Abstract
The two cases described here appear to represent the infrequently reported entity of "unilateral cone (cone-rod) dystrophy." Both cases give the suggestion that daylight vision can be affected by abnormalities in visual signals in the proximal retina, after they leave the cone photoreceptors themselves. The ERG waveform changes in these two cases are consistent with a deficit in signaling by the hyperpolarizing bipolar cells, and the complaint of abnormal color perception in both cases presented here raises the possibility that the OFF-pathway through hyperpolarizing bipolar cells may be important for color processing.
Full text
PDF















Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Brigell M., Celesia G. G. Electrophysiological evaluation of the neuro-ophthalmology patient: an algorithm for clinical use. Semin Ophthalmol. 1992 Mar;7(1):65–78. doi: 10.3109/08820539209065094. [DOI] [PubMed] [Google Scholar]
- Carr R. E. Congenital stationary nightblindness. Trans Am Ophthalmol Soc. 1974;72:448–487. [PMC free article] [PubMed] [Google Scholar]
- Dick E., Miller R. F. Light-evoked potassium activity in mudpuppy retina: its relationship to the b-wave of the electroretinogram. Brain Res. 1978 Oct 13;154(2):388–394. doi: 10.1016/0006-8993(78)90711-4. [DOI] [PubMed] [Google Scholar]
- Dolan R. P., Schiller P. H. Evidence for only depolarizing rod bipolar cells in the primate retina. Vis Neurosci. 1989;2(5):421–424. doi: 10.1017/s0952523800012311. [DOI] [PubMed] [Google Scholar]
- Evers H. U., Gouras P. Three cone mechanisms in the primate electroretinogram: two with, one without off-center bipolar responses. Vision Res. 1986;26(2):245–254. doi: 10.1016/0042-6989(86)90019-2. [DOI] [PubMed] [Google Scholar]
- Knapp A. G., Schiller P. H. The contribution of on-bipolar cells to the electroretinogram of rabbits and monkeys. A study using 2-amino-4-phosphonobutyrate (APB). Vision Res. 1984;24(12):1841–1846. doi: 10.1016/0042-6989(84)90016-6. [DOI] [PubMed] [Google Scholar]
- Ripps H. Night blindness revisited: from man to molecules. Proctor lecture. Invest Ophthalmol Vis Sci. 1982 Nov;23(5):588–609. [PubMed] [Google Scholar]
- Slaughter M. M., Miller R. F. 2-amino-4-phosphonobutyric acid: a new pharmacological tool for retina research. Science. 1981 Jan 9;211(4478):182–185. doi: 10.1126/science.6255566. [DOI] [PubMed] [Google Scholar]
- Slaughter M. M., Miller R. F. An excitatory amino acid antagonist blocks cone input to sign-conserving second-order retinal neurons. Science. 1983 Mar 11;219(4589):1230–1232. doi: 10.1126/science.6131536. [DOI] [PubMed] [Google Scholar]
- Slaughter M. M., Miller R. F. Bipolar cells in the mudpuppy retina use an excitatory amino acid neurotransmitter. Nature. 1983 Jun 9;303(5917):537–538. doi: 10.1038/303537a0. [DOI] [PubMed] [Google Scholar]
- Smith E. L., 3rd, Harwerth R. S., Crawford M. L., Duncan G. C. Contribution of the retinal ON channels to scotopic and photopic spectral sensitivity. Vis Neurosci. 1989 Sep;3(3):225–239. doi: 10.1017/s0952523800009986. [DOI] [PubMed] [Google Scholar]
- Zervas J. P., Smith J. L. Neuro-ophthalmic presentation of cone dysfunction syndromes in the adult. J Clin Neuroophthalmol. 1987 Dec;7(4):202–218. [PubMed] [Google Scholar]
