Abstract
During the past 10 years, the use of methamphetamine has increased rapidly in the West and throughout the United States. Because of this increase, our attention has focused on methamphetamine's toxicity. Methamphetamine and related compounds generate many of the same toxic effects as cocaine. Because of methamphetamine's widespread use, clinicians should be familiar with its medical effects and toxicity and with treatment options for acute and long-term effects of methamphetamine abuse.
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- Albertson T. E., Walby W. F., Derlet R. W. Stimulant-induced pulmonary toxicity. Chest. 1995 Oct;108(4):1140–1149. doi: 10.1378/chest.108.4.1140. [DOI] [PubMed] [Google Scholar]
- Arnett E. N., Battle W. E., Russo J. V., Roberts W. C. Intravenous injection of talc-containing drugs intended for oral use. A cause of pulmonary granulomatosis and pulmonary hypertension. Am J Med. 1976 May 10;60(5):711–718. doi: 10.1016/0002-9343(76)90508-8. [DOI] [PubMed] [Google Scholar]
- Bailey D. N., Shaw R. F. Cocaine- and methamphetamine-related deaths in San Diego County (1987): homicides and accidental overdoses. J Forensic Sci. 1989 Mar;34(2):407–422. [PubMed] [Google Scholar]
- Bashour T. T. Acute myocardial infarction resulting from amphetamine abuse: a spasm-thrombus interplay? Am Heart J. 1994 Dec;128(6 Pt 1):1237–1239. doi: 10.1016/0002-8703(94)90757-9. [DOI] [PubMed] [Google Scholar]
- Beckett A. H., Rowland M. Urinary excretion kinetics of amphetamine in man. J Pharm Pharmacol. 1965 Oct;17(10):628–639. doi: 10.1111/j.2042-7158.1965.tb07575.x. [DOI] [PubMed] [Google Scholar]
- Cadier M. A., Clarke J. A. Ecstasy and Whizz at a rave resulting in a major burn plus complications. Burns. 1993 Jun;19(3):239–240. doi: 10.1016/0305-4179(93)90158-5. [DOI] [PubMed] [Google Scholar]
- Call T. D., Hartneck J., Dickinson W. A., Hartman C. W., Bartel A. G. Acute cardiomyopathy secondary to intravenous amphetamine abuse. Ann Intern Med. 1982 Oct;97(4):559–560. doi: 10.7326/0003-4819-97-4-559. [DOI] [PubMed] [Google Scholar]
- Callaway C. W., Clark R. F. Hyperthermia in psychostimulant overdose. Ann Emerg Med. 1994 Jul;24(1):68–76. doi: 10.1016/s0196-0644(94)70165-2. [DOI] [PubMed] [Google Scholar]
- Catanzarite V. A., Stein D. A. 'Crystal' and pregnancy--methamphetamine-associated maternal deaths. West J Med. 1995 May;162(5):454–457. [PMC free article] [PubMed] [Google Scholar]
- Chan P., Chen J. H., Lee M. H., Deng J. F. Fatal and nonfatal methamphetamine intoxication in the intensive care unit. J Toxicol Clin Toxicol. 1994;32(2):147–155. doi: 10.3109/15563659409000444. [DOI] [PubMed] [Google Scholar]
- Cho A. K. Ice: a new dosage form of an old drug. Science. 1990 Aug 10;249(4969):631–634. doi: 10.1126/science.249.4969.631. [DOI] [PubMed] [Google Scholar]
- Chynn K. Y. Acute subarachnoid hemorrhage. JAMA. 1975 Jul 7;233(1):55–56. [PubMed] [Google Scholar]
- Citron B. P., Halpern M., McCarron M., Lundberg G. D., McCormick R., Pincus I. J., Tatter D., Haverback B. J. Necrotizing angiitis associated with drug abuse. N Engl J Med. 1970 Nov 5;283(19):1003–1011. doi: 10.1056/NEJM197011052831901. [DOI] [PubMed] [Google Scholar]
