Abstract
Skin testing is reliable and useful to rule out penicillin allergy in most patients who have a history of previous reactions. When we tested 291 inpatients in the University of Washington hospitals for the presence or absence of penicillin allergy, of 97 with a history of penicillin allergy, 12 (12.4%) had positive skin tests. Of 194 patients with no or an unknown history, only 4 (2%) had positive skin tests. Two of the 16 who had positive skin tests (12.5%) reacted only to minor determinant mixtures. Of the skin test-negative patients, 261 were treated with one of the penicillins and only two had any reactions.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Adkinson N. F., Jr, Thompson W. L., Maddrey W. C., Lichtenstein L. M. Routine use of penicillin skin testing on an inpatient service. N Engl J Med. 1971 Jul 1;285(1):22–24. doi: 10.1056/NEJM197107012850104. [DOI] [PubMed] [Google Scholar]
- Green G. R., Rosenblum A. H., Sweet L. C. Evaluation of penicillin hypersensitivity: value of clinical history and skin testing with penicilloyl-polylysine and penicillin G. A cooperative prospective study of the penicillin study group of the American Academy of Allergy. J Allergy Clin Immunol. 1977 Dec;60(6):339–345. doi: 10.1016/0091-6749(77)90064-1. [DOI] [PubMed] [Google Scholar]
- Levine B. B., Zolov D. M. Prediction of penicillin allergy by immunological tests. J Allergy. 1969 Apr;43(4):231–244. doi: 10.1016/0021-8707(69)90066-5. [DOI] [PubMed] [Google Scholar]
- Mendelson L. M., Ressler C., Rosen J. P., Selcow J. E. Routine elective penicillin allergy skin testing in children and adolescents: study of sensitization. J Allergy Clin Immunol. 1984 Jan;73(1 Pt 1):76–81. doi: 10.1016/0091-6749(84)90487-1. [DOI] [PubMed] [Google Scholar]
- Sullivan T. J., Wedner H. J., Shatz G. S., Yecies L. D., Parker C. W. Skin testing to detect penicillin allergy. J Allergy Clin Immunol. 1981 Sep;68(3):171–180. doi: 10.1016/0091-6749(81)90180-9. [DOI] [PubMed] [Google Scholar]
- Warrington R. J., Simons F. E., Ho H. W., Gorski B. A. Diagnosis of penicillin allergy by skin testing: the Manitoba experience. Can Med Assoc J. 1978 Apr 8;118(7):787–791. [PMC free article] [PubMed] [Google Scholar]