Skip to main content
PMC home page
The Journal of Physiology logoLink to The Journal of Physiology
. 1976 Jul;259(2):501–522. doi: 10.1113/jphysiol.1976.sp011479

Inhibition of food intake in the rat following complete absorption of glucose delivered into the stomach, intestine or liver.

D A Booth, S P Jarman
PMCID: PMC1309042  PMID: 957255

Abstract

1. Solutions of glucose or other carbohydrates were administered during the dark or light period of the circadian cycle to rats which had been only briefly deprived of food. 2. food was restored to the animals at various times after administration of a glucose load by stomach tube. With delays between loading and access to food of up to 3 hr by night and 2 hr by day, subsequent food intake was less than intake after non-nutritive loads. 3. measurement of the glucose content of the gastrointestinal tract at various times after glucose loading showed that this depression of intake was still apparent even when the rat was offered food some time after complete absorption of the stomach load. 4. infusion of a glucose solution into the duodenum or the hepatic protal vein also inhibited subsequent food intake. 5. in all cases, the inhibition of food intake was expressed as a decrease in the size of the first meal after restoring access to food. 6. these results provide the first demonstration that the entry of normal amounts of carbohydrate into the body by the physiological route is followed by depression of food intake which lasts until after absorption is complete.

Full text

PDF
501

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BOGDANOVE E. M., BARKER S. B. Effect of phlorhizin on intestinal absorption of glucose, galactose, fructose, mannose, and sorbose. Proc Soc Exp Biol Med. 1950 Oct;75(1):77–80. doi: 10.3181/00379727-75-18106. [DOI] [PubMed] [Google Scholar]
  2. Baron P., Griffaton G., Lowy R. Effets comparés d'une injection i.p. de fructose et de glucose sur le métabolisme du foie de rat. Ann Nutr Aliment. 1969;23(4):223–232. [PubMed] [Google Scholar]
  3. Booth D. A., Jarman S. P. Ontogeny and insulin-dependence of the satiation which follows carbohydrate absorption in the rat. Behav Biol. 1975 Oct;15(2):159–172. doi: 10.1016/s0091-6773(75)91507-2. [DOI] [PubMed] [Google Scholar]
  4. Booth D. A., Lovett D., McSherry G. M. Postingestive modulation of the sweetness preference gradient in the rat. J Comp Physiol Psychol. 1972 Mar;78(3):485–512. doi: 10.1037/h0092970. [DOI] [PubMed] [Google Scholar]
  5. Booth D. A., Lovett D., Simson P. C. Subcutaneous dialysis in the study of the effects of nutrients on feeding. Physiol Behav. 1970 Oct;5(10):1201–1203. doi: 10.1016/0031-9384(70)90216-7. [DOI] [PubMed] [Google Scholar]
  6. Booth D. A. Postabsorptively induced suppression of appetite and the energostatic control of feeding. Physiol Behav. 1972 Aug;9(2):199–202. doi: 10.1016/0031-9384(72)90235-1. [DOI] [PubMed] [Google Scholar]
  7. Booth D. A. Satiety and behavioral caloric compensation following intragastric glucose loads in the rat. J Comp Physiol Psychol. 1972 Mar;78(3):412–432. doi: 10.1037/h0032291. [DOI] [PubMed] [Google Scholar]
  8. Booth D. A. Some characteristics of feeding during streptoxotocin-induced diabetes in the rat. J Comp Physiol Psychol. 1972 Aug;80(2):238–249. doi: 10.1037/h0032968. [DOI] [PubMed] [Google Scholar]
  9. CSAKY T. Z., GLENN J. E. Urinary recovery of 3-methylglucose administered to rats. Am J Physiol. 1957 Jan;188(1):159–162. doi: 10.1152/ajplegacy.1956.188.1.159. [DOI] [PubMed] [Google Scholar]
