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. 2026 Mar 2;14:1354. Originally published 2025 Dec 3. [Version 2] doi: 10.12688/f1000research.173727.2

Aligning Sleep Patterns with Educational Schedules in Iran: Policy Recommendations for Enhancing Health and Academic Success

Ali Zakiei 1, Arash Ziapour 2, Mohammad-Taher Moradi 1,a, Habibolah Khazaei 1
PMCID: PMC12976609  PMID: 41822905

Version Changes

Revised. Amendments from Version 1

Update Text (Version 2):     This revised version addresses reviewer comments by: (1) clarifying the Iranian focus in title, introduction, and throughout; (2) providing explicit evidence-based justification for the 8:30 AM start time citing AAP (2014) and Yip et al. (2022); (3) acknowledging the 9:00 PM activity cutoff as a logical derivation requiring further research; (4) adding statistical context to obesity risks (AORs, CIs, age definitions); (5) incorporating discussion of age-related sleep differences and social jetlag; (6) broadening sleep hygiene education to include multiple barriers (socioeconomic status, screen time); (7) completing and verifying all references; and (8) softening causal language throughout. All reviewer comments were addressed point-by-point.

Abstract

Background

This policy brief examines the significant misalignment between the biological sleep patterns of students and the early start times of most educational institutions, specifically within the context of the Iranian educational system. Chronic sleep deprivation in this population is associated with detrimental effects on academic performance, mental and physical health, and interpersonal relationships.

Policy and implications

Compelling evidence indicates that early school schedules, dictated by historical and economic factors rather than student biology, force adolescents and young adults into a state of chronic sleep deficit. This has clear impacts, including impaired cognitive function, increased risks of obesity and cardiometabolic disease, and academic burnout. Studies confirm that delaying start times is an effective intervention to reduce these problems.

Recommendations

This brief recommends systematic changes, including later school and university start times, the integration of sleep hygiene education into curricula, strict limits on late-evening activities, and the use of flexible learning models. Supporting these structural changes, systems for monitoring student well-being and educating families are also advised.

Conclusions

Aligning educational schedules with biological sleep needs is a critical public health intervention. Comprehensive strategies that combine schedule adjustments, education, and support services offer the greatest benefit for student health and academic success. Future research should focus on pilot implementations and socio-economic barriers specific to Iran to ensure equitable implementation.

Keywords: Sleep, Education, Children, Adolescent Health, School Start Times, Circadian Rhythms, Academic Performance, Policy Analysis

Introduction

Sleep is recognized as a vital and structured process that follows a regular, cyclical pattern each night. This organized sequence of events ensures the optimal restoration of both physical and mental functions. 1 Indeed, sleep plays a crucial role in human psychological and physical health and is a key factor in regulating emotion, cognition, psychosocial development, and physical growth. 2 Inappropriate sleep patterns constitute a serious risk factor for poor physical health 3 and significantly diminish quality of life. 4 It is essential for individuals to maintain proper sleep schedules and obtain sufficient sleep, as sleep insufficiency impairs daily functioning and incurs substantial human, social, and economic costs. 5 Since sleep timing is a critical aspect, 6 sleep should occur within an appropriate temporal framework.

Healthy sleep necessitates several conditions, including adequate duration, satisfactory quality, appropriate timing, and consistent regularity. It also depends on the absence of sleep disorders. 7 However, healthy sleep, or sleep hygiene, often receives insufficient attention today, and school and university schedules frequently disregard student sleep patterns in their educational planning. 8 The scale of the issue is significant, with studies indicating that a considerable portion (e.g., over 60% in some epidemiological studies) of the student population exhibits poor sleep hygiene and insufficient sleep quantity. 9

In Iran, schools typically commence between 7:30 and 8:00 AM, and no national policy currently requires consideration of student sleep biology in scheduling decisions. Iranian studies have documented that a substantial proportion of students exhibit poor sleep hygiene and insufficient sleep duration, 8 , 9 and that poor sleep quality is associated with academic burnout. 10 However, no published research has examined the effects of delayed school start times in Iranian schools. This policy brief therefore synthesizes international evidence and proposes recommendations specifically for the Iranian educational system, while identifying critical gaps that require local investigation.

