Skip to main content
NCBI home page
Journal of the Royal Society of Medicine logoLink to Journal of the Royal Society of Medicine
. 2002;95(Suppl 41):27–31.

Macrolides in the respiratory tract in cystic fibrosis.

Adam Jaffé 1, Mark Rosenthal 1
PMCID: PMC1308634  PMID: 12216272

Full Text

The Full Text of this article is available as a PDF (73.1 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abe S., Nakamura H., Inoue S., Takeda H., Saito H., Kato S., Mukaida N., Matsushima K., Tomoike H. Interleukin-8 gene repression by clarithromycin is mediated by the activator protein-1 binding site in human bronchial epithelial cells. Am J Respir Cell Mol Biol. 2000 Jan;22(1):51–60. doi: 10.1165/ajrcmb.22.1.3400. [DOI] [PubMed] [Google Scholar]
  2. Akai S., Okayama H., Shimura S., Tanno Y., Sasaki H., Takishima T. Delta F508 mutation of cystic fibrosis gene is not found in chronic bronchitis with severe obstruction in Japan. Am Rev Respir Dis. 1992 Sep;146(3):781–783. doi: 10.1164/ajrccm/146.3.781. [DOI] [PubMed] [Google Scholar]
  3. Anderson R. Erythromycin and roxithromycin potentiate human neutrophil locomotion in vitro by inhibition of leukoattractant-activated superoxide generation and autooxidation. J Infect Dis. 1989 May;159(5):966–973. doi: 10.1093/infdis/159.5.966. [DOI] [PubMed] [Google Scholar]
  4. Aoshiba K., Nagai A., Konno K. Erythromycin shortens neutrophil survival by accelerating apoptosis. Antimicrob Agents Chemother. 1995 Apr;39(4):872–877. doi: 10.1128/aac.39.4.872. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Armstrong D. S., Grimwood K., Carlin J. B., Carzino R., Gutièrrez J. P., Hull J., Olinsky A., Phelan E. M., Robertson C. F., Phelan P. D. Lower airway inflammation in infants and young children with cystic fibrosis. Am J Respir Crit Care Med. 1997 Oct;156(4 Pt 1):1197–1204. doi: 10.1164/ajrccm.156.4.96-11058. [DOI] [PubMed] [Google Scholar]
  6. Ashitani J., Mukae H., Nakazato M., Ihi T., Mashimoto H., Kadota J., Kohno S., Matsukura S. Elevated concentrations of defensins in bronchoalveolar lavage fluid in diffuse panbronchiolitis. Eur Respir J. 1998 Jan;11(1):104–111. doi: 10.1183/09031936.98.11010104. [DOI] [PubMed] [Google Scholar]
  7. Auerbach H. S., Williams M., Kirkpatrick J. A., Colten H. R. Alternate-day prednisone reduces morbidity and improves pulmonary function in cystic fibrosis. Lancet. 1985 Sep 28;2(8457):686–688. doi: 10.1016/s0140-6736(85)92929-0. [DOI] [PubMed] [Google Scholar]
  8. Balfour-Lynn I. M., Klein N. J., Dinwiddie R. Randomised controlled trial of inhaled corticosteroids (fluticasone propionate) in cystic fibrosis. Arch Dis Child. 1997 Aug;77(2):124–130. doi: 10.1136/adc.77.2.124. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Brugiere O., Milleron B., Antoine M., Carette M. F., Philippe C., Mayaud C. Diffuse panbronchiolitis in an Asian immigrant. Thorax. 1996 Oct;51(10):1065–1067. doi: 10.1136/thx.51.10.1065. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Davies J. C., Stern M., Dewar A., Caplen N. J., Munkonge F. M., Pitt T., Sorgi F., Huang L., Bush A., Geddes D. M. CFTR gene transfer reduces the binding of Pseudomonas aeruginosa to cystic fibrosis respiratory epithelium. Am J Respir Cell Mol Biol. 1997 Jun;16(6):657–663. doi: 10.1165/ajrcmb.16.6.9191467. [DOI] [PubMed] [Google Scholar]
  11. Desaki M., Takizawa H., Ohtoshi T., Kasama T., Kobayashi K., Sunazuka T., Omura S., Yamamoto K., Ito K. Erythromycin suppresses nuclear factor-kappaB and activator protein-1 activation in human bronchial epithelial cells. Biochem Biophys Res Commun. 2000 Jan 7;267(1):124–128. doi: 10.1006/bbrc.1999.1917. [DOI] [PubMed] [Google Scholar]
