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. Author manuscript; available in PMC: 2026 Mar 18.
Published in final edited form as: Ohio J Public Health. 2025 Sep 26;7(2):10.18061/ojph.6420. doi: 10.18061/ojph.6420

Resilience and Mental Health in Southwest Ohio During the COVID-19 Pandemic

Emmanuel-Sathya Gray 1,2,3, Bridget Murphy 2,3, Stacey M Gomes 2,3,4, Constance A Mara 2,5, Melinda Butsch Kovacic 6,7,8, Sharon M Watkins 9, Anna M Hood 10, Monica J Mitchell 1,2,3,5, Lori E Crosby 2,3,5
PMCID: PMC12995372  NIHMSID: NIHMS2135572  PMID: 41853123

Abstract

Introduction:

During COVID-19, anxiety and depression rates spiked across the US and continued to climb after August 2020. Research from the early months of COVID-19 suggests that resilience and meaning and purpose were associated with positive mental health outcomes in this context. Little is understood about how this association persists after 5+ months of ongoing disaster exposure, as was the case for COVID-19. The goal was to examine this relationship in adults in Southwest Ohio.

Methods:

Resilience, meaning-and-purpose, anxiety and depression symptom surveys were completed electronically between August 1 and November 30, 2020. Regression analyses examined relationships between these factors and sociodemographic variables.

Results:

Participants (N=98) reported anxiety and depression in mild ranges. Age was negatively associated with anxiety (p=.03). Meaning-and-purpose was negatively associated with both anxiety (p=.002) and depression (p<.001). Resilience was negatively associated with depression (p=.001). Further, reporting a mental health condition moderated the relationship between resilience and anxiety (p=.03), such that higher resilience was associated with higher anxiety in individuals reporting a mental health condition.

Conclusions:

Our study found associations between anxiety and depression symptoms and both meaning-and-purpose and resilience. The moderated relationship between resilience and anxiety symptoms supports the importance of assessing mental health status, particularly during public health emergencies. Regardless of mental health status, higher meaning-and-purpose was associated with lower anxiety and depression. Additional research is needed to better understand the role of meaning-and-purpose and resilience during future public health challenges.

Keywords: Brief Resilience Scale, Meaning and Purpose, COVID-19, Disaster, mental health

Introduction

Consistent with previous epidemics,13 the COVID-19 pandemic had a major impact on adult mental health across the United States (US).4 From April to December 2020, clinically significant anxiety and depression was present in 31.5 to 45.8% and 21.8 to 39% of adults, respectively.58 This was a dramatic increase from previous 12-month estimates for generalized anxiety disorder and major depressive episodes (2.9% and 9.3%, respectively).5,9 National and state trends demonstrated a continual rise of reported depression and anxiety symptoms peaking in December 2020-January 2021.10,11 In Ohio, increases in the severity of anxiety and depression scores between August and December 2020 averaged 1.5% and 1.8%, respectively.10 One longitudinal study using data from the Ohio Medicaid Assessment Survey, found the prevalence of Mental Health Impairment (MHI; a severe indicator of disruption in functioning) rose to 8.2% in 2021, compared with 7.5% in 2019. Increases in MHI during that year were steepest for Black adults, females, and those younger, aged 19 to 24 years.12

A much smaller body of research has explored how strengths-based factors—characteristics, including resilience and meaning and purpose, indicative of effective psychological coping with stressful events—are impacted. Resilience, the ability to “bounce back” from stressful events without prolonged disruptions in functioning, has been found to be the most common psychological response to the stress of disasters.13,14 In a recent study during the COVID-19 pandemic, Wong and colleagues found 72.8% of a global sample reported normal-to-high levels of resilience using the Brief Resilience Scale (BRS), whereas in the Americas and Europe this was reported in only 63.6% of the population.15 Factors related to resilience in a disaster include older age and social support.4,1518 Pre-COVID-19-pandemic resilience has been associated with lower COVID-19-related anxiety and depression.19,20 In one study of 1270 older adults (age 55+), resilience was associated with better mental health outcomes at five subsequent timepoints between April and June 2020.21 Meaning and purpose (meaning-and-purpose), the degree to which a person feels their life has meaning, purpose, fulfillment, and a sense of direction, has been associated with better mental health outcomes following stressful events,22 and was found to be a latent protective factor for developing depression symptoms during COVID-19.23

