestinian adolescents, adopting a 50% prevalence estimate was intended to ensure a conservative and statistically rigorous approach.

The only significant methodological weakness of this study is the use of convenience sampling, which introduces a possible selection bias and prevents the results from being generalised to the entire adolescent population of Palestine. However, this limitation is perfectly managed. The authors justify it due to the difficult conditions for research in the region, openly declare it, and explain its consequences.

We appreciate the reviewer’s balanced evaluation of this limitation. We have made every effort to transparently report the use of convenience sampling, justify it within the challenging research context, and clearly state its implications for generalisability in the manuscript.

The ‘Discussion’ section is particularly robust. The authors not only report their findings, but also contextualise them within the global scientific literature, discussing both the evidence that supports them and that which contradicts them.

We are grateful for this encouraging feedback. Considerable effort was devoted to ensuring that the discussion provided a critical and balanced synthesis of the findings within the broader international literature.

The study is a very good example of rigorous and ethical research in an environment with logistical constraints.

We sincerely thank the reviewer for this thoughtful and affirming comment. Conducting rigorous and ethical research under challenging conditions was a central priority of this study, and we greatly appreciate the reviewer’s recognition of this effort.

Reviewer #2: Thank you for the opportunity to review this manuscript. It represents a commendable effort, and the article is generally well written and clearly communicated. I found it an engaging read. I do, however, have several important observations that I believe the authors should address to further strengthen the work.

We thank the reviewer for positive and encouraging comments on the manuscript.

Most of the concerns regarding this article stem from the limited information provided to evaluate the extent of bias introduced, particularly given the impossibility of randomization in the sample selection. This last consideration is a common issue in some attempts to establish population metrics, and it is well justified in this case in the text.

We thank the reviewer for this thoughtful observation. We acknowledge that convenience sampling introduces potential selection bias. To mitigate this, participants were recruited from diverse settings across the West Bank (community centers and social media platforms) to enhance demographic and geographic representation within the constraints of political instability and restricted institutional access. As the reviewer notes, such limitations are common in conflict-affected settings where probability-based sampling is not feasible, as justified in the Methods section. These limitations are clearly outlined in the manuscript, and we emphasized that the findings can’t be generalized to the broader Palestinian population.

Although the final sample size is more than double the initially estimated target, the risk of substantial bias remains considerable. The authors acknowledge several potential sources of bias in their limitations section; however, they do not provide sufficient data to assess the magnitude of these issues, among others.

We thank the reviewer for this comment. we agree with the reviewer that a large sample size does not eliminate the risk of bias. Formal estimation of bias was not possible because the study relied on non-probability sampling and no population registry or sampling frame was available for comparison with non-participants. This limitation is now clarified in the Limitations section, and findings are interpreted cautiously.

• Participation bias. The sampling strategy appears to favor individuals with auditory problems, which could significantly distort the representativeness of the findings. This potential bias is not discussed when comparing the results with other studies that may have relied on more representative sampling strategies.

Response: We agree that participation bias is a potential limitation. Participation bias is discussed in the limitations section of the revised manuscript.

• Access-related participation bias. A greater likelihood of participation among individuals with easier access to digital platforms introduces another layer of bias, potentially confounding, in an epidemiological fashion, the reported associations and limiting the external validity of the findings.

Response: We agree that individuals' accessibility to digital platforms might be variable, and this bias is also added to the limitations section in the revised manuscript.

• Lack of quality control. No procedures are described to verify the identity or characteristics of respondents. While this is a recognized challenge in open surveys, it should be explicitly addressed, particularly given that the study population is narrowly defined in terms of age.

Response: We agree that the lack of identity confirmation may impact the participants' recruitment quality control, even though it may facilitate participants' approval to participate. We have included this in the limitations section. Identity confirmation was not applicable in our study setting; the precision of age-specific findings requires future studies with stricter verification protocols.

• Reflection about the instrument. Although I was not previously familiar with this instrument, it appears to have been widely applied across different settings. However, several methodological aspects require clarification. Was the instrument reverse-translated to ensure linguistic accuracy? Was a pilot study conducted prior to full implementation? In addition, given the length of the questionnaire, how did the authors account for the potential bias arising from respondent fatigue, whereby answers toward the end may be less accurate or consistent?