Policy outcomes and implications

This policy brief is evidence-informed policy synthesis of the international current scientific literature on adolescent sleep, circadian rhythms, and school start times, with the objective of applying this evidence to the Iranian educational context. We prioritized evidence from authoritative policy statements (e.g., American Academy of Pediatrics, 2014), 11 meta-analyses, 12 and systematic reviews, 13 and integrated these with epidemiological data on sleep patterns among Iranian students. 8 10

A fundamental conflict exists between the rigid schedules of educational institutions and the biological clocks of students. Despite compelling evidence on adolescent sleep needs, school start times are often dictated by history and logistics, not student physiology. 14 This conflict is exacerbated by modern lifestyles that push bedtimes later, while long commutes and early class times force students to wake prematurely. This misalignment between educational schedules and circadian rhythms exposes students to the well-documented consequences of chronic sleep deprivation, thereby putting at risk their health, safety, and academic performance. Research has shown that sleep problems during the educational years are linked to broader psychosocial challenges, underscoring the multifaceted impact of sleep on student well-being. 9

The core problem lies in the direct impact of early start times on sleep duration and quality. Early classes force students to wake earlier, which, even with unchanged bedtimes, truncates total sleep time and leads to a cumulative sleep deficit. This forced sleep restriction is associated with significant issues, including academic burnout and declined academic performance. 10, 15 The consequences, however, extend far beyond the classroom, demonstrating measurable physiological consequences. Inadequate sleep is linked to poorer diet quality, decreased insulin sensitivity, and hyperglycemia. 16 The scale of this impact is staggering. In adolescents, very short sleep (<7 hours) can increase the odds of obesity by 69% (adjusted odds ratio [AOR] = 1.69; 95% CI: 1.39–2.05) and elevated waist circumference by 49% (AOR = 1.49; 95% CI: 1.28–1.73). 17 This study defined adolescents as individuals aged 10–19 years. This significantly elevates their long-term risk for type 2 diabetes and cardiovascular disease. While these correlational data are compelling, we must also consider confounding factors like academic stress and familial pressures.

Revising school start times is therefore an evidence-based necessity, not just an optional adjustment. It is crucial for protecting student well-being and educational productivity. The core of the issue is chronobiological: when early schedules conflict with students’ innate circadian rhythms, the resulting sleep deficit directly undermines their academic performance, mental health, and behavior. Empirical evidence demonstrates the solution. Results from a systematic review indicated that delaying school start times significantly increases students’ nightly sleep duration by at least 30 minutes, primarily due to a later wake-up time. 18 Also, this policy change is associated with improved school attendance, reduced tardiness, decreased daytime sleepiness, and enhanced academic performance. 18 These findings highlight the need to reevaluate school timing policies. It is now widely argued that delayed start times allow students to experience more and better-quality sleep, leading to reduced daytime sleepiness, improved cognitive and academic performance, 19, 20 and better overall physical and mental health. 11, 12 Successful implementation, however, requires a multi-systemic approach that considers potential conflicts with parental work schedules and the pervasive culture of intensive extracurricular commitments. In general, flexibility in the educational schedule could be proposed as a practical and acceptable alternative to a fixed later start time, provided that students are encouraged to adhere to a consistent sleep schedule. 21

Actionable recommendations

Based on the analysis of policy outcomes and implications, we propose the following coordinated actions for educational policymakers and institutions.

Mandate evidence-based start times

Consider adopting a national guideline recommending that schools aim for start times no earlier than 8:30 AM, beginning with pilot implementations in selected provinces. The American Academy of Pediatrics (2014) 11 explicitly recommends this threshold to allow adolescents the opportunity to achieve 8.5–9.5 hours of sleep. 11 This is supported by meta-analytic evidence 12 demonstrating that start times within the 8:30–8:59 AM window are associated with significantly longer sleep duration (effect size = 0.184, p < 0.05) and better overall sleep (effect size = 0.316, p < 0.05) compared with earlier start times.