  10. CUATRECASAS P., SEGAL S. MAMMALIAN GALACTOKINASE. DEVELOPMENTAL AND ADAPTIVE CHARACTERISTICS IN THE RAT LIVER. J Biol Chem. 1965 Jun;240:2382–2388. [PubMed] [Google Scholar]
  11. Campbell C. S., Davis J. D. Licking rate of rats is reduced by intraduodenal and intraportal glucose infusion. Physiol Behav. 1974 Mar;12(3):357–365. doi: 10.1016/0031-9384(74)90110-3. [DOI] [PubMed] [Google Scholar]
  12. DAHLQVIST A. METHOD FOR ASSAY OF INTESTINAL DISACCHARIDASES. Anal Biochem. 1964 Jan;7:18–25. doi: 10.1016/0003-2697(64)90115-0. [DOI] [PubMed] [Google Scholar]
  13. Davis J. D., Campbell C. S., Gallagher R. J., Zurakov M. A. Disappearance of a humoral satiety factor during food deprivation. J Comp Physiol Psychol. 1971 Jun;75(3):476–482. doi: 10.1037/h0030933. [DOI] [PubMed] [Google Scholar]
  14. Davis J. D. The effectiveness of some sugars in stimulating licking behavior in the rat. Physiol Behav. 1973 Jul;11(1):39–45. doi: 10.1016/0031-9384(73)90120-0. [DOI] [PubMed] [Google Scholar]
  15. Debons A. F., Krimsky I., From A., Pattinian H. Phlorizin inhibition of hypothalamic necrosis induced by gold thioglucose. Am J Physiol. 1974 Mar;226(3):574–578. doi: 10.1152/ajplegacy.1974.226.3.574. [DOI] [PubMed] [Google Scholar]
  16. Ehman G. K., Albert D. J., Jamieson J. L. Injections into the duodenum and the induction of satiety in the rat. Can J Psychol. 1971 Apr;25(2):147–166. doi: 10.1037/h0082376. [DOI] [PubMed] [Google Scholar]
  17. FISHER R. B., PARSONS D. S. Galactose absorption from the surviving small intestine of the rat. J Physiol. 1953 Feb 27;119(2-3):224–232. doi: 10.1113/jphysiol.1953.sp004840. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. HOLDSWORTH C. D., DAWSON A. M. ABSORPTION OF FRUCTOSE IN MAN. Proc Soc Exp Biol Med. 1965 Jan;118:142–145. doi: 10.3181/00379727-118-29780. [DOI] [PubMed] [Google Scholar]
  19. JACOBS H. L. EVALUATION OF THE OSMOTIC EFFECTS OF GLUCOSE LOADS IN FOOD SATIATION. J Comp Physiol Psychol. 1964 Apr;57:309–310. doi: 10.1037/h0047835. [DOI] [PubMed] [Google Scholar]
  20. KIYASU J. Y., CHAIKOFF I. L. On the manner of transport of absorbed fructose. J Biol Chem. 1957 Feb;224(2):935–939. [PubMed] [Google Scholar]
  21. LE MAGNEN J. Effets des administrations post-prandiales de glucose sur l'établissement des appétits. C R Seances Soc Biol Fil. 1959;153(2):212–215. [PubMed] [Google Scholar]
  22. Le Magnen J., Tallon S. L'effet du jeûne préalable sur les caractéristiques temporelles de la prise d'aliments chez le rat. J Physiol (Paris) 1968 Mar-Apr;60(2):143–154. [PubMed] [Google Scholar]
  23. Le Magnen J., Tallon S. La périodicité spontanée de la prise d'aliments and libitum du rat blanc. J Physiol (Paris) 1966 May-Jun;58(3):323–349. [PubMed] [Google Scholar]
  24. Levitsky D. A. Feeding patterns of rats in response to fasts and changes in environmental conditions. Physiol Behav. 1970 Mar;5(3):291–300. doi: 10.1016/0031-9384(70)90101-0. [DOI] [PubMed] [Google Scholar]
  25. MORGAN H. E., REGEN D. M., PARK C. R. IDENTIFICATION OF A MOBILE CARRIER-MEDIATED SUGAR TRANSPORT SYSTEM IN MUSCLE. J Biol Chem. 1964 Feb;239:369–374. [PubMed] [Google Scholar]
  26. Niijima A. Afferent impulse discharges from glucoreceptors in the liver of the guinea pig. Ann N Y Acad Sci. 1969 May 15;157(2):690–700. doi: 10.1111/j.1749-6632.1969.tb12914.x. [DOI] [PubMed] [Google Scholar]
  27. Novin D., VanderWeele D. A., Rezek M. Infusion of 2-deoxy-D-glucose into the hepatic-portal system causes eating: evidence for peripheral glucoreceptors. Science. 1973 Aug 31;181(4102):858–860. doi: 10.1126/science.181.4102.858. [DOI] [PubMed] [Google Scholar]