  12. Dupont M. J., Lapointe J. R. Quantitative effect of roxithromycin and rifampicin on mucoid cultures from directly plated sputum of cystic fibrosis patients chronically colonized with Pseudomonas aeruginosa. Drugs Exp Clin Res. 1990;16(12):597–605. [PubMed] [Google Scholar]
  13. Eigen H., Rosenstein B. J., FitzSimmons S., Schidlow D. V. A multicenter study of alternate-day prednisone therapy in patients with cystic fibrosis. Cystic Fibrosis Foundation Prednisone Trial Group. J Pediatr. 1995 Apr;126(4):515–523. doi: 10.1016/s0022-3476(95)70343-8. [DOI] [PubMed] [Google Scholar]
  14. Everard M. L., Sly P., Brenan S., Ryan G. Macrolide antibiotics in diffuse panbronchiolitis and in cystic fibrosis. Eur Respir J. 1997 Dec;10(12):2926–2926. doi: 10.1183/09031936.97.10122926. [DOI] [PubMed] [Google Scholar]
  15. Frederiksen B., Koch C., Høiby N. Antibiotic treatment of initial colonization with Pseudomonas aeruginosa postpones chronic infection and prevents deterioration of pulmonary function in cystic fibrosis. Pediatr Pulmonol. 1997 May;23(5):330–335. doi: 10.1002/(sici)1099-0496(199705)23:5<330::aid-ppul4>3.0.co;2-o. [DOI] [PubMed] [Google Scholar]
  16. Gant T. W., O'Connor C. K., Corbitt R., Thorgeirsson U., Thorgeirsson S. S. In vivo induction of liver P-glycoprotein expression by xenobiotics in monkeys. Toxicol Appl Pharmacol. 1995 Aug;133(2):269–276. doi: 10.1006/taap.1995.1151. [DOI] [PubMed] [Google Scholar]
  17. Hand W. L., Hand D. L., King-Thompson N. L. Antibiotic inhibition of the respiratory burst response in human polymorphonuclear leukocytes. Antimicrob Agents Chemother. 1990 May;34(5):863–870. doi: 10.1128/aac.34.5.863. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Høiby N. Diffuse panbronchiolitis and cystic fibrosis: East meets West. Thorax. 1994 Jun;49(6):531–532. doi: 10.1136/thx.49.6.531. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Høiby N., Koch C. Cystic fibrosis. 1. Pseudomonas aeruginosa infection in cystic fibrosis and its management. Thorax. 1990 Nov;45(11):881–884. doi: 10.1136/thx.45.11.881. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Ichikawa Y., Koga H., Tanaka M., Nakamura M., Tokunaga N., Kaji M. Neutrophilia in bronchoalveolar lavage fluid of diffuse panbronchiolitis. Chest. 1990 Oct;98(4):917–923. doi: 10.1378/chest.98.4.917. [DOI] [PubMed] [Google Scholar]
  21. Ichikawa Y., Ninomiya H., Koga H., Tanaka M., Kinoshita M., Tokunaga N., Yano T., Oizumi K. Erythromycin reduces neutrophils and neutrophil-derived elastolytic-like activity in the lower respiratory tract of bronchiolitis patients. Am Rev Respir Dis. 1992 Jul;146(1):196–203. doi: 10.1164/ajrccm/146.1.196. [DOI] [PubMed] [Google Scholar]
  22. Ichimiya T., Takeoka K., Hiramatsu K., Hirai K., Yamasaki T., Nasu M. The influence of azithromycin on the biofilm formation of Pseudomonas aeruginosa in vitro. Chemotherapy. 1996 May-Jun;42(3):186–191. doi: 10.1159/000239440. [DOI] [PubMed] [Google Scholar]
  23. Jaffé A., Francis J., Rosenthal M., Bush A. Long-term azithromycin may improve lung function in children with cystic fibrosis. Lancet. 1998 Feb 7;351(9100):420–420. doi: 10.1016/S0140-6736(05)78360-4. [DOI] [PubMed] [Google Scholar]
  24. Kadota J., Sakito O., Kohno S., Sawa H., Mukae H., Oda H., Kawakami K., Fukushima K., Hiratani K., Hara K. A mechanism of erythromycin treatment in patients with diffuse panbronchiolitis. Am Rev Respir Dis. 1993 Jan;147(1):153–159. doi: 10.1164/ajrccm/147.1.153. [DOI] [PubMed] [Google Scholar]