Enforce an evening activity curfew

Extracurricular and academic activities should be scheduled to conclude by 9:00 PM. The American Academy of Pediatrics (2014) 11 states that the average teenager has difficulty falling asleep before 11:00 PM and requires 8.5–9.5 hours of sleep. 11 Finishing activities by 9:00 PM allows approximately two hours for commuting, evening meals, hygiene, and time to wind down before sleep, a period consistent with healthy sleep hygiene principles. 11 This facilitates a bedtime near 11:00 PM, which is necessary to achieve the recommended 8.5–9.5 hours of sleep before an 8:30 AM start. 11 While direct empirical evidence validating this specific 9:00 PM cutoff in adolescent populations is currently lacking, it represents a logical derivation from established pediatric sleep recommendations and allows for the pre-sleep routines essential for healthy sleep onset.

Integrate comprehensive sleep hygiene education

This education should include specific, practical strategies for managing digital device use before bedtime and addressing academic stress, both of which have been identified as factors influencing insufficient sleep and poor sleep timing in adolescents. 11 Additionally, emerging evidence suggests that maladaptive personality traits, particularly negative affectivity, disinhibition, and psychoticism, are associated with poor sleep hygiene behaviors (e.g., nighttime mobile phone use, late bedtime) and insufficient sleep duration in young adult populations. 8 While factors such as socioeconomic status may play a role, current evidence from adolescent-specific research, remains limited. 12 To support these efforts, systems for monitoring student sleep patterns and well-being should be established to allow for counseling and early intervention for those at risk of sleep deprivation or disorders. The educational message should promote healthy sleep patterns by emphasizing that sleep regularity, alongside duration, is critical for academic success and general health.

Address social jetlag and sleep consistency

Students and faculty should be informed about the benefits of maintaining a consistent sleep-wake schedule across the entire week, including weekends, to stabilize circadian rhythms and mitigate the effects of social jetlag. A systematic review by Chaput et al. (2020) found that social jetlag is associated with adverse health outcomes, whereas weekend catch-up sleep is associated with better health in adult populations. 13 Although these findings need to be confirmed in adolescent cohorts, they highlight the importance of reducing circadian misalignment in students.

Additionally, we must educate families to guide lifestyle modifications that support healthy sleep at home. Finally, schools should create inherent system flexibility by exploring blended or online learning models. These formats can grant students autonomy over their schedules, allowing them to prioritize sleep without compromising academic responsibilities.

Limitations of the analysis

While our recommendations are grounded in evidence, we acknowledge several limitations.

First, this policy brief applies evidence primarily from North American and European studies to the Iranian context. Direct empirical data on the effects of delayed school start times in Iran are currently lacking. Cultural attitudes toward sleep, parental work schedules, transportation infrastructure, school system logistics, and extracurricular activity patterns may differ substantially from the settings in which most studies were conducted. Pilot implementations and context-specific research are urgently needed before national-scale policy adoption can be recommended with confidence.

Second, the specific start time (8:30 AM) is supported by AAP policy and meta-analytic evidence, but the proposed activity cutoff (9:00 PM) is a logical derivation rather than an empirically validated threshold. Further research is needed to identify optimal scheduling parameters across different school levels and cultural contexts.

Third, our reliance on observational studies, which show correlation rather than proven causation. Future research must also address the limited data within specific socio-cultural contexts, such as Iran, to ensure these policies are equitably implemented.

Conclusions/Discussion

Aligning educational schedules with student sleep biology is a critical public health intervention. Thoughtfully planned curricula and supportive policies can significantly improve students’ mental sharpness, overall health, and academic performance. To achieve this, the body clocks of adolescents and young adults must be a primary factor in setting school start times and daily schedules. The circadian phase delay is most pronounced during adolescence, making later school start times a critical, evidence-based intervention for middle and high school students. 11, 12 Research consistently shows that start times of 8:30 AM or later are associated with improved sleep duration, better academic performance, enhanced mental health, and reduced health and safety risks in this population. 11, 12 While delaying start times for older students is strongly supported, the impact on elementary school students is less direct. They often retain earlier start times due to logistical considerations (e.g., busing, childcare) and differing sleep biology. However, this aspect of scheduling is based on practical trade-offs rather than a robust body of comparative research. 11, 12 This alignment is plausibly expected to reduce long-term risk of cardiometabolic diseases, although longitudinal intervention data in the Iranian context are lacking. The most substantial benefits for student health and academic performance will likely arise from comprehensive approaches that integrate schedule adjustments, targeted education, and robust student support services.

