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. 1979;77:367–421.

The association of viruses with urveal melanoma.

D M Albert
PMCID: PMC1311713  PMID: 545833

Abstract

Electron microscopic examination of 57 ocular melanomas (54 human, two feline and one canine) revealed the presence of viral particles in six specimens. Herpesviruses particles were observed in one human specimen and were passed in human fibroblasts (WI-38), where they gave rise to intranuclear inclusions. A-type oncornavirus particles (oncogenic RNA virus) were observed in a second case, both in cells of tumor directly removed from an enucleated eye as well as in cells grown in tissue culture. In three human specimens and one feline specimen, togavirus particles were observed. Rubella is a member of this group, and the possibility that the presence of togavirus in these tumors is the result of latent ocular infection by rubella virus is raised. Herpes virus and RNA tumor viruses are widely considered as having a possible etiologic role for certain human cancers. The observation of togavirus is unexpected, as this virus has not been previously implicated in human or animal tumors. Injection of an RNA tumor virus (Gardner strain feline sarcoma virus) into the anterior chamber of newborn kittens resulted in the development of iris and ciliary body melanomas, many of which showed invasion and, in one instance, metastasis. This is the first animal model of a viral-induced uveal melanoma, and the histology and ultrastructure are described. These results emphasize the need for the continued investigation of the role of these viruses in uveal melanoma.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aaronson S. A., Todaro G. J., Freeman A. E. Human sarcoma cells in culture. Identification by colony-forming ability on monolayers of normal cells. Exp Cell Res. 1970 Jul;61(1):1–5. doi: 10.1016/0014-4827(70)90250-8. [DOI] [PubMed] [Google Scholar]
  2. Adam E., Rawls W. E., Melnick J. L. The association of herpesvirus type 2 infection and cervical cancer. Prev Med. 1974 Mar;3(1):122–141. doi: 10.1016/0091-7435(74)90068-1. [DOI] [PubMed] [Google Scholar]
  3. Albert D. M., Lahav M., Colby E. D., Shadduck J. A., Sang D. N. Retinal neoplasia and dysplasia. I. Induction by feline leukemia virus. Invest Ophthalmol Vis Sci. 1977 Apr;16(4):325–337. [PubMed] [Google Scholar]
  4. Albert D. M., Rabson A. S., Dalton A. J. In vitro neoplastic transformation of uveal and retinal tissue by oncogenic DNA viruses. Invest Ophthalmol. 1968 Aug;7(4):357–365. [PubMed] [Google Scholar]
  5. Albert D. M., Rabson A. S., Grimes P. A., Von Sallmann L. Neoplastic transformation in vitro of hamster lens epithelium by simian virus 40. Science. 1969 May 30;164(3883):1077–1078. doi: 10.1126/science.164.3883.1077. [DOI] [PubMed] [Google Scholar]
  6. Albert D. M., Rabson A. S. The role of viruses in the pathogenesis of ocular tumors. Int Ophthalmol Clin. 1972 Spring;12(1):195–224. [PubMed] [Google Scholar]
  7. Albert D. M., Spencer W. H. Toward a cure for eye cancers. Arch Ophthalmol. 1973 Aug;90(2):89–89. doi: 10.1001/archopht.1973.01000050091001. [DOI] [PubMed] [Google Scholar]
  8. Albert D. M., Tso M. O., Rabson A. S. In vitro growth of pure cultures of retinal pigment epithelium. Arch Ophthalmol. 1972 Jul;88(1):63–69. doi: 10.1001/archopht.1972.01000030065014. [DOI] [PubMed] [Google Scholar]
  9. Aoki T., Walling M. J., Bushar G. S., Liu M., Hsu K. C. Natural antibodies in sera from healthy humans to antigens on surfaces of type C RNA viruses and cells from primates. Proc Natl Acad Sci U S A. 1976 Jul;73(7):2491–2495. doi: 10.1073/pnas.73.7.2491. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Arya S. K., Zeigel R. F., Horoszewicz J. S., Carter W. A. RNA tumor virus-like activities in human solid tissues: endogenous RNA:DNA polymerase activities in the prostate. J Surg Oncol. 1976;8(4):321–332. doi: 10.1002/jso.2930080411. [DOI] [PubMed] [Google Scholar]
  11. Aurelian L., Schumann B., Marcus R. L., Davis H. J. Antibody to HSV-2 induced tumor specific antigens in serums from patients with cervical carcinoma. Science. 1973 Jul 13;181(4095):161–164. doi: 10.1126/science.181.4095.161. [DOI] [PubMed] [Google Scholar]
  12. Aurelian L., Strnad B. C. Herpesvirus type 2-related antigens and their relevance to humoral and cell-mediated immunity in patients with cervical cancer. Cancer Res. 1976 Feb;36(2 Pt 2):810–820. [PubMed] [Google Scholar]
  13. Axel R., Gulati S. C., Spiegelman S. Particles containing RNA-instructed DNA polymerase and virus-related RNA in human breast cancers. Proc Natl Acad Sci U S A. 1972 Nov;69(11):3133–3137. doi: 10.1073/pnas.69.11.3133. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. BERNHARD W. The detection and study of tumor viruses with the electron microscope. Cancer Res. 1960 Jun;20:712–727. [PubMed] [Google Scholar]
  15. BIERRING F., EGEBERG J., JENSEN O. A. ELECTRON MICROSCOPY OF A MALIGNANT MELANOMA OF THE CHOROID. Acta Ophthalmol (Copenh) 1963;41:224–235. doi: 10.1111/j.1755-3768.1963.tb02431.x. [DOI] [PubMed] [Google Scholar]
  16. BIERRING F., JENSEN O. A. ELECTRON MICROSCOPY OF MELANOMAS OF THE HUMAN UVEAL TRACT: THE ULTRASTRUCTURE OF FOUR MALIGNANT MELANOMAS OF THE MIXED CELL TYPE. Acta Ophthalmol (Copenh) 1964;42:665–671. doi: 10.1111/j.1755-3768.1964.tb00916.x. [DOI] [PubMed] [Google Scholar]
