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. 2011 Dec 9;9(12):1924. doi: 10.2903/j.efsa.2011.1924

Scientific Opinion on Flavouring Group Evaluation 96 (FGE.96): Consideration of 88 flavouring substances considered by EFSA for which EU production volumes / anticipated production volumes have been submitted on request by DG SANCO. Addendum to FGE. 51, 52, 53, 54, 56, 58, 61, 62, 63, 64, 68, 69, 70, 71, 73, 76, 77, 79, 80, 83, 84, 85 and 87

EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF)
PMCID: PMC13093198  PMID: 42015974

Abstract

The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to consider evaluations of flavouring substances assessed since 2000 by the Joint FAO/WHO Expert Committee on Food Additives (the JECFA), and to decide whether further evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. The present FGE.96 concerns 88 JECFA‐evaluated substances from different FGEs. Common for all the 88 substances was that for none of them European production volumes were available at the time for the first consideration of the FGEs in question. As a consequence, no MSDI could be calculated for EU and accordingly the substances could not be considered by EFSA using the evaluation Procedure. Industry has now provided production volumes for these substances. Based on these newly provided production figures, MSDI values for EU have been calculated and based on these MSDI values the substances have been re‐considered by the stepwise approach (the Procedure) that integrates information on structure‐activity relationships, intake from current uses, toxicological threshold of concern, and available data on metabolism and toxicity. In the FGEs in question, genotoxicity of the substances considered in FGE.96 has already been addressed. For none of the substances a concern for genotoxicity was identified. The Panel concluded that 87 of the substances do not give rise to safety concerns at the levels of dietary intake, estimated on the basis of the MSDI approach. However, for the substance 2‐acetyl‐1‐ethylpyrrole [FL‐no: 14.045], the Panel could not identify an appropriate NOAEL and accordingly additional data are required. Besides the safety assessment of these flavouring substances, the specifications for the materials of commerce have also been considered and for eight stereoisomeric substances [FL‐no: 06.040, 08.073, 09.371, 09.780, 10.050, 13.060, 13.161 and 16.039], the stereoisomeric composition has to be specified further.

Keywords: Footnote 8, European anticipated production volume, MSDI

EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF) ; Scientific Opinion on Flavouring Group Evaluation 96 (FGE.96): Consideration of 88 flavouring substances considered by EFSA for which EU production volumes / anticipated production volumes have been submitted on request by DG SANCO. Addendum to FGE. 51, 52, 53, 54, 56, 58, 61, 62, 63, 64, 68, 69, 70, 71, 73, 76, 77, 79, 80, 83, 84, 85 and 87. EFSA Journal 2011;9(12):1924. [60 pp.]. doi: 10.2903/j.efsa.2011.1924.

Panel members: Arturo Anadon, Mona‐Lise Binderup, Wilfried Bursch, Laurence Castle, Riccardo Crebelli, Karl‐Heinz Engel, Roland Franz, Nathalie Gontard, Thomas Haertle, Trine Husøy, Klaus‐Dieter Jany, Catherine Leclercq, Jean Claude Lhuguenot, Wim Mennes, Maria Rosaria Milana, Karla Pfaff, Kettil Svensson, Fidel Toldra, Rosemary Waring, Detlef Wölfle

Correspondence: CEF-unit@efsa.europa.eu

Acknowledgement: The Panel wishes to thank the members of the Working Groups on Flavourings for the preparation of this Opinion: Ulla Beckman Sundh, Vibe Beltoft, Wilfried Bursch, Angelo Carere, Karl‐Heinz Engel, Henrik Frandsen, Rainer Gürtler, Frances Hill, Trine Husøy, John Christian Larsen, Pia Lund, Wim Mennes, Gerard Mulder, Karin Nørby, Gerard Pascal, Iona Pratt, Gerrit Speijers, Harriet Wallin and EFSA's staff member Kim Rygaard Nielsen for the preparatory work on this scientific Opinion.