Acknowledgments

The authors thank Dr. Dhahbi Wissem and Dr. Mikaela Irene Fudolig for their detailed and constructive peer review. Their critiques regarding evidence justification, scope clarification, and recommendation specificity substantially strengthened this policy brief. The authors used an artificial intelligence tool exclusively for language editing, polishing, and grammatical accuracy checks. The intellectual content, analysis, and conclusions of this work are entirely the author’s own.

Funding Statement

The author(s) declared that no grants were involved in supporting this work.

[version 2; peer review: 2 approved

Data availability

No data are associated with this article.

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F1000Res. 2026 Mar 14. doi: 10.5256/f1000research.196992.r464206

Reviewer response for version 2

Atanu Kumar Pati 1

  1. The title of the revised manuscript looks appropriate. However, to make it closer to the domain of chronobiology, the title should read somewhat like this: “Circadian Alignment of School Schedules in Iran: Implications for Student Health and Achievement,” or maybe “Circadian Misalignment Between School Schedules and Adolescent Sleep in Iran: Policy Implications for Health and Academic Performance.”

  2. The recommended opening and closing times for the Iranian Schools are not convincing. Why should they end their activity at 21:00 or 22:00? To the best of my knowledge, the Tehran International School opens at 07:00 and closes at 17:00. Another School, Iranzamin School, opens at 08:00 and closes at 15:00.

  3. Further, 1 MIN READ (May 13, 2025) published in IRANWIRE reveals that Iran’s Education Ministry announced that Iranian schools should begin at 06:00 in order to implement energy-saving measures. It further added that a single-shift school should operate between 06:00 and 13:00. In a 2-shift school, the first shift and the second shift should operate between 06:00-09:30, and 10:00-13:00, respectively.

  4. In light of this scenario the recommended policy looks challenging for implementation. The authors did not discuss these aspects adequately.

  5. The authors also did not discuss adequately the possible effect of school timings on the adolescent students with different chronotypes.

  6. The text of the policy brief in its revised version is iterative in many places. The authors should revise the text of the policy brief. The literature review also appears to be inadequate. They should have given examples of the countries where the delay of school start time has been implemented. It has also been known that both too little and too much sleep are harmful.

  7. Having said all this, the attempt of the authors to frame a policy brief addressing Circadian Misalignment Between School Schedules and Adolescent Sleep in Iran is worthwhile.

Does the paper provide a comprehensive overview of the policy and the context of its implementation in a way which is accessible to a general reader?

Partly

Is the discussion on the implications clearly and accurately presented and does it cite the current literature?

Partly

Are the recommendations made clear, balanced, and justified on the basis of the presented arguments?

No

Reviewer Expertise:

Chronobiology

I confirm that I have read this submission and believe that I have an appropriate level of expertise to state that I do not consider it to be of an acceptable scientific standard, for reasons outlined above.

F1000Res. 2026 Mar 10. doi: 10.5256/f1000research.196992.r463720

Reviewer response for version 2

Mikaela Irene Fudolig 1

The revised version addressed my biggest concerns with the first version.

Does the paper provide a comprehensive overview of the policy and the context of its implementation in a way which is accessible to a general reader?

Partly

Is the discussion on the implications clearly and accurately presented and does it cite the current literature?

Partly

Are the recommendations made clear, balanced, and justified on the basis of the presented arguments?

Partly

Reviewer Expertise:

computational social science

I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard.

F1000Res. 2026 Mar 4. doi: 10.5256/f1000research.196992.r463721

Reviewer response for version 2

Dhahbi Wissem 1

The revised manuscript has been significantly strengthened through the incorporation of specific evidence and structural adjustments. The authors have successfully transitioned the brief from a generalized discussion to a context-specific analysis focused on the Iranian educational system. The inclusion of empirical thresholds for school start times and the clarification of statistical data regarding health risks have addressed previous concerns regarding scientific rigor. The intellectual framework now effectively bridges chronobiological theory with actionable national policy recommendations.

Does the paper provide a comprehensive overview of the policy and the context of its implementation in a way which is accessible to a general reader?

Partly

Is the discussion on the implications clearly and accurately presented and does it cite the current literature?

Partly

Are the recommendations made clear, balanced, and justified on the basis of the presented arguments?

Partly

Reviewer Expertise:

Sports medicine and Reahbilitation

I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard.

