Erratum to: Cell Oncol.
DOI 10.1007/s13402-011-0024-x
In the above mentioned review two errors in the legend of Fig. 1 has escaped the author’s attention during proofreading. The correct legend of Fig. 1 should read:
Fig. 1.
Eukaryotic DNA mismatch repair. Single nucleotide mismatches, as well as 1 nucleotide loops typically occurring at microsatellite mononucleotide repeated sequences, are recognized by the MutSα heterodimer formed by MSH2 and MSH6; this complex binds to DNA as a sliding clamp after MSH2 ADP has been exchanged for ATP (upper panel). The heterodimer MutLα, formed by MLH1 and PMS2, then binds to MutSα. The MutSα-MutLα complex moves along the DNA until it meets the DNA polymerase complex, PCNA and Exo I. The exonuclease then removes up to several hundred bases from the newly synthesized DNA strand, to allow correct resynthesis of DNA by the replicative polymerase. IDL of two or more nucleotides are preferentially recognized by the MutSβ complex, formed by MSH2 and MSH3 (lower panel). After binding to DNA, MutSβ exchanges ADP for ATP and recruits the MutLα complex, a heterodimer of MLH1 and PMS2 heterodimer. Subsequently, excision and resynthesis are performed as described for the repair of single base mismatches. MLH1 may also form heterodimers with MLH3 and PMS1 to form respectively the MutLγ and MutLβ complexes, but their roles in human MMR function are not entirely clear
Footnotes
The online version of the original article can be found at 10.1007/s13402-011-0024-x.