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. 1985 Mar;142(3):358–363.

Psychosocial Events and Subsequent Illness—A Review

Donald E Girard 1,2, James B Reuler 1,2, Ransom J Arthur 1,2
PMCID: PMC1306027  PMID: 3993013

Abstract

The public readily accepts the relationship between psychosocial events and illness and acknowledges that stress is important in the acquisition of disease. However, scientific documentation of these relationships has not been convincing and many clinicians remain skeptical. In this review we survey selected studies from socioepidemiologic, psychologic and physiologic research, chosen for their methodologic rigor, that help clarify the relationship between psychosocial events and illness. We conclude (1) though difficult to prove, available data support a positive relationship between psychosocial events and illness, and (2) psychologic well-being is important for good physical health.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BYERS S. O., FRIEDMAN M., ROSENMAN R. H., FREED S. C. Excretion of 3-methoxy-4-hydroxymandelic acid in men with behavior pattern associated with high incidence of coronary artery disease. Fed Proc. 1962 Jul-Aug;21(4):99–101. [PubMed] [Google Scholar]
  2. Bahnson C. B. Stress and cancer: the state of the art. Part 1. Psychosomatics. 1980 Dec;21(12):975–981. doi: 10.1016/S0033-3182(80)73571-5. [DOI] [PubMed] [Google Scholar]
  3. Bahnson C. B. Stress and cancer: the state of the art. Part 2. Psychosomatics. 1981 Mar;22(3):207–220. doi: 10.1016/S0033-3182(81)73533-3. [DOI] [PubMed] [Google Scholar]
  4. Bartrop R. W., Luckhurst E., Lazarus L., Kiloh L. G., Penny R. Depressed lymphocyte function after bereavement. Lancet. 1977 Apr 16;1(8016):834–836. doi: 10.1016/s0140-6736(77)92780-5. [DOI] [PubMed] [Google Scholar]
  5. Conner R. L., Vernikos-Danellis J., Levine S. Stress, fighting and neuroendocrine function. Nature. 1971 Dec 31;234(5331):564–566. doi: 10.1038/234564a0. [DOI] [PubMed] [Google Scholar]
  6. Eastwood M. R., Trevelyan H. Stress and coronary heart disease. J Psychosom Res. 1971 Sep;15(3):289–292. doi: 10.1016/0022-3999(71)90040-7. [DOI] [PubMed] [Google Scholar]
  7. FRIEDMAN M., ROSENMAN R. H. Association of specific overt behavior pattern with blood and cardiovascular findings; blood cholesterol level, blood clotting time, incidence of arcus senilis, and clinical coronary artery disease. J Am Med Assoc. 1959 Mar 21;169(12):1286–1296. doi: 10.1001/jama.1959.03000290012005. [DOI] [PubMed] [Google Scholar]
  8. FUNKENSTEIN D. H. Nor-epinephrine-like and epinephrine-like substances in relation to human behavior. J Nerv Ment Dis. 1956 Jul;124(1):58–68. doi: 10.1097/00005053-195607000-00009. [DOI] [PubMed] [Google Scholar]
  9. Frankenhaeuser M., Gardell B. Underload and overload in working life: outline of a multidisciplinary approach. J Human Stress. 1976 Sep;2(3):35–46. doi: 10.1080/0097840X.1976.9936068. [DOI] [PubMed] [Google Scholar]
  10. Friedman M., Byers S. O., Diamant J., Rosenman R. H. Plasma catecholamine response of coronary-prone subjects (type A) to a specific challenge. Metabolism. 1975 Feb;24(2):205–210. doi: 10.1016/0026-0495(75)90022-0. [DOI] [PubMed] [Google Scholar]
  11. Gordon T., Garcia-Palmieri M. R., Kagan A., Kannel W. B., Schiffman J. Differences in coronary heart disease in Framingham, Honolulu and Puerto Rico. J Chronic Dis. 1974 Sep;27(7-8):329–344. doi: 10.1016/0021-9681(74)90013-7. [DOI] [PubMed] [Google Scholar]