  17. BINGGELI M. F. Abnormal intranuclear and cytoplasmic formations associated with a chemically induced, transplantable chicken sarcoma. J Biophys Biochem Cytol. 1959 Jan 25;5(1):143–152. doi: 10.1083/jcb.5.1.143. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Balda B. R., Hehlmann R., Cho J. R., Spiegelman S. Oncornavirus-like particles in human skin cancers. Proc Natl Acad Sci U S A. 1975 Sep;72(9):3697–3700. doi: 10.1073/pnas.72.9.3697. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Baltimore D. RNA-dependent DNA polymerase in virions of RNA tumour viruses. Nature. 1970 Jun 27;226(5252):1209–1211. doi: 10.1038/2261209a0. [DOI] [PubMed] [Google Scholar]
  20. Bauer G. RNA-dependent DNA polymerase (reverse transcriptase). Blut. 1977 Jul 20;35(1):3–9. doi: 10.1007/BF01006959. [DOI] [PubMed] [Google Scholar]
  21. Benveniste R. E., Todaro G. J. Evolution of type C viral genes: evidence for an Asian origin of man. Nature. 1976 May 13;261(5556):101–108. doi: 10.1038/261101a0. [DOI] [PubMed] [Google Scholar]
  22. Bolognesi D. P., Montelaro R. C., Frank H., Schäfer W. Assembly of type C oncornaviruses: a model. Science. 1978 Jan 13;199(4325):183–186. doi: 10.1126/science.202022. [DOI] [PubMed] [Google Scholar]
  23. Boulanger P. A., Torpier G., Biserte G. Investigation on intranuclear paracrystalline inclusions induced by adenovirus 5 in KB cells. J Gen Virol. 1970 Feb;6(2):329–332. doi: 10.1099/0022-1317-6-2-329. [DOI] [PubMed] [Google Scholar]
  24. Brodsky I., Fuscaldo A. A., Erlick B. J., Fuscaldo K. E. Effect of busulfan on oncornavirus-like activity in platelets and chromosomes in polycythemia vera and essential thrombocythemia. J Natl Cancer Inst. 1977 Jul;59(1):61–67. doi: 10.1093/jnci/59.1.61. [DOI] [PubMed] [Google Scholar]
  25. Bronson D. L., Ritzi D. M., Fraley E. E., Dalton A. J. Morphologic evidence for retrovirus production by epithelial cells derived from a human testicular tumor metastasis. J Natl Cancer Inst. 1978 Jun;60(6):1305–1308. doi: 10.1093/jnci/60.6.1305. [DOI] [PubMed] [Google Scholar]
  26. Calafat J., Ressang A. A. Morphogenesis of bovine leukemia virus. Virology. 1977 Jul 1;80(1):42–53. doi: 10.1016/0042-6822(77)90379-8. [DOI] [PubMed] [Google Scholar]
  27. Chandra P. Search for RNA tumor viruses in human malignancy. Naturwissenschaften. 1976 Sep;63(9):431–431. doi: 10.1007/BF00599413. [DOI] [PubMed] [Google Scholar]
  28. Chandra P., Steel L. K. Purification, biochemical characterization and serological analysis of cellular deoxyribonucleic acid polymerases and a reverse transcriptase from spleen of a patient with myelofibrotic syndrome. Biochem J. 1977 Dec 1;167(3):513–524. doi: 10.1042/bj1670513f. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Chopra H. C., Mason M. M. A new virus in a spontaneous mammary tumor of a rhesus monkey. Cancer Res. 1970 Aug;30(8):2081–2086. [PubMed] [Google Scholar]
  30. Coates H. L., Pearson G. R., Neel H. B., 3rd, Weiland L. H., Devine K. D. An immunologic basis for detection of occult primary malignancies of the head and neck. Cancer. 1978 Mar;41(3):912–918. doi: 10.1002/1097-0142(197803)41:3<912::aid-cncr2820410319>3.0.co;2-5. [DOI] [PubMed] [Google Scholar]
  31. Colcher D., Spiegelman S., Schlom J. Sequence homology between the RNA of Mason-Pfizer monkey virus and the RNA of human malignant breast tumors. Proc Natl Acad Sci U S A. 1974 Dec;71(12):4975–4979. doi: 10.1073/pnas.71.12.4975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Cook B., O'Sullivan F., Leung J., Morse P., Graham B., Chapman A. L. Transformation of human embryo cells with the use of cell-free extracts of a human rhabdomyosarcoma cell line (HUS-2): brief communication. J Natl Cancer Inst. 1978 May;60(5):979–984. doi: 10.1093/jnci/60.5.979. [DOI] [PubMed] [Google Scholar]
  33. Corallini A., Barbanti-Brodano G., Bortoloni W., Nenci I., Cassai E., Tampieri M., Portolani M., Borgatti M. High incidence of ependymomas induced by BK virus, a human papovavirus: brief communication. J Natl Cancer Inst. 1977 Nov;59(5):1561–1564. doi: 10.1093/jnci/59.5.1561. [DOI] [PubMed] [Google Scholar]
  34. Corallini A., Barbanti-Brodano G., Portolani M., Balboni P. G., Grossi M. P., Possati L., Honorati C., La Placa M., Mazzoni A., Caputo A. Antibodies to BK virus structural and tumor antigens in human sera from normal persons and from patients with various diseases, including neoplasia. Infect Immun. 1976 Jun;13(6):1684–1691. doi: 10.1128/iai.13.6.1684-1691.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Cotter S. M. Feline leukemia virus induced disorders in the cat. Vet Clin North Am. 1976 Aug;6(3):367–378. doi: 10.1016/s0091-0279(76)50055-4. [DOI] [PubMed] [Google Scholar]
  36. Cuatico W., Cheung C. H., Sy F. Detection of viral-like cores from the urine of patients with genito-urinary malignancies. Cancer. 1978 Feb;41(2):706–711. doi: 10.1002/1097-0142(197802)41:2<706::aid-cncr2820410242>3.0.co;2-p. [DOI] [PubMed] [Google Scholar]
  37. Cuatico W., Woldron R., Jr, Tyschenko W. Biochemical evidence for viral-like characteristics in cerebrospinal fluids of brain tumor patients. Cancer. 1977 May;39(5):2240–2246. doi: 10.1002/1097-0142(197705)39:5<2240::aid-cncr2820390542>3.0.co;2-p. [DOI] [PubMed] [Google Scholar]
  38. Darai G., Braun R., Flügel R. M., Munk K. Malignant transformation of rat embryo fibroblasts by herpes simplex virus types 1 and 2 at suboptimal temperature. Nature. 1977 Feb 24;265(5596):744–746. doi: 10.1038/265744a0. [DOI] [PubMed] [Google Scholar]
