Table 3.
Correlation of ERCC4 (rs6498486) polymorphism with clinicopathological properties of the cases
| Category | Cases (N= 150) | ERCC4 (rs6498486) | |||
|---|---|---|---|---|---|
| HZ + VH | NH | OR (95% CI) | P-value | ||
| Age (years) | |||||
| ≤40 | 53 | 50 | 3 | Ref. | _ |
| > 40 | 97 | 83 | 14 | 0.356 (0.0974 to 1.2992) | 0.1178 |
| Grade | |||||
| I | 6 | 4 | 2 | Ref. | _ |
| II | 126 | 116 | 10 | 5.8 (0.9434 to 35.6600) | 0.0578 |
| III | 18 | 16 | 2 | 4.0 (0.4235 to 37.7791) | 0.2263 |
| Nodal status | |||||
| Negative | 58 | 54 | 4 | Ref. | _ |
| Positive | 92 | 84 | 8 | 0.78 (0.2233 to 2.7093) | 0.69 |
| Stages | |||||
| I | 20 | 19 | 1 | Ref. | _ |
| II | 48 | 43 | 5 | 0.453 (0.0495 to 4.1423) | 0.483 |
| III | 73 | 67 | 6 | 0.59 (0.0666 to 5.1860 | 0.632 |
| IV | 9 | 9 | 0 | 1.46 (0.0543 to 39.3605) | 0.821 |
| Cancer histology | |||||
| Invasive ductal carcinoma | 71 | 65 | 6 | Ref. | _ |
| Ductal carcinoma in-situ | 35 | 33 | 2 | 1.523 (0.2913 to 7.9645) | 0.62 |
| Invasive lobular carcinoma | 13 | 13 | 0 | 2.68 (0.1423 to 50.4577) | 0.510 |
| Infiltrating ductal carcinoma | 24 | 21 | 3 | 0.65 (0.1485 to 2.8121) | 0.561 |
| Metastatic ductal carcinoma | 5 | 5 | 0 | 1.1 (0.0541 to 22.0402) | 0.95 |
| Others | 2 | 2 | 0 | 0.5 (0.0214 to 11.4818) | 0.662 |
P<0.05 was considered statistically significant (bold). HZ= Heterozygote; VH= Variant homozygote; NH= Normal homozygote