Response: To minimize respondent fatigue, the questionnaire was structured to allow participants to pause and resume, reducing the likelihood of inconsistent responses toward the end.

The questionnaire was an Arabic translation version of ESIT-SQ, which was used as a study tool in a recent Palestinian study, the questionnaire underwent a forward-backward translation process to ensure language accuracy in prior research.

A pilot study was executed before the comprehensive data collection to evaluate the clarity, relevance, and feasibility of the questionnaire. The pilot research data were excluded from the final analysis.

• Survey outreach. An estimation of the total population reached through different recruitment strategies would be valuable for evaluating coverage and representativeness.

• Attrition and completion rates. The manuscript does not report the number of participants who completed the survey relative to the number of attempts. It is implausible that all individuals who began the survey completed it. Similarly, it is unclear whether all data fields were fully completed, or whether the survey platform required mandatory responses to proceed. Clarifying this aspect would be essential, as attrition rates and missing data patterns are key indicators of data quality and potential bias.

Response: To prevent attrition and incomplete responses, all fields of the manuscript were mandatory, and only complete responses could be submitted. Thus, the response rate calculation was not applicable.

In summary, while the sample size achieved is commendable, the absence of detailed information on recruitment, response validation, and attrition undermines confidence in the robustness and representativeness of the findings.

The presentation of results is excessively detailed, which diminishes the reader’s ability to discern the specific contributions of the article. Given that the topic is described as multifactorial and that the supporting evidence for associations with diverse risk factors remains generally weak, the simultaneous testing of a large number of variables is problematic. Moreover, some analyses based on the absence of associations within the dataset are presented but not adequately developed in the discussion. I recommend that the authors streamline their results by emphasizing those factors that appear most compelling or most closely aligned with the evidence introduced in the background, thereby strengthening the coherence and contribution of the manuscript.

We appreciate the reviewer's suggestion. Given the exploratory nature of the study and the topic's varied background, we attempted to maintain a full presentation of data to ensure transparency and prevent selective reporting. Both significant and non-significant findings were considered instructive and relevant to current research. The Discussion section concentrates on the factors that are most closely related to earlier evidence, allowing for easier interpretation while keeping the overall results.

Related to the previous point and regarding to the limited robustness of the sample, the use of modeling strategies may be problematic. The article would benefit from adopting a more explicitly exploratory tone, consistently avoiding the implication that the findings are representative of the entire population. For example, the results should be systematically framed as applying in “this sample of young Palestinians”, or something similar, rather than presented as generalizable estimates. In this light, the modeling exercises can still be considered valuable, but their contribution should be interpreted as illustrative and exploratory, rather than as evidence of definitive or population-level veracity.

We completely agree that, given the sample's constraints, the study should take a more clearly exploratory approach. The phrasing in the revised manuscript has been carefully altered to minimize implications of population-level generalizability. Results are now regularly presented as applicable to "this sample of young Palestinians" rather than the general population.

There appears to be a systematic error in how prevalence percentages are calculated and communicated. For example, the second paragraph of the Discussion states that girls have a higher prevalence than boys, yet the percentages reported (32.7% and 14.3%) are inconsistent with the tabulated data. Using the authors’ own figures—730 girls in total (Table 1), of whom 370 have tinnitus (Table 6)—the prevalence among girls should be 370/730 ≈ 50.7%, not 32.7%. This suggests the denominator used was the total sample rather than the sex-specific subgroup. Please carefully review all other variables to ensure this error is not repeated, and re-evaluate whether comparisons with external studies remain valid in light of the corrected estimates.

Response: Thank you for your notice. The mentioned numbers were based on calculations using the total sample as a denominator. However, it is more logical to use the sex specific subgroup number. Numbers have been revised, and proper corrections have been made.

Reviewer #3: The partial consideration of tinnitus as a psychosocial symptom is striking, given the context, both in the introduction and the discussion. The allusion to the healthcare costs of the problem is taken out of context and is not revisited in the discussion; it might be better to remove it.

We thank the reviewer for this insightful comment. We agree that tinnitus should be conceptualized within a broader psychosocial framework. Accordingly, we have revised both the introduction and the discussion by adding a paragraph to each section that more explicitly acknowledges the psychosocial dimensions of tinnitus. (Page 3/ Introduction, Page 39/Discussion).