Adoption date: 25 November 2010

Published date: 9 December 2011

Question number: EFSA‐Q‐2010‐01246

On request from: European Commission

References

  1. Butterworth KR, Carpanini FMB, Gaunt IF, Hardy J, Kiss IS and Gangolli SD, 1975b. Short‐term toxicity of dimethyl sulphide in the rat. Food Cosmet. Toxicol. 13, 15–22. [DOI] [PubMed] [Google Scholar]
  2. Cheng MC, 1982. A subchronic oral toxicity study of T0332.04 in rats. Sugy No. 80063, Vol. 1 Hazleton Laboratories, Madison, Wisconsin, USA. Unpublished report to the Flavor Manufacturers Association. Submitted to WHO by the Flavor and Extract Manufacturers Association of the United States, Washington DC, USA. [Google Scholar]
  3. EC , 1996a. Regulation No 2232/96 of the European Parliament and of the Council of 28 October 1996. Official Journal of the European Communities 23.11.1996, L 299, 1–4. [Google Scholar]
  4. EC , 1996b. Reports of the Scientific Committee for Food (Thirty‐fifth series). Food science and techniques series. Luxembourg: Office for Official Publications of the European Communities. ISBN 92–827‐5 14 1‐4. [Google Scholar]
  5. EC , 1999a. Commission Decision 1999/217/EC of 23 February 1999 adopting a register of flavouring substances used in or on foodstuffs. Official Journal of the European Communities 27.3.1999, L 84, 1–137. [Google Scholar]
  6. EC , 2000a. Commission Regulation No 1565/2000 of 18 July 2000 laying down the measures necessary for the adoption of an evaluation programme in application of Regulation (EC) No 2232/96. Official Journal of the European Communities 19.7.2000, L 180, 8–16. [Google Scholar]
  7. EC , 2009a. Commission Decision 2009/163/EC of 26 February 2009 amending Decision 1999/217/EC as regards the Register of flavouring substances used in or on foodstuffs. Official Journal of the European Union 27.2.2009, L 55, 41.
  8. EFFA , 2010a. EFFA Letters to EFSA for clarification of specifications and isomerism for which data were requested in published FGEs.
  9. EFFA , 2010c. European production volumes for selected flavouring substances (footnote 8 substances). Private communication from EFFA to DG SANCO. February 2010.
  10. EFSA , 2004b. Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Material in Contact with Food on a Request from the Commission related to para hydroxybenzoates (E214‐219). The EFSA Journal 83, 1–26. [Google Scholar]
  11. EFSA , 2005c. Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with food on a request from the Commission related to Flavouring Group Evaluation 13: Furfuryl and furan derivatives with and without additional side‐chain substituents and heteroatoms from chemical group 14 (Commission Regulation (EC) No 1565/2000 of 18 July 2000). Adopted on 27 April 2005. EFSA‐Q‐2003‐156.
  12. EFSA , 2006l. Statement of the Scientific Panel of Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from the Commission concerning the use of lactic acid and sodium lactate and sodium lactate for poultry carcass decontamination. Adopted on 4 May 2006. EFSA Q‐2005‐107B. [Online] www.efsa.europa.eu/cs/BlobServer/Statement/afc_stat_lactic%20acid_en,0.pdf?ssbinary=yrue [As of October 2008]. [DOI] [PMC free article] [PubMed]
  13. EFSA , 2008ab. Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with food on a request from the Commission related to Flavouring Group Evaluation 58: Consideration of phenol derivatives evaluated by JECFA (55th meeting) structurally related to ring substituted phenolic substances evaluated by EFSA in FGE.22 (2006) (Commission Regulation (EC) No 1565/2000 of 18 July 2000). Adopted on 3 July 2007. EFSA‐Q‐2008‐032J.
