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. 1986 May;144(5):580–585.

Response of Paraneoplastic Syndromes to Antineoplastic Therapy

Maurie Markman 1
PMCID: PMC1306707  PMID: 3521097

Abstract

The development of a clinically apparent paraneoplastic syndrome in a patient with malignant disease is cause for considerable concern as the symptoms can be as serious and difficult to deal with as those produced by the cancer itself. While the information in the medical literature concerning the response of paraneoplastic processes to specific antineoplastic therapy is limited, case reports and small series would suggest that a number of syndromes are alleviated with successful treatment of the underlying neoplasm. As treatment programs for advanced malignant disease improve, a larger percentage of patients suffering from the effects of paraneoplastic processes will benefit from therapy directed at their cancer.

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Selected References

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  1. ALANIS B. F., FLANAGAN J. F. Myopathy and hypercalcemia occurring with carcinoma of the kidney. J Am Med Assoc. 1959 Dec 12;171:2076–2080. doi: 10.1001/jama.1959.03010330038010. [DOI] [PubMed] [Google Scholar]
  2. ARUNDELL F. D., WILKINSON R. D., HASERICK J. R. Dermatomyositis and malignant neoplasms in adults. A survey of twenty years' experience. Arch Dermatol. 1960 Nov;82:772–775. doi: 10.1001/archderm.1960.01580050114017. [DOI] [PubMed] [Google Scholar]
  3. AUTH T. L., CHODOFF P. Transient cerebellar syndrome from extracerebral carcinoma. Neurology. 1957 May;7(5):370–372. doi: 10.1212/wnl.7.5.370. [DOI] [PubMed] [Google Scholar]
  4. Abeloff M. D., Trump D. L., Baylin S. B. Ectopic adrenocorticotrophic (ACTH) syndrome and small cell carcinoma of the lung-assessment of clinical implications in patients on combination chemotherapy. Cancer. 1981 Sep 1;48(5):1082–1087. doi: 10.1002/1097-0142(19810901)48:5<1082::aid-cncr2820480505>3.0.co;2-j. [DOI] [PubMed] [Google Scholar]
  5. Al-Khader A. A., Lien J. W., Aber G. M. Cyclophosphamide alone in the treatment of adult patients with minimal change glomerulonephritis. Clin Nephrol. 1979 Jan;11(1):26–30. [PubMed] [Google Scholar]
  6. Allan R. N., Dykes P. W., Harris O. D., Oates G. D. Dermatomyositis associated with hepatic secondaries from carcinoma of the colon. Gastroenterology. 1972 Jun;62(6):1227–1231. [PubMed] [Google Scholar]
  7. Allan S. G., Lockhart S. P., Leonard R. C., Smyth J. F. Paraneoplastic hypercalcaemia in ovarian carcinoma. Br Med J (Clin Res Ed) 1984 Jun 9;288(6432):1714–1715. doi: 10.1136/bmj.288.6432.1714. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Altaffer L. F., 3rd, Chenault O. W., Jr Paraneoplastic endocrinopathies associated with renal tumors. J Urol. 1979 Nov;122(5):573–577. doi: 10.1016/s0022-5347(17)56511-8. [DOI] [PubMed] [Google Scholar]
  9. Amatruda T. T., Jr, Upton G. V. Paraneoplastic syndromes. Hyperadrenocorticism and ACTH-releasing factor. Ann N Y Acad Sci. 1974;230:168–180. doi: 10.1111/j.1749-6632.1974.tb14445.x. [DOI] [PubMed] [Google Scholar]
  10. Antman K. H., Skarin A. T., Mayer R. J., Hargreaves H. K., Canellos G. P. Microangiopathic hemolytic anemia and cancer: a review. Medicine (Baltimore) 1979 Sep;58(5):377–384. doi: 10.1097/00005792-197909000-00004. [DOI] [PubMed] [Google Scholar]
  11. Apple D., Kreines K. Cushing's syndrome due to ectopic ACTH production by a nasal paraganglioma. Am J Med Sci. 1982 Jan-Feb;283(1):32–35. doi: 10.1097/00000441-198201000-00005. [DOI] [PubMed] [Google Scholar]
  12. Atkinson M. K., McElwain T. J., Peckham M. J., Thomas P. P. Hypertrophic pulmonary osteoarthropathy in Hodgkin's disease: reversal with chemotherapy. Cancer. 1976 Oct;38(4):1729–1734. doi: 10.1002/1097-0142(197610)38:4<1729::aid-cncr2820380446>3.0.co;2-#. [DOI] [PubMed] [Google Scholar]
  13. BRAIN R., HENSON R. A. Neurological syndromes associated with carcinoma: the carcinomatous neuromyopathies. Lancet. 1958 Nov 8;2(7054):971–975. doi: 10.1016/s0140-6736(58)90471-9. [DOI] [PubMed] [Google Scholar]