  39. Darai G., Munk K. Neoplastic transformation of rat embryo cells with herpes simplex virus. Int J Cancer. 1976 Oct 15;18(4):469–481. doi: 10.1002/ijc.2910180412. [DOI] [PubMed] [Google Scholar]
  40. David-West T. S., Isoun T. T., David-West A. S. Effect of route of inoculation on histopathological changes induced in mice by dugbe virus (a Nigerian tick-borne virus). Br J Exp Pathol. 1974 Aug;55(4):421–426. [PMC free article] [PubMed] [Google Scholar]
  41. De Noronha F., Post J. E., Norcross N. L., Rickard C. G. Induction of group-specific interspecies antibody in a cat by immunization with disrupted feline leukaemia virus. Nat New Biol. 1972 Jan 5;235(53):14–15. doi: 10.1038/newbio235014a0. [DOI] [PubMed] [Google Scholar]
  42. Dirksen E. R., Levy J. A. Virus-like particles in placentas from normal individuals and patients with systemic lupus erythematosus. J Natl Cancer Inst. 1977 Oct;59(4):1187–1192. doi: 10.1093/jnci/59.4.1187. [DOI] [PubMed] [Google Scholar]
  43. Dougherty E., 3rd Comments on electron microscopy of feline leukemia and sarcoma viruses. J Am Vet Med Assoc. 1971 Mar 15;158(6 Suppl):1116+–1116+. [PubMed] [Google Scholar]
  44. Dougherty E., 3rd, Rickard C. G. Ultrastructural studies of feline leukemia virus. J Ultrastruct Res. 1970 Sep;32(5):472–476. doi: 10.1016/s0022-5320(70)80023-5. [DOI] [PubMed] [Google Scholar]
  45. Duff R., Rapp F. Properties of hamster embryo fibroblasts transformed in vitro after exposure to ultraviolet-irradiated herpes simplex virus type 2. J Virol. 1971 Oct;8(4):469–477. doi: 10.1128/jvi.8.4.469-477.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  46. Dumont J., Liabeuf A., Henle W., Feingold N., Kourilsky F. M. Anti-EBV antibody titers in non-Hodgkin lymphomas. Int J Cancer. 1976 Jul 15;18(1):14–23. doi: 10.1002/ijc.2910180104. [DOI] [PubMed] [Google Scholar]
  47. EPSTEIN M. A., ACHONG B. G., BARR Y. M. VIRUS PARTICLES IN CULTURED LYMPHOBLASTS FROM BURKITT'S LYMPHOMA. Lancet. 1964 Mar 28;1(7335):702–703. doi: 10.1016/s0140-6736(64)91524-7. [DOI] [PubMed] [Google Scholar]
  48. Essex M., Cotter S. M., Sliski A. H., Hardy W. D., Jr, Stephenson J. R., Aaronson S. A., Jarrett O. Horizontal transmission of feline leukemia virus under natural conditions in a feline leukemia cluster household. Int J Cancer. 1977 Jan;19(1):90–96. doi: 10.1002/ijc.2910190113. [DOI] [PubMed] [Google Scholar]
  49. Essex M. Horizontally and vertically transmitted oncornaviruses of cats. Adv Cancer Res. 1975;21:175–248. doi: 10.1016/s0065-230x(08)60973-2. [DOI] [PubMed] [Google Scholar]
  50. FELDHERR C. M. The nuclear annuli as pathways for nucleocytoplasmic exchanges. J Cell Biol. 1962 Jul;14:65–72. doi: 10.1083/jcb.14.1.65. [DOI] [PMC free article] [PubMed] [Google Scholar]
  51. FRANCOIS J., RABAEY M., LAGASSE A. Examen au microscope électronique d'un sarcome de l'uvée. Ophthalmologica. 1959 Feb;137(2):65–73. doi: 10.1159/000303482. [DOI] [PubMed] [Google Scholar]
  52. Finch J. T., Klug A. The structure of viruses of the papilloma-polyoma type 3. Structure of rabbit papilloma virus, with an appendix on the topography of contrast in negative-staining for electron-microscopy. J Mol Biol. 1965 Aug;13(1):1–12. doi: 10.1016/s0022-2836(65)80075-4. [DOI] [PubMed] [Google Scholar]
  53. Francis D. P., Essex M., Hardy W. D., Jr Excretion of feline leukaemia virus by naturally infected pet cats. Nature. 1977 Sep 15;269(5625):252–254. doi: 10.1038/269252a0. [DOI] [PubMed] [Google Scholar]
  54. Fridlender B., Asher Y., Weinberg-Zahlering E., Becker Y. Interaction of ultraviolet-irradiated herpes simplex virus type 1 with BSC-1 cells. J Gen Virol. 1978 May;39(2):371–375. doi: 10.1099/0022-1317-39-2-371. [DOI] [PubMed] [Google Scholar]
  55. Friedrich E. G., Jr, Kaufman R. H., Lynch P. J., Woodruff D. Vulvar histology after neutral red photoinactivation of herpes simplex virus. Obstet Gynecol. 1976 Nov;48(5):564–570. [PubMed] [Google Scholar]
  56. Friend D. S. Cytochemical staining of multivesicular body and golgi vesicles. J Cell Biol. 1969 Apr;41(1):269–279. doi: 10.1083/jcb.41.1.269. [DOI] [PMC free article] [PubMed] [Google Scholar]
  57. Furlong D., Swift H., Roizman B. Arrangement of herpesvirus deoxyribonucleic acid in the core. J Virol. 1972 Nov;10(5):1071–1074. doi: 10.1128/jvi.10.5.1071-1074.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  58. GRANBOULAN N., TOURNIER P., WICKER R., BERNHARD W. An electron microscope study of the development of SV40 virus. J Cell Biol. 1963 May;17:423–441. doi: 10.1083/jcb.17.2.423. [DOI] [PMC free article] [PubMed] [Google Scholar]
  59. GROSS L. A filterable agent, recovered from Ak leukemic extracts, causing salivary gland carcinomas in C3H mice. Proc Soc Exp Biol Med. 1953 Jun;83(2):414–421. doi: 10.3181/00379727-83-20376. [DOI] [PubMed] [Google Scholar]
  60. Gardner S. D., Field A. M., Coleman D. V., Hulme B. New human papovavirus (B.K.) isolated from urine after renal transplantation. Lancet. 1971 Jun 19;1(7712):1253–1257. doi: 10.1016/s0140-6736(71)91776-4. [DOI] [PubMed] [Google Scholar]
  61. Geder K. M., Lausch R., O'Neill F., Rapp F. Oncogenic transformation of human embryo lung cells by human cytomegalovirus. Science. 1976 Jun 11;192(4244):1134–1137. doi: 10.1126/science.179143. [DOI] [PubMed] [Google Scholar]
