Abstract
The contention of the author is that an informatics infrastructure is essential for evidenced-based practice. Five building blocks of an informatics infrastructure for evidence-based practice are proposed: 1) standardized terminologies and structures, 2) digital sources of evidence, 3) standards that facilitate health care data exchange among heterogeneous systems, 4) informatics processes that support the acquisition and application of evidence to a specific clinical situation, and 5) informatics competencies. Selected examples illustrate how each of these building blocks supports the application of evidence to practice and the building of evidence from practice. Although a number of major challenges remain, medical informatics can provide solutions that have the potential to decrease unintended variation in practice and health care errors.
A number of authors have highlighted the ubiquity of variation in practice and have urged that clinicians move toward evidence-based practice.1–4 However, a number of barriers have been identified. These include the rapid rate of medical knowledge development, inadequate access to clinically relevant information at the point of need, increased workload and patient complexity, and difficulty translating the evidence for use with a particular patient.5–8
While recognizing that medical informatics is not the panacea for reducing all barriers to evidence-based practice, the contention of the author is that an informatics infrastructure is essential for such practice. This contention is based on two underlying premises. First, in contrast to traditional conceptualizations of evidence-based practice, which typically refer to randomized clinical trials, systematic reviews, and practice guidelines as the sources of evidence that are integrated with clinical expertise for practice decisions,9 evidence is more broadly conceptualized as a continuum of synthesized information. This continuum ranges from the “gold standard” of randomized clinical trial findings to aggregated data from the encounters of an individual clinician or experiences of an individual client. This is consistent with the vision of informatics pioneer Marsden Scott Blois, who stated that clinicians at the point of care should be able to query a database to answer questions such as “What did I do the last time I saw a similar patient?”10 Second, most definitions of evidence-based practice (e.g., those given by Sackett et al.9 and Friedland11) focus on accessing, critically analyzing, and applying evidence to practice. In contrast, the second underlying premise of the author is that an informatics infrastructure for evidence-based practice must also facilitate the building of evidence from clinical practice.
Five components are proposed as the building blocks of an informatics infrastructure for evidence-based practice: 1) standardized terminologies and structures (i.e., terminology models), 2) digital sources of evidence, 3) standards that facilitate health care data exchange among heterogeneous systems, 4) informatics processes that support the acquisition and application of evidence to a specific clinical situation, and 5) informatics competencies. Table 1▶ displays selected examples of how the building blocks support the application of evidence to practice and the generation of evidence from practice.
Table 1.
Examples of How Proposed Building Blocks of an Informatics Infrastructure for Evidence-based Practice Support Applying Evidence to Practice and Building Evidence from Practice
Building Block | Applying Evidence to Practice | Building Evidence from Practice |
---|---|---|
Standardized terminologies and structures | Provide basis for indexing digital sources of evidence and matching sources to clinician-specific needs | Facilitate the creation of “computable” electronic patient records |
Standards for representation of knowledge facilitate the application of decision support rules | Formalize the documentation of the clinical decision-making process | |
“Computable” representations of terminol- ogies support data aggregation and re-use across heterogeneous representations | ||
Digital sources of evidence | Provide access to evidence | Acquire, monitor, and transform physiologic data in real time. |
Data exchange standards | Support the communication among computer- based systems to bring together patient data and decision logic | Support aggregation of data across time and geography to link process to outcomes |
Facilitate the delivery of tailored health-related messages based on patient-specific data. | ||
Informatics processes | Integrate and link heterogeneous sources of evidence | Perform data modeling and aggregation in clinical data respositories |
Present clinician alerts related to potential adverse events | Perform data mining | |
Use decision analytic techniques to tailor evidence to specific patients | ||
Informatics competencies | Retrieve clinically relevant sources of evidence through the use of search tools | Analyze individual practice patterns over time from clinical data repository |
Perform critical analysis of evidence for its applicability to practice | Evaluate effects of evidence-based practice recommendations in the clinical setting |
Tremendous progress in the development of the individual building blocks of an informatics infrastructure for evidence-based practice has occurred. In particular, sources of digital knowledge have rapidly increased. Representative sources are shown in Table 2▶ .
Table 2.
Examples of Types and Sources of Digital Evidence
Types | Sources |
---|---|
Bibliographic: | |
Primary literature— | |
Traditional | medline, Cumulative Index of Nursing and Allied Health Literature (cinahl) |
Full text | OVID database; individual journals (e.g., British Medical Journal, Australian Electronic Journal of Nursing Education) |
Structured reporting | Trial bank |
Synthesized— | |
Electronic textbooks | Harrison's Principles of Medicine, Kaplan and Sadock's Comprehensive Textbook of Psychiatry |
Systematic reviews | Cochrane Collaboration, Joanna Briggs Institute for Evidence-based Nursing & Midwifery |
Practice parameters: | |
Standards of care | American Association of Critical Care Nurses |
Practice guidelines | National Guideline Clearinghouse, American Academy of Pediatrics |
Disease management plans | American Diabetes Association |
Comparative databases: | National Nursing Quality Indicator Database, Health Plan Employer Data and Information Set (HEDIS); California Office of Statewide Health Planning and Development |
Knowledge bases: | |
Diagnostic decision support | DXplain, Iliad |
Pharmacy | National Drug Data File, Micromedix |
Genomic | Genbank, Molecular Modeling Database |
However, major challenges remain. These include:
Development of business models that support cost-effective and efficient development and dissemination of high-quality digital sources of evidence12
Achievement of consensus standards for describing, organizing, obtaining access to, and archiving electronic information sources12
Optimization of information retrieval strategies for clinical relevance8,13
Integration of the evidence-based practice infrastructure building blocks to support the context-specific retrieval and application of evidence in practice and to facilitate the development of evidence from practice
Incorporation of principles of evidence-based practice and the supporting informatics tools into clinical processes and organizational structures
Development of informatics competencies related to evidence-based practice in the health care professional work force
Although these challenges are not small, they suggest areas in which medical informatics can contribute solutions that have the potential to decrease unintended variation in practice and health care errors.
Acknowledgments
The author thanks participants in the IMIA Nursing Informatics Postconference, May 2000, in Rotorua, New Zealand, for their thoughtful discussion and comments on the presentation of an earlier draft.
This paper is based on a presentation given at the IMIA Nursing Informatics Postconference, May 2000, in Rotorua, New Zealand. Its preparation was supported by grant NR04423 from the National Institutes of Health.
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