  14. EFSA , 2008ad. Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with food on a request from the Commission related to Flavouring Group Evaluation 62: Linear and branched‐chain aliphatic unsaturated, unconjugated alcohols, aldehydes, acids, and related esters evaluated by JECFA (61st meeting) structurally related to esters of branched‐ and straight‐chain aliphatic saturated primary alcohols and of one secondary alcohol, and branched‐ and straight‐chain unsaturated carboxylic acids evaluated by EFSA in FGE.05 (2005) and to straight‐ and branched‐chain aliphatic unsaturated primary alcohols, aldehydes, carboxylic acids, and esters evaluated by EFSA in FGE.06 (2004) (Commission Regulation (EC) No 1565/2000 of 18 July 2000). Adopted on 3 July 2007. EFSA‐Q‐2008‐032N.
  15. EFSA , 2008ae. Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with food on a request from the Commission related to Flavouring Group Evaluation 63: Consideration of aliphatic secondary alcohols, ketones and related esters evaluated by JECFA (59th meeting) structurally related to saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched‐chain carboxylic acids evaluated by EFSA in FGE.07 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000). Adopted on 7 July 2007. EFSA‐Q‐2008‐032O.
  16. EFSA , 2008af. Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with food on a request from the Commission related to Flavouring Group Evaluation 85: Consideration of miscellaneous nitrogen‐containing substances evaluated by JECFA (65th meeting) (Commission Regulation (EC) No 1565/2000 of July 2000). Adopted on 22 May 2008. EFSA‐Q‐2008‐069.
  17. EFSA , 2008aj. Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with food on a request from the Commission related to Flavouring Group Evaluation 51: Consideration of alicyclic ketones and secondary alcohols and related esters evaluated by JECFA (59th meeting) and structurally related to alicyclic ketones, secondary alcohols and related esters evaluated by EFSA in FGE.09 (2004) (Commission Regulation (EC) No 1565/2000 of 18 July 2000). Adopted on 16 May 2008. EFSA‐Q‐2008‐032B.
  18. EFSA , 2008am. Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with food on a request from the Commission related to Flavouring Group Evaluation 69: Consideration of aromatic substituted secondary alcohols, ketones and related esters evaluated by JECFA (57th meeting) structurally related to aromatic ketones from chemical group 21 evaluated by EFSA in FGE.16 (2006) (Commission Regulation (EC) No 1565/2000 of 18 July 2000). Adopted on 31 January 2008. EFSA‐Q‐2008‐053.
  19. EFSA , 2008an. Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with food on a request from the Commission related to Flavouring Group Evaluation 73: Consideration of alicyclic primary alcohols, aldehydes, acids and related esters evaluated by JECFA (59th meeting) structurally related to primary saturated or unsaturated alicyclic alcohol, aldehyde and esters evaluated by EFSA in FGE.12 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000). Adopted on 6 March 2008. EFSA‐Q‐2008‐057.
  20. EFSA , 2008ao. Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with food on a request from the Commission related to Flavouring Group Evaluation 84: Consideration of Anthranilate derivatives evaluated by JECFA (65th meeting) (Commission Regulation (EC) No 1565/2000 of 18 July 2000). Adopted on 1 April 2008. EFSA‐Q‐2008‐068.
  21. EFSA , 2008ap. Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with food on a request from the Commission related to Flavouring Group Evaluation 76: Consideration of sulphur‐containing heterocyclic compounds evaluated by JECFA (59th meeting) structurally related to thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29, miscellaneous substances from chemical group 30 evaluated by EFSA in FGE.21(Commission Regulation (EC) No 1565/2000 of 18 July 2000). Adopted on 31 January 2008. EFSA‐Q‐2008‐060.