  12. Greer S., Morris T. Psychological attributes of women who develop breast cancer: a controlled study. J Psychosom Res. 1975 Apr;19(2):147–153. doi: 10.1016/0022-3999(75)90062-8. [DOI] [PubMed] [Google Scholar]
  13. Henry J. P., Cassel J. C. Psychosocial factors in essential hypertension. Recent epidemiologic and animal experimental evidence. Am J Epidemiol. 1969 Sep;90(3):171–200. doi: 10.1093/oxfordjournals.aje.a121062. [DOI] [PubMed] [Google Scholar]
  14. Hinkle L. E., Jr, Whitney L. H., Lehman E. W., Dunn J., Benjamin B., King R., Plakun A., Flehinger B. Occupation, education, and coronary heart disease. Risk is influenced more by education and background than by occupational experiences, in the Bell System. Science. 1968 Jul 19;161(3838):238–246. doi: 10.1126/science.161.3838.238. [DOI] [PubMed] [Google Scholar]
  15. House J. S., McMichael A. J., Wells J. A., Kaplan B. H., Landerman L. R. Occupational stress and health among factory workers. J Health Soc Behav. 1979 Jun;20(2):139–160. [PubMed] [Google Scholar]
  16. Hurst M. W., Jenkins C. D., Rose R. M. The relation of psychological stress to onset of medical illness. Annu Rev Med. 1976;27:301–312. doi: 10.1146/annurev.me.27.020176.001505. [DOI] [PubMed] [Google Scholar]
  17. Keys A., Aravanis C., Blackburn H., Van Buchem F. S., Buzina R., Djordjevic B. S., Fidanza F., Karvonen M. J., Menotti A., Puddu V. Probability of middle-aged men developing coronary heart disease in five years. Circulation. 1972 Apr;45(4):815–828. doi: 10.1161/01.cir.45.4.815. [DOI] [PubMed] [Google Scholar]
  18. MEYER R. J., HAGGERTY R. J. Streptococcal infections in families. Factors altering individual susceptibility. Pediatrics. 1962 Apr;29:539–549. [PubMed] [Google Scholar]
  19. Marmot M. G., Syme S. L. Acculturation and coronary heart disease in Japanese-Americans. Am J Epidemiol. 1976 Sep;104(3):225–247. doi: 10.1093/oxfordjournals.aje.a112296. [DOI] [PubMed] [Google Scholar]
  20. Mason J. W. A review of psychoendocrine research on the pituitary-adrenal cortical system. Psychosom Med. 1968 Sep-Oct;30(5 Suppl):576–607. [PubMed] [Google Scholar]
  21. Mason J. W. A review of psychoendocrine research on the sympathetic-adrenal medullary system. Psychosom Med. 1968 Sep-Oct;30(5 Suppl):631–653. doi: 10.1097/00006842-196809000-00022. [DOI] [PubMed] [Google Scholar]
  22. Medalie J. H., Snyder M., Groen J. J., Neufeld H. N., Goldbourt U., Riss E. Angina pectoris among 10,000 men. 5 year incidence and univariate analysis. Am J Med. 1973 Nov;55(5):583–594. doi: 10.1016/0002-9343(73)90179-4. [DOI] [PubMed] [Google Scholar]
  23. OSTFELD A. M., LEBOVITS B. Z., SHEKELLE R. B., PAUL O. A PROSPECTIVE STUDY OF THE RELATIONSHIP BETWEEN PERSONALITY AND CORONARY HEART DISEASE. J Chronic Dis. 1964 Mar;17:265–276. [PubMed] [Google Scholar]
  24. Rabkin J. G., Struening E. L. Live events, stress, and illness. Science. 1976 Dec 3;194(4269):1013–1020. doi: 10.1126/science.790570. [DOI] [PubMed] [Google Scholar]
  25. Reus V. I., Joseph M. S., Dallman M. F. ACTH levels after the dexamethasone suppression test in depression. N Engl J Med. 1982 Jan 28;306(4):238–239. doi: 10.1056/NEJM198201283060414. [DOI] [PubMed] [Google Scholar]
  26. Riley V. Psychoneuroendocrine influences on immunocompetence and neoplasia. Science. 1981 Jun 5;212(4499):1100–1109. doi: 10.1126/science.7233204. [DOI] [PubMed] [Google Scholar]
