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. 2016 Feb 18;14(2):4395. doi: 10.2903/j.efsa.2016.4395

Safety and efficacy of manganese compounds (E5) as feed additives for all animal species: manganous carbonate; manganous chloride, tetrahydrate; manganous oxide; manganous sulphate, monohydrate; manganese chelate of amino acids, hydrate; manganese chelate of glycine, hydrate, based on a dossier submitted by FEFANA asbl

EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
PMCID: PMC13093161  PMID: 42016897

Abstract

The Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) has assessed five manganese compounds: manganous chloride, tetrahydrate; manganous sulphate, monohydrate; manganous oxide; manganese chelate of amino acids, hydrate; manganese chelate of glycine, hydrate. The safety assessment is based on the assumption that the current maximum total contents of manganese authorised in feed are respected. All manganese compounds under application are considered safe for all animal species/categories. The mean manganese intake of the European population includes already the manganese from animal products and does not pose a toxicological concern. The effect of dietary manganese fed to animals on tissue concentrations is limited. Supplementation of feed with the manganese compounds under assessment would consequently not affect consumer exposure and is of no concern for consumer safety. All manganese compounds are considered as eye irritants, the manganese chelate of glycine and the manganese chelate of amino acids as irritants to skin and the latter one as dermal sensitiser. However, the presence of nickel in all additives may induce contact dermatitis. Exposure to manganese in dust of all additives and to nickel (except manganous chloride and manganous oxide) poses a risk to users by inhalation. The use of the manganese compounds under assessment in animal nutrition for all animal species is not expected to pose a risk to the environment. The manganese compounds under assessment are recognised as efficacious sources of manganese in meeting animals’ requirements.

Keywords: nutritional additive, compounds of trace elements, manganese, manganese compounds, safety, environment, efficacy

Suggested citation: EFSA FEEDAP Panel (EFSA Panel on Additives and Products or Substances used in Animal Feed) , 2016. Scientific opinion on the safety and efficacy of manganese compounds (E5) as feed additives for all animal species: manganous carbonate; manganous chloride, tetrahydrate; manganous oxide; manganous sulphate, monohydrate; manganese chelate of amino acids, hydrate; manganese chelate of glycine, hydrate, based on a dossier submitted by FEFANA asbl. EFSA Journal 2016;14(2):4395, 44 pp. doi: 10.2903/j.efsa.2016.4395

Panel members: Gabriele Aquilina, Giovanna Azimonti, Vasileios Bampidis, Maria de Lourdes Bastos, Georges Bories, Andrew Chesson, Pier Sandro Cocconcelli, Gerhard Flachowsky, Jürgen Gropp, Boris Kolar, Maryline Kouba, Secundino López Puente, Marta López‐Alonso, Alberto Mantovani, Baltasar Mayo, Fernando Ramos, Guido Rychen, Maria Saarela, Roberto Edoardo Villa, Robert John Wallace and Pieter Wester

Correspondence: feedap@efsa.europa.eu

Acknowledgement: The Panel wishes to thank the members of the Working Group on Trace Elements, including Noël Dierick, Mikolaj Antoni Gralak, Christer Hogstrand, Lubomir Leng and Johannes Westendorf, for the preparatory work on this scientific opinion.

Amendment: An editorial correction was carried out that does not materially affect the contents or outcome of this scientific output. The addendum of the EURL report was recorded in the Section 2.1. To avoid confusion, the older version has been removed from the EFSA Journal, but is available on request, as is a version showing all the changes made.

Erratum: The recommendation concerning the user safety has been deleted; the sections on Recommendations and Summary have been amended accordingly. To avoid confusion, the older version has been removed from the EFSA Journal, but is available on request, as is a version showing all the changes made.

Adoption date: 27 January 2016

Published date: 18 February 2016

Updated: 22 December 2016

Question number: EFSA‐Q‐2012‐00437

On request from: European Commission

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