  62. Geder L., Sanford E. J., Rohner T. J., Rapp F. Cytomegalovirus and cancer of the prostate: in vitro transformation of human cells. Cancer Treat Rep. 1977 Mar-Apr;61(2):139–146. [PubMed] [Google Scholar]
  63. Ghadially F. N., Parry E. W. Ultrastructure of a human hepatocellular carcinoma and surrounding non-neoplastic liver. Cancer. 1966 Dec;19(12):1989–2004. doi: 10.1002/1097-0142(196612)19:12<1989::aid-cncr2820191226>3.0.co;2-r. [DOI] [PubMed] [Google Scholar]
  64. Glaser R., Nonoyama M., Hampar B., Croce C. M. Studies on the association of the Epstein-Barr virus genome and human chromosomes. J Cell Physiol. 1978 Sep;96(3):319–325. doi: 10.1002/jcp.1040960307. [DOI] [PubMed] [Google Scholar]
  65. Green M. R., Mackey J. K., Green M. Multiple copies of human adenovirus 12 genomes are integrated in virus-induced hamster tumors. J Virol. 1977 Apr;22(1):238–242. doi: 10.1128/jvi.22.1.238-242.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  66. Green M. Adenoviruses-model systems of virus replication, human cell molecular biology, and neoplastic transformation. Perspect Biol Med. 1978 Spring;21(3):373–397. doi: 10.1353/pbm.1978.0024. [DOI] [PubMed] [Google Scholar]
  67. Greenberg S. D., Smith M. N., Spjut H. J. Bronchiolo-alveolar carcinoma-cell of origin. Am J Clin Pathol. 1975 Feb;63(2):153–167. doi: 10.1093/ajcp/63.2.153. [DOI] [PubMed] [Google Scholar]
  68. Gross L. Editorial: The role of C-type and other oncogenic virus particles in cancer and leukemia. N Engl J Med. 1976 Mar 25;294(13):724–725. doi: 10.1056/NEJM197603252941313. [DOI] [PubMed] [Google Scholar]
  69. Gross L. Facts and theories on viruses causing cancer and leukemia. Proc Natl Acad Sci U S A. 1974 May;71(5):2013–2017. doi: 10.1073/pnas.71.5.2013. [DOI] [PMC free article] [PubMed] [Google Scholar]
  70. HOGAN M. J., FEENEY L. Ultrastructure of malignant melanomas of the choroid. Invest Ophthalmol. 1962 Aug;1:544–555. [PubMed] [Google Scholar]
  71. HUEBNER R. J., ROWE W. P., LANE W. T. Oncogenic effects in hamsters of human adenovirus types 12 and 18. Proc Natl Acad Sci U S A. 1962 Dec 15;48:2051–2058. doi: 10.1073/pnas.48.12.2051. [DOI] [PMC free article] [PubMed] [Google Scholar]
  72. Hampar B., Hatanaka M., Aulakh G., Derge J. G., Lee L., Showalter S. Type C virus activation in "nontransformed" mouse cells by uv-irradiated herpes simplex virus. Virology. 1977 Feb;76(2):876–881. doi: 10.1016/0042-6822(77)90269-0. [DOI] [PubMed] [Google Scholar]
  73. Heine U. I., Todaro G. J. New type B retrovirus isolates associated with kinetochores and centrioles of the host cell. J Gen Virol. 1978 Apr;39(1):41–52. doi: 10.1099/0022-1317-39-1-41. [DOI] [PubMed] [Google Scholar]
  74. Henderson B. E., Louie E. W., Jing J. S., Alena B. Epstein-Barr virus and nasopharyngeal carcinoma: is there an etiologic relationship? J Natl Cancer Inst. 1977 Nov;59(5):1393–1395. doi: 10.1093/jnci/59.5.1393. [DOI] [PubMed] [Google Scholar]
  75. Henle W., Henle G. Evidence for an etiologic relation of the Epstein-Barr virus to human malignancies. Laryngoscope. 1977 Apr;87(4 Pt 1):467–473. doi: 10.1288/00005537-197704000-00001. [DOI] [PubMed] [Google Scholar]
  76. Hirsch M. S., Kelly A. P., Chapin D. S., Fuller T. C., Black P. H., Kurth R. Immunity to antigens associated with primate C-type oncoviruses in pregnant women. Science. 1978 Mar 24;199(4335):1337–1340. doi: 10.1126/science.204010. [DOI] [PubMed] [Google Scholar]
  77. Honess R. W., Watson D. H. Unity and diversity in the herpesviruses. J Gen Virol. 1977 Oct;37(1):15–37. doi: 10.1099/0022-1317-37-1-15. [DOI] [PubMed] [Google Scholar]
  78. Hsiung G. D. Virological studies of guinea pig leukemia: an overview with reference to herpesvirus and oncornavirus. Fed Proc. 1977 Aug;36(9):2285–2289. [PubMed] [Google Scholar]
  79. Huang E. S., Roche J. K. Cytomegalovirus D.N.A. and adenocarcinoma of the colon: Evidence for latent viral infection. Lancet. 1978 May 6;1(8071):957–960. doi: 10.1016/s0140-6736(78)90248-9. [DOI] [PubMed] [Google Scholar]
  80. Huebner R. J., Todaro G. J. Oncogenes of RNA tumor viruses as determinants of cancer. Proc Natl Acad Sci U S A. 1969 Nov;64(3):1087–1094. doi: 10.1073/pnas.64.3.1087. [DOI] [PMC free article] [PubMed] [Google Scholar]
  81. Ito R., Mishima Y. Particles in the cisternae of the endoplasmic reticulum of Fortner's amelanotic and melanotic malignant melanomas. J Invest Dermatol. 1967 Mar;48(3):268–272. doi: 10.1038/jid.1967.45. [DOI] [PubMed] [Google Scholar]
  82. Iwamoto T., Jones I. S., Howard G. M. Ultrastructural comparison of spindle A, spindle B, and epithelioid-type cells in uveal malignant melanoma. Invest Ophthalmol. 1972 Nov;11(11):873–889. [PubMed] [Google Scholar]
  83. JARRETT W. F., CRAWFORD E. M., MARTIN W. B., DAVIE F. A VIRUS-LIKE PARTICLE ASSOCIATED WITH LEUKEMIA (LYMPHOSARCOMA). Nature. 1964 May 9;202:567–569. doi: 10.1038/202567a0. [DOI] [PubMed] [Google Scholar]
  84. Jarrett O., Hardy W. D., Jr, Golder M. C., Hay D. The frequency of occurrence of feline leukaemia virus subgroups in cats. Int J Cancer. 1978 Mar 15;21(3):334–337. doi: 10.1002/ijc.2910210314. [DOI] [PubMed] [Google Scholar]
  85. Jarrett W. F. Cat leukemia and its viruses. Adv Vet Sci Comp Med. 1975;19:165–193. [PubMed] [Google Scholar]
  86. Judson S. C., Henle W., Henle G. A cluster of Epstein-Barr-virus-associated American Burkitt's lymphoma. N Engl J Med. 1977 Sep 1;297(9):464–468. doi: 10.1056/NEJM197709012970902. [DOI] [PubMed] [Google Scholar]