In addition, as healthcare costs were not analyzed in the present study and were not revisited in the discussion, we have removed the paragraph referring to the economic burden of tinnitus from the introduction to improve coherence and maintain focus on the study objectives

Attachment

Submitted filename: 12-01-2026 Responses.docx

pone.0344420.s004.docx (21.3KB, docx)

Decision Letter 1

Paul H Delano

29 Jan 2026

Dear Dr. ALQUB,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

Please submit your revised manuscript by Mar 15 2026 11:59PM. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at plosone@plos.org . When you're ready to submit your revision, log on to https://www.editorialmanager.com/pone/ and select the 'Submissions Needing Revision' folder to locate your manuscript file.

  • A letter that responds to each point raised by the academic editor and reviewer(s). You should upload this letter as a separate file labeled 'Response to Reviewers'.

  • A marked-up copy of your manuscript that highlights changes made to the original version. You should upload this as a separate file labeled 'Revised Manuscript with Track Changes'.

  • An unmarked version of your revised paper without tracked changes. You should upload this as a separate file labeled 'Manuscript'.

If applicable, we recommend that you deposit your laboratory protocols in protocols.io to enhance the reproducibility of your results. Protocols.io assigns your protocol its own identifier (DOI) so that it can be cited independently in the future. For instructions see: https://journals.plos.org/plosone/s/submission-guidelines#loc-laboratory-protocols . Additionally, PLOS ONE offers an option for publishing peer-reviewed Lab Protocol articles, which describe protocols hosted on protocols.io. Read more information on sharing protocols at https://plos.org/protocols?utm_medium=editorial-email&utm_source=authorletters&utm_campaign=protocols .

We look forward to receiving your revised manuscript.

Kind regards,

Paul H Delano, Ph.D.

Academic Editor

PLOS One

Journal Requirements:

1. If the reviewer comments include a recommendation to cite specific previously published works, please review and evaluate these publications to determine whether they are relevant and should be cited. There is no requirement to cite these works unless the editor has indicated otherwise.

2. Please review your reference list to ensure that it is complete and correct. If you have cited papers that have been retracted, please include the rationale for doing so in the manuscript text, or remove these references and replace them with relevant current references. Any changes to the reference list should be mentioned in the rebuttal letter that accompanies your revised manuscript. If you need to cite a retracted article, indicate the article’s retracted status in the References list and also include a citation and full reference for the retraction notice.

[Note: HTML markup is below. Please do not edit.]

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

Reviewer #2: (No Response)

Reviewer #3: All comments have been addressed

**********

2. Is the manuscript technically sound, and do the data support the conclusions??>

Reviewer #2: Yes

Reviewer #3: Partly

**********

3. Has the statistical analysis been performed appropriately and rigorously? -->?>

Reviewer #2: Yes

Reviewer #3: Yes

**********

4. Have the authors made all data underlying the findings in their manuscript fully available??>

The PLOS Data policy

Reviewer #2: Yes

Reviewer #3: Yes

**********

5. Is the manuscript presented in an intelligible fashion and written in standard English??>

Reviewer #2: Yes

Reviewer #3: Yes

**********

Reviewer #2: I’d like to thank the authors for their thoughtful revision of the text. This revised version shows clear effort to improve the manuscript, and several points raised in the initial review have been addressed in a satisfactory manner.

I appreciate the clearer acknowledgment of the study’s exploratory nature and tone, the more explicit discussion of limitations related to the sampling strategy, and the expanded description of the questionnaire (i.e. prior validation, pilot testing)

Some other comments appear to have been addressed mainly at a declarative level. While additional limitations are now mentioned, their implications are not always incorporated into the interpretation of results or comparisons with other studies. This does not detract substantially from the manuscript.

However, I would like to draw attention to one specific issue that remains unresolved and requires further careful revision. Although the authors state that prevalence calculations were corrected, the revised manuscript continues to report sex-specific prevalence percentages using the total sample as the denominator rather than sex-specific denominators. For instance, the proportion of females with tinnitus is still reported as 32.7% (370/1131) in both the abstract and Table 6, whereas the sex-specific prevalence would be approximately 50.7% (370/730), as correctly reflected in the discussion section.

