Error in Figure
In the original publication [1], there was a mistake in Figure 4G and Figure 5 as published. The bonds of IL1β in Figure 4 were copied by mistake, and the corrected Figure 4 appears below. In addition, Figure 5C was also copied by mistake, and the corrected Figure 5 appears below. The authors state that the scientific conclusions are unaffected. This correction was approved by the Academic Editor. The original publication has also been updated.
Figure 4.
Effects of protopine on inflammatory response in mice with LPS-induced AKI (n = 8 mice per group). (A) Effects of protopine on inflammation accumulation in mice with LPS-induced AKI detected by small animal imaging. (B–E) Effects of protopine on inflammatory cytokines in mice with LPS-induced AKI. (F,G) Effects of protopine on TLR4 signaling pathway in mice with LPS-induced AKI. (F1) TLR4. (F2) Myd88. (F3) p-p65/p65. (G1) NLRP3. (G2) Caspase1/pro Caspase1. (G3) IL-1β. (G4) IL1R1. (G5) GSDMD. * p < 0.05, ** p < 0.01 compared with the LPS group. (LPRO: low-dose protopine; MPRO: medium-dose protopine; HPRO: high-dose protopine; LPS: lipopolysaccharide; AKI: acute kidney injury; TLR4: toll-like receptor 4; NLRP3: nod receptor heat protein domain associated protein 3; IL-1β: interleukin-1β; IL1R1: interleukin-1 receptor 1; GSDMD: gasdermin; MyD88: myeloid differentiation factor88).
Figure 5.
Effects of protopine on the blood cell subtype in mice with. LPS-induced AKI (n = 8 mice per group). (A) Gating Strategy. (B) Effects of protopine on the blood cell subtype ratio in mice with LPS-induced AKI. (C,D) Effects of protopine on the ratio of CD45+Ly-6G+ and CD45+F4/80+ in mice with LPS-induced AKI. ** p < 0.01 compared with the LPS group. (LPRO: low-dose protopine; MPRO: medium-dose protopine; HPRO: high-dose protopine; LPS: lipopolysaccharide; AKI: acute kidney injury).
Footnotes
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Reference
- 1.Zhang B., Zeng M., Li M., Kan Y., Li B., Xu R., Wu Y., Wang S., Zheng X., Feng W. Protopine Protects Mice against LPS-Induced Acute Kidney Injury by Inhibiting Apoptosis and Inflammation via the TLR4 Signaling Pathway. Molecules. 2020;25:15. doi: 10.3390/molecules25235523. [DOI] [PMC free article] [PubMed] [Google Scholar]