  87. KIRSCHSTEIN R. L., RABSON A. S., PETERS E. A. ONCOGENIC ACTIVITY OF ADENOVIRUS 12 IN THYMECTOMIZED BALB/C AND C3H/HEN MICE. Proc Soc Exp Biol Med. 1964 Oct;117:198–200. doi: 10.3181/00379727-117-29535. [DOI] [PubMed] [Google Scholar]
  88. KROLL A. J., KUWABARA T. ELECTRON MICROSCOPY OF UVEAL MELANOMA: A COMPARISON OF SPINDLE AND EPITHELIOID CELLS. Arch Ophthalmol. 1965 Mar;73:378–386. doi: 10.1001/archopht.1965.00970030380017. [DOI] [PubMed] [Google Scholar]
  89. Kaplan H. S., Goodenow R. S., Epstein A. L., Gartner S., Declève A., Rosenthal P. N. Isolation of a type C RNA virus from an established human histiocytic lymphoma cell line. Proc Natl Acad Sci U S A. 1977 Jun;74(6):2564–2568. doi: 10.1073/pnas.74.6.2564. [DOI] [PMC free article] [PubMed] [Google Scholar]
  90. Kawakami T. G., Theilen G. H., Dungworth D. L., Munn R. J., Beall S. G. "C"-type viral particles in plasma of cats with feline leukemia. Science. 1967 Nov;158(3804):1049–1050. doi: 10.1126/science.158.3804.1049. [DOI] [PubMed] [Google Scholar]
  91. Kawana T., Cornish J. D., Smith M. F., Aurelian L. Frequency of antibody to a virus-induced tumor-associated antigen (AG-4) in Japanese sera from patients with cervical cancer and controls. Cancer Res. 1976 Jun;36(6):1910–1914. [PubMed] [Google Scholar]
  92. Kay S. Morphologic aspects of nuclear bodies in a case of bronchiolar-alveolar carcinoma of the lung. Hum Pathol. 1977 Mar;8(2):224–230. doi: 10.1016/s0046-8177(77)80083-x. [DOI] [PubMed] [Google Scholar]
  93. Kelly F., Boccara M. Susceptibility of teratocarcinoma cells to adenovirus type 2. Nature. 1976 Jul 29;262(5567):409–411. doi: 10.1038/262409a0. [DOI] [PubMed] [Google Scholar]
  94. Kessel R. G., Beams H. W. Annulate lamellae and "yolk nuclei" in oocytes of the dragonfly, Libellula pulchella. J Cell Biol. 1969 Jul;42(1):185–201. doi: 10.1083/jcb.42.1.185. [DOI] [PMC free article] [PubMed] [Google Scholar]
  95. Kit S., Dubbs D. R. Regulation of herpesvirus thymidine kinase activity in LM(TK) cells transformed by ultraviolet light-irradiated herpes simplex virus. Virology. 1977 Jan;76(1):331–340. doi: 10.1016/0042-6822(77)90306-3. [DOI] [PubMed] [Google Scholar]
  96. Kobayashi S., Mukai N. Retinoblastoma-like tumors induced in rats by human adenovirus. Invest Ophthalmol. 1973 Nov;12(11):853–856. [PubMed] [Google Scholar]
  97. Krakower J. M., Aaronson S. A. Seroepidemiologic assessment of feline leukaemia virus infection risk for man. Nature. 1978 Jun 8;273(5662):463–464. doi: 10.1038/273463a0. [DOI] [PubMed] [Google Scholar]
  98. Krakower J. M., Barbacid M., Aaronson S. A. Radioimmunoassay for mammalian type C viral reverse transcriptase. J Virol. 1977 May;22(2):331–339. doi: 10.1128/jvi.22.2.331-339.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  99. Krishan A., Uzman B. G., Hedley-Whyte E. T. Nuclear bodies: a component of cell nuclei in hamster tissues and human tumors. J Ultrastruct Res. 1967 Aug 30;19(5):563–572. doi: 10.1016/s0022-5320(67)80082-0. [DOI] [PubMed] [Google Scholar]
  100. Kucera L. S., Gusdon J. P., Edwards I., Herbst G. Oncogenic transformation of rat embryo fibroblasts with photoinactivated herpes simplex virus: rapid in vitro cloning of transformed cells. J Gen Virol. 1977 Jun;35(3):473–485. doi: 10.1099/0022-1317-35-3-473. [DOI] [PubMed] [Google Scholar]
  101. LEVITT J., NAUDE W. D., POLSON A. PURIFICATION AND ELECTRON MICROSCOPY OF PANTROPIC RIFT VALLEY FEVER VIRUS. Virology. 1963 Jul;20:530–533. doi: 10.1016/0042-6822(63)90103-x. [DOI] [PubMed] [Google Scholar]
  102. LWOFF A. The concept of virus. J Gen Microbiol. 1957 Oct;17(2):239–253. doi: 10.1099/00221287-17-2-239. [DOI] [PubMed] [Google Scholar]
  103. Laird H. M., Jarrett O., Crighton G. W., Jarrett W. F. An electron microscopic study of virus particles in spontaneous leukemia in the cat. J Natl Cancer Inst. 1968 Oct;41(4):867–878. [PubMed] [Google Scholar]
  104. Lapis K., Radnót M. Surface properties of human melanoma cells. Am J Ophthalmol. 1971 Mar;71(3):740–750. doi: 10.1016/0002-9394(71)90436-3. [DOI] [PubMed] [Google Scholar]
  105. Lecatsas G., Malherbe H. H., Strickland-Cholmley M. Electronmicroscopical characterisation of simian papovavirus SA12. J Med Microbiol. 1977 Nov;10(4):477–478. doi: 10.1099/00222615-10-4-477. [DOI] [PubMed] [Google Scholar]
  106. Lee W. R. The fine structure of three malignant melanomas of the iris. Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1973 Aug 23;188(2):91–108. doi: 10.1007/BF00407830. [DOI] [PubMed] [Google Scholar]
  107. Leibold W., Huldt G., Flanagan T. D., Andersson M., Dalens M., Wright D. H., Voller A., Klein G. Tumorigenicity of Epstein-Barr virus (EBV)-transformed lymphoid line cells in autologous squirrel monkeys. Int J Cancer. 1976 Apr 15;17(4):533–541. doi: 10.1002/ijc.2910170417. [DOI] [PubMed] [Google Scholar]
  108. Levy J. A. Endogenous C-type viruses in normal and "abnormal" cell development. Cancer Res. 1977 Aug;37(8 Pt 2):2957–2968. [PubMed] [Google Scholar]
  109. Levy J. A. Endogenous C-type viruses: double agents in natural life processes. Biomedicine. 1976 May;24(2):84–93. [PubMed] [Google Scholar]
  110. Lo R. C., Howatson A. F. Identification of type C viruses by electron microscopy. Cancer Res. 1978 Apr;38(4):932–938. [PubMed] [Google Scholar]
  111. MELNICK J. L. Papova virus group. Science. 1962 Mar 30;135(3509):1128–1130. doi: 10.1126/science.135.3509.1128. [DOI] [PubMed] [Google Scholar]