While reporting percentages using the total sample as the denominator in a “2×2 table” format can be acceptable if clearly justified and consistently communicated, the use of these percentages in the abstract is potentially misleading. Moreover, when comparing the tables in the revised manuscript with those in the original version, I do not observe any changes to the numerical values. This suggests that, beyond revisiting the calculations in the tables themselves, it is important to carefully review all related interpretations and summaries of the data to ensure consistency and accuracy throughout the manuscript.

While this appears to be a technical oversight, correcting it is important, as it affects subgroup comparisons and the interpretation of the findings. I therefore encourage the authors to revisit all prevalence calculations, ensure that appropriate denominators are used throughout, and update any related interpretations accordingly.

Overall, the manuscript has improved. and addressing this remaining issue would further strengthen its internal consistency and clarity.

Reviewer #3: Two comments regarding the insertions made in the introduction and conclusions, in response to my observations on the first version of the manuscript. (1) Highlighting the greater (but marginal) risk attributed to the age of 17 years is delicate. From a developmental perspective, adolescent development encompasses different classifications; one of the most traditional distinguishes adolescence into early, middle, and late age ranges. The article with which this study is compared and which purportedly supports its findings (ref. 20) compares age ranges (11–14 years and 14–18 years) rather than single-year ages. Moreover, the single-year ages of 15 and 17 years, which are used as points of comparison in the present study, are included within the same age range of middle adolescence from a developmental standpoint, both evolutionarily and in the cited study. This is relevant because the use of age ranges is developmentally grounded in the understanding that adolescents are undergoing continuous development, without absolute thresholds, within a phase of the life cycle that has been relatively understudied and whose upper age limit has been extended (Baird, S., Choonara, S., Azzopardi, P. S., Banati, P., Bessant, J., Biermann, O., Capon, A., Claeson, M., Collins, P. Y., De Wet-Billings, N., Dogra, S., Dong, Y., Francis, K. L., Gebrekristos, L. T., Groves, A. K., Hay, S. I., Imbago-Jácome, D., Jenkins, A. P., Kabiru, C. W., … Viner, R. M. (2025)). In addition, from a technical standpoint, the statistical test applied to the age variable in the present study evaluates the statistical hypothesis of difference versus no difference across the set of ages as a whole, rather than differences between specific single-year ages. (2) Reference 58 acknowledges contextual elements, including collective violence (I suggest review : World Health Organization. (2004). Preventing violence: A guide to implementing the recommendations of the World report on violence and health (ISBN: 9241592079). World Health Organization. Page 1) as a risk factor for PTSD, in which tinnitus would be an associated symptom of a broader clinical condition. In light of this background, I would like to invite the authors to think critically on the investigative, ethical, and epistemic perspective that challenges us all to question the value, energy, and level of detail involved in studying tinnitu as a specific symptom in relation to the adverse childhood experiences (ACEs or Adverse Childhood Events) that adolescents—understood as members of the species in a critical developmental phase that shapes their personal and societal futures—are experiencing in contexts that would make it desirable to consider variables not captured by standardized instruments developed in other settings, as frequently occurs in countries with levels of development different from those considered “developed.”

**********

what does this mean? ). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy

Reviewer #2: No

Reviewer #3: No

**********

[NOTE: If reviewer comments were submitted as an attachment file, they will be attached to this email and accessible via the submission site. Please log into your account, locate the manuscript record, and check for the action link "View Attachments". If this link does not appear, there are no attachment files.]

To ensure your figures meet our technical requirements, please review our figure guidelines: https://journals.plos.org/plosone/s/figures

You may also use PLOS’s free figure tool, NAAS, to help you prepare publication quality figures: https://journals.plos.org/plosone/s/figures#loc-tools-for-figure-preparation.

NAAS will assess whether your figures meet our technical requirements by comparing each figure against our figure specifications.

PLoS One. 2026 Mar 9;21(3):e0344420. doi: 10.1371/journal.pone.0344420.r004

Author response to Decision Letter 2


18 Feb 2026

Reviewer #2: I’d like to thank the authors for their thoughtful revision of the text. This revised version shows clear effort to improve the manuscript, and several points raised in the initial review have been addressed in a satisfactory manner.