  28. Oomura Y., Ooyama H., Sugimori M., Nakamura T., Yamada Y. Glucose inhibition of the glucose-sensitive neurone in the rat lateral hypothalamus. Nature. 1974 Feb 1;247(5439):284–286. doi: 10.1038/247284a0. [DOI] [PubMed] [Google Scholar]
  29. Pilcher C. W., Jarman S. P., Booth D. A. Route of glucose to the brain from food in the mouth of the rat. J Comp Physiol Psychol. 1974 Jul;87(1):56–61. doi: 10.1037/h0036588. [DOI] [PubMed] [Google Scholar]
  30. Pruvost M., Duquesnel J., Cabanac M. Injection de glucose dans le territoire porte chez l'homme, absence d'alliésthesie négative en réponse à des stimulus sucrés. Physiol Behav. 1973 Sep;11(3):355–358. doi: 10.1016/0031-9384(73)90012-7. [DOI] [PubMed] [Google Scholar]
  31. Rowland N., Meile M. J., Nicolaïdis S. Action inadéquate des apports parentéraux sur l'insulinosécrétion et sur le contrôle du comportement alimentaire chez le rat. C R Acad Sci Hebd Seances Acad Sci D. 1973 Oct 29;277(17):1783–1786. [PubMed] [Google Scholar]
  32. Russek M. Demonstration of the influence of an hepatic glucosensitive mechanism on food-intake. Physiol Behav. 1970 Oct;5(10):1207–1209. doi: 10.1016/0031-9384(70)90218-0. [DOI] [PubMed] [Google Scholar]
  33. Russek M. Hepatic receptors and the neurophysiological mechanisms controlling feeding behavior. Neurosci Res (N Y) 1971;4:213–282. doi: 10.1016/b978-0-12-512504-8.50012-3. [DOI] [PubMed] [Google Scholar]
  34. SEGAL S., ROTH H., BERTOLI D. GALACTOSE METABOLISM BY RAT LIVER TISSUE: INFLUENCE OF AGE. Science. 1963 Dec 6;142(3597):1311–1313. doi: 10.1126/science.142.3597.1311. [DOI] [PubMed] [Google Scholar]
  35. SMITH M., DUFFY M. Some physiological factors that regulate eating behavior. J Comp Physiol Psychol. 1957 Dec;50(6):601–608. doi: 10.1037/h0042807. [DOI] [PubMed] [Google Scholar]
  36. Scharrer E., Thomas D. W., Mayer J. Absence of effect of intraaortal glucose infusions upon spontaneous meals of rats. Pflugers Arch. 1974;351(4):315–322. doi: 10.1007/BF00593317. [DOI] [PubMed] [Google Scholar]
  37. Schmitt M. Influences of hepatic portal receptors on hypothalamic feeding and satiety centers. Am J Physiol. 1973 Nov;225(5):1089–1095. doi: 10.1152/ajplegacy.1973.225.5.1089. [DOI] [PubMed] [Google Scholar]
  38. Smith M. H., Jr Effects of intravenous injections on eating. J Comp Physiol Psychol. 1966 Feb;61(1):11–14. doi: 10.1037/h0022870. [DOI] [PubMed] [Google Scholar]
  39. Steffens A. B. Plasma insulin content in relation to blood glucose level and meal pattern in the normal and hypothalamic hyperphagic rat. Physiol Behav. 1970 Feb;5(2):147–151. doi: 10.1016/0031-9384(70)90058-2. [DOI] [PubMed] [Google Scholar]
  40. Vanderweele D. A., Novin D., Rezek M., Sanderson J. D. Duodenal or hepatic-portal glucose perfusion: evidence for duodenally-based satiety. Physiol Behav. 1974 Mar;12(3):467–473. doi: 10.1016/0031-9384(74)90124-3. [DOI] [PubMed] [Google Scholar]
  41. Yin T. H., Hamilton C. L., Brobeck J. R. Effect of body fluid disturbance on feeding in the rat. Am J Physiol. 1970 Apr;218(4):1054–1059. doi: 10.1152/ajplegacy.1970.218.4.1054. [DOI] [PubMed] [Google Scholar]
  42. Yin T. H., Tsai C. T. Effects of glucose on feeding in relation to routes of entry in rats. J Comp Physiol Psychol. 1973 Nov;85(2):258–264. doi: 10.1037/h0035012. [DOI] [PubMed] [Google Scholar]

Articles from The Journal of Physiology are provided here courtesy of The Physiological Society

RESOURCES