Retraction: Hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of Alzheimer’s disease

This is a retraction of Ramesh Kandimalla, Maria Manczak, Xiangling Yin, Rui Wang, P. Hemachandra Reddy, Hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of Alzheimer’s disease, Human Molecular Genetics, Volume 27, Issue 1, 12 October 2017, Pages 30–40, https://doi.org/10.1093/hmg/ddx381

In March 2025, a reader contacted the journal with concerns about the wild-type data presented in Figure 1B, C, and D in this article. In June 2025, the Editors published an expression of concern¹ while they investigated these concerns in line with COPE guidance.

The journal contacted the authors who indicated that wild-type mouse data had been reused across three articles published in the journal, and the results were not consistent for all measures in the three articles, with the Wild-type results for the Morris Water Maze Test being different in Manczak, et al.² Although the authors previously explained that the wild-type mouse data had been reused, the Editors consulted with an independent reviewer and disagreed with the data re-use and found the discrepancies between latency and speed data (also in Manczak et al.), which are inherently connected, problematic. Considering this and the two other articles, the Editors no longer have confidence in the data and results presented in the article.

The journal has notified all authors of this decision prior to publication of this retraction notice, and they disagree with the decision to retract.