I appreciate the clearer acknowledgment of the study’s exploratory nature and tone, the more explicit discussion of limitations related to the sampling strategy, and the expanded description of the questionnaire (i.e. prior validation, pilot testing)

Some other comments appear to have been addressed mainly at a declarative level. While additional limitations are now mentioned, their implications are not always incorporated into the interpretation of results or comparisons with other studies. This does not detract substantially from the manuscript.

However, I would like to draw attention to one specific issue that remains unresolved and requires further careful revision. Although the authors state that prevalence calculations were corrected, the revised manuscript continues to report sex-specific prevalence percentages using the total sample as the denominator rather than sex-specific denominators. For instance, the proportion of females with tinnitus is still reported as 32.7% (370/1131) in both the abstract and Table 6, whereas the sex-specific prevalence would be approximately 50.7% (370/730), as correctly reflected in the discussion section.

While reporting percentages using the total sample as the denominator in a “2×2 table” format can be acceptable if clearly justified and consistently communicated, the use of these percentages in the abstract is potentially misleading. Moreover, when comparing the tables in the revised manuscript with those in the original version, I do not observe any changes to the numerical values. This suggests that, beyond revisiting the calculations in the tables themselves, it is important to carefully review all related interpretations and summaries of the data to ensure consistency and accuracy throughout the manuscript.

Response: The percentages were revised and corrected using the sex-specific denominators rather than the total sample.

While this appears to be a technical oversight, correcting it is important, as it affects subgroup comparisons and the interpretation of the findings. I therefore encourage the authors to revisit all prevalence calculations, ensure that appropriate denominators are used throughout, and update any related interpretations accordingly.

Overall, the manuscript has improved. and addressing this remaining issue would further strengthen its internal consistency and clarity.

Reviewer #3: Two comments regarding the insertions made in the introduction and conclusions, in response to my observations on the first version of the manuscript.

(1) Highlighting the greater (but marginal) risk attributed to the age of 17 years is delicate. From a developmental perspective, adolescent development encompasses different classifications; one of the most traditional distinguishes adolescence into early, middle, and late age ranges. The article with which this study is compared and which purportedly supports its findings (ref. 20) compares age ranges (11–14 years and 14–18 years) rather than single-year ages. Moreover, the single-year ages of 15 and 17 years, which are used as points of comparison in the present study, are included within the same age range of middle adolescence from a developmental standpoint, both evolutionarily and in the cited study. This is relevant because the use of age ranges is developmentally grounded in the understanding that adolescents are undergoing continuous development, without absolute thresholds, within a phase of the life cycle that has been relatively understudied and whose upper age limit has been extended (Baird, S., Choonara, S., Azzopardi, P. S., Banati, P., Bessant, J., Biermann, O., Capon, A., Claeson, M., Collins, P. Y., De Wet-Billings, N., Dogra, S., Dong, Y., Francis, K. L., Gebrekristos, L. T., Groves, A. K., Hay, S. I., Imbago-Jácome, D., Jenkins, A. P., Kabiru, C. W., … Viner, R. M. (2025)). In addition, from a technical standpoint, the statistical test applied to the age variable in the present study evaluates the statistical hypothesis of difference versus no difference across the set of ages as a whole, rather than differences between specific single-year ages.

Response: Thank you for providing this important and constructive remark. We completely agree that interpreting age-related data in adolescent necessitates careful conceptual and methodological considerations. As a result, we have tempered the terminology in discussion sections to avoid the impression that age 17 represents a discrete developmental category. Instead, we refer to the data as a marginal variance observed throughout middle adolescence, rather than evidence of a discrete age-specific risk. We have also included a brief line in the Discussion to acknowledge modern perspectives that emphasize adolescence's flexibility and stretched upper border (e.g., Baird et al., 2025), emphasizing the absence of hard developmental thresholds.

(2) Reference 58 acknowledges contextual elements, including collective violence (I suggest review : World Health Organization. (2004). Preventing violence: A guide to implementing the recommendations of the World report on violence and health (ISBN: 9241592079). World Health Organization. Page 1) as a risk factor for PTSD, in which tinnitus would be an associated symptom of a broader clinical condition. In light of this background, I would like to invite the authors to think critically on the investigative, ethical, and epistemic perspective that challenges us all to question the value, energy, and level of detail involved in studying tinnitu as a specific symptom in relation to the adverse childhood experiences (ACEs or Adverse Childhood Events) that adolescents—understood as members of the species in a critical developmental phase that shapes their personal and societal futures—are experiencing in contexts that would make it desirable to consider variables not captured by standardized instruments developed in other settings, as frequently occurs in countries with levels of development different from those considered “developed.”