  112. MORGAN C., HOWE C., ROSE H. M. Structure and development of viruses as observed in the electron microscope. V. Western equine encephalomyelitis virus. J Exp Med. 1961 Jan 1;113:219–234. doi: 10.1084/jem.113.1.219. [DOI] [PMC free article] [PubMed] [Google Scholar]
  113. Mattern C. F., Takemoto K. K., DeLeva A. M. Electron microscopic observations on multiple polyoma virus-related particles. Virology. 1967 Jul;32(3):378–392. doi: 10.1016/0042-6822(67)90288-7. [DOI] [PubMed] [Google Scholar]
  114. Mayer R. J., Smith R. G., Gallo R. C. Reverse transcriptase in normal rhesus monkey placenta. Science. 1974 Sep 6;185(4154):864–867. doi: 10.1126/science.185.4154.864. [DOI] [PubMed] [Google Scholar]
  115. McAllister R. M., Nelson-Rees W. A., Peer M., Laug W. E., Isaacs H., Jr, Gilden R. V., Rongey R. W., Gardner M. B. Childhood sarcomas and lymphomas. Characterization of new cell lines and search for type-C virus. Cancer. 1975 Nov;36(5):1804–1814. doi: 10.1002/1097-0142(197511)36:5<1804::aid-cncr2820360535>3.0.co;2-l. [DOI] [PubMed] [Google Scholar]
  116. McCombs R. M. Role of oncornaviruses in carcinoma of the prostate. Cancer Treat Rep. 1977 Mar-Apr;61(2):131–132. [PubMed] [Google Scholar]
  117. McCullough B., Schaller J., Shadduck J. A., Yohn D. S. Induction of malignant melanomas associated with fibrosarcomas in gnotobiotic cats inoculated with Gardner-feline fibrosarcoma virus. J Natl Cancer Inst. 1972 Jun;48(6):1893–1895. [PubMed] [Google Scholar]
  118. McGavran M. H., Easterday B. C. Rift Valley Fever Virus Hepatitis: Light and Electron Microscopic Studies in the Mouse. Am J Pathol. 1963 May;42(5):587–607. doi: 10.21236/ad0410394. [DOI] [PMC free article] [PubMed] [Google Scholar]
  119. McNutt N. S., Fawcett D. W. The ultrastructure of the cat myocardium. II. Atrial muscle. J Cell Biol. 1969 Jul;42(1):46–67. doi: 10.1083/jcb.42.1.46. [DOI] [PMC free article] [PubMed] [Google Scholar]
  120. Meyer J., Neuwald P. D., Lai S. P., Maizel J. V., Jr, Westphal H. Electron microscopy of late adenovirus type 2 mRNA hybridized to double-stranded viral DNA. J Virol. 1977 Mar;21(3):1010–1018. doi: 10.1128/jvi.21.3.1010-1018.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  121. Mickey D. D., Stone K. R., Stone M. P., Paulson D. F. Morphologic and immunologic studies of human prostatic carcinoma. Cancer Treat Rep. 1977 Mar-Apr;61(2):133–138. [PubMed] [Google Scholar]
  122. Mondal H. Occurrence of particle-bound reverse transcriptase in human amniotic fluid. Biochem Biophys Res Commun. 1977 Nov 7;79(1):67–75. doi: 10.1016/0006-291x(77)90061-4. [DOI] [PubMed] [Google Scholar]
  123. Mukai N., Nakajima T., Freddo T., Jacobson M., Dunn M. Retinoblastoma-like neoplasm induced in C3H/BifB/Ki strain mice by human adenovirus serotype 12. Acta Neuropathol. 1977 Aug 16;39(2):147–155. doi: 10.1007/BF00703321. [DOI] [PubMed] [Google Scholar]
  124. Murphy F. A., Harrison A. K., Whitfield S. G. Bunyaviridae: morphologic and morphogenetic similarities of Bunyamwera serologic supergroup viruses and several other arthropod-borne viruses. Intervirology. 1973;1(4):297–316. doi: 10.1159/000148858. [DOI] [PubMed] [Google Scholar]
  125. Nadol J. B., Jr Viral particles in nasopharyngeal carcinoma. Laryngoscope. 1977 Nov;87(11):1932–1937. doi: 10.1002/lary.1977.87.11.1932. [DOI] [PubMed] [Google Scholar]
  126. Nahmias A. J., Naib Z. M., Josey W. E. Epidemiological studies relating genital herpetic infection to cervical carcinoma. Cancer Res. 1974 May;34(5):1111–1117. [PubMed] [Google Scholar]
  127. Newell N., Lai C. J., Khoury G., Kelly T. J., Jr Electron microscope study of the base sequence homology between simian virus 40 and human papovavirus BK. J Virol. 1978 Jan;25(1):193–201. doi: 10.1128/jvi.25.1.193-201.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  128. Nooter K., Overdevest J., Dubbes R., Koch G., Bentvelzen P., Zurcher C., Coolen J., Calafat J. Type-C oncovirus isolate from human leukemic bone marrow: further in vitro and in vivo characterization. Int J Cancer. 1978 Jan 15;21(1):27–34. doi: 10.1002/ijc.2910210107. [DOI] [PubMed] [Google Scholar]
  129. Ohno T., Sweet R. W., Dejak D., Spiegelman S. Purification and characterization of the DNA polymerase of human breast cancer particles. Proc Natl Acad Sci U S A. 1977 Feb;74(2):764–768. doi: 10.1073/pnas.74.2.764. [DOI] [PMC free article] [PubMed] [Google Scholar]
  130. Ohtsuki Y., Seman G., Dmochowski L., Bowen J. M., Johnson D. E. Virus-like particles in a case of human prostate carcinoma. J Natl Cancer Inst. 1977 May;58(5):1493–1496. doi: 10.1093/jnci/58.5.1493. [DOI] [PubMed] [Google Scholar]
  131. Orth G., Favre M., Croissant O. Characterization of a new type of human papillomavirus that causes skin warts. J Virol. 1977 Oct;24(1):108–120. doi: 10.1128/jvi.24.1.108-120.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  132. Panem S., Ordóez N. G., Kirstein W. H., Katz A. I., Spargo B. H. C-type virus expression in systemic lupus erythematosus. N Engl J Med. 1976 Aug 26;295(9):470–475. doi: 10.1056/NEJM197608262950903. [DOI] [PubMed] [Google Scholar]
  133. Panet A., Berliner H. Binding of tRNA to reverse transcriptase of RNA tumor viruses. J Virol. 1978 May;26(2):214–220. doi: 10.1128/jvi.26.2.214-220.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  134. Parsons P. G., Klucis E., Goss P. D., Pope J. H., Little J. H., Davis N. C. Oncornavirus-like particles in malignant melanoma and control biopsies. Int J Cancer. 1976 Dec 15;18(6):757–763. doi: 10.1002/ijc.2910180606. [DOI] [PubMed] [Google Scholar]