Much of the data investigating associations between resilience, meaning-and-purpose, and mental health were collected during the first few months of the pandemic; little is known about the relationship of these factors specifically in the state of Ohio. Disaster-exposures typically are not prolonged, with resilience and decreases in psychological symptoms observed within 1–6 months following exposure.13,14,16,24 However, in the case of COVID-19, estimates of anxiety and depression continued to rise nationally as well as in Ohio more than 5 months following the US emergency declaration.10 It is unclear whether associations between resilience, meaning-and-purpose, and mental health would remain after 5+ months of continuous disaster exposure, prior to effective treatments or vaccines, and while emergency governmental supports were expiring.11,25,26

The aim of the current study is to examine the relationship between strengths-based psychological factors (resilience and meaning-and-purpose) and anxiety and depression symptoms in a sample of Southwestern Ohio adults, 5–8 months following the US COVID-19 emergency declaration11 (August–November, 2020). We hypothesized that resilience17,19,21,27,28 and meaning-and-purpose22,23,29,30 would have a significant, negative association with anxiety and depression symptoms beyond relevant sociodemographics, such as age, gender, racial/ethnic identity, self-reported mental health condition, and neighborhood distress.4,1518 We also hypothesized that these associations would be moderated by self-report of a pre-existing mental health condition.17,19,27,31

Methods

Data from the current study comes from a larger prospective cohort study conducted during the COVID-19 pandemic by Hood and colleagues32 with cohorts in the US, United Kingdom (UK), and Mexico. The use of multiple cohorts was intended to enable analysis of differing attitudes towards COVID-19, helping to gauge health policy effectiveness and public perception. Participants completed mental health and strengths-based measures monthly, and poll questions daily about the COVID-19 pandemic (e.g., did you have difficulty following masking recommendations today?). The current study uses data (anxiety, depression, resilience, and meaning-and-purpose measures) from the US cohort collected August–November 2020.

Participants

Participants were recruited via flyers, cultural brokers, social media, websites, word of mouth and local agencies serving Black and Latine/Hispanic populations. The goal was to have demographics that reflected the major metropolitan municipality in the region (i.e. Cincinnati, Ohio; targets 41% Black and 4% Latine/Hispanic, respectively).33 Participants were eligible if they were ages 18 and older, US residents, could read in English or Spanish, and had access to a phone, computer/ tablet to complete measures electronically. A convenience sample was recruited among adults who lived or worked in Cincinnati, and included those with residences across the tri-state (Ohio-Kentucky-Indiana). All participants reviewed the informed consent form and provided their electronic signature before completing study measures. The cohort study was reviewed and found to be exempt by the main institution’s Institutional Review Board.

Measures

Baseline sociodemographic data included age, gender, race/ethnicity, relationship status, education, employment, essential worker status, and caregiver status. Self-reported, pre-existing mental health condition (mental health condition hereafter) was collected as a yes-no question. Measures included in the analyses for the present study were the PROMIS® Short Form Anxiety v1.0 (7a),34 Patient Health Questionnaire-9 (PHQ-9),35,36 Brief Resilience Scale (BRS),28 and PROMIS® Short Form Meaning and Purpose v1.0 (4a).37 Distressed Community Index (DCI) scores were assigned based on zip code.38 See Table 1.

Table 1.

Participant Characteristics (N=98)ae

Characteristic Value Characteristic Value

Age in years (18–73, n=96), M(SD) 46.24 (14.07) County Area, n(%)
Racial/Ethnic Identity, n(%)  Cincinnati Metro 88 (89.8)
 Asian 1 (1)  Other 4 (4.1)
 Black, Non-Hispanic 46 (46.9)  Missing 6 (6.1)
 Latine/x/Hispanic 7 (7.1) State, n(%)
 White, Non-Hispanic 39 (39.8)  Ohio 81 (82.7)
 Mixed/Multiple groups 3 (3.1)  Kentucky 10 (10.2)
 Missing 2 (2)  Indiana 1 (1)
Gender Identity, n(%)  Missing 6 (6.1)
 Female 73 (74.5) Caregiver Status, n(%) 30 (30.6)
 Male 23 (23.5)  Parent 28 (28.6)
 Missing 2 (2)  Grandparent 1 (1)
DCI Quintile, n(%)  Other 1 (1)
 1-Resourced 23 (23.5) Relationship Status, n(%)
 2 15 (15.3)  In a relationship 19 (19.4)
 3 15 (15.3)  Married 44 (44.9)
 4 22 (22.4)  Single 32 (32.7)
 5-Distressed 17 (17.3)  Widowed 1 (1)
 Missing 6 (6.1)  Missing 2 (2)
Mental Health Condition, n(%) Education, n(%)
 Yes 15 (15.3)  < High School 2 (2)
 No 80 (81.6)  High School 7 (7.1)
 Prefer not to say 1 (1)  Some College 19 (19.4)
 Missing 2 (2)  College Grad 35 (35.7)
 Post Grad Degree 33 (33.7)
Measure Scores n M(SD)  Missing 2 (2)
PROMIS Anxiety b 93 55.29 (9.47) Employment Status, n(%)
 Mental Health Cond. 14 63.80 (9.35)  Employed 72 (73.5)
 No Mental Health Cond. 79 53.79 (8.72)  Unemployed 7 (7.1)
PHQ-9 c 92 5.34 (5.14)  Disabled 2 (2)
 Mental Health Cond. 14 11.00 (6.39)  Retired 5 (5.1)
 No Mental Health Cond. 78 4.33 (4.22)  Homemaker 3 (3.1)
Brief Resilience Scale d 93 3.72 (0.81)  Student 1 (1)
 Mental Health Cond. 14 3.00 (1.08)  Other 2 (2)
 No Mental Health Cond. 79 3.84 (0.69)  Missing 6 (6.1)
PROMIS Meaning & Purpose e 94 55.20 (10.34) Essential Worker, n(%)
 Mental Health Cond. 14 45.94 (13.90)  Yes 40 (40.8)
 No Mental Health Cond. 80 56.82 (8.74)  No 37 (37.8)
 Missing 21 (21.4)
a