Response: Thank you for this comment. We agree with the importance of situating tinnitus within the broader clinical and contextual framework of adolescent health, as tinnitus may represent an associated symptom of conditions such as PTSD, particularly in contexts marked by collective violence and adverse childhood experiences (ACEs). In response, we have included this point in the discussion and the suggested reference has been included.

The sentence included in the discussion: Moreover, while tinnitus emerged as a reported symptom, it should be understood within the broader context of trauma-related conditions such as PTSD, particularly in conflict-affected areas such as Palestine, where the population, including all age groups, is frequently experiencing collective violence and adverse childhood experiences (ACEs)

Attachment

Submitted filename: 14-02-2026 Responses.docx

pone.0344420.s005.docx (18.4KB, docx)

Decision Letter 2

Paul H Delano

19 Feb 2026

Prevalence and Associated Risk Factors of Tinnitus Among Palestinian Adolescents Aged 15–18: A Cross-Sectional Study

PONE-D-25-46042R2

Dear Dr. ALQUB,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

An invoice will be generated when your article is formally accepted. Please note, if your institution has a publishing partnership with PLOS and your article meets the relevant criteria, all or part of your publication costs will be covered. Please make sure your user information is up-to-date by logging into Editorial Manager at Editorial Manager®  and clicking the ‘Update My Information' link at the top of the page. For questions related to billing, please contact billing support .

If your institution or institutions have a press office, please notify them about your upcoming paper to help maximize its impact. If they’ll be preparing press materials, please inform our press team as soon as possible -- no later than 48 hours after receiving the formal acceptance. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information, please contact onepress@plos.org.

Kind regards,

Paul H Delano, Ph.D.

Academic Editor

PLOS One

Additional Editor Comments (optional):

Reviewers' comments:

Acceptance letter

Paul H Delano

PONE-D-25-46042R2

PLOS One

Dear Dr. ALQUB,

I'm pleased to inform you that your manuscript has been deemed suitable for publication in PLOS One. Congratulations! Your manuscript is now being handed over to our production team.

At this stage, our production department will prepare your paper for publication. This includes ensuring the following:

* All references, tables, and figures are properly cited

* All relevant supporting information is included in the manuscript submission,

* There are no issues that prevent the paper from being properly typeset

You will receive further instructions from the production team, including instructions on how to review your proof when it is ready. Please keep in mind that we are working through a large volume of accepted articles, so please give us a few days to review your paper and let you know the next and final steps.

Lastly, if your institution or institutions have a press office, please let them know about your upcoming paper now to help maximize its impact. If they'll be preparing press materials, please inform our press team within the next 48 hours. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information, please contact onepress@plos.org.

You will receive an invoice from PLOS for your publication fee after your manuscript has reached the completed accept phase. If you receive an email requesting payment before acceptance or for any other service, this may be a phishing scheme. Learn how to identify phishing emails and protect your accounts at https://explore.plos.org/phishing.

If we can help with anything else, please email us at customercare@plos.org.

Thank you for submitting your work to PLOS ONE and supporting open access.

Kind regards,

PLOS ONE Editorial Office Staff

on behalf of

Dr. Paul H Delano

Academic Editor

PLOS One

Associated Data

    This section collects any data citations, data availability statements, or supplementary materials included in this article.

    Supplementary Materials

    S1 File. Questionnaire.

    (DOCX)

    pone.0344420.s001.docx (33KB, docx)
    S2 File. SPSS Data Modified.

    (PDF)

    pone.0344420.s002.pdf (477.7KB, pdf)
    Attachment

    Submitted filename: 12-01-2026 Responses.docx

    pone.0344420.s004.docx (21.3KB, docx)
    Attachment

    Submitted filename: 14-02-2026 Responses.docx

    pone.0344420.s005.docx (18.4KB, docx)

    Data Availability Statement

    All relevant data are within the manuscript and its Supporting Information files.


    Articles from PLOS One are provided here courtesy of PLOS

    RESOURCES