  14. BRUNNER M. J., LOBRAICO R. V., Jr Dermatomyositis as an index of malignant neoplasm: report of a case and review of the literature. Ann Intern Med. 1951 May;34(5):1269–1273. doi: 10.7326/0003-4819-34-5-1269. [DOI] [PubMed] [Google Scholar]
  15. Barnes B. E., Mawr B. Dermatomyositis and malignancy. A review of the literature. Ann Intern Med. 1976 Jan;84(1):68–76. doi: 10.7326/0003-4819-84-1-68. [DOI] [PubMed] [Google Scholar]
  16. Barton C. H., Vaziri N. D., Spear G. S. Nephrotic syndrome associated with adenocarcinoma of the breast. Am J Med. 1980 Feb;68(2):308–312. doi: 10.1016/0002-9343(80)90373-3. [DOI] [PubMed] [Google Scholar]
  17. Behrman S., Forman L. Dermatomyositis. Proc R Soc Med. 1939 Oct;32(12):1575–1577. doi: 10.1177/003591573903201205. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Benfield G. F. Primary lymphosarcoma of lung associated with hypertrophic pulmonary osteoarthropathy. Thorax. 1979 Apr;34(2):279–280. doi: 10.1136/thx.34.2.279. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Bertelsen C. A., Eilber F. R. Paraneoplastic syndromes with soft-tissue sarcoma: a report of two unusual cases. J Surg Oncol. 1983 Nov;24(3):170–172. doi: 10.1002/jso.2930240304. [DOI] [PubMed] [Google Scholar]
  20. Bick R. L. Disseminated intravascular coagulation and related syndromes: etiology, pathophysiology, diagnosis, and management. Am J Hematol. 1978;5(3):265–282. doi: 10.1002/ajh.2830050311. [DOI] [PubMed] [Google Scholar]
  21. Block N. L., Whitmore W. F., Jr Leukemoid reaction, thrombocytosis and hypercalcemia associated with bladder cancer. J Urol. 1973 Dec;110(6):660–663. doi: 10.1016/s0022-5347(17)60308-2. [DOI] [PubMed] [Google Scholar]
  22. Brain M. C., Azzopardi J. G., Baker L. R., Pineo G. F., Roberts P. D., Dacie J. V. Microangiopathic haemolytic anaemia and mucin-forming adenocarcinoma. Br J Haematol. 1970 Feb;18(2):183–193. doi: 10.1111/j.1365-2141.1970.tb01433.x. [DOI] [PubMed] [Google Scholar]
  23. Brennan L. V., Craddock P. R. Limbic encephalopathy as a nonmetastatic complication of oat cell lung cancer. Its reversal after treatment of the primary lung lesion. Am J Med. 1983 Sep;75(3):518–520. doi: 10.1016/0002-9343(83)90358-3. [DOI] [PubMed] [Google Scholar]
  24. Brodovsky H. S., Samuels M. L., Migliore P. J., Howe C. D. Chronic lymphocytic leukemia, Hodgkin's disease, and the nephrotic syndrome. Arch Intern Med. 1968 Jan;121(1):71–75. [PubMed] [Google Scholar]
  25. Bruyland M., Van Belle S., Schallier D., Ebinger G., Martin J. J. Good response of a paraneoplastic neuromyopathy to cyclophosphamide. Cancer Treat Rep. 1984 May;68(5):787–789. [PubMed] [Google Scholar]
  26. Bukowski R. M., Sheeler L., Cunningham J., Esselstyn C. Successful combination chemotherapy for metastatic parathyroid carcinoma. Arch Intern Med. 1984 Feb;144(2):399–400. [PubMed] [Google Scholar]
  27. Bunn P. A., Jr, Nugent J. L., Matthews M. J. Central nervous system metastases in small cell bronchogenic carcinoma. Semin Oncol. 1978 Sep;5(3):314–322. [PubMed] [Google Scholar]
  28. CURTIS A. C., BLAYLOCK H. C., HARRELL E. R., Jr Malignant lesions associated with dermatomyositis. J Am Med Assoc. 1952 Nov 1;150(9):844–846. doi: 10.1001/jama.1952.03680090008004. [DOI] [PubMed] [Google Scholar]
  29. Calabro J. J. Cancer and arthritis. Arthritis Rheum. 1967 Dec;10(6):553–567. doi: 10.1002/art.1780100608. [DOI] [PubMed] [Google Scholar]
  30. Callen J. P., Hyla J. F., Bole G. G., Jr, Kay D. R. The relationship of dermatomyositis and polymyositis to internal malignancy. Arch Dermatol. 1980 Mar;116(3):295–298. [PubMed] [Google Scholar]
