Error in Table
In the original publication [1], there was a mistake in Table 2 as published. Plasma total cholesterol (TC) values were mistakenly reported as log-transformed data. The corrected values are:
HFHC: 6.51 (3.60–8.71) [initially and faulty reported as 0.81 (0.56–0.94)]
HFLC: 8.88 (5.52–12.09) [initially and faulty reported as 0.95 (0.74–1.08)]
The corrected Table 2 appears below. The authors state that the scientific conclusions are unaffected. This correction was approved by the Academic Editor. The original publication has also been updated.
Table 2.
Plasma and liver biochemistry.
| Experimental Groups | 2-Way ANOVA | ||||||
|---|---|---|---|---|---|---|---|
| LFHC | LFLC | HFHC | HFLC | HF vs. LF | VitC | Int. | |
| Plasma | |||||||
| ALT (U/L) 1 | 68 (56–87) | 62 (51–74) | 105 (69–118) | 86 (59–94) | ** | ns | ns |
| AST (U/L) 1 | 220 (86–472) | 227 (89–382) | 279 (157–390) | 193 (147–372) | ns | ns | ns |
| GGT (U/L) 1 | 73 (64–80) | 57 (49–72) | 89 (73–105) | 93 (77–113) | **** | ns | * |
| TG (mM) 2 | 0.70 (0.60–0.81) |
0.79 (0.62–1.03) |
0.56 (0.53–0.69) |
0.74 (0.65–1.00) |
ns | ** | ns |
| TC (mM) 3 | <0.65 | <0.65 | 6.51 (3.60–8.71) |
8.88 (5.52–12.09) |
- | ns | - |
| Total VitC (µM) 1 | 33.89 (26.91–38.77) |
2.69 (2.27–2.88) |
28.70 (21.59–38.39) |
2.71 (2.49–2.88) |
ns | **** | ns |
| Liver | |||||||
| TG (µmol/g) 1 | 16.3 (15.7–21.1) |
19.9 (14.9–23.9) |
36.8 (32.6–43.0) |
38.7 (34.7–41.5) |
**** | ns | ns |
| TC (µmol/g) 4 | 17.7 ± 2.8 | 17.6 ± 4.4 | 39.7 ± 6.1 | 38.9 ± 6.6 | **** | ns | ns |
| TotalVitC (nmol/g) 5 | 1136 (886–1396) |
68.0 (49.6–154) |
889 (738–1036) |
61.2 (33.3–107) |
** | **** | ns |
Data are presented as medians with quartiles (Q25–Q75) in brackets or means ± SDs. 1 Log-transformed data were analyzed via two-way ANOVA. 2 Reciprocally transformed data were analyzed via two-way ANOVA. 3 Log-transformed data were analyzed via a Student’s t-test, TC data in the low-fat groups were under detection level of 0.65 mM. One animal from LFHC was excluded from the VitC analysis. 4 Data were analyzed via two-way ANOVA. 5 Square root-transformed data were analyzed via two-way ANOVA. * p < 0.05, ** p < 0.01, **** p < 0.0001. ALT: alanine aminotransferase, AST: aspartate aminotransferase, GGT: gamma-glutamyl transferase, TG: triglycerides, TC: total cholesterol, VitC: vitamin C, LFHC: low-fat high-VitC, LFLC: low-fat low-VitC, HFHC: high-fat high-VitC, HFLC: high-fat low-VitC, Int.: interaction.
Error in Figure and Legend
In the original publication, there was a mistake in the figure and legend for Figure 3. The figure and legend indicate fibrosis fraction as a percentage (%) and should only be fraction. The portal inflammation scale was misstated as 0–1 in the legend and should be corrected to 0–2. The correct Figure 3 and legend appear below. The authors state that the scientific conclusions are unaffected.
Figure 3.
Histopathological scoring and fibrosis quantification. All data except steatosis location are presented as individual scores with medians. (a) Steatosis scores on a scale of 0–3, (b) prevalence of different steatosis locations, (c) lobular inflammation scores on a scale of 0–3, (d) portal inflammation scores on a scale of 0–2, (e) ballooning scores on a scale of 0–2, (f) MASLD/NAFLD activity scores (NAS) on a scale of 0–8, (g) fibrosis scores on a scale of 0–4, (h) fibrosis fractions. Histopathological scoring data were analyzed with non-parametric Kruskal–Wallis’ test and Dunn’s test for multiple comparisons. Fibrosis fractions were log-transformed and analyzed via two-way ANOVA. *** p < 0.001, **** p < 0.0001, ns: not statistically significant. LFHC: low-fat high-VitC, LFLC: low-fat low-VitC, HFHC: high-fat high-VitC, HFLC: high-fat low-VitC.
Footnotes
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Reference
- 1.Pedersen K., Poojari A., Colberg S.F., Mechernsee S.M., Iversen J.F., Barrès R., Lykkesfeldt J., Tveden-Nyborg P. A Guinea Pig Model of Pediatric Metabolic Dysfunction-Associated Steatohepatitis: Poor Vitamin C Status May Advance Disease. Nutrients. 2025;17:291. doi: 10.3390/nu17020291. [DOI] [PMC free article] [PubMed] [Google Scholar]