- Conci F., D'Angelo V., Tampieri D., Vecchi G. Intracerebral hemorrhage and angiographic beading following amphetamine abuse. Ital J Neurol Sci. 1988 Feb;9(1):77–81. doi: 10.1007/BF02334412. [DOI] [PubMed] [Google Scholar]
- Croft C. H., Firth B. G., Hillis L. D. Propylhexedrine-induced left ventricular dysfunction. Ann Intern Med. 1982 Oct;97(4):560–561. doi: 10.7326/0003-4819-97-4-560. [DOI] [PubMed] [Google Scholar]
- Davis G. G., Swalwell C. I. Acute aortic dissections and ruptured berry aneurysms associated with methamphetamine abuse. J Forensic Sci. 1994 Nov;39(6):1481–1485. [PubMed] [Google Scholar]
- Deloach-Banta L. J. Lichenoid drug eruption: crystal methamphetamine or adulterants? Cutis. 1994 Feb;53(2):97–98. [PubMed] [Google Scholar]
- Derlet R. W., Albertson T. E. Emergency department presentation of cocaine intoxication. Ann Emerg Med. 1989 Feb;18(2):182–186. doi: 10.1016/s0196-0644(89)80111-8. [DOI] [PubMed] [Google Scholar]
- Derlet R. W., Rice P., Horowitz B. Z., Lord R. V. Amphetamine toxicity: experience with 127 cases. J Emerg Med. 1989 Mar-Apr;7(2):157–161. doi: 10.1016/0736-4679(89)90263-1. [DOI] [PubMed] [Google Scholar]
- Ellinwood E. H., Jr Assault and homicide associated with amphetamine abuse. Am J Psychiatry. 1971 Mar;127(9):1170–1175. doi: 10.1176/ajp.127.9.1170. [DOI] [PubMed] [Google Scholar]
- Foley R. J., Kapatkin K., Verani R., Weinman E. J. Amphetamine-induced acute renal failure. South Med J. 1984 Feb;77(2):258–260. doi: 10.1097/00007611-198402000-00035. [DOI] [PubMed] [Google Scholar]
- Furst S. R., Fallon S. P., Reznik G. N., Shah P. K. Myocardial infarction after inhalation of methamphetamine. N Engl J Med. 1990 Oct 18;323(16):1147–1148. doi: 10.1056/NEJM199010183231617. [DOI] [PubMed] [Google Scholar]
- Gary N. E., Saidi P. Methamphetamine intoxication. A speedy new treatment. Am J Med. 1978 Mar;64(3):537–540. doi: 10.1016/0002-9343(78)90249-8. [DOI] [PubMed] [Google Scholar]
- Gawin F. H., Ellinwood E. H., Jr Cocaine and other stimulants. Actions, abuse, and treatment. N Engl J Med. 1988 May 5;318(18):1173–1182. doi: 10.1056/NEJM198805053181806. [DOI] [PubMed] [Google Scholar]
- Ginsberg M. D., Hertzman M., Schmidt-Nowara W. W. Amphetamine intoxication with coagulopathy, hyperthermia, and reversible renal failure. A syndrome resembling heatstroke. Ann Intern Med. 1970 Jul;73(1):81–85. doi: 10.7326/0003-4819-73-1-81. [DOI] [PubMed] [Google Scholar]
- Gorman E. M., Morgan P., Lambert E. Y. Qualitative research considerations and other issues in the study of methamphetamine use among men who have sex with other men. NIDA Res Monogr. 1995;157:156–181. [PubMed] [Google Scholar]
- Gospe S. M., Jr Transient cortical blindness in an infant exposed to methamphetamine. Ann Emerg Med. 1995 Sep;26(3):380–382. doi: 10.1016/s0196-0644(95)70090-0. [DOI] [PubMed] [Google Scholar]
- Hall A. P., Lyburn I. D., Spears F. D., Riley B. An unusual case of Ecstasy poisoning. Intensive Care Med. 1996 Jul;22(7):670–671. doi: 10.1007/BF01709744. [DOI] [PubMed] [Google Scholar]
- Henry J. A., Jeffreys K. J., Dawling S. Toxicity and deaths from 3,4-methylenedioxymethamphetamine ("ecstasy") Lancet. 1992 Aug 15;340(8816):384–387. doi: 10.1016/0140-6736(92)91469-o. [DOI] [PubMed] [Google Scholar]