Table 1 includes the total number in each group followed by the percentage in each group in parentheses for categorical variables. Age and Measure Scores are presented as mean (standard deviation). PROMIS = Patient Reported Outcomes Measurement Information System. DCI = Distressed Community Index. Mental Health Condition = self-reported, pre-existing mental health condition.

b

PROMIS Anxiety Scoring34: Less than 55=None to slight; 55.0–59.9=Mild; 60.0–69.9=Moderate; 70 and over=Severe. Total: n=93; Mental Health Condition, n=14; No Mental Health Cond., n=79. Test for significant difference: Mental Health Condition mean was significantly higher, t17.89=3.73, p=.002; 95%CI 4.37, 15.65.

c

PHQ-9 Scoring35,36: 0–4=None; 5–9=Mild; 10–14=Moderate; 15–19=Moderately Severe; 20–27=Severe. Total: n=92; Mental Health Cond., n=14; No Mental Health Condition, n=78. Test for significant difference: Mental Health Condition mean was significantly higher, t15.42=−3.76, p=.002; 95%CI −10.43, −2.90.

d

Brief Resilience Scale Scoring28: Range 1–5; higher scores indicate greater resilience. Total: n=93; Mental Health Condition, n=14; No Mental Health Cond., n=79. Test for significant difference: Mental Health Cond. mean was significantly lower, t15.23=2.82, p=.01; 95%CI 0.21, 1.48.

e

ePROMIS Meaning & Purpose Scoring37: The United States M(SD)=50(10); higher scores indicate greater meaning & purpose. Total: n=94; Mental Health Condition, n=14; No Mental Health Cond., n=80. Test for significant difference: Mental Health Cond. mean was significantly lower, t15.13=2.83, p=.01; 95%CI 2.69, 19.06.

Data Analysis

Descriptive statistics were computed for all demographic variables as well as the primary outcome variables. To test the hypothesis that resilience and meaning-and-purpose would have a significant, negative association with anxiety and depression, and that the associations between anxiety or depression and resilience and meaning-and-purpose would be moderated by whether or not the participant reported a mental health condition, we conducted several linear regression models:

  • Model 1a) PROMIS anxiety scores was the outcome and the primary predictors were PROMIS meaning-and-purpose and BRS scores, with age, DCI, gender, race/ethnicity, and mental health condition as covariates.
    • Model 1b) same as 1a, with a moderation of BRS scores by mental health condition added.
    • Model 1c) same as 1a, with a moderation of PROMIS meaning-and-purpose scores by mental health condition added.
  • Model 2a) PHQ-9 scores as the outcome and the primary predictors were PROMIS meaning-and-purpose scores and BRS scores, with age, DCI, gender, race/ethnicity, and mental health condition as covariates in the model.
    • Model 2b) same as 2a, with a moderation of BRS scores by mental health condition added.
    • Model 2c) same as 2a, with a moderation of PROMIS meaning-and-purpose scores by mental health condition added.

All analyses were conducted in Stata version 18.39 Multiple imputation in Stata with 100 imputed datasets was used to address intermittent missing data, assumed to be missing at random.