  31. Canney P. A., Moore M., Wilkinson P. M., James R. D. Ovarian cancer antigen CA125: a prospective clinical assessment of its role as a tumour marker. Br J Cancer. 1984 Dec;50(6):765–769. doi: 10.1038/bjc.1984.254. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Cantrell E. G. Nephrotic syndrome cured by removal of gastric carcinoma. Br Med J. 1969 Jun 21;2(5659):739–740. doi: 10.1136/bmj.2.5659.739. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Carr I. The Ophelia syndrome: memory loss in Hodgkin's disease. Lancet. 1982 Apr 10;1(8276):844–845. doi: 10.1016/s0140-6736(82)91887-6. [DOI] [PubMed] [Google Scholar]
  34. Cassileth P. A., Trotman B. W. Inappropriate antidiuretic hormone in Hodgkin's disease. Am J Med Sci. 1973 Mar;265(3):233–235. doi: 10.1097/00000441-197303000-00008. [DOI] [PubMed] [Google Scholar]
  35. Clamon G. H., Evans W. K., Shepherd F. A., Humphrey J. G. Myasthenic syndrome and small cell cancer of the lung. Variable response to antineoplastic therapy. Arch Intern Med. 1984 May;144(5):999–1000. [PubMed] [Google Scholar]
  36. Cohen M. H., Bunn P. A., Jr, Ihde D. C., Fossieck B. E., Jr, Minna J. D. Chemotherapy rather than demeclocycline for inappropriate secretion of antidiuretic hormone. N Engl J Med. 1978 Jun 22;298(25):1423–1424. doi: 10.1056/NEJM197806222982515. [DOI] [PubMed] [Google Scholar]
  37. Collins A. J., Bloomfield C. D., Peterson B. A., McKenna R. W., Edson J. R. Acute promyelocytic leukemia. Management of the coagulopathy during daunorubicin-prednisone remission induction. Arch Intern Med. 1978 Nov;138(11):1677–1680. doi: 10.1001/archinte.138.11.1677. [DOI] [PubMed] [Google Scholar]
  38. Copeman P. W., Alexander S. Dermatomyositis. Adenocarcinoma of male breast. Detection of antibodies to the neoplasm in the serum. Proc R Soc Med. 1967 Feb;60(2):183–185. doi: 10.1177/003591576706000234. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. Cormia F. E. Pruritus, an uncommon but important symptom of systemic carcinoma. Arch Dermatol. 1965 Jul;92(1):36–39. [PubMed] [Google Scholar]
  40. Croft P. B., Wilkinson M. The course and prognosis in some types of carcinomatous neuromyopathy. Brain. 1969 Mar;92(1):1–8. doi: 10.1093/brain/92.1.1. [DOI] [PubMed] [Google Scholar]
  41. DOWLING G. B. Scleroderma and dermatomyositis. Br J Dermatol. 1955 Aug-Sep;67(8-9):275–290. doi: 10.1111/j.1365-2133.1955.tb12735.x. [DOI] [PubMed] [Google Scholar]
  42. Dathan J. R., Heyworth M. F., MacIver A. G. Nephrotic syndrome in chronic lymphocytic leukaemia. Br Med J. 1974 Sep 14;3(5932):655–657. doi: 10.1136/bmj.3.5932.655. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. Eagan R. T., Maurer L. H., Forcier R. J., Tulloh M. Proceedings: Small cell carcinoma of the lung: staging, paraneoplastic syndromes, treatment, and survival. Cancer. 1974 Feb;33(2):527–532. doi: 10.1002/1097-0142(197402)33:2<527::aid-cncr2820330230>3.0.co;2-r. [DOI] [PubMed] [Google Scholar]
  44. Eagen J. W. Glomerulopathies of neoplasia. Kidney Int. 1977 May;11(5):297–303. doi: 10.1038/ki.1977.47. [DOI] [PubMed] [Google Scholar]
  45. Ehrenreich T., Porush J. G., Churg J., Garfinkel L., Glabman S., Goldstein M. H., Grishman E., Yunis S. L. Treatment of idiopathic membranous nephropathy. N Engl J Med. 1976 Sep 30;295(14):741–746. doi: 10.1056/NEJM197609302951401. [DOI] [PubMed] [Google Scholar]
  46. Faiman C., Colwell J. A., Ryan R. J., Hershman J. M., Shields T. W. Gonadotropin secretion from a bronchogenic carcinoma. Demonstration by radioimmunoassay. N Engl J Med. 1967 Dec 28;277(26):1395–1399. doi: 10.1056/NEJM196712282772604. [DOI] [PubMed] [Google Scholar]
  47. Fam A. G., Cross E. G. Hypertrophic osteoarthropathy, phalangeal and synovial metastases associated with bronchogenic carcinoma. J Rheumatol. 1979 Nov-Dec;6(6):680–686. [PubMed] [Google Scholar]
  48. Fichman M., Bethune J. Effects of neoplasms on renal electrolyte function. Ann N Y Acad Sci. 1974;230:448–472. doi: 10.1111/j.1749-6632.1974.tb14479.x. [DOI] [PubMed] [Google Scholar]
  49. Flint G. L., Flam M., Soter N. A. Acquired ichthyosis. A sign of nonlymphoproliferative malignant disorders. Arch Dermatol. 1975 Nov;111(11):1446–1447. doi: 10.1001/archderm.111.11.1446. [DOI] [PubMed] [Google Scholar]