  27. Rose G., Marmot M. G. Social class and coronary heart disease. Br Heart J. 1981 Jan;45(1):13–19. doi: 10.1136/hrt.45.1.13. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Rosenman R. H., Brand R. J., Jenkins D., Friedman M., Straus R., Wurm M. Coronary heart disease in Western Collaborative Group Study. Final follow-up experience of 8 1/2 years. JAMA. 1975 Aug 25;233(8):872–877. [PubMed] [Google Scholar]
  29. STAMLER J., LINDBERG H. A., BERKSON D. M., SHAFFER A., MILLER W., POINDEXTER A. Prevalence and incidence of coronary heart disease in strata of the labor force of a Chicago industrial corporation. J Chronic Dis. 1960 Apr;11:405–420. doi: 10.1016/0021-9681(60)90046-1. [DOI] [PubMed] [Google Scholar]
  30. SYME S. L., HYMAN M. M., ENTERLINE P. E. SOME SOCIAL AND CULTURAL FACTORS ASSOCIATED WITH THE OCCURRENCE OF CORONARY HEART DISEASE. J Chronic Dis. 1964 Mar;17:277–289. [PubMed] [Google Scholar]
  31. Sachar E. J. Neuroendocrine dysfunction in depressive illness. Annu Rev Med. 1976;27:389–396. doi: 10.1146/annurev.me.27.020176.002133. [DOI] [PubMed] [Google Scholar]
  32. Schildkraut J. J. Biogenic amines and affective disorders. Annu Rev Med. 1974;25(0):333–348. doi: 10.1146/annurev.me.25.020174.002001. [DOI] [PubMed] [Google Scholar]
  33. Shekelle R. B., Ostfeld A. M., Paul O. Social status and incidence of coronary heart disease. J Chronic Dis. 1969 Dec;22(6):381–394. doi: 10.1016/0021-9681(69)90002-2. [DOI] [PubMed] [Google Scholar]
  34. Shekelle R. B., Raynor W. J., Jr, Ostfeld A. M., Garron D. C., Bieliauskas L. A., Liu S. C., Maliza C., Paul O. Psychological depression and 17-year risk of death from cancer. Psychosom Med. 1981 Apr;43(2):117–125. doi: 10.1097/00006842-198104000-00003. [DOI] [PubMed] [Google Scholar]
  35. Theorell T., Lind E., Fröberg J., Karlsson C. G., Levi L. A longitudinal study of 21 subjects with coronary heart disease: life changes, catecholamine excretion and related biochemical reactions. Psychosom Med. 1972 Nov-Dec;34(6):505–516. doi: 10.1097/00006842-197211000-00003. [DOI] [PubMed] [Google Scholar]
  36. Theorell T. Selected illnesses and somatic factors in relation to two psychosocial stress indices - a prospective study on middle-aged construction building workers. J Psychosom Res. 1976;20(1):7–20. doi: 10.1016/0022-3999(76)90095-7. [DOI] [PubMed] [Google Scholar]
  37. Thomas C. B., Duszynski K. R., Shaffer J. W. Family attitudes reported in youth as potential predictors of cancer. Psychosom Med. 1979 Jun;41(4):287–302. doi: 10.1097/00006842-197906000-00003. [DOI] [PubMed] [Google Scholar]
  38. Thomas C. B., Greenstreet R. L. Psychobiological characteristics in youth as predictors of five disease states: suicide, mental illness, hypertension, coronary heart disease and tumor. Johns Hopkins Med J. 1973 Jan;132(1):16–43. [PubMed] [Google Scholar]
  39. Thomas C. B., McCabe O. L. Precursors of premature disease and death: habits of nervous tension. Johns Hopkins Med J. 1980 Oct;147(4):137–145. [PubMed] [Google Scholar]
  40. Timio M., Gentili S., Pede S. Free adrenaline and noradrenaline excretion related to occupational stress. Br Heart J. 1979 Oct;42(4):471–474. doi: 10.1136/hrt.42.4.471. [DOI] [PMC free article] [PubMed] [Google Scholar]
  41. Vaillant G. E. Natural history of male psychologic health: effects of mental health on physical health. N Engl J Med. 1979 Dec 6;301(23):1249–1254. doi: 10.1056/NEJM197912063012302. [DOI] [PubMed] [Google Scholar]

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