  135. Pass F., Reissig M., Shah K. V., Eisinger M., Orth G. Identification of an immunologically distinct papillomavirus from lesions of epidermodysplasia verruciformis. J Natl Cancer Inst. 1977 Oct;59(4):1107–1112. doi: 10.1093/jnci/59.4.1107. [DOI] [PubMed] [Google Scholar]
  136. Portolani M., Barbanti-Brodano G., Placa M. L. Malignant transformation of hamster kidney cells by BK virus. J Virol. 1975 Feb;15(2):420–422. doi: 10.1128/jvi.15.2.420-422.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  137. Portugal F. H. Cell transformation with herpes simplex viruses. Nature. 1977 Sep 15;269(5625):196–196. doi: 10.1038/269196a0. [DOI] [PubMed] [Google Scholar]
  138. ROWE W. P., HUEBNER R. J., GILMORE L. K., PARROTT R. H., WARD T. G. Isolation of a cytopathogenic agent from human adenoids undergoing spontaneous degeneration in tissue culture. Proc Soc Exp Biol Med. 1953 Dec;84(3):570–573. doi: 10.3181/00379727-84-20714. [DOI] [PubMed] [Google Scholar]
  139. Rapp F. Herpesviruses, venereal disease, and cancer. Am Sci. 1978 Nov-Dec;66(6):670–674. [PubMed] [Google Scholar]
  140. Rapp F., Li J. L., Jerkofsky M. Transformation of mammalian cells by DNA-containing viruses following photodynamic inactivation. Virology. 1973 Oct;55(2):339–346. doi: 10.1016/0042-6822(73)90173-6. [DOI] [PubMed] [Google Scholar]
  141. Rapp F., Reed C. Experimental evidence for the oncogenic potential of herpes simplex virus. Cancer Res. 1976 Feb;36(2 Pt 2):800–806. [PubMed] [Google Scholar]
  142. Rapp F., Westmoreland D. Cell transformation by DNA-containing viruses. Biochim Biophys Acta. 1976 Jul 16;458(2):167–211. doi: 10.1016/0304-419x(76)90005-6. [DOI] [PubMed] [Google Scholar]
  143. Rapp U. R., Todaro G. J. Generation of oncogenic type C viruses: rapidly leukemogenic viruses derived from C3H mouse cells in vivo and in vitro. Proc Natl Acad Sci U S A. 1978 May;75(5):2468–2472. doi: 10.1073/pnas.75.5.2468. [DOI] [PMC free article] [PubMed] [Google Scholar]
  144. Rawls W. E., Garfield C. H., Seth P., Adam E. Serological and epidemiological considerations of the role of herpes simplex virus type 2 in cervical cancer. Cancer Res. 1976 Feb;36(2 Pt 2):829–835. [PubMed] [Google Scholar]
  145. Reid T. W., Albert D. M. RNA-dependent DNA-polymerase activity in human tumors. Biochem Biophys Res Commun. 1972 Jan 31;46(2):383–390. doi: 10.1016/s0006-291x(72)80150-5. [DOI] [PubMed] [Google Scholar]
  146. Reid T. W., Albert D. M., Rabson A. S., Russell P., Craft J., Chu E. W., Tralka T. S., Wilcox J. L. Characteristics of an established cell line of retinoblastoma. J Natl Cancer Inst. 1974 Aug;53(2):347–360. doi: 10.1093/jnci/53.2.347. [DOI] [PubMed] [Google Scholar]
  147. Rhim J. S. Malignant transformation of rat embryo cells by a herpesvirus isolated from L2C guinea pig leukemia. Virology. 1977 Oct 1;82(1):100–110. doi: 10.1016/0042-6822(77)90036-8. [DOI] [PubMed] [Google Scholar]
  148. Rickard C. G., Post J. E., Noronha F., Barr L. M. A transmissible virus-induced lymphocytic leukemia of the cat. J Natl Cancer Inst. 1969 Jun;42(6):987–1014. [PubMed] [Google Scholar]
  149. Rinaldo C. R., Jr, Richter B. S., Black P. H., Callery R., Chess L., Hirsch M. S. Replication of herpes simplex virus and cytomegalovirus in human leukocytes. J Immunol. 1978 Jan;120(1):130–136. [PubMed] [Google Scholar]
  150. Rous P. Viruses and tumour causation. An appraisal of present knowledge. Nature. 1965 Jul 31;207(996):457–463. doi: 10.1038/207457a0. [DOI] [PubMed] [Google Scholar]
  151. Russell P., Gregerson D. S., Albert D. M., Reid T. W. Characteristics of a retrovirus associated with a hamster melanoma. J Gen Virol. 1979 May;43(2):317–326. doi: 10.1099/0022-1317-43-2-317. [DOI] [PubMed] [Google Scholar]
  152. SMITH K. O., MELNICK J. L. A method for staining virus particles and identifying their nucleic acid type in the electron microscope. Virology. 1962 Jul;17:480–490. doi: 10.1016/0042-6822(62)90143-5. [DOI] [PubMed] [Google Scholar]
  153. STEWART S. E., EDDY B. E., BORGESE N. Neoplasms in mice inoculated with a tumor agent carried in tissue culture. J Natl Cancer Inst. 1958 Jun;20(6):1223–1243. doi: 10.1093/jnci/20.6.1223. [DOI] [PubMed] [Google Scholar]
  154. SWEET B. H., HILLEMAN M. R. The vacuolating virus, S.V. 40. Proc Soc Exp Biol Med. 1960 Nov;105:420–427. doi: 10.3181/00379727-105-26128. [DOI] [PubMed] [Google Scholar]
  155. SWIFT H. The fine structure of annulate lamellae. J Biophys Biochem Cytol. 1956 Jul 25;2(4 Suppl):415–418. doi: 10.1083/jcb.2.4.415. [DOI] [PMC free article] [PubMed] [Google Scholar]
  156. Sanford E. J., Geder L., Laychock A., Rohner T. J., Jr, Rapp F. Evidence for the association of cytomegalovirus with carcinoma of the prostate. J Urol. 1977 Nov;118(5):789–792. doi: 10.1016/s0022-5347(17)58194-x. [DOI] [PubMed] [Google Scholar]
  157. Sankaranarayanan K., Hyde B. B. Ultrastructural studies of a nuclear body in peas with characteristics of both chromatin and nucleoli. J Ultrastruct Res. 1965 Jun;12(5):748–761. doi: 10.1016/s0022-5320(65)80059-4. [DOI] [PubMed] [Google Scholar]
  158. Sarma P. S., Baskar J. F., Gilden R. V., Gardner M. B., Huebner R. J. In vitro isolation and characterization of the GA strain of feline sarcoma virus. Proc Soc Exp Biol Med. 1971 Sep;137(4):1333–1336. doi: 10.3181/00379727-137-35783. [DOI] [PubMed] [Google Scholar]