  22. EFSA , 2010aq. Opinion of the Scientific Panel on contact Materials, Enzymes, Flavourings and Processing Aids on a request from Commission related to Flavouring Group Evaluation 62, Revision 1 (FGE.62Rev1): Consideration of of linear and branched‐chain aliphatic unsaturated, unconjugated alcohols, aldehydes, acids, and related esters evaluated by JECFA (61st and 68th meeting) structurally related to branched‐ and straight‐chain unsaturated carboxylic acids and esters of these with aliphatic saturated alcohols evaluated by EFSA in FGE.05Rev2 (2010) and to straight‐ and branched‐chain aliphatic unsaturated primary alcohols, aldehydes, carboxylic acids, and esters evaluated by EFSA in FGE.06Rev1 (2008) (Commission Regulation (EC) No 1565/2000 of 18 July 2000). Adopted on 26 November 2009. EFSA‐Q‐2009‐00907.
  23. EFSA , 2008aw. Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with food on a request from the Commission related to Flavouring Group Evaluation 75: Consideration of tetrahydrofuran derivatives and a furanone derivative evaluated by JECFA (63rdmeeting) structurally related to tetrahydrofurfuran derivatives evaluated by EFSA in FGE.33 (2008) (Commission Regulation (EC) No 1565/2000 of 18 July 2000). Adopted on 1 April 2008. EFSA‐Q‐2008‐059.
  24. EFSA , 2008az. Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with food on a request from the Commission related to Flavouring Group Evaluation 87: Consideration of bicyclic secondary alcohols, ketones and related esters evaluated by JECFA (63rd meeting) structurally related to bicyclic secondary alcohols, ketones and related esters evaluated by EFSA in FGE.47 (2008) (Commission Regulation (EC) No 1565/2000 of 18 July 2000). Adopted on 22 May 2008. EFSA‐Q‐2008‐071.
  25. EFSA , 2008bm. Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with food on a request from the Commission related to Flavouring Group Evaluation 79: Consideration of amino acids and related substances evaluated by JECFA (63rd meeting) structurally related to amino acids from chemical group 34 evaluated by EFSA in FGE.26Rev1 (2008) (Commission Regulation (EC) No 1565/2000 of 18 July 2000). Adopted on 29 November 2007. EFSA‐Q‐2008‐063.
  26. EFSA , 2008e. Minutes of the 30th Plenary meeting of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food, Held in Parma on 20–22 May 2008. Parma, 9 July 2008. [Online]. Available: www.efsa.europa.eu/cs/BlobServer/Event_Meeting/afc_minutes_30thplen_en.pdf?ssbinary=yrue
  27. EFSA , 2008j. Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with food on a request from the Commission related to Flavouring Group Evaluation 05, Revision 1: Esters of branched‐ and straight‐chain aliphatic saturated primary alcohols and of one secondary alcohol, and branched‐ and straight‐chain unsaturated carboxylic acids from chemical groups 1, 2, and 5 (Commission Regulation (EC) No 1565/2000 of 18 July). Adopted on 27 September 2007. EFSA‐Q‐2003‐148B.
  28. EFSA , 2008t. Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with food on a request from the Commission related to Flavouring Group Evaluation 24, Revision 1: Pyridine, pyrrole, indole and quinoline derivatives from chemical group 28 (Commission Regulation (EC) No 1565/2000 of 18 July). Adopted on 27 September 2007. EFSA‐Q‐2003‐167B.
  29. EFSA , 2008y. Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with food on a request from the Commission related to Flavouring Group Evaluation 52: Hydroxy‐ and alkoxy‐substituted benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters evaluated by EFSA in FGE.20 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000). Adopted on 3 July 2007. EFSA‐Q‐2008‐032C.
  30. EFSA , 2009af. Opinion of the Scientific Panel on Contact Materials, Enzymes, Flavourings and Processing Aids on a request from the Commission related to Flavouring Group Evaluation 54, Revision 1: Consideration of benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal. benzoic acids and related esters evaluated by EFSA in FGE.20Rev1 (Commission Regulation (EC) No 1565/2000 of 18 July 2000). Adopted on 26 March 2009. EFSA‐Q‐2009‐00483.
