Abstract
Our study shows that use of a small dose of subconjunctival 5-FU provides significantly lower postoperative intraocular pressure than does no antimetabolite treatment. Morphology of the postoperative blebs suggests that increased filtration results in lower intraocular pressure in the 5-FU group. Corneal epithelial defects were as common with a low dose as with higher doses previously described.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Allen R. C., Bellows A. R., Hutchinson B. T., Murphy S. D. Filtration surgery in the treatment of neovascular glaucoma. Ophthalmology. 1982 Oct;89(10):1181–1187. doi: 10.1016/s0161-6420(82)34672-2. [DOI] [PubMed] [Google Scholar]
- Bellows A. R., Johnstone M. A. Surgical management of chronic glaucoma in aphakia. Ophthalmology. 1983 Jul;90(7):807–813. doi: 10.1016/s0161-6420(83)34483-3. [DOI] [PubMed] [Google Scholar]
- Bäräny E. H., Linnër E., Lütjen-Drecoll E., Rohen J. W. Structural and functional effects of trabeculectomy in cynomolgus monkeys. I. Light microscopy. Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1972;184(1):1–28. doi: 10.1007/BF00410492. [DOI] [PubMed] [Google Scholar]
- Gressel M. G., Heuer D. K., Parrish R. K., 2nd Trabeculectomy in young patients. Ophthalmology. 1984 Oct;91(10):1242–1246. doi: 10.1016/s0161-6420(84)34179-3. [DOI] [PubMed] [Google Scholar]
- Gressel M. G., Parrish R. K., 2nd, Folberg R. 5-fluorouracil and glaucoma filtering surgery: I. An animal model. Ophthalmology. 1984 Apr;91(4):378–383. doi: 10.1016/s0161-6420(84)34277-4. [DOI] [PubMed] [Google Scholar]
- Herschler J., Agness D. A modified filtering operation for neovascular glaucoma. Arch Ophthalmol. 1979 Dec;97(12):2339–2341. doi: 10.1001/archopht.1979.01020020555011. [DOI] [PubMed] [Google Scholar]
- Heuer D. K., Parrish R. K., 2nd, Gressel M. G., Hodapp E., Desjardins D. C., Skuta G. L., Palmberg P. F., Nevárez J. A., Rockwood E. J. 5-Fluorouracil and glaucoma filtering surgery. III. Intermediate follow-up of a pilot study. Ophthalmology. 1986 Dec;93(12):1537–1546. doi: 10.1016/s0161-6420(86)33542-5. [DOI] [PubMed] [Google Scholar]
- Knapp A., Heuer D. K., Stern G. A., Driebe W. T., Jr Serious corneal complications of glaucoma filtering surgery with postoperative 5-fluorouracil. Am J Ophthalmol. 1987 Feb 15;103(2):183–187. doi: 10.1016/s0002-9394(14)74224-2. [DOI] [PubMed] [Google Scholar]
- Regan E. F. Scleral Cautery with Iridectomy-An Experimental Study. Trans Am Ophthalmol Soc. 1963;61:219–231. [PMC free article] [PubMed] [Google Scholar]
- Schwartz A. L., Anderson D. R. Trabecular surgery. Arch Ophthalmol. 1974 Aug;92(2):134–138. doi: 10.1001/archopht.1974.01010010140012. [DOI] [PubMed] [Google Scholar]
- Stewart R. H., Kimbrough R. L., Bachh H., Allbright M. Trabeculectomy and modifications of trabeculectomy. Ophthalmic Surg. 1979 Jan;10(1):76–80. [PubMed] [Google Scholar]