- Hong R., Matsuyama E., Nur K. Cardiomyopathy associated with the smoking of crystal methamphetamine. JAMA. 1991 Mar 6;265(9):1152–1154. [PubMed] [Google Scholar]
- Hughes J. C., McCabe M., Evans R. J. Intracranial haemorrhage associated with ingestion of 'ecstasy'. Arch Emerg Med. 1993 Dec;10(4):372–374. doi: 10.1136/emj.10.4.372. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jackson J. G. The hazards of smokable methamphetamine. N Engl J Med. 1989 Sep 28;321(13):907–907. doi: 10.1056/nejm198909283211321. [DOI] [PubMed] [Google Scholar]
- Johnson T. D., Berenson M. M. Methamphetamine-induced ischemic colitis. J Clin Gastroenterol. 1991 Dec;13(6):687–689. doi: 10.1097/00004836-199112000-00015. [DOI] [PubMed] [Google Scholar]
- Jones A. L., Jarvie D. R., McDermid G., Proudfoot A. T. Hepatocellular damage following amphetamine intoxication. J Toxicol Clin Toxicol. 1994;32(4):435–444. doi: 10.3109/15563659409011046. [DOI] [PubMed] [Google Scholar]
- Kalant H., Kalant O. J. Death in amphetamine users: causes and rates. Can Med Assoc J. 1975 Feb 8;112(3):299–304. [PMC free article] [PubMed] [Google Scholar]
- Katsumata S., Sato K., Kashiwade H., Yamanami S., Zhou H., Yonemura I., Nakajima H., Hasekura H. Sudden death due presumably to internal use of methamphetamine. Forensic Sci Int. 1993 Dec;62(3):209–215. doi: 10.1016/0379-0738(93)90209-s. [DOI] [PubMed] [Google Scholar]
- Kendrick W. C., Hull A. R., Knochel J. P. Rhabdomyolysis and shock after intravenous amphetamine administration. Ann Intern Med. 1977 Apr;86(4):381–387. doi: 10.7326/0003-4819-86-4-381. [DOI] [PubMed] [Google Scholar]
- Kipke M. D., O'Connor S., Palmer R., MacKenzie R. G. Street youth in Los Angeles. Profile of a group at high risk for human immunodeficiency virus infection. Arch Pediatr Adolesc Med. 1995 May;149(5):513–519. doi: 10.1001/archpedi.1995.02170180043006. [DOI] [PubMed] [Google Scholar]
- Klatt E. C., Montgomery S., Namiki T., Noguchi T. T. Misrepresentation of stimulant street drugs: a decade of experience in an analysis program. J Toxicol Clin Toxicol. 1986;24(5):441–450. doi: 10.3109/15563658608992606. [DOI] [PubMed] [Google Scholar]
- Kramer J. C., Fischman V. S., Littlefield D. C. Amphetamine abuse. Pattern and effects of high doses taken intravenously. JAMA. 1967 Jul 31;201(5):305–309. doi: 10.1001/jama.201.5.305. [DOI] [PubMed] [Google Scholar]
- Lake C. R., Quirk R. S. CNS stimulants and the look-alike drugs. Psychiatr Clin North Am. 1984 Dec;7(4):689–701. [PubMed] [Google Scholar]
- Lam D., Goldschlager N. Myocardial injury associated with polysubstance abuse. Am Heart J. 1988 Mar;115(3):675–680. doi: 10.1016/0002-8703(88)90820-4. [DOI] [PubMed] [Google Scholar]
- Lewman L. V. Fatal pulmonary hypertension from intravenous injection of methylphenidate (Ritalin) tablets. Hum Pathol. 1972 Mar;3(1):67–70. doi: 10.1016/s0046-8177(72)80054-6. [DOI] [PubMed] [Google Scholar]
- Logan B. K. Methamphetamine and driving impairment. J Forensic Sci. 1996 May;41(3):457–464. [PubMed] [Google Scholar]
- Lukes S. A. Intracerebral hemorrhage from an arteriovenous malformation after amphetamine injection. Arch Neurol. 1983 Jan;40(1):60–61. doi: 10.1001/archneur.1983.04050010080027. [DOI] [PubMed] [Google Scholar]