Results

Participant Characteristics

Participants (N=98) were from the tri-state region of Ohio, n=81(82.7%), Kentucky, n=10(10.2%), and Indiana, n=1(1%), with most residing in the Greater Cincinnati Metro area, n=88(89.8%). The majority identified as female, n=73(74.5%), and reported their racial/ethnic identity as Asian, n=1(1%), Black, n=46(46.9%), Latine/Hispanic, n=7(7.1%), White, n=39(39.8%), and Mixed/Multiple, n=3(3.1%). Most reported employment, n=72(73.5%), and nearly half, n=44(44.9%), reported being married. There was representation from all five quintiles in the distribution of community distress (Table 1).

Overall, participants’ (n=93) average PROMIS anxiety scores fell in the mild range, M(SD)=55.29(9.47). Those reporting a mental health condition (n=14) had a mean anxiety score in the moderate range, M(SD)=63.80(9.35)—significantly higher than that of those without a mental health condition n=79, M(SD)=53.79(8.72); t17.89=3.73, p=.002; 95%CI 4.37, 15.65.

On average, participants (n=92) reported PHQ-9 depression scores in the mild range, M(SD)=5.34(5.14). Those reporting a mental health condition (n=14) had a mean PHQ-9 in the moderate range, M(SD)=11.00(6.39)—significantly higher than that of those without a mental health condition, n=78, M(SD)=4.33(4.22); t15.42=−3.76, p=.002; 95%CI −10.43, −2.90. See Table 1 for psychometrics.

Regression and Moderation Analyses

In Model 1a analyses, Age, M(SD)=46.24(14.07), was significantly, negatively associated with anxiety, b=−0.15, p=.03, 95%CI=−0.28, −0.01; no other sociodemographic variables were significant predictors. Meaning-and-purpose, M(SD)=55.20(10.34), was significantly, negatively associated with anxiety, b=−0.29, p=.002, 95%CI=−0.46, −0.11. Resilience, M(SD)=3.72(0.81), was not significantly associated with anxiety (see Table 2 in the Appendix).

Model 1b, testing the moderation between resilience and mental health condition, was significant for anxiety, b=5.16, p=.03, 95%CI=0.39, 9.94, such that when a mental health condition was not reported, higher resilience was associated with lower anxiety, whereas when a mental health condition was reported, higher resilience was associated with higher anxiety. In Model 1c, the moderation for meaning-and-purpose was not significant (Figure 1; see also Table 2 in the Appendix).

Figure 1.

Figure 1.

Graphed Moderationsa

aFigure 1 depicts self-reported mental health condition as a moderator between resilience or meaning-and-purpose and mental health outcomes (depression and anxiety symptoms): Top row (a, c) depicts moderation between resilience and mental health scores; bottom row (b, d) depicts moderation between meaning-and-purpose and mental health scores; left-hand column (a, b) depicts moderation with PROMIS anxiety scores; right hand column (c, d) depicts moderation with PHQ-9 depression scores. Graphs were made using Stata. Asterisk (*) denotes a significant moderation effect.

In Model 2a analyses, sociodemographic variables were not significantly associated with depression scores. Meaning-and-purpose, b=−0.21, p<.001, 95%CI=−0.29, −0.13, and resilience, b=−2.09, p=.001, 95%CI=−3.34, −0.84 were both significantly, negatively associated with depression. Model 2b moderation analyses were not significant (Figure 1; see also Table 2 in the Appendix). In Model 2c analyses, the moderation for meaning-and-purpose was not significant.

Discussion

The current study assessed associations between the strengths-based factors of resilience and meaning-and-purpose, and anxiety and depression in Southwestern Ohio adults 5–8 months into the US COVID-19 emergency. Consistent with data collected during the first few months of COVID-19,23 having a higher sense of meaning-and-purpose was significantly associated with lower depression. Our study additionally found an association between higher meaning-and-purpose and lower anxiety. These associations rose to significance over and above relevant sociodemographic variables, except for age, where younger age predicted higher anxiety.

Similar to meaning-and-purpose, higher resilience was associated with lower depression. Resilience was also associated with lower anxiety, however this was dependent upon whether a mental health condition was reported. For those without a mental health condition, higher resilience was associated with lower anxiety as expected. For those with a mental health condition, higher resilience was associated with higher anxiety. At the same time, resilience was lower overall in participants with a mental health condition, compared to those without.

COVID-19 studies indicate that higher-than-normal anxiety and depression symptoms persisted well into this prolonged disaster.6,12,40 It is possible that those with a mental health condition may have a different experience during a disaster with respect to anxiety and depression. For example, Castellvi and colleagues found significant differences in resilience during COVID-19 based on mental health condition status (i.e., none, incidence, persistence, recovering), such that those experiencing a persistent mental health condition reported lower resilience.27 It could be that those with a mental health condition require additional supports to foster resilience whereas those without are able to reap more benefits from an internal sense of resilience. Additional research is needed to understand this relationship, especially in the context of long-term disaster exposures (e.g., a global pandemic).

