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. 1977;75:285–315.

The Seventh Frederick H. Verhoeff Lecture. Collagenase and collagenase inhibitors.

J François
PMCID: PMC1311552  PMID: 206998

Abstract

Besides EDTA and cysteine, cystine and penicillamine are the best collagenase inhibitors. The collagenase is produced by the leucocytes. The action mechanism of the collagenase inhibitors is due to the chelation of Zn ions. The best clinical indications for collagenase inhibitors are punctate epithelial keratitis, chemical burns, recurrent corneal erosions in keratoconus, trophic postinfectious ulcerations of the cornea (metaherpetic ulcers), and descemetoceles.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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