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. 2017 Jun 23;19(2):199–205. doi: 10.3233/CBM-160512

In situ memory T cells and patterns of invasion predict outcome in patients with early-stage oral squamous cell carcinoma

Shan Wang a, Jiankai Xu b, Yan Meng a, Dongxia Qiang a, Changsheng Sun a, Lei Shi a, Eryang Zhao a,*
PMCID: PMC13020719  PMID: 28282802

Abstract

PURPOSE:

The objective of this study was to explore the prognostic value of in situ memory T cells and patterns of invasion (POI) in early stage oral squamous cell carcinoma (OSCC).

METHODS:

One hundred fifty-seven patients with early stage (cT1T2N0) OSCC were identified from a pre-existing database of patients with oral cancer and were classified by POI according to hematoxylin-eosin staining. We examined the impact of the immunohistochemical expression of CD45RO in OSCC. Overall survival (OS) curves were calculated using the Kaplan-Meier method.

RESULTS:

Margin status was significantly associated with local recurrence in early stage OSCC (p= 0.000), and depth of invasion was also associated with regional recurrence (2 mm: p= 0.034; 4 mm: p= 0.015). The expression of CD45RO (p= 0.021) and POI (p= 0.027) individually was associated with OS, and patients in the group with combination score tended to have worse OS (p= 0.012).

CONCLUSION:

Combined evaluation of POI and CD45RO might prove to be a useful indicator for high-risk patients with occult metastases from early stage OSCC.

Keywords: CD45RO, patterns of invasion, oral squmaous cell cacinoma, early stage

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