Correction: Regulation of immune microenvironments by polyetheretherketone surface topography for improving osseointegration

Correction: Journal of Nanobiotechnology (2025) 23:199

10.1186/s12951-025-03272-7

In this article, Figs. 7 and 8 appeared incorrectly and have now been corrected in the original publication. This error does not affect the scientific conclusions of the paper, so no changes to the main text or conclusion are necessary. For completeness and transparency, the old incorrect and corrected versions of these figures are displayed below.

Fig. 7.

In vitro osteogenic differentiation of pre-osteoblasts cultured on different PEEK specimens. (a) Schematic of osteogenic differentiation of pre-osteoblasts using conditioned medium derived from the supernatant of RAW 264.7 MΦs and osteogenic medium. (b) ALP activity of pre-osteoblasts cultured on different PEEK specimens without MΦ supernatants. (c) ALP activity of pre-osteoblasts cultured on different PEEK specimens in the presence of MΦ supernatants collected from corresponding PEEK specimens. (d) ALP staining of pre-osteoblasts cultured on different PEEK specimens with MΦ supernatants collected on day 7 and day 14. (e) Alizarin red S staining of pre-osteoblasts cultured on different PEEK specimens with MΦ supernatants collected on day 14 and day 21. (f) Gene expression of osteogenesis-related genes of pre-osteoblasts cultured on various PEEK specimens in the presence of MΦ supernatants. n = 3 independent experiments per group; *P < 0.05 and **P < 0.01

Fig. 8.

In vivo osseointegration of PEEK implants prepared from P, SP450, and SP750. (a) Schematic of the placement of PEEK implants. (b) Micro-CT images of reconstructed 3D images of surrounding bones without implants. (c) Corresponding quantitative analysis of micro-CT results of BV/TV, Tb.N, Tb.Sp, and Tb.Th. (d) Histological images of methylene blue-acid fuchsin staining. (e) Bone-implant contact ratio. (f) Sequential fluorescent labeling. (g) Analysis of the fluorochrome-labeled new bone area. (h) Representative immunofluorescence staining of CD206 and iNOS. (i) Quantitative analysis of CD206 and iNOS positively-stained areas. (j) Representative immunohistochemical staining of IL-4 and IL-6. (k) Quantitative analysis of positively stained cells. n = 3 independent experiments per group; *P < 0.05 and **P < 0.01

Incorrect Fig. 7.

Fig. 7.

In vitro osteogenic differentiation of pre-osteoblasts cultured on different PEEK specimens. (a) Schematic of osteogenic differentiation of pre-osteoblasts using conditioned medium derived from the supernatant of RAW 264.7 MΦs and osteogenic medium. (b) ALP activity of pre-osteoblasts cultured on different PEEK specimens without MΦ supernatants. (c) ALP activity of pre-osteoblasts cultured on different PEEK specimens in the presence of MΦ supernatants collected from corresponding PEEK specimens. (d) ALP staining of pre-osteoblasts cultured on different PEEK specimens with MΦ supernatants collected on day 7 and day 14. (e) Alizarin red S staining of pre-osteoblasts cultured on different PEEK specimens with MΦ supernatants collected on day 14 and day 21. (f) Gene expression of osteogenesis-related genes of pre-osteoblasts cultured on various PEEK specimens in the presence of MΦ supernatants. n = 3 independent experiments per group; *P < 0.05 and **P < 0.01

Correct Fig. 7.

Incorrect Fig. 8.

Fig. 8.

In vivo osseointegration of PEEK implants prepared from P, SP450, and SP750. (a) Schematic of the placement of PEEK implants. (b) Micro-CT images of reconstructed 3D images of surrounding bones without implants. (c) Corresponding quantitative analysis of micro-CT results of BV/TV, Tb.N, Tb.Sp, and Tb.Th. (d) Histological images of methylene blue-acid fuchsin staining. (e) Bone-implant contact ratio. (f) Sequential fluorescent labeling. (g) Analysis of the fluorochrome-labeled new bone area. (h) Representative immunofluorescence staining of CD206 and iNOS. (i) Quantitative analysis of CD206 and iNOS positively-stained areas. (j) Representative immunohistochemical staining of IL-4 and IL-6. (k) Quantitative analysis of positively stained cells. n = 3 independent experiments per group; *P < 0.05 and **P < 0.01

Correct Fig. 8.

The original article has been corrected.