- Lundh H., Tunving K. An extrapyramidal choreiform syndrome caused by amphetamine addiction. J Neurol Neurosurg Psychiatry. 1981 Aug;44(8):728–730. doi: 10.1136/jnnp.44.8.728. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Matick H., Anderson D., Brumlik J. Cerebral vasculitis associated with oral amphetamine overdose. Arch Neurol. 1983 Apr;40(4):253–254. doi: 10.1001/archneur.1983.04050040083018. [DOI] [PubMed] [Google Scholar]
- Mendelson J., Jones R. T., Upton R., Jacob P., 3rd Methamphetamine and ethanol interactions in humans. Clin Pharmacol Ther. 1995 May;57(5):559–568. doi: 10.1016/0009-9236(95)90041-1. [DOI] [PubMed] [Google Scholar]
- Meston C. M., Gorzalka B. B. Psychoactive drugs and human sexual behavior: the role of serotonergic activity. J Psychoactive Drugs. 1992 Jan-Mar;24(1):1–40. doi: 10.1080/02791072.1992.10471616. [DOI] [PubMed] [Google Scholar]
- Molitor F., Truax S. R., Ruiz J. D., Sun R. K. Association of methamphetamine use during sex with risky sexual behaviors and HIV infection among non-injection drug users. West J Med. 1998 Feb;168(2):93–97. [PMC free article] [PubMed] [Google Scholar]
- O'Neill M. E., Arnolda L. F., Coles D. M., Nikolic G. Acute amphetamine cardiomyopathy in a drug addict. Clin Cardiol. 1983 Apr;6(4):189–191. doi: 10.1002/clc.4960060407. [DOI] [PubMed] [Google Scholar]
- Pecha R. E., Prindiville T., Pecha B. S., Camp R., Carroll M., Trudeau W. Association of cocaine and methamphetamine use with giant gastroduodenal ulcers. Am J Gastroenterol. 1996 Dec;91(12):2523–2527. [PubMed] [Google Scholar]
- Pitts D. K., Marwah J. Cocaine and central monoaminergic neurotransmission: a review of electrophysiological studies and comparison to amphetamine and antidepressants. Life Sci. 1988;42(9):949–968. doi: 10.1016/0024-3205(88)90425-0. [DOI] [PubMed] [Google Scholar]
- Puder K. S., Kagan D. V., Morgan J. P. Illicit methamphetamine: analysis, synthesis, and availability. Am J Drug Alcohol Abuse. 1988;14(4):463–473. doi: 10.3109/00952998809001564. [DOI] [PubMed] [Google Scholar]
- Rhee K. J., Albertson T. E., Douglas J. C. Choreoathetoid disorder associated with amphetamine-like drugs. Am J Emerg Med. 1988 Mar;6(2):131–133. doi: 10.1016/0735-6757(88)90050-2. [DOI] [PubMed] [Google Scholar]
- Richards J. R., Derlet R. W., Duncan D. R. Methamphetamine toxicity: treatment with a benzodiazepine versus a butyrophenone. Eur J Emerg Med. 1997 Sep;4(3):130–135. doi: 10.1097/00063110-199709000-00003. [DOI] [PubMed] [Google Scholar]
- Robertson C. H., Jr, Reynolds R. C., Wilson J. E., 3rd Pulmonary hypertension and foreign body granulomas in intravenous drug abusers. Documentation by cardiac catheterization and lung biopsy. Am J Med. 1976 Nov;61(5):657–664. doi: 10.1016/0002-9343(76)90144-3. [DOI] [PubMed] [Google Scholar]
- Rothrock J. F., Rubenstein R., Lyden P. D. Ischemic stroke associated with methamphetamine inhalation. Neurology. 1988 Apr;38(4):589–592. doi: 10.1212/wnl.38.4.589. [DOI] [PubMed] [Google Scholar]