  31. EFSA , 2009aj. Opinion of the Scientific Panel on Contact Materials, Enzymes, Flavourings and Processing Aids on a request from the Commission related to Flavouring Group Evaluation 61, Revision 1: Consideration of aliphatic acetals evaluated by JECFA (57th meeting) structurally related to acetals of branched‐ and straight‐chain aliphatic saturated primary alcohols and branched‐ and straight‐chain saturated aldehydes and one orthoester of formic acid evaluated by EFSA in FGE.03Rev1 (2008) (Commission Regulation (EC) No 1565/2000 of 18 July 2000). Adopted on 26 March 2009. EFSA‐Q‐2009‐00484.
  32. EFSA , 2009ak. Opinion of the Scientific Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids on a request from the Commission related to Flavouring Group Evaluation 68 (FGE.68): Consideration of cinnamyl alcohol and related flavouring agents evaluated by JECFA (55th meeting) structurally related to aryl‐substituted saturated and unsaturated primary alcohol/aldehyde/acid/ester derivatives evaluated by EFSA in FGE.15Rev1 (2008). EFSA Journal 2009; 7 (11): 2009. [51 pp.]. doi:10.2903/j.efsa.2009.1032. Available online: www.efsa.europa.eu. Adopted on 26 March 2009. EFSA‐Q‐2008‐032T. [Google Scholar]
  33. EFSA , 2009aq. Opinion of the Scientific Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids on a request from the Commission related to Flavouring Group Evaluation 53, Revision 1 (FGE.53Rev1): Consideration of phenethyl alcohol, aldehyde, acid and related acetals and esters evaluated by JECFA (59th meeting) and stucturally related to phenethyl alcohol, aldehyde, esters and related phenylacetic acid esters evaluated by EFSA in FGE.14Rev1 (2009) and one phenoxyethyl ester evaluated in FGE.23Rev1 (2008) (Commission Regulation (EC) No 1565/2000 of 18 July 2000). Adopted on 26 March 2009. EFSA‐Q‐2009‐00482.
  34. EFSA , 2009at. Opinion of the Scientific Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids on a request from the Commission related to Flavouring Group Evaluation 70 (FGE.70): Consideration of aliphatic, alicyclic, linear, alpha, beta‐unsaturated, di‐ and trienals and related alcohols, acids and esters evaluated by JECFA (61st meeting) (Commission Regulation (EC) No 1565/2000 of 18 July 2000). Adopted on 23 July 2009. EFSA‐Q‐2008‐054.
  35. EFSA , 2009au. Opinion of the Scientific Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids on a request from the Commission related to Flavouring Group Evaluation 80, Revision 1 (FGE.80Rev1): Consideration of alicyclic, alicyclic‐fused and aromatic‐fused ring lactones evaluated by JECFA (61st meeting) structurally related to a aromatic lactone evaluated by EFSA in FGE.27 (2008) (Commission Regulation (EC) No 1565/2000 of 18 July 2000). Adopted on 17 June 2009. EFSA‐Q‐2009‐00559).
  36. EFSA , 2009i. Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with food on a request from the Commission related to Flavouring Group Evaluation 56: Consideration of monocyclic and alcohols, ketones and related esters evaluated by JECFA (63rd meeting) structurally related to secondary alicyclic saturated and unsaturated alcohols, ketones and esters containing secondary alicyclic alcohols and an ester of a phenol carboxylic acid evaluated by EFSA in FGE.09Rev1 (2008) (Commission Regulation (EC) No 1565/2000 of 18 July 2000). Adopted on 1 April 2008. EFSA‐Q‐2003‐032G.
  37. EFSA , 2009p. Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with food on a request from the Commission related to Flavouring Group Evaluation 64: Consideration of aliphatic acyclic diols, triols, and related substances evaluated by JECFA (57th meeting) structurally related to aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 evaluated by EFSA in FGE.10Rev1 (EFSA, 2008ab) (Commission Regulation (EC) No 1565/2000 of 18 July 2000). Adopted on 31 January 2008. EFSA‐Q‐2008‐032P.
  38. EFSA , 2009q. Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with food on a request from the Commission related to Flavouring Group Evaluation 77: Consideration of Pyridine, Pyrrole and Quinoline Derivatives evaluated by JECFA (63rd meeting) structurally related to Pyridine, Pyrrole, Indole and Quinoline Derivatives evaluated by EFSA in FGE.24Rev1 (2008) (Commission Regulation (EC) No 1565/2000 of 18 July 2000). Adopted on 31 January 2008. EFSA‐Q‐2008‐061.
