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. 2002 Jul;83(1):299–308. doi: 10.1016/S0006-3495(02)75170-9

Adhesion of nanoparticles to vesicles: a Brownian dynamics simulation.

Hiroshi Noguchi 1, Masako Takasu 1
PMCID: PMC1302148  PMID: 12080121

Abstract

We studied the interaction of bilayer vesicles and adhesive nanoparticles using a Brownian dynamics simulation. The nanoparticles are simple models of proteins or colloids. The adhering nanoparticle induces the morphological change of the vesicle: budding, formation of two vesicles in which only outer monolayers are connected, and fission. We also show that the nanoparticle promotes the fusion process: fusion-pore opening from a stalk intermediate, a neck-like structure that only connects outer monolayers of two vesicles. The nanoparticle bends the stalk, and induces the pore opening.

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Selected References

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