  50. Gagel R. F., Costanza M. E., DeLellis R. A., Norton R. A., Bloom S. R., Miller H. H., Ucci A., Nathanson L. Streptozocin-treated Verner-Morrison Syndrome: plasma vasoactive intestinal peptide and tumor responses. Arch Intern Med. 1976 Dec;136(12):1429–1435. [PubMed] [Google Scholar]
  51. Gagliano R. G., Costanzi J. J., Beathard G. A., Sarles H. E., Bell J. D. The nephrotic syndrome associated with neoplasia: an unusual paraneoplastic syndrome. Report of a case and review of the literature. Am J Med. 1976 Jun;60(7):1026–1031. doi: 10.1016/0002-9343(76)90575-1. [DOI] [PubMed] [Google Scholar]
  52. Ghosh L., Muehrcke R. C. Nephrotic syndrome: a prodrome to lymphoma. Ann Intern Med. 1970 Mar;72(3):379–382. doi: 10.7326/0003-4819-72-3-379. [DOI] [PubMed] [Google Scholar]
  53. Goldberg R. S., Pilcher D. B., Yates J. W. The aggressive surgical management of hypercalcemia due to ectopic parathormone production. Cancer. 1980 May 15;45(10):2652–2654. doi: 10.1002/1097-0142(19800515)45:10<2652::aid-cncr2820451027>3.0.co;2-0. [DOI] [PubMed] [Google Scholar]
  54. Goldstraw P., Walbaum P. R. Hypertrophic pulmonary osteoarthropathy and its occurrence with pulmonary metastases from renal carcinoma. Thorax. 1976 Apr;31(2):205–211. doi: 10.1136/thx.31.2.205. [DOI] [PMC free article] [PubMed] [Google Scholar]
  55. Gouttard, Domenach, Riffat Présentation d'une observation de dermatomyosite-para-néoplasique. J Med Lyon. 1972 Apr 20;53(227):565–568. [PubMed] [Google Scholar]
  56. Gralnick H. R., Bagley J., Abrell E. Heparin treatment for the hemorrhagic diathesis of acute promyelocytic leukemia. Am J Med. 1972 Feb;52(2):167–174. doi: 10.1016/0002-9343(72)90066-6. [DOI] [PubMed] [Google Scholar]
  57. Greco F. A., Kolins J., Rajjoub R. K., Brereton H. D. Hodgkin's disease and granulomatous angiitis of the central nervous system. Cancer. 1976 Nov;38(5):2027–2032. doi: 10.1002/1097-0142(197611)38:5<2027::aid-cncr2820380527>3.0.co;2-h. [DOI] [PubMed] [Google Scholar]
  58. Gropp C., Havemann K., Scheuer A. Ectopic hormones in lung cancer patients at diagnosis and during therapy. Cancer. 1980 Jul 15;46(2):347–354. doi: 10.1002/1097-0142(19800715)46:2<347::aid-cncr2820460223>3.0.co;2-s. [DOI] [PubMed] [Google Scholar]
  59. Grupe W. E., Makker S. P., Ingelfinger J. R. Chlorambucil treatment of frequently relapsing nephrotic syndrome. N Engl J Med. 1976 Sep 30;295(14):746–749. doi: 10.1056/NEJM197609302951402. [DOI] [PubMed] [Google Scholar]
  60. HARRISON J. W., SCHERBEL A. L. Rheumatic musculoskeletal symptoms associated with carcinoma of the prostate gland. Postgrad Med. 1960 Sep;28:274–283. doi: 10.1080/00325481.1960.11713045. [DOI] [PubMed] [Google Scholar]
  61. HOLLING H. E., BRODEY R. S. Pulmonary hypertrophic osteoarthropathy. JAMA. 1961 Dec 9;178:977–982. doi: 10.1001/jama.1961.03040490003002. [DOI] [PubMed] [Google Scholar]
  62. Hainsworth J. D., Workman R., Greco F. A. Management of the syndrome of inappropriate antidiuretic hormone secretion in small cell lung cancer. Cancer. 1983 Jan 1;51(1):161–165. doi: 10.1002/1097-0142(19830101)51:1<161::aid-cncr2820510131>3.0.co;2-p. [DOI] [PubMed] [Google Scholar]
  63. Hall T. C. Proceedings: Ectopic synthesis and paraneoplastic syndromes. Cancer Res. 1974 Aug;34(8):2088–2091. [PubMed] [Google Scholar]
  64. Hammond D., Winnick S. Paraneoplastic erythrocytosis and ectopic erythropoietins. Ann N Y Acad Sci. 1974;230:219–227. doi: 10.1111/j.1749-6632.1974.tb14452.x. [DOI] [PubMed] [Google Scholar]
  65. Hancock B., Richmond J., Powell T., Emmanuel I. G. Intrathoracic Hodgkin's disease presenting as hypertrophic osteoarthropathy. Br J Radiol. 1976 Jul;49(583):647–649. doi: 10.1259/0007-1285-49-583-647. [DOI] [PubMed] [Google Scholar]
  66. Harris P. L. Dermatomyositis associated with carcinoma of the breast. Proc R Soc Med. 1975 Sep;68(9):598–598. doi: 10.1177/003591577506800928. [DOI] [PMC free article] [PubMed] [Google Scholar]
  67. Hawley R. J., Cohen M. H., Saini N., Armbrustmacher V. W. The carcinomatous neuromyopathy of oat cell lung cancer. Ann Neurol. 1980 Jan;7(1):65–72. doi: 10.1002/ana.410070112. [DOI] [PubMed] [Google Scholar]
