Abstract
In 1981 the California Medical Association (CMA) adopted the position that clinical ecology does not constitute a valid medical discipline and that scientific and clinical evidence to support the diagnosis of “environmental illness” and “cerebral allergy” or the concept of massive environmental allergy is lacking. As a result of requests from clinical ecologists for an opportunity to present to CMA evidence justifying their diagnostic and treatment methods, the chair of the CMA Scientific Board, Allen W. Mathies, Jr, MD, appointed a task force in 1984 to review clinical ecology. The task force conducted an extensive literature review and held a hearing.
Clinical ecology is based on two main hypotheses: first, that the total load of low-dose environmental stressors is important in the induction of illness; and, second, that changes in the frequency of and intervals between exposures to specific substances can mask the clinical manifestations of or alter the degree of sensitivity to those substances. Treatment methods used by clinical ecologists include avoidance, symptom-neutralizing doses of diluted extract of the offending agents, rotation diets and an ecologically sound workplace and home.
The task force recognizes that certain environmental chemicals and allergens produce well-defined syndromes in humans and that some patients suffer from illnesses that are not readily diagnosed and for which only supportive therapy exists. The conclusions of the task force are
• There is no convincing evidence that supports the hypotheses on which clinical ecology is based.
• Clinical ecologists have not identified specific, recognizable diseases caused by exposure to low level-environmental stressors.
• Methods to diagnose and treat such undefined conditions have not been shown to be effective.
• The practice of clinical ecology can be considered experimental only when its practitioners adhere to scientifically sound research protocols and inform their patients about the experimental nature of their practice.
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Selected References
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- Anderson J. A. Non-immunologically-mediated food sensitivity. Nutr Rev. 1984 Mar;42(3):109–116. doi: 10.1111/j.1753-4887.1984.tb02299.x. [DOI] [PubMed] [Google Scholar]
- Blalock J. E., Archer D. L., Johnson H. M. Anticellular and immunosuppressive activities of foodborne phenolic compounds. Proc Soc Exp Biol Med. 1981 Jul;167(3):391–393. doi: 10.3181/00379727-167-41185. [DOI] [PubMed] [Google Scholar]
- Burr M. L., Merrett T. G. Food intolerance: a community survey. Br J Nutr. 1983 Mar;49(2):217–219. doi: 10.1079/bjn19830028. [DOI] [PubMed] [Google Scholar]
- Egger J., Carter C. M., Graham P. J., Gumley D., Soothill J. F. Controlled trial of oligoantigenic treatment in the hyperkinetic syndrome. Lancet. 1985 Mar 9;1(8428):540–545. doi: 10.1016/s0140-6736(85)91206-1. [DOI] [PubMed] [Google Scholar]
- Finn R., Fennerty A. G., Ahmad R. Hydrocarbon exposure and glomerulonephritis. Clin Nephrol. 1980 Oct;14(4):173–175. [PubMed] [Google Scholar]
- Grieco M. H. Controversial practices in allergy. JAMA. 1982 Jun 11;247(22):3106–3111. [PubMed] [Google Scholar]
- Lowell F. C. Editorial: Some untested diagnostic and therapeutic procedures in clinical allergy. J Allergy Clin Immunol. 1975 Sep;56(3):168–169. doi: 10.1016/0091-6749(75)90088-3. [DOI] [PubMed] [Google Scholar]
- McGovern J. J., Jr, Lazaroni J. A., Hicks M. F., Adler J. C., Cleary P. Food and chemical sensitivity. Clinical and immunologic correlates. Arch Otolaryngol. 1983 May;109(5):292–297. doi: 10.1001/archotol.1983.00800190014004. [DOI] [PubMed] [Google Scholar]
- Miller J. B. A double-blind study of food extract injection therapy: a preliminary report. Ann Allergy. 1977 Mar;38(3):185–191. [PubMed] [Google Scholar]
- Miller J. B. Treatment of active herpes virus infections with influenza virus vaccine. Ann Allergy. 1979 May;42(5):295–305. [PubMed] [Google Scholar]
- Monro J., Carini C., Brostoff J. Migraine is a food-allergic disease. Lancet. 1984 Sep 29;2(8405):719–721. doi: 10.1016/s0140-6736(84)92626-6. [DOI] [PubMed] [Google Scholar]
- Price K., Smith S. E. Cheese reaction and tyramine. Lancet. 1971 Jan 16;1(7690):130–131. doi: 10.1016/s0140-6736(71)90858-0. [DOI] [PubMed] [Google Scholar]
- Rea W. J. Environmentally triggered thrombophlebitis. Ann Allergy. 1976 Aug;37(2):101–109. [PubMed] [Google Scholar]
- Rea W. J., Peters D. W., Smiley R. E., Edgar R., Greenberg M., Fenyves E. Recurrent environmentally triggered thrombophlebitis: a five-year follow-up. Ann Allergy. 1981 Nov;47(5 Pt 1):338–344. [PubMed] [Google Scholar]
- Rea W. J., Podell R. N., Williams M. L., Fenyves E., Sprague D. E., Johnson A. R. Elimination of oral food challenge reaction by injection of food extracts. A double-blind evaluation. Arch Otolaryngol. 1984 Apr;110(4):248–252. doi: 10.1001/archotol.1984.00800300040009. [DOI] [PubMed] [Google Scholar]
- Rea W. J., Podell R. N., Williams M. L., Fenyves E., Sprague D. E., Johnson A. R. Elimination of oral food challenge reaction by injection of food extracts. A double-blind evaluation. Arch Otolaryngol. 1984 Apr;110(4):248–252. doi: 10.1001/archotol.1984.00800300040009. [DOI] [PubMed] [Google Scholar]
- Reisman R. E. Presidential address. Standards of practice--our responsibility. J Allergy Clin Immunol. 1981 Jul;68(1):1–4. doi: 10.1016/0091-6749(81)90115-9. [DOI] [PubMed] [Google Scholar]
- Terr A. I. Environmental illness. A clinical review of 50 cases. Arch Intern Med. 1986 Jan;146(1):145–149. doi: 10.1001/archinte.146.1.145. [DOI] [PubMed] [Google Scholar]