  159. Sarma P. S., Log T., Skuntz S., Krishnan S., Burkley K. Experimental horizontal transmission of feline leukemia viruses of subgroups A, B, and C. J Natl Cancer Inst. 1978 Apr;60(4):871–874. doi: 10.1093/jnci/60.4.871. [DOI] [PubMed] [Google Scholar]
  160. Sarma P. S., Log T., Theilen G. H. ST feline sarcoma virus. Biological characteristics and in vitro propagation. Proc Soc Exp Biol Med. 1971 Sep;137(4):1444–1448. doi: 10.3181/00379727-137-35807. [DOI] [PubMed] [Google Scholar]
  161. Sarma P. S., Sharar A. L., McDonough S. The SM strain of feline sarcoma virus. Biologic and antigenic characterization of virus. Proc Soc Exp Biol Med. 1972 Sep;140(4):1365–1368. doi: 10.3181/00379727-140-36675. [DOI] [PubMed] [Google Scholar]
  162. Simar L. J. Ultrastructure et constitution des corps nucléaires dans les plasmocytes. Z Zellforsch Mikrosk Anat. 1969;99(2):235–251. [PubMed] [Google Scholar]
  163. Singer I. I., Rhode S. L., 3rd Replication process of the parvovirus H-1. VII. Electron microscopy of replicative-form DNA synthesis. J Virol. 1977 Feb;21(2):713–723. doi: 10.1128/jvi.21.2.713-723.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  164. Smith G. C., Heberling R. L., Helmke R. J., Barker S. T., Kalter S. S. Oncornavirus-like particles in squirrel monkey (Saimiri sciureus) placenta and placenta culture. J Natl Cancer Inst. 1977 Sep;59(3):975–979. doi: 10.1093/jnci/59.3.975. [DOI] [PubMed] [Google Scholar]
  165. Smith T. W., Albert D. M., Robinson N., Calnek B. W., Schwabe O. Ocular manifestations of Marek's disease. Invest Ophthalmol. 1974 Aug;13(8):586–592. [PubMed] [Google Scholar]
  166. Snyder S. P. Spontaneous feline fibrosarcomas: transmissibility and ultrastructure of associated virus-like particles. J Natl Cancer Inst. 1971 Nov;47(5):1079–1085. [PubMed] [Google Scholar]
  167. Snyder S. P., Theilen G. H. Transmissible feline fibrosarcoma. Nature. 1969 Mar 15;221(5185):1074–1075. doi: 10.1038/2211074a0. [DOI] [PubMed] [Google Scholar]
  168. Spiegelman S., Axel R., Baxt W., Kufe D., Schlom J. Human cancer and animal viral oncology. Cancer. 1974 Oct;34(4 Suppl):suppl–suppl:1420. doi: 10.1002/1097-0142(197410)34:8+<1406::aid-cncr2820340812>3.0.co;2-r. [DOI] [PubMed] [Google Scholar]
  169. Spoendlin H., Kistler G. Papova-virus in human laryngeal papillomas. Arch Otorhinolaryngol. 1978 Jan 30;218(3-4):289–292. doi: 10.1007/BF00455564. [DOI] [PubMed] [Google Scholar]
  170. Stanbridge E. Mycoplasmas and cell cultures. Bacteriol Rev. 1971 Jun;35(2):206–227. doi: 10.1128/br.35.2.206-227.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  171. Steel C. M., Philipson J., Arthur E., Gardiner S. E., Newton M. S., McIntosh R. V. Possibility of EB virus preferentially transforming a subpopulation of human B lymphocytes. Nature. 1977 Dec 22;270(5639):729–731. doi: 10.1038/270729a0. [DOI] [PubMed] [Google Scholar]
  172. TOUSIMIS A. J., HILLEMAN M. R. Electron microscopy of type 4 adenovirus strain R1-67. Virology. 1957 Dec;4(3):499–508. doi: 10.1016/0042-6822(57)90082-x. [DOI] [PubMed] [Google Scholar]
  173. Takahashi M., Mishima Y. A sequence of virus-like particle formation in the ergastoplasm of Greene's malignant melanoma cells. Cancer. 1969 Nov;24(5):904–911. doi: 10.1002/1097-0142(196911)24:5<904::aid-cncr2820240507>3.0.co;2-j. [DOI] [PubMed] [Google Scholar]
  174. Temin H. M., Mizutani S. RNA-dependent DNA polymerase in virions of Rous sarcoma virus. Nature. 1970 Jun 27;226(5252):1211–1213. doi: 10.1038/2261211a0. [DOI] [PubMed] [Google Scholar]
  175. Temin H. M. The DNA provirus hypothesis. Science. 1976 Jun 11;192(4244):1075–1080. doi: 10.1126/science.58444. [DOI] [PubMed] [Google Scholar]
  176. Temin H. M. The protovirus hypothesis: speculations on the significance of RNA-directed DNA synthesis for normal development and for carcinogenesis. J Natl Cancer Inst. 1971 Feb;46(2):3–7. [PubMed] [Google Scholar]
  177. Theilen G. H., Kawakami T. G., Rush J. D., Munn R. J. Replication of cat leukemia virus in cell suspension cultures. Nature. 1969 May 10;222(5193):589–590. doi: 10.1038/222589b0. [DOI] [PubMed] [Google Scholar]
  178. Tobin S. M., Wilson W. D., Fish E. N., Papsin F. R. Relation of herpesvirus hominis type II to carcinoma of the cervix. An animal model for the induction of long-term latency of herpesvirus hominis type II. Obstet Gynecol. 1978 Jun;51(6):707–712. [PubMed] [Google Scholar]
  179. Todaro G. J. RNA-tumour-virus genes and transforming genes: patterns of transmission. Br J Cancer. 1978 Feb;37(2):139–158. doi: 10.1038/bjc.1978.23. [DOI] [PMC free article] [PubMed] [Google Scholar]
  180. Todaro G. J., Sherr C. J., Sen A., King N., Daniel M. D., Fleckenstein B. Endogenous New World primate type C viruses isolated from owl monkey (Aotus trivirgatus) kidney cell line. Proc Natl Acad Sci U S A. 1978 Feb;75(2):1004–1008. doi: 10.1073/pnas.75.2.1004. [DOI] [PMC free article] [PubMed] [Google Scholar]
  181. Trumper P. A., Epstein M. A., Giovanella B. C. Activation in vitro by BUdR of a productive EB virus infection in the epithelial cells of nasopharyngeal carcinoma. Int J Cancer. 1976 May 15;17(5):578–587. doi: 10.1002/ijc.2910170505. [DOI] [PubMed] [Google Scholar]
  182. Van Tieghem N., Vercammen-Grandjean A., Beaumont L., Lejeune F. J. Pseudotypes de VSV, après culture dans un mélanome humain. Arch Int Physiol Biochim. 1978 Feb;86