F1000Res. 2026 Jan 12. doi: 10.5256/f1000research.191566.r449459

Reviewer response for version 1

Dhahbi Wissem 1

General Comments

This policy brief addresses a relevant topic in chronobiology and public health: the misalignment between educational schedules and the circadian rhythms of adolescents and young adults. While the premise is supported by general consensus in sleep medicine, the manuscript in its current form suffers from significant gaps in scientific rigor, referencing, and specificity.

Major Weaknesses:

Lack of Evidence-Based Justification for Specific Metrics: The authors propose specific policy changes, such as a start time of "8:30 AM" and an activity cutoff of "9:00–10:00 PM". However, the text fails to provide the specific chronobiological data or literature that identifies these exact timestamps as the optimal thresholds. Without citing data on sleep latency or commute times, these numbers appear arbitrary.

1

Ambiguity in Scope and Methodology: The authors state the brief is based on a "synthesis and analysis of the current scientific literature". However, the methodology for this synthesis is opaque. Furthermore, the scope is inconsistent; the recommendations read as global/universal, yet the limitations section abruptly introduces "specific socio-cultural contexts, such as Iran", suggesting a regional focus that is not reflected in the title or introduction.

1

Reference and Formatting Errors: The reference list is incomplete, with References 1 and 2 appearing as empty placeholders. This is a fundamental lapse in academic presentation.

Minor Weaknesses:

Repetitive Phrasing: The text frequently reiterates the link between sleep and health without deepening the argument or introducing new variables.

Over-reliance on Odds Ratios without Context: Statistics regarding obesity risks (69%) are presented without sufficient context regarding the population, age group, or study design from which they were derived.

Specific Comments

Abstract

Page 1, Paragraph 2 (Policy and implications): The text states, "A systematic review of the literature confirms that delaying start times is an effective intervention". You must specify which systematic review is being referred to here. A policy brief must be precise in its attribution of evidence.

Introduction

Page 3, Paragraph 1: The statement "sleep hygiene, receives insufficient attention today" is a generalization. This requires a citation or a qualification (e.g., "in educational policy planning") to be scientifically valid.

Page 3, Paragraph 1: The authors claim a "considerable portion of the student population exhibits poor sleep hygiene". Quantify "considerable" using prevalence data from recent epidemiological studies to strengthen the impact of the problem statement.

Policy Outcomes and Implications

Page 3, Paragraph 2: The manuscript argues that school start times are "dictated by history and logistics, not student physiology". While logically sound, this argument requires citations regarding the historical development of school schedules to differentiate between assumption and fact.

Page 3, Paragraph 3: The claim "In adolescents, very short sleep can increase the odds of obesity by 69% and elevated waist circumference by 49%" needs immediate context. Are these Adjusted Odds Ratios (AOR)? Which specific age bracket defines "adolescents" in the cited study?

Page 3, Paragraph 3: The sentence "Results from a systematic review indicated that delaying school start times significantly increases students' nightly sleep duration by at least 30 minutes" is missing its citation marker in the text flow. It appears the authors intended to cite Reference 14 here, but the link is not explicit.

Actionable Recommendations

Page 4, Paragraph 1: The recommendation "classes not begin before 8:30 AM" is scientifically weak without justification. Why 8:30 AM? Why not 9:00 AM or 10:00 AM? The American Academy of Pediatrics and other bodies have issued specific statements; the authors should reference such guidelines or specific chronotype data (e.g., shifts in melatonin secretion onset) to justify this exact time.

Page 4, Paragraph 1: The recommendation for activities to conclude by "9:00-10:00 PM" fails to account for commute time, post-activity hygiene, and meal consumption. If a student finishes at 10:00 PM, they may not sleep until midnight, potentially negating the benefit of an 8:30 AM start. This recommendation needs a more rigorous calculation of "time-to-bed" mechanics.

Page 4, Paragraph 1: The mention of "personality traits" as a factor in sleep hygiene adherence seems to specifically highlight the authors' own work (Reference 11). Ensure this is balanced with broader literature on behavioral barriers to sleep hygiene (e.g., socioeconomic status, blue light exposure).