  68. Hickey W. F., Garnick M. B., Henderson I. C., Dawson D. M. Primary cerebral venous thrombosis in patients with cancer--a rarely diagnosed paraneoplastic syndrome. Report of three cases and review of the literature. Am J Med. 1982 Nov;73(5):740–750. doi: 10.1016/0002-9343(82)90418-1. [DOI] [PubMed] [Google Scholar]
  69. Higgins G. A., Recant L., Fischman A. B. The glucagonoma syndrome: surgically curable diabetes. Am J Surg. 1979 Jan;137(1):142–148. doi: 10.1016/0002-9610(79)90025-4. [DOI] [PubMed] [Google Scholar]
  70. Holtz G., Johnson T. R., Jr, Schrock M. E. Paraneoplastic hypercalcemia in ovarian tumors. Obstet Gynecol. 1979 Oct;54(4):483–487. [PubMed] [Google Scholar]
  71. Holtz G. Paraneoplastic hypercalcemia in gynecologic malignancy. Obstet Gynecol Surv. 1980 Mar;35(3):129–136. doi: 10.1097/00006254-198003000-00001. [DOI] [PubMed] [Google Scholar]
  72. Horowitz H. I. Treatment of defibrination syndromes (other than those of pregnancy) and fibrinolytic disorders. Mod Treat. 1968 Mar;5(2):384–400. [PubMed] [Google Scholar]
  73. Hyman L. R., Burkholder P. M., Joo P. A., Segar W. E. Malignant lymphoma and nephrotic syndrome. A clinicopathologic analysis with light, immunofluorescence, and electron microscopy of the renal lesions. J Pediatr. 1973 Feb;82(2):207–212. doi: 10.1016/s0022-3476(73)80156-8. [DOI] [PubMed] [Google Scholar]
  74. Jenkyn L. R., Brooks P. L., Forcier R. J., Maurer L. H., Ochoa J. Remission of the Lambert-Eaton syndrome and small cell anaplastic carcinoma of the lung induced by chemotherapy and radiotherapy. Cancer. 1980 Sep 1;46(5):1123–1127. doi: 10.1002/1097-0142(19800901)46:5<1123::aid-cncr2820460508>3.0.co;2-l. [DOI] [PubMed] [Google Scholar]
  75. Jermanovich N. B., Giammarco R., Ginsberg S. J., Tinsley R. W., Jones D. B. Small cell anaplastic carcinoma of the lung with mesangial proliferative glomerulonephritis. Arch Intern Med. 1982 Feb;142(2):397–399. [PubMed] [Google Scholar]
  76. Kahn C. R., Levy A. G., Gardner J. D., Miller J. V., Gorden P., Schein P. S. Pancreatic cholera: benefical effects of treatment with streptozotocin. N Engl J Med. 1975 May 1;292(18):941–945. doi: 10.1056/NEJM197505012921803. [DOI] [PubMed] [Google Scholar]
  77. Kessinger A., Lemon H. M., Foley J. F. The glucagonoma syndrome and its management. J Surg Oncol. 1977;9(5):419–424. doi: 10.1002/jso.2930090502. [DOI] [PubMed] [Google Scholar]
  78. Khandekar J. D., Oyer D., Miller H. J., Vick N. A. Neurologic involvement in glucagonoma syndrome: response to combination chemotherapy with 5-fluorouracil and streptozotocin. Cancer. 1979 Dec;44(6):2014–2016. doi: 10.1002/1097-0142(197912)44:6<2014::aid-cncr2820440608>3.0.co;2-m. [DOI] [PubMed] [Google Scholar]
  79. Lange P. H., McIntire K. R., Waldmann T. A., Hakala T. R., Fraley E. E. Serum alpha fetoprotein and human chorionic gonadotropin in the diagnosis and management of nonseminomatous germ-cell testicular cancer. N Engl J Med. 1976 Nov 25;295(22):1237–1240. doi: 10.1056/NEJM197611252952207. [DOI] [PubMed] [Google Scholar]
  80. Lee J. C., Yamauchi H., Hopper J., Jr The association of cancer and the nephrotic syndrome. Ann Intern Med. 1966 Jan;64(1):41–51. doi: 10.7326/0003-4819-64-1-41. [DOI] [PubMed] [Google Scholar]
  81. Leibowitz M. R., Weiss R., Smith E. H. Pityriasis rotunda. A cutaneous sign of malignant disease in two patients. Arch Dermatol. 1983 Jul;119(7):607–609. doi: 10.1001/archderm.119.7.607. [DOI] [PubMed] [Google Scholar]
  82. Lester W. M., Robertson D. I. Hypertrophic osteoarthropathy complicating metastatic ovarian adenocarcinoma. Can J Surg. 1981 Sep;24(5):520-1, 523. [PubMed] [Google Scholar]
  83. Li T. C., Reed C. E., Stubenbord W. T., Jr, Ettinghausen S., Peterson C. M., Jovanovic L., Poffenbarger P. L. Surgical cure of hypoglycemia associated with cystosarcoma phyllodes and elevated nonsuppressible insulin-like protein. Am J Med. 1983 Jun;74(6):1080–1084. doi: 10.1016/0002-9343(83)90823-9. [DOI] [PubMed] [Google Scholar]