Limitations and Future Directions

This study has several limitations. Although virtual survey collection allowed participation from a geographic area larger than Cincinnati, Ohio, a small sample size limits generalizability. This sample included high proportions of Black and Latine/Hispanic participants exceeding the percentages for Cincinnati residents, however, the sample included fewer members of other racialized groups.33 Finally, the cross-sectional nature of the study limits the ability to draw inferences over time. Future studies with longitudinal data are needed given the potential that resilience interventions might be beneficial (see Chen & Bonanno41).

Conclusions

The current study found that 5–8 months into the COVID-19 emergency, regardless of mental health condition, higher meaning-and-purpose was associated with lower anxiety and depression. Higher resilience was also associated with lower depression; however higher resilience was only associated with lower anxiety in those without a mental health condition. The only sociodemographic variable to show a significant association with mental health symptoms was age, with younger age predicting higher anxiety. Taken together, in situations of prolonged disaster, meaning-and-purpose, resilience, and the presence of a pre-existing mental health condition may be effective targets for intervention in Southwest Ohioans.

Public Health Implications

Emphasizing meaning-and-purpose during disasters may improve management of symptoms and well-being. This study demonstrates that embedding meaning-and-purpose and resilience strategies into public health messaging and communications (e.g., town halls) during prolonged periods of disaster uncertainty may be beneficial.

Abbreviations

BRS

Brief Resilience Scale

COVID-19

coronavirus disease

DCI

Distressed Community Index

PHQ-9

Patient Health Questionnaire-9

PROMIS

Patient-Reported Outcomes Measurement Information System

Appendix

Table 2.

Regressions Predicting Anxiety and Depression (N=98)ac

Coefficient SE p 95%CI

Anxiety Predictors
Variable (Model 1a)ac
 Gender 0.12 2.03 .95 −3.92, 4.16
 Race 0.43 1.95 .83 −3.45, 4.32
Age −0.15 * 0.07 .03 −0.28, −0.01
 DCI −0.07 1.93 .97 −3.90, 3.77
 Mental Health Cond. (MHC) −11.30 8.50 .19 −28.21, 5.62
Meaning & Purpose (M&P) −0.29 ** 0.09 .002 −0.46, −0.11
 Resilience −2.22 1.36 .11 −4.93, 0.48
Moderationc
Resilience x MHC (Model 1b) 5.16 * 2.40 .03 0.39, 9.94
 M&P x MHC (Model 1c) 0.14 0.21 .51 −0.27, 0.55
Depression Predictors
Variable (Model 2a)ac
 Gender −0.81 1.05 .44 −2.90, 1.28
 Race −0.84 0.92 .37 −2.67, 1.00
 Age −0.02 0.03 .60 −0.08, 0.05
 DCI −0.19 0.83 .82 −1.85, 1.46
 Mental Health Cond. (MHC) −5.13 5.63 .37 −16.34, 6.08
Meaning & Purpose (M&P) −0.21 *** 0.04 <.001 −0.29, −0.13
Resilience −2.09 ** 0.63 .001 −3.34, −0.84
Moderationc
 Resilience x MHC (Model 2b) 2.68 1.99 .18 −1.28, 6.65
 M&P x MHC (Model 2c) 0.07 0.14 .62 −0.20, 0.34
*

p < .05

**

p < .01

***

p < .001

a

DCI=Distressed Communities Index. Mental Health Cond. (MHC)=self-reported, pre-existing mental health condition. SE=standard error. 95%CI= 95% confidence interval. Significant associations are italicised with asterisks.

b

Gender is dichotomized female/male. Race is dichotomized White/Black. DCI is dichotomized categories 1–3 and 4–5. MHC is dichotomized yes/no whether someone has reported a pre-existing mental health condition. Significant predictors: Anxiety (Age, M&P, and Resilience x MHC Moderation); Depression (M&P, and Resilience). Prediction trend, but non-significant: Anxiety (Resilience, and MHC); Depression (Resilience x MHC Moderation).

c

Model 1 is inclusive of all predictors and a Resilience x MHC moderation effect (significant for anxiety; similar, but non-significant, trend for depression). Model 2 is inclusive of all predictors and a M&P x MHC moderation effect (non-significant for both anxiety and depression).

Footnotes

Conflicts of Interest

The authors report no conflicts of interest.

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