  39. EFSA , 2010a. Opinion of the Scientific Panel on contact Materials, Enzymes, Flavourings and Processing Aids on a request from the Commission related to Flavouring Group Evaluation 71: Consideration of aliphatic, linear, alpha, beta‐unsaturated carboxylic acids and related esters evaluated by JECFA (63rd meeting) structurally related to esters of branched‐ and straight‐chain unsaturated carboxylic acids. Esters of these and straight‐chain aliphatic saturated alcohols evaluated by in FGE.05Rev2 (2009) (Commission Regulation (EC) No 1565/2000 of 18 July 2000). Adopted on 25 November 2009. EFSA‐Q‐2008‐055.
  40. EFSA , 2010b. Opinion of the Scientific Panel on contact Materials, Enzymes, Flavourings and Processing Aids on a request from the Commission related to Flavouring Group Evaluation 83Rev1: Consideration of ethyl maltol and two 6‐keto‐1, 4‐dioxane derivatives substances evaluated by JECFA (65th meeting) (Commission Regulation (EC) No 1565/2000 of 18 July 2000). Adopted on 25 November 2009. EFSA‐Q‐2008‐00909.
  41. Gessler NN, Bezzubov AA, Podlepa EM and Bykhovsky VY, 1991. Metabolism of S‐Methylmethionine (Vitamin U) in animals. Appl. Biochem. Microbiol., 27, 358–363. [PubMed] [Google Scholar]
  42. Gulati DK, Hope E, Barnes LH, Russel S and Poonacha KB, 1990a. Reproductive toxicity of ethylene glycol monomethyl ether (CAS No. 109–86‐4) in Sprague‐Dawley rats, litter two, 1‐76. Unpublished report from Environmental Health Research and Testing, Inc. (NTIS‐PB 90–252313), Springfield, Virginia, USA: Department of Commerce (as cited by JECFA, 2002a).
  43. Gulati DK, Hope E, Christman KL, Barnes LH and Russell S, 1990b. Reproductive toxicity of ethylene glycol monomethyl ether (CAS No. 109–86‐4) in Sprague‐Dawley rats, litter two, 1‐76. Unpublished report from Environmental Health Research and Testing, Inc. (NTIS‐PB 90–252321), Springfield, Virginia, USA: Department of Commerce (as cited by JECFA, 2002a).
  44. JECFA , 1974d. Toxicological evaluation of some anticaking agents, antimicrobials, antioxidants, emulsifiers and thickening agents. 1973. Toxicological monographs: WHO Food Additives Series, no. 5. [PubMed]
  45. JECFA , 1986a. Evaluation of certain food additives and contaminants. Twenty‐ninth Meeting of the Joint FAO/WHO Expert Committee on Food Additives. WHO Technical Report Series, no. 733. [PubMed]
  46. JECFA , 1995. Evaluation of certain food additives and contaminants. Forty‐fourth Meeting of the Joint FAO/WHO Expert Committee on Food Additives. 14–23 February 1995. WHO Technical Report Series, no. 859. Geneva.
  47. JECFA , 1996a. Toxicological evaluation of certain food additives. The forty‐fourth meeting of the Joint FAO/WHO Expert Committee on Food Additives and contaminants. WHO Food Additives Series: 35. IPCS, WHO, Geneva.
  48. JECFA , 1997a. Evaluation of certain food additives and contaminants. Forty‐sixth report of the Joint FAO/WHO Expert Committee on Food Additives. Geneva, 6–15 February 1996. WHO Technical Report Series, no. 868. Geneva. [PubMed]
  49. JECFA , 1999b. Evaluation of certain food additives and contaminants. Forty‐ninth report of the Joint FAO/WHO Expert Committee on Food Additives. Rome, 17–26 June 1997. WHO Technical Report Series, no. 884. Geneva. [PubMed]
  50. JECFA , 2000b. Evaluation of certain food additives and contaminants. Fifty‐third meeting of the Joint FAO/WHO Expert Committee on Food Additives. WHO Technical Report Series no. 896. Geneva, 1–10 June 1999.
  51. JECFA , 2002a. Safety evaluation of certain food additives and contaminants. Fifty‐seventh meeting of the Joint FAO/WHO Expert Committee on Food Additives. WHO Food Additives Series: 48. IPCS, WHO, Geneva.
  52. JECFA , 2002b. Evaluation of certain food additives and contaminants. Fifty‐seventh report of the Joint FAO/WHO Expert Committee on Food Additives. WHO Technical Report Series, no. 909. Geneva, 5–14 June 2001.