  84. Liddle G. W., Nicholson W. E., Island D. P., Orth D. N., Abe K., Lowder S. C. Clinical and laboratory studies of ectopic humoral syndromes. Recent Prog Horm Res. 1969;25:283–314. doi: 10.1016/b978-0-12-571125-8.50009-0. [DOI] [PubMed] [Google Scholar]
  85. Lofters W. S., Walker T. M. Hodgkin's disease and hypertrophic pulmonary osteoarthropathy. Complete clearing following radiotherapy. West Indian Med J. 1978 Dec;27(4):227–230. [PubMed] [Google Scholar]
  86. Lohrmann H. P., Adam W., Heymer B., Kubanek B. Microangiopathic hemolytic anemia in metastatic carcinoma. Report of eight cases. Ann Intern Med. 1973 Sep;79(3):368–375. doi: 10.7326/0003-4819-79-3-368. [DOI] [PubMed] [Google Scholar]
  87. Lokich J. J. Pulmonary osteoarthropathy. Association with mesenchymal tumor metastases to the lungs. JAMA. 1977 Jul 4;238(1):37–39. doi: 10.1001/jama.238.1.37. [DOI] [PubMed] [Google Scholar]
  88. MCDONALD W. I. Cortical cerebellar degeneration with ovarian carcinoma. Neurology. 1961 Apr;11(4):328–334. doi: 10.1212/wnl.11.4.328. [DOI] [PubMed] [Google Scholar]
  89. Markham M., Abeloff M. D. Small-cell lung cancer and limbic encephalitis. Ann Intern Med. 1982 Jun;96(6 Pt 1):785–785. doi: 10.7326/0003-4819-96-6-785_1. [DOI] [PubMed] [Google Scholar]
  90. Marks L. J., Steinke J., Podolsky S., Egdahl R. H. Hypoglycemia associated with neoplasia. Ann N Y Acad Sci. 1974;230:147–160. doi: 10.1111/j.1749-6632.1974.tb14443.x. [DOI] [PubMed] [Google Scholar]
  91. Martin J. K., Jr, Moertel C. G., Adson M. A., Schutt A. J. Surgical treatment of functioning metastatic carcinoid tumors. Arch Surg. 1983 May;118(5):537–542. doi: 10.1001/archsurg.1983.01390050021004. [DOI] [PubMed] [Google Scholar]
  92. Marynick S. P., Fagadau W. R., Duncan L. A. Malignant glucagonoma syndrome: response to chemotherapy. Ann Intern Med. 1980 Sep;93(3):453–454. doi: 10.7326/0003-4819-93-3-453. [DOI] [PubMed] [Google Scholar]
  93. McDonald J., Murphy A. V., Arneil G. C. Long-term assessment of cyclophosphamide therapy for nephrosis in children. Lancet. 1974 Oct 26;2(7887):980–982. doi: 10.1016/s0140-6736(74)92073-x. [DOI] [PubMed] [Google Scholar]
  94. Melmed S., Ezrin C., Kovacs K., Goodman R. S., Frohman L. A. Acromegaly due to secretion of growth hormone by an ectopic pancreatic islet-cell tumor. N Engl J Med. 1985 Jan 3;312(1):9–17. doi: 10.1056/NEJM198501033120103. [DOI] [PubMed] [Google Scholar]
  95. Metz S. A., McRae J. R., Robertson R. P. Prostaglandins as mediators of paraneoplastic syndromes: review and up-date. Metabolism. 1981 Mar;30(3):299–316. doi: 10.1016/0026-0495(81)90156-6. [DOI] [PubMed] [Google Scholar]
  96. Metz S. A., Weintraub B., Rosen S. W., Singer J., Robertson R. P. Ectopic secretion of chorionic gonadotropin by a lung carcinoma. Pituitary gonadotropin and subunit secretion and prolonged chemotherapeutic remission. Am J Med. 1978 Aug;65(2):325–333. doi: 10.1016/0002-9343(78)90827-6. [DOI] [PubMed] [Google Scholar]
  97. Moertel C. G. Treatment of the carcinoid tumor and the malignant carcinoid syndrome. J Clin Oncol. 1983 Nov;1(11):727–740. doi: 10.1200/JCO.1983.1.11.727. [DOI] [PubMed] [Google Scholar]
  98. Moorthy A. V., Zimmerman S. W., Burkholder P. M. Nephrotic syndrome in Hodgkin's disease. Evidence for pathogenesis alternative to immune complex deposition. Am J Med. 1976 Oct;61(4):471–477. doi: 10.1016/0002-9343(76)90325-9. [DOI] [PubMed] [Google Scholar]
  99. Muggia F. M., Ultmann J. E. Glomerulonephritis or nephrotic syndrome in malignant lymphoma, reticulum-cell type. Lancet. 1971 Apr 17;1(7703):805–805. doi: 10.1016/s0140-6736(71)91252-9. [DOI] [PubMed] [Google Scholar]
  100. Oberg K., Alm G., Lindström H., Lundqvist G. Successful treatment of therapy-resistant pancreatic cholera with human leucocyte interferon. Lancet. 1985 Mar 30;1(8431):725–727. doi: 10.1016/s0140-6736(85)91265-6. [DOI] [PubMed] [Google Scholar]
