Abstract
Polycystic ovarian disease represents a poorly defined spectrum of clinical disorders having oligo-ovulation or anovulation as a common feature. There is no single, universally accepted biochemical or clinical definition. Clinical findings usually include anovulation resulting in irregular uterine bleeding and infertility, androgen excess resulting in hirsutism and acne, and obesity. The patho-physiology involves altered functions of the hypothalamus, pituitary, ovary and adrenal glands, resulting in failure of folliculogenesis to regularly proceed to ovulation. The cause of the initiating event in this disease process remains enigmatic. Therapy for the various abnormalities in polycystic ovarian disease is tailored to a patient's needs and may include preventing endometrial hyperplasia, controlling irregular uterine bleeding, controlling hirsutism and inducing ovulation.
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Selected References
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- Chang R. J., Nakamura R. M., Judd H. L., Kaplan S. A. Insulin resistance in nonobese patients with polycystic ovarian disease. J Clin Endocrinol Metab. 1983 Aug;57(2):356–359. doi: 10.1210/jcem-57-2-356. [DOI] [PubMed] [Google Scholar]
- Erickson G. F., Hsueh A. J., Quigley M. E., Rebar R. W., Yen S. S. Functional studies of aromatase activity in human granulosa cells from normal and polycystic ovaries. J Clin Endocrinol Metab. 1979 Oct;49(4):514–519. doi: 10.1210/jcem-49-4-514. [DOI] [PubMed] [Google Scholar]
- Falaschi P., del Pozo E., Rocco A., Toscano V., Petrangeli E., Pompei P., Frajese G. Prolactin release in polycystic ovary. Obstet Gynecol. 1980 May;55(5):579–582. [PubMed] [Google Scholar]
- Goldzieher J. W. Polycystic ovarian disease. Fertil Steril. 1981 Apr;35(4):371–394. doi: 10.1016/s0015-0282(16)45429-4. [DOI] [PubMed] [Google Scholar]
- Katz M., Carr P. J. Abnormal luteinizing hormone response patterns to synthetic gonadotrophin releasing hormone in patients with polycystic ovarian syndrome. J Endocrinol. 1976 Aug;70(2):163–171. doi: 10.1677/joe.0.0700163. [DOI] [PubMed] [Google Scholar]
- Lachelin G. C., Barnett M., Hopper B. R., Brink G., Yen S. S. Adrenal function in normal women and women with the polycystic ovary syndrome. J Clin Endocrinol Metab. 1979 Dec;49(6):892–898. doi: 10.1210/jcem-49-6-892. [DOI] [PubMed] [Google Scholar]
- Lobo R. A., Goebelsmann U., Horton R. Evidence for the importance of peripheral tissue events in the development of hirsutism in polycystic ovary syndrome. J Clin Endocrinol Metab. 1983 Aug;57(2):393–397. doi: 10.1210/jcem-57-2-393. [DOI] [PubMed] [Google Scholar]
- Rebar R., Judd H. L., Yen S. S., Rakoff J., Vandenberg G., Naftolin F. Characterization of the inappropriate gonadotropin secretion in polycystic ovary syndrome. J Clin Invest. 1976 May;57(5):1320–1329. doi: 10.1172/JCI108400. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shapiro G., Evron S. A novel use of spironolactone: treatment of hirsutism. J Clin Endocrinol Metab. 1980 Sep;51(3):429–432. doi: 10.1210/jcem-51-3-429. [DOI] [PubMed] [Google Scholar]
- Tanabe K., Gagliano P., Channing C. P., Nakamura Y., Yoshimura Y., Iizuka R., Fortuny A., Sulewski J., Rezai N. Levels of inhibin-F activity and steroids in human follicular fluid from normal women and women with polycystic ovarian disease. J Clin Endocrinol Metab. 1983 Jul;57(1):24–31. doi: 10.1210/jcem-57-1-24. [DOI] [PubMed] [Google Scholar]
- Wang C. F., Gemzell C. The use of human gonadotropins for the induction of ovulation in women with polycystic ovarian disease. Fertil Steril. 1980 May;33(5):479–486. doi: 10.1016/s0015-0282(16)44711-4. [DOI] [PubMed] [Google Scholar]
- Yen S. S. The polycystic ovary syndrome. Clin Endocrinol (Oxf) 1980 Feb;12(2):177–207. doi: 10.1111/j.1365-2265.1980.tb02132.x. [DOI] [PubMed] [Google Scholar]