1

Limitations

Page 4, Paragraph 3: The sudden mention of "Iran" is jarring. If this policy brief is intended for the Iranian educational system, the title and introduction must reflect that specificity (e.g., "Policy Recommendations for the Iranian Educational System"). If it is global, this limitation should be framed more broadly regarding non-Western socio-cultural contexts.

References

Page 4, References Section: References 1 and 2 are missing entirely. This indicates a lack of final proofreading before submission.

Page 4, Reference 11: The citation year is listed as "2025". Ensure this is correct and already published/in-press, as future-dated citations can be problematic if the volume/issue is not finalized.

Scientific Quality and Methodology

Logic: The logical flow is generally sound (Problem -> Evidence -> Solution), but the "Solution" phase lacks the granular data required for implementation.

Statistics: The manuscript relies on secondary reporting of statistics (e.g., odds ratios). No original statistical analysis is performed, which is acceptable for a Policy Brief, provided the sources are cited accurately. However, the lack of confidence intervals for the reported percentages weakens the statistical presentation.

Writing: The writing style is functional but repetitive. The authors acknowledge using AI for language editing. While the grammar is generally correct, the text lacks the nuance of expert human argumentation in the "Recommendations" section.

Does the paper provide a comprehensive overview of the policy and the context of its implementation in a way which is accessible to a general reader?

Partly

Is the discussion on the implications clearly and accurately presented and does it cite the current literature?

Partly

Are the recommendations made clear, balanced, and justified on the basis of the presented arguments?

Partly

Reviewer Expertise:

Sports medicine and Reahbilitation

I confirm that I have read this submission and believe that I have an appropriate level of expertise to state that I do not consider it to be of an acceptable scientific standard, for reasons outlined above.

F1000Res. 2026 Jan 12. doi: 10.5256/f1000research.191566.r441527

Reviewer response for version 1

Mikaela Irene Fudolig 1

The authors make a good case for changing class schedules to address the lack of sleep among students. Literature is cited for the link between delaying the start time of school and enhanced academic performance and decreased sleepiness. While the deleterious effects of a lack of sleep on health are mentioned, the correlation between delayed school start times and improved health measures are not included ("It is now widely argued that delayed start times...leading to...better overall physical and mental health" has no associated references). If this is due to a lack of studies in this matter, this should be mentioned.

The brief lacks justification for the specifics in the actionable recommendations. The authors propose that classes should not begin before 8:30AM and that school activities should conclude by 9-10PM. However, there is no mention in the brief why these times were chosen. To justify these schedules, we need to know the time that students (generally) go to bed and get up from bed that are optimal for them. To illustrate: if students are shown to need to wake up by 9AM to feel rested, then simply mandating school to not start before 8:30AM will not fix the problem. In this case, perhaps a compressed school schedule to allow for a later start time, or one expanded to include weekends (perhaps extracurriculars may be moved to weekends to allow for a longer time for academic subjects during the weekdays), may be more beneficial. Table 4 in Reference 9 of the brief shows that the children in their sample had a mean usual wake time of 9.54 (I assume this is in hours?) on weekends, which is way beyond the 8:30AM proposed. My colleagues and I have also studied sleep patterns among university students and found that weekend sleep patterns are different from those during vacation, indicating weekend compensation due to weekday sleep debt (Fudolig, et al. "Collective sleep and activity patterns of college students from wearable devices,"  npj Complexity  2, 32 (2025)). Whether something similar has been observed for school-age children should also be discussed in the brief if the authors wish to stick with suggesting a start time that is earlier than the weekend wake times in the study they cited.

The authors also did not mention how the policy would address if and how sleep times vary with age. Do young children sleep the same as adolescents? How will this impact the policy?

Overall, I was convinced by the authors that sleep timing and duration of students must be taken into account when developing policy in order to improve well-being and academic achievement. However, I believe the authors have to support their specific actionable recommendations with more studies.

Does the paper provide a comprehensive overview of the policy and the context of its implementation in a way which is accessible to a general reader?

Partly

Is the discussion on the implications clearly and accurately presented and does it cite the current literature?

Partly

Are the recommendations made clear, balanced, and justified on the basis of the presented arguments?

Partly

Reviewer Expertise:

computational social science

I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.

Associated Data

    This section collects any data citations, data availability statements, or supplementary materials included in this article.

    Data Availability Statement

    No data are associated with this article.


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