  101. Oberg K., Funa K., Alm G. Effects of leukocyte interferon on clinical symptoms and hormone levels in patients with mid-gut carcinoid tumors and carcinoid syndrome. N Engl J Med. 1983 Jul 21;309(3):129–133. doi: 10.1056/NEJM198307213090301. [DOI] [PubMed] [Google Scholar]
  102. Odell W. D., Wolfsen A. R. Humoral syndromes associated with cancer. Annu Rev Med. 1978;29:379–406. doi: 10.1146/annurev.me.29.020178.002115. [DOI] [PubMed] [Google Scholar]
  103. Oldenburg W. A., van Heerden J. A., Sizemore G. W., Abboud C. F., Sheedy P. F., 2nd Hypercalcemia and primary hepatic tumors. Arch Surg. 1982 Oct;117(10):1363–1366. doi: 10.1001/archsurg.1982.01380340077018. [DOI] [PubMed] [Google Scholar]
  104. Omenn G. S., Roth S. I., Baker W. H. Hyperparathyroidism associated with malignant tumors of nonparathyroid origin. Cancer. 1969 Nov;24(5):1004–1011. doi: 10.1002/1097-0142(196911)24:5<1004::aid-cncr2820240520>3.0.co;2-p. [DOI] [PubMed] [Google Scholar]
  105. Orth D. N., Liddle G. W. Results of treatment in 108 patients with Cushing's syndrome. N Engl J Med. 1971 Jul 29;285(5):243–247. doi: 10.1056/NEJM197107292850501. [DOI] [PubMed] [Google Scholar]
  106. PEARSON C. M. PATTERNS OF POLYMYOSITIS AND THEIR RESPONSES TO TREATMENT. Ann Intern Med. 1963 Dec;59:827–838. doi: 10.7326/0003-4819-59-6-827. [DOI] [PubMed] [Google Scholar]
  107. Paone J. F., Jeyasingham K. Remission of cerebellar dysfunction after pneumonectomy for bronchogenic carcinoma. N Engl J Med. 1980 Jan 17;302(3):156–156. doi: 10.1056/NEJM198001173020305. [DOI] [PubMed] [Google Scholar]
  108. Peck B. Hypertrophic osteoarthropathy with Hodgkin's disease in the mediastinum. JAMA. 1977 Sep 26;238(13):1400–1401. [PubMed] [Google Scholar]
  109. REWCASTLE N. B. SUBACUTE CEREBELLAR DEGENERATION WITH HODGKIN'S DISEASE. Arch Neurol. 1963 Oct;9:407–413. doi: 10.1001/archneur.1963.00460100095011. [DOI] [PubMed] [Google Scholar]
  110. Rao G. M., Guruprakash G. H., Poulose K. P., Bhaskar G. Improvement in hypertrophic pulmonary osteoarthropathy after radiotherapy to metastasis. AJR Am J Roentgenol. 1979 Nov;133(5):944–946. doi: 10.2214/ajr.133.5.944. [DOI] [PubMed] [Google Scholar]
  111. Rassam J. W., Anderson G. Incidence of paramalignant disorders in bronchogenic carcinoma. Thorax. 1975 Feb;30(1):86–90. doi: 10.1136/thx.30.1.86. [DOI] [PMC free article] [PubMed] [Google Scholar]
  112. Rees L. H. The biosynthesis of hormones by non-endocrine tumours--a review. J Endocrinol. 1975 Oct;67(1):143–175. doi: 10.1677/joe.0.0670143. [DOI] [PubMed] [Google Scholar]
  113. Robinson W. L., Mitas J. A., 2nd, Haerr R. W., Cohen I. M. Remission and exacerbation of tumor-related nephrotic syndrome with treatment of the neoplasm. Cancer. 1984 Sep 15;54(6):1082–1084. doi: 10.1002/1097-0142(19840915)54:6<1082::aid-cncr2820540625>3.0.co;2-3. [DOI] [PubMed] [Google Scholar]
  114. Rose J. D. Membranous glomerulonephritis, dermatomyositis, and bronchial carcinoma. Br Med J. 1979 Sep 15;2(6191):641–641. doi: 10.1136/bmj.2.6191.641. [DOI] [PMC free article] [PubMed] [Google Scholar]
  115. SCHERBEL A. L., MCCORMACK L. J., MACKENZIE A. H., ATDJIAN M. ASSOCIATION OF CERTAIN CONNECTIVE TISSUE SYNDROMES AND MALIGNANT DISEASE. Postgrad Med. 1964 Jun;35:619–628. doi: 10.1080/00325481.1964.11695155. [DOI] [PubMed] [Google Scholar]
  116. Sack G. H., Jr, Levin J., Bell W. R. Trousseau's syndrome and other manifestations of chronic disseminated coagulopathy in patients with neoplasms: clinical, pathophysiologic, and therapeutic features. Medicine (Baltimore) 1977 Jan;56(1):1–37. [PubMed] [Google Scholar]
  117. Schumacher H. R., Jr Articular manifestations of hypertrophic pulmonary osteoarthropathy in bronchogenic carcinoma. Arthritis Rheum. 1976 May-Jun;19(3):629–636. doi: 10.1002/art.1780190317. [DOI] [PubMed] [Google Scholar]
  118. Shnider B. I., Manalo A. Paraneoplastic syndromes: unusual manifestations of malignant disease. Dis Mon. 1979 Feb;25(5):1–6U. doi: 10.1016/s0011-5029(79)80013-9. [DOI] [PubMed] [Google Scholar]