- Salanova V., Taubner R. Intracerebral haemorrhage and vasculitis secondary to amphetamine use. Postgrad Med J. 1984 Jun;60(704):429–430. doi: 10.1136/pgmj.60.704.429. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sato M. A lasting vulnerability to psychosis in patients with previous methamphetamine psychosis. Ann N Y Acad Sci. 1992 Jun 28;654:160–170. doi: 10.1111/j.1749-6632.1992.tb25965.x. [DOI] [PubMed] [Google Scholar]
- Schaiberger P. H., Kennedy T. C., Miller F. C., Gal J., Petty T. L. Pulmonary hypertension associated with long-term inhalation of "crank" methamphetamine. Chest. 1993 Aug;104(2):614–616. doi: 10.1378/chest.104.2.614. [DOI] [PubMed] [Google Scholar]
- Scheel-Krüger J. Behavioural and biochemical comparison of amphetamine derivatives, cocaine, benztropine and tricyclic anti-depressant drugs. Eur J Pharmacol. 1972 Apr;18(1):63–73. doi: 10.1016/0014-2999(72)90132-x. [DOI] [PubMed] [Google Scholar]
- Schepens P. J., Pauwels A., Van Damme P., Musuku A., Beaucourt L., Selala M. I. Drugs of abuse and alcohol in weekend drivers involved in car crashes in Belgium. Ann Emerg Med. 1998 May;31(5):633–637. doi: 10.1016/s0196-0644(98)70210-0. [DOI] [PubMed] [Google Scholar]
- Screaton G. R., Singer M., Cairns H. S., Thrasher A., Sarner M., Cohen S. L. Hyperpyrexia and rhabdomyolysis after MDMA ("ecstasy") abuse. Lancet. 1992 Mar 14;339(8794):677–678. doi: 10.1016/0140-6736(92)90834-p. [DOI] [PubMed] [Google Scholar]
- Simpson D. L., Rumack B. H. Methylenedioxyamphetamine. Clinical description of overdose, death, and review of pharmacology. Arch Intern Med. 1981 Oct;141(11):1507–1509. doi: 10.1001/archinte.141.11.1507. [DOI] [PubMed] [Google Scholar]
- Smith D. E., Fischer C. M. An analysis of 310 cases of acute high-dose methamphetamine toxicity in Haight-Ashbury. Clin Toxicol. 1970 Mar;3(1):117–124. doi: 10.3109/15563657008990106. [DOI] [PubMed] [Google Scholar]
- Smith H. J., Roche A. H., Jausch M. F., Herdson P. B. Cardiomyopathy associated with amphetamine administration. Am Heart J. 1976 Jun;91(6):792–797. doi: 10.1016/s0002-8703(76)80545-5. [DOI] [PubMed] [Google Scholar]
- Sperling L. S., Horowitz J. L. Methamphetamine-induced choreoathetosis and rhabdomyolysis. Ann Intern Med. 1994 Dec 15;121(12):986–986. doi: 10.7326/0003-4819-121-12-199412150-00019. [DOI] [PubMed] [Google Scholar]
- Stewart J. L., Meeker J. E. Fetal and infant deaths associated with maternal methamphetamine abuse. J Anal Toxicol. 1997 Oct;21(6):515–517. doi: 10.1093/jat/21.6.515. [DOI] [PubMed] [Google Scholar]
- Vega W. A., Kolody B., Hwang J., Noble A. Prevalence and magnitude of perinatal substance exposures in California. N Engl J Med. 1993 Sep 16;329(12):850–854. doi: 10.1056/NEJM199309163291207. [DOI] [PubMed] [Google Scholar]
- Wilson J. M., Kalasinsky K. S., Levey A. I., Bergeron C., Reiber G., Anthony R. M., Schmunk G. A., Shannak K., Haycock J. W., Kish S. J. Striatal dopamine nerve terminal markers in human, chronic methamphetamine users. Nat Med. 1996 Jun;2(6):699–703. doi: 10.1038/nm0696-699. [DOI] [PubMed] [Google Scholar]
- ZALIS E. G., PARMLEY L. F., Jr FATAL AMPHETAMINE POISONING. Arch Intern Med. 1963 Dec;112:822–826. doi: 10.1001/archinte.1963.03860060060004. [DOI] [PubMed] [Google Scholar]
- de Man R. A., Wilson J. H., Tjen H. S. Acuut leverfalen door methyleendioxymetamfetamine ('ecstacy'). Ned Tijdschr Geneeskd. 1993 Apr 3;137(14):727–729. [PubMed] [Google Scholar]