  53. JECFA , 2006b. Evaluation of certain food additives. Sixty‐fifth report of the Joint FAO/WHO Expert Committee on Food Additives. WHO Technical Report Series, no. 934. Geneva, 7–16 June 2005.
  54. JECFA , 2006c. Joint FAO/WHO Expert Committee on Food Additives. Sixty‐seventh meeting. Rome, 20–29 June 2006, Summary and Conclusions. Issued 7 July 2006.
  55. JECFA , 2006d. Safety evaluation of certain food additives and contaminants. Sixty‐fifth meeting of the Joint FAO/WHO Expert Committee on Food Additives, WHO Food Additives Series: 56. IPCS, WHO, Geneva.
  56. JECFA , 2007b. Evaluation of certain food additives. Sixty‐seventh report of the Joint FAO/WHO Expert Committee on Food Additives. WHO Technical Report Series, no. 940. DRAFT. Rome, 20–29 June 2005.
  57. Karlsson P, 1963. Introduction to modern biochemistry. Academic Press, New York. [Google Scholar]
  58. Lynch DW, Moorman TR, Lewis TR, Stober P, Hamlin RD and Schueler RL, 1990. Subchronic inhalation of triethylamine vapor in Fischer F344 rats: organ system toxicity. Toxicol. Ind. Health. 6, 403–414. [DOI] [PubMed] [Google Scholar]
  59. Moore GE, 2002. 28‐dietary toxicity study in rodents. Study No. 11326. Product Safety Labs, East Brunswick, New Jersey, USA. Unpublished report to the Flavor Manufacturers Association. Submitted to WHO by the Flavor and Extract Manufacturers Association of the United States, Washington DC, USA.
  60. Morgareidge K and Oser BL, 1970g. 90‐Day feeding studies in rats with 2,2′dithiodithiophene (2‐thienyldisulfide). Food and Drug Research Laboratories, Inc. Lab. no. 0034. August 24, 1970. Unpublished report submitted by EFFA to FLAVIS Secretariat.
  61. Peano S, 1981. Thirtheen week repeated dose study of the test article TT189 (4‐acetyl‐2‐methylpyrimidine) orally administered to Sprague Dawley Charles Riover CD (SD) BR rats at the doseage of 1 mg/kg/d. as cited by EFSA (FGE.XX)). Unpublished report by Instituto di Richerche Biomediche. Submitted to WHO by the Flavor and Extract Manufacterers Association of the United States, Washington DC, USA. As cited by JECFA (FAS 56).
  62. Posternak NM, Linder A and Vodoz CA, 1969. Summaries of toxicological data. Toxicological tests on flavouring matters. Food Cosmet. Toxicol. 7, 405–407. [DOI] [PubMed] [Google Scholar]
  63. Posternak JM, Dufour JJ, Rogg C and Vodoz CA, 1975. Summaries of toxicological data. Toxicological tests on flavouring matters. II. Pyrazines and other compounds. Food Cosmet. Toxicol. 13, 487–490. [DOI] [PubMed] [Google Scholar]
  64. SCF , 1999a. Opinion on a programme for the evaluation of flavouring substances (expressed on 2 December 1999). Scientific Committee on Food. SCF/CS/FLAV/TASK/11 Final 6/12/1999. Annex I the minutes of the 119th Plenary meeting. European Commission, Health & Consumer Protection Directorate‐General.
  65. Shellenberger TE, 1970g. Subacute toxicity evaluation of 2‐methyl‐5, 7‐dihydrothieno(3,4‐d)pyrimidine with rats. Gulf South research Institute. Unpublished report to the Flavor and extract Manufacturers Association. Submitted to WHO by the Flavor and Extract Manufacterers Association of the United States, Washington DC, USA. As cited by JECFA (FAS 56).
  66. Til HP and van der Meulen HC, 1971. Subchronic (90‐day) toxicity study with 2‐acetylpyridine in albino rats. Centraal Instituut Voor Voedingsonderzioek, Netherlands. Report no. R3373. February, 1971. Unpublished report submitted by EFFA to FLAVIS Secretariat.
  67. Voet D and Voet JG, 2004. Biochemistry. John Wiley & Sons, New York. [DOI] [PubMed] [Google Scholar]
  68. Wheldon GH, Amyes SJ, Street AE, Hague PH and Mawdesley‐Thomas LE, 1970. Toxicity of Wa 4295, Sa 927, Stl 3048, and Wa 3328 in dietary administration to rats over a period of 13 weeks. Huntingdon Research Centre. 17 April, 1970. Unpublished report submitted by EFFA to SCF.

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