  119. Singer F. R., Powell D., Minkin C., Bethune J. E., Brickman A., Coburn J. W. Hypercalcemia in reticulum cell sarcoma without hyperparathyroidism of skeletal metastases. Ann Intern Med. 1973 Mar;78(3):365–369. doi: 10.7326/0003-4819-78-3-365. [DOI] [PubMed] [Google Scholar]
  120. Skrabanek P., McPartlin J., Powell D. Tumor hypercalcemia and "ectopic hyperparathyroidism". Medicine (Baltimore) 1980 Jul;59(4):262–282. doi: 10.1097/00005792-198007000-00003. [DOI] [PubMed] [Google Scholar]
  121. Smith B. Skeletal muscle necrosis associated with cainoma. J Pathol. 1969 Feb;97(2):207–210. doi: 10.1002/path.1710970204. [DOI] [PubMed] [Google Scholar]
  122. Steinfeld A. D., Munzenrider J. E. The response of hypertrophic pulmonary osteoarthropathy to radiotherapy. Radiology. 1974 Dec;113(3):709–711. doi: 10.1148/113.3.709. [DOI] [PubMed] [Google Scholar]
  123. Stewart A. F., Romero R., Schwartz P. E., Kohorn E. I., Broadus A. E. Hypercalcemia associated with gynecologic malignancies: biochemical characterization. Cancer. 1982 Jun 1;49(11):2389–2394. doi: 10.1002/1097-0142(19820601)49:11<2389::aid-cncr2820491128>3.0.co;2-w. [DOI] [PubMed] [Google Scholar]
  124. Stolinsky D. C. Paraneoplastic syndromes. West J Med. 1980 Mar;132(3):189–208. [PMC free article] [PubMed] [Google Scholar]
  125. Strauss G. M., Weitzman S. A., Aoki T. T. Dimethyltriazenoimidazole carboxamide therapy of malignant glucagonoma. Ann Intern Med. 1979 Jan;90(1):57–58. doi: 10.7326/0003-4819-90-1-57. [DOI] [PubMed] [Google Scholar]
  126. Sunnenberg T. D., Kitchens C. S. Dermatomyositis associated with malignant melanoma. Parallel occurrence, remission, and relapse of the two processes in a patient. Cancer. 1983 Jun 1;51(11):2157–2158. doi: 10.1002/1097-0142(19830601)51:11<2157::aid-cncr2820511135>3.0.co;2-q. [DOI] [PubMed] [Google Scholar]
  127. Susens G. P., Hendrickson C., Barto D. A., Sams B. J. Letter: Disseminated intravascular coagulation syndrome with metastatic melanoma: Remission after treatment with 5-(3,3-dimethyl-1-triazeno) imidazole-4-carboxamide (DTIC). Ann Intern Med. 1976 Feb;84(2):175–176. doi: 10.7326/0003-4819-84-2-175. [DOI] [PubMed] [Google Scholar]
  128. TAVEL M. E. A new look at an old syndrome: delirium tremens. Arch Intern Med. 1962 Feb;109:129–134. doi: 10.1001/archinte.1962.03620140001001. [DOI] [PubMed] [Google Scholar]
  129. Tagnon H. J. Paraneoplastic syndromes. I. Endocrine paraneoplasia. Eur J Cancer Clin Oncol. 1981 Sep;17(9):969–985. doi: 10.1016/s0277-5379(81)80002-8. [DOI] [PubMed] [Google Scholar]
  130. Tyler H. R. Paraneoplastic syndromes of nerve muscle, and neuromuscular junction. Ann N Y Acad Sci. 1974;230:348–357. doi: 10.1111/j.1749-6632.1974.tb14468.x. [DOI] [PubMed] [Google Scholar]
  131. Ullal S. R. Hypertrophic osteoarthropathy and leiomyoma of the esophagus. Am J Surg. 1972 Mar;123(3):356–358. doi: 10.1016/0002-9610(72)90301-7. [DOI] [PubMed] [Google Scholar]
  132. Vasudevan C. P., Suppiah P., Udoshi M. B., Lusins J. Reversible autonomic neuropathy and hypertrophic osteoarthropathy in a patient with bronchogenic carcinoma. Chest. 1981 Apr;79(4):479–481. doi: 10.1378/chest.79.4.479. [DOI] [PubMed] [Google Scholar]
  133. WILSON E., FINLEY A. G., KILLINGBACK M. TRIPLE PRIMARY CARCINOMATA OF RECTUM, BREAST, AND TRANSVERSE COLON ASSOCIATED WITH DERMATOMYOSITIS. Br Med J. 1965 Jul 10;2(5453):80–83. doi: 10.1136/bmj.2.5453.80. [DOI] [PMC free article] [PubMed] [Google Scholar]
  134. Weiner L. P., Herndon R. M., Narayan O., Johnson R. T., Shah K., Rubinstein L. J., Preziosi T. J., Conley F. K. Isolation of virus related to SV40 from patients with progressive multifocal leukoencephalopathy. N Engl J Med. 1972 Feb 24;286(8):385–390. doi: 10.1056/NEJM197202242860801. [DOI] [PubMed] [Google Scholar]
  135. Zornoza J., Cangir A., Green B. Hypertrophic osteoarthropathy associated with nasopharyngeal carcinoma. AJR Am J Roentgenol. 1977 Apr;128(4):679–681. doi: 10.2214/ajr.128.4.679. [DOI] [PubMed] [Google Scholar]

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