  25. Kawasaki S., Takizawa H., Ohtoshi T., Takeuchi N., Kohyama T., Nakamura H., Kasama T., Kobayashi K., Nakahara K., Morita Y. Roxithromycin inhibits cytokine production by and neutrophil attachment to human bronchial epithelial cells in vitro. Antimicrob Agents Chemother. 1998 Jun;42(6):1499–1502. doi: 10.1128/aac.42.6.1499. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Khair O. A., Devalia J. L., Abdelaziz M. M., Sapsford R. J., Davies R. J. Effect of erythromycin on Haemophilus influenzae endotoxin-induced release of IL-6, IL-8 and sICAM-1 by cultured human bronchial epithelial cells. Eur Respir J. 1995 Sep;8(9):1451–1457. [PubMed] [Google Scholar]
  27. Khan T. Z., Wagener J. S., Bost T., Martinez J., Accurso F. J., Riches D. W. Early pulmonary inflammation in infants with cystic fibrosis. Am J Respir Crit Care Med. 1995 Apr;151(4):1075–1082. doi: 10.1164/ajrccm/151.4.1075. [DOI] [PubMed] [Google Scholar]
  28. Klein J. O. History of macrolide use in pediatrics. Pediatr Infect Dis J. 1997 Apr;16(4):427–431. doi: 10.1097/00006454-199704000-00025. [DOI] [PubMed] [Google Scholar]
  29. Kobayashi H. Biofilm disease: its clinical manifestation and therapeutic possibilities of macrolides. Am J Med. 1995 Dec 29;99(6A):26S–30S. doi: 10.1016/s0002-9343(99)80282-4. [DOI] [PubMed] [Google Scholar]
  30. Koyama H., Nishimura K., Mio T., Ikeda A., Sugiura N., Izumi T. Bronchial responsiveness and acute bronchodilator response in chronic obstructive pulmonary disease and diffuse panbronchiolitis. Thorax. 1994 Jun;49(6):540–544. doi: 10.1136/thx.49.6.540. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Lallemand J. Y., Stoven V., Annereau J. P., Boucher J., Blanquet S., Barthe J., Lenoir G. Induction by antitumoral drugs of proteins that functionally complement CFTR: a novel therapy for cystic fibrosis? Lancet. 1997 Sep 6;350(9079):711–712. doi: 10.1016/s0140-6736(05)63510-6. [DOI] [PubMed] [Google Scholar]
  32. Mukae H., Kadota J., Ashitani J., Taniguchi H., Mashimoto H., Kohno S., Matsukura S. Elevated levels of soluble adhesion molecules in serum of patients with diffuse panbronchiolitis. Chest. 1997 Dec;112(6):1615–1621. doi: 10.1378/chest.112.6.1615. [DOI] [PubMed] [Google Scholar]
  33. Nagai H., Shishido H., Yoneda R., Yamaguchi E., Tamura A., Kurashima A. Long-term low-dose administration of erythromycin to patients with diffuse panbronchiolitis. Respiration. 1991;58(3-4):145–149. doi: 10.1159/000195915. [DOI] [PubMed] [Google Scholar]
  34. Nakashio S., Susa C., Qiu S., Kijima A., Iwasawa H., Shimomura H., Kanemitsu K., Hori S., Mizushima Y., Shimada J. [Antimicrobial activity of clarithromycin and its effect on bacterial adherence to medical material]. Jpn J Antibiot. 1993 Jun;46(6):428–436. [PubMed] [Google Scholar]
  35. Oda H., Kadota J., Kohno S., Hara K. Erythromycin inhibits neutrophil chemotaxis in bronchoalveoli of diffuse panbronchiolitis. Chest. 1994 Oct;106(4):1116–1123. doi: 10.1378/chest.106.4.1116. [DOI] [PubMed] [Google Scholar]
  36. Ordoñez C. L., Stulbarg M., Grundland H., Liu J. T., Boushey H. A. Effect of clarithromycin on airway obstruction and inflammatory markers in induced sputum in cystic fibrosis: a pilot study. Pediatr Pulmonol. 2001 Jul;32(1):29–37. doi: 10.1002/ppul.1085. [DOI] [PubMed] [Google Scholar]
  37. Piedimonte G., Wolford E. T., Fordham L. A., Leigh M. W., Wood R. E. Mediastinal lymphadenopathy caused by Mycobacterium avium-intracellulare complex in a child with normal immunity: successful treatment with anti-mycobacterial drugs and laser bronchoscopy. Pediatr Pulmonol. 1997 Oct;24(4):287–291. doi: 10.1002/(sici)1099-0496(199710)24:4<287::aid-ppul8>3.0.co;2-h. [DOI] [PubMed] [Google Scholar]
  38. Ripoll L., Reinert P., Pépin L. F., Lagrange P. H. Interaction of macrolides with alpha dornase during DNA hydrolysis. J Antimicrob Chemother. 1996 May;37(5):987–991. doi: 10.1093/jac/37.5.987. [DOI] [PubMed] [Google Scholar]
  39. Sakito O., Kadota J., Kohno S., Abe K., Shirai R., Hara K. Interleukin 1 beta, tumor necrosis factor alpha, and interleukin 8 in bronchoalveolar lavage fluid of patients with diffuse panbronchiolitis: a potential mechanism of macrolide therapy. Respiration. 1996;63(1):42–48. doi: 10.1159/000196514. [DOI] [PubMed] [Google Scholar]
  40. Seki K., Abo W., Yamamoto Y., Matsuura A. Identification of novel mutations of the CFTR gene in a Japanese patient with cystic fibrosis. Tohoku J Exp Med. 1999 Apr;187(4):323–328. doi: 10.1620/tjem.187.323. [DOI] [PubMed] [Google Scholar]
  41. Takizawa H., Desaki M., Ohtoshi T., Kawasaki S., Kohyama T., Sato M., Nakajima J., Yanagisawa M., Ito K. Erythromycin and clarithromycin attenuate cytokine-induced endothelin-1 expression in human bronchial epithelial cells. Eur Respir J. 1998 Jul;12(1):57–63. doi: 10.1183/09031936.98.12010057. [DOI] [PubMed] [Google Scholar]
  42. Takizawa H., Desaki M., Ohtoshi T., Kawasaki S., Kohyama T., Sato M., Tanaka M., Kasama T., Kobayashi K., Nakajima J. Erythromycin modulates IL-8 expression in normal and inflamed human bronchial epithelial cells. Am J Respir Crit Care Med. 1997 Jul;156(1):266–271. doi: 10.1164/ajrccm.156.1.9612065. [DOI] [PubMed] [Google Scholar]
  43. Tamaoki J., Isono K., Sakai N., Kanemura T., Konno K. Erythromycin inhibits Cl secretion across canine tracheal epithelial cells. Eur Respir J. 1992 Feb;5(2):234–238. [PubMed] [Google Scholar]
  44. Tamaoki J., Tagaya E., Sakai A., Konno K. Effects of macrolide antibiotics on neurally mediated contraction of human isolated bronchus. J Allergy Clin Immunol. 1995 Apr;95(4):853–859. doi: 10.1016/s0091-6749(95)70129-x. [DOI] [PubMed] [Google Scholar]
  45. Tarlow M. J., Block S. L., Harris J., Kolokathis A. Future indications for macrolides. Pediatr Infect Dis J. 1997 Apr;16(4):457–462. doi: 10.1097/00006454-199704000-00030. [DOI] [PubMed] [Google Scholar]
  46. Tateda K., Ishii Y., Matsumoto T., Furuya N., Nagashima M., Matsunaga T., Ohno A., Miyazaki S., Yamaguchi K. Direct evidence for antipseudomonal activity of macrolides: exposure-dependent bactericidal activity and inhibition of protein synthesis by erythromycin, clarithromycin, and azithromycin. Antimicrob Agents Chemother. 1996 Oct;40(10):2271–2275. doi: 10.1128/aac.40.10.2271. [DOI] [PMC free article] [PubMed] [Google Scholar]
  47. Torre D., Broggini M., Bottà V., Sampietro C., Busarello R., Garberi C. In vitro and ex vivo effects of recent and new macrolide antibiotics on chemotaxis of human polymorphonuclear leukocytes. J Chemother. 1991 Aug;3(4):236–239. doi: 10.1080/1120009x.1991.11739097. [DOI] [PubMed] [Google Scholar]
  48. Tredaniel J., Zalcman G., Gerber F., D'Agay M. F., Capron F., Frija J., Hirsch A. Diffuse panbronchiolitis: efficacy of low-dose erythromycin. Respir Med. 1993 Apr;87(3):229–230. doi: 10.1016/0954-6111(93)90099-l. [DOI] [PubMed] [Google Scholar]
  49. Villagrasa V., Berto L., Cortijo J., Perpina M., Sanz C., Morcillo E. J. Effects of erythromycin on chemoattractant-activated human polymorphonuclear leukocytes. Gen Pharmacol. 1997 Oct;29(4):605–609. doi: 10.1016/s0306-3623(96)00566-6. [DOI] [PubMed] [Google Scholar]
  50. Yamasaki T. [Adherence of Pseudomonas aeruginosa to mouse tracheal epithelium--the effect of antimicrobial agents]. Kansenshogaku Zasshi. 1990 May;64(5):575–583. doi: 10.11150/kansenshogakuzasshi1970.64.575. [DOI] [PubMed] [Google Scholar]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press

RESOURCES