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Journal of the Royal Society of Medicine logoLink to Journal of the Royal Society of Medicine
. 2002;95(Suppl 42):3–7.

Adipose tissue and fatty acid metabolism in humans.

Michael D Jensen 1
PMCID: PMC1308942  PMID: 12216324

Abstract

It is now clear that there are major regional differences in adipose tissue function as regards the uptake and release of fatty acids. Visceral adiposity is a good predictor of abnormal regulation of adipose tissue fuel export, but it is not the source of excess systemic FFA in humans. Regional differences in adipose tissue uptake of fatty acids may be an important determinant of body fat distribution, which in turn appears to predict abnormalities of fatty acid metabolism.

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Selected References

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  1. Basu A., Basu R., Shah P., Vella A., Rizza R. A., Jensen M. D. Systemic and regional free fatty acid metabolism in type 2 diabetes. Am J Physiol Endocrinol Metab. 2001 Jun;280(6):E1000–E1006. doi: 10.1152/ajpendo.2001.280.6.E1000. [DOI] [PubMed] [Google Scholar]
  2. Ferrannini E., Barrett E. J., Bevilacqua S., DeFronzo R. A. Effect of fatty acids on glucose production and utilization in man. J Clin Invest. 1983 Nov;72(5):1737–1747. doi: 10.1172/JCI111133. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Guo Z., Hensrud D. D., Johnson C. M., Jensen M. D. Regional postprandial fatty acid metabolism in different obesity phenotypes. Diabetes. 1999 Aug;48(8):1586–1592. doi: 10.2337/diabetes.48.8.1586. [DOI] [PubMed] [Google Scholar]
  4. Jensen M. D. Gender differences in regional fatty acid metabolism before and after meal ingestion. J Clin Invest. 1995 Nov;96(5):2297–2303. doi: 10.1172/JCI118285. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Jensen M. D., Haymond M. W., Rizza R. A., Cryer P. E., Miles J. M. Influence of body fat distribution on free fatty acid metabolism in obesity. J Clin Invest. 1989 Apr;83(4):1168–1173. doi: 10.1172/JCI113997. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Jensen M. D., Johnson C. M. Contribution of leg and splanchnic free fatty acid (FFA) kinetics to postabsorptive FFA flux in men and women. Metabolism. 1996 May;45(5):662–666. doi: 10.1016/s0026-0495(96)90040-2. [DOI] [PubMed] [Google Scholar]
  7. Jensen M. D., Kanaley J. A., Reed J. E., Sheedy P. F. Measurement of abdominal and visceral fat with computed tomography and dual-energy x-ray absorptiometry. Am J Clin Nutr. 1995 Feb;61(2):274–278. doi: 10.1093/ajcn/61.2.274. [DOI] [PubMed] [Google Scholar]
  8. Kelley D. E., Mokan M., Simoneau J. A., Mandarino L. J. Interaction between glucose and free fatty acid metabolism in human skeletal muscle. J Clin Invest. 1993 Jul;92(1):91–98. doi: 10.1172/JCI116603. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Lafontan M., Dang-Tran L., Berlan M. Alpha-adrenergic antilipolytic effect of adrenaline in human fat cells of the thigh: comparison with adrenaline responsiveness of different fat deposits. Eur J Clin Invest. 1979 Aug;9(4):261–266. doi: 10.1111/j.1365-2362.1979.tb00883.x. [DOI] [PubMed] [Google Scholar]
  10. Lewis G. F., Uffelman K. D., Szeto L. W., Weller B., Steiner G. Interaction between free fatty acids and insulin in the acute control of very low density lipoprotein production in humans. J Clin Invest. 1995 Jan;95(1):158–166. doi: 10.1172/JCI117633. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Martin M. L., Jensen M. D. Effects of body fat distribution on regional lipolysis in obesity. J Clin Invest. 1991 Aug;88(2):609–613. doi: 10.1172/JCI115345. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Meek S. E., Nair K. S., Jensen M. D. Insulin regulation of regional free fatty acid metabolism. Diabetes. 1999 Jan;48(1):10–14. doi: 10.2337/diabetes.48.1.10. [DOI] [PubMed] [Google Scholar]
  13. Mårin P., Odén B., Björntorp P. Assimilation and mobilization of triglycerides in subcutaneous abdominal and femoral adipose tissue in vivo in men: effects of androgens. J Clin Endocrinol Metab. 1995 Jan;80(1):239–243. doi: 10.1210/jcem.80.1.7829619. [DOI] [PubMed] [Google Scholar]
  14. Mårin P., Rebuffé-Scrive M., Björntorp P. Uptake of triglyceride fatty acids in adipose tissue in vivo in man. Eur J Clin Invest. 1990 Apr;20(2):158–165. doi: 10.1111/j.1365-2362.1990.tb02263.x. [DOI] [PubMed] [Google Scholar]
  15. Nguyen T. T., Hernández Mijares A., Johnson C. M., Jensen M. D. Postprandial leg and splanchnic fatty acid metabolism in nonobese men and women. Am J Physiol. 1996 Dec;271(6 Pt 1):E965–E972. doi: 10.1152/ajpendo.1996.271.6.E965. [DOI] [PubMed] [Google Scholar]
  16. Nielsen S., Jensen M. D. Relationship between urinary albumin excretion, body composition, and hyperinsulinemia in normotensive glucose-tolerant adults. Diabetes Care. 1999 Oct;22(10):1728–1733. doi: 10.2337/diacare.22.10.1728. [DOI] [PubMed] [Google Scholar]
  17. Romanski S. A., Nelson R. M., Jensen M. D. Meal fatty acid uptake in adipose tissue: gender effects in nonobese humans. Am J Physiol Endocrinol Metab. 2000 Aug;279(2):E455–E462. doi: 10.1152/ajpendo.2000.279.2.E455. [DOI] [PubMed] [Google Scholar]
  18. Roust L. R., Jensen M. D. Postprandial free fatty acid kinetics are abnormal in upper body obesity. Diabetes. 1993 Nov;42(11):1567–1573. doi: 10.2337/diab.42.11.1567. [DOI] [PubMed] [Google Scholar]
  19. Steinberg H. O., Tarshoby M., Monestel R., Hook G., Cronin J., Johnson A., Bayazeed B., Baron A. D. Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation. J Clin Invest. 1997 Sep 1;100(5):1230–1239. doi: 10.1172/JCI119636. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Unger R. H. Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications. Diabetes. 1995 Aug;44(8):863–870. doi: 10.2337/diab.44.8.863. [DOI] [PubMed] [Google Scholar]

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