Author Correction: Myocardial reprogramming by HMGN1 underlies heart defects in trisomy 21

Correction to: Nature 10.1038/s41586-025-09593-9 Published online 22 October 2025

During the proof stage of this paper, the description of the statistical method in the legend for Fig. 4e was incorrectly edited to “Two-sided Fisher’s exact test, p value reported on graph.” The correct statistical method used, as stated during the peer review process, was a directional score test for equality of proportions using a Chi-square approximation. We have now corrected this in the figure legend to state “One-sided Chi-squared analysis, p value reported on graph.” We also note that the p value for comparison of WT to Tg animals is 0.036, not 0.032 as originally presented in the figure. The conclusions of this panel are unchanged.

For Extended Data Fig. 9d, we note that the statistical tests performed and significance values of presented comparisons are shown correctly. To prevent confusion in interpreting our calculations, we have amended Extended Data Fig. 9d to include the results of Hmgn^+/– genotype and the associated p value in comparison to WT animals (ns). The figure legend now includes total animals measured (n = 267) and significance value of WT and Hmgn^+/– comparison (p = 0.8168).

The Methods sections “MicroCT” and “Postnatal survival assay” have also been corrected to reflect these changes. All changes are included in the HTML and PDF versions of this article.