Abstract
1. The regulation of cerebrospinal fluid (c.s.f.) potassium concentration was studied using the cat choroid plexus isolated in a chamber in situ. 2. Hyperkalaemia (plasma potassium concentration greater than 6 m-equiv/l.) caused relatively small increases in c.s.f. potassium concentration. 3. Alterations in c.s.f. potassium concentration (c.s.f. K = 0-15 or 6-56 m-equiv/l.) were countered by changes in potassium concentration of the produced fluid or in the rate of potassium transport which returned c.s.f. potassium towards normal. 4. The data indicate that potassium concentration in c.s.f. secreted by the choroid plexus is actively regulated by the plexus whether the primary alteration in potassium occurs in plasma or c.s.f.
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Selected References
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- Ames A., 3rd, Higashi K., Nesbett F. B. Relation of potassium concentration in choroidplexus fluid to that in plasma. J Physiol. 1965 Dec;181(3):506–515. doi: 10.1113/jphysiol.1965.sp007779. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BEKAERT J., DEMEESTER G. The influence of glucose and insulin upon the potassium concentration of serum and cerebrospinal fluid. Arch Int Physiol. 1951 Jul;59(2):262–264. doi: 10.3109/13813455109145012. [DOI] [PubMed] [Google Scholar]
- BEKAERT J., DEMEESTER G. The influence of the infusion of potassium chloride on the cerebrospinal fluid concentration of potassium. Arch Int Physiol. 1951 Sep;59(3):393–394. doi: 10.3109/13813455109145026. [DOI] [PubMed] [Google Scholar]
- Bradbury M. W., Davson H. The transport of potassium between blood, cerebrospinal fluid and brain. J Physiol. 1965 Nov;181(1):151–174. doi: 10.1113/jphysiol.1965.sp007752. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bradbury M. W., Kleeman C. R. Stability of the potassium content of cerebrospinal fluid and brain. Am J Physiol. 1967 Aug;213(2):519–528. doi: 10.1152/ajplegacy.1967.213.2.519. [DOI] [PubMed] [Google Scholar]
- Bradbury M. W., Segal M. B., Wilson J. Transport of potassium at the blood-brain barrier. J Physiol. 1972 Mar;221(3):617–632. doi: 10.1113/jphysiol.1972.sp009771. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bradbury M. W., Stulcová B. Efflux mechanism contributing to the stability of the potassium concentration in cerebrospinal fluid. J Physiol. 1970 Jun;208(2):415–430. doi: 10.1113/jphysiol.1970.sp009128. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cameron I. R., Kleeman C. R. The effect of acute hyperkalaemia on the blood-c.s.f. potential difference. J Physiol. 1970 Apr;207(2):68P–69P. [PubMed] [Google Scholar]
- Cserr H. Potassium exchange between cerebrospinal fluid, plasma, and brain. Am J Physiol. 1965 Dec;209(6):1219–1226. doi: 10.1152/ajplegacy.1965.209.6.1219. [DOI] [PubMed] [Google Scholar]
- DOMER F. R., WHITCOMB M. STUDIES OF K42 MOVEMENT BETWEEN THE BLOOD AND THE CEREBROSPINAL FLUID OF CATS. J Pharmacol Exp Ther. 1964 Jul;145:52–57. [PubMed] [Google Scholar]
- HELD D., FENCL V., PAPPENHEIMER J. R. ELECTRICAL POTENTIAL OF CEREBROSPINAL FLUID. J Neurophysiol. 1964 Sep;27:942–959. doi: 10.1152/jn.1964.27.5.942. [DOI] [PubMed] [Google Scholar]
- Johanson C. E., Reed D. J., Woodbury D. M. Active transport of sodium and potassium by the choroid plexus of the rat. J Physiol. 1974 Sep;241(2):359–372. doi: 10.1113/jphysiol.1974.sp010660. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Katzman R., Graziani L., Kaplan R., Escriva A. Exchange of cerebrospinal fluid potassium with blood and brain. Study in normal and Ouabain perfused cats. Arch Neurol. 1965 Nov;13(5):513–524. doi: 10.1001/archneur.1965.00470050061007. [DOI] [PubMed] [Google Scholar]
- Miner L. C., Reed D. J. Composition of fluid obtained from choroid plexus tissue isolated in a chamber in situ. J Physiol. 1972 Dec;227(1):127–139. doi: 10.1113/jphysiol.1972.sp010023. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pesce M. A., Strande C. S. A new micromethod for determination of protein in cerebrospinal fluid and urine. Clin Chem. 1973 Nov;19(11):1265–1267. [PubMed] [Google Scholar]
- Pollay M., Kaplan R., Nelson K. M. Potassium transport across the choroidal ependyma. Life Sci II. 1973 Jun 8;12(4):479–487. doi: 10.1016/0024-3205(73)90341-x. [DOI] [PubMed] [Google Scholar]
- WELCH K. SECRETION OF CEREBROSPINAL FLUID BY CHOROID PLEXUS OF THE RABBIT. Am J Physiol. 1963 Sep;205:617–624. doi: 10.1152/ajplegacy.1963.205.3.617. [DOI] [PubMed] [Google Scholar]
- Wright E. M. Mechanisms of ion transport across the choroid plexus. J Physiol. 1972 Oct;226(2):545–571. doi: 10.1113/jphysiol.1972.sp009997. [DOI] [PMC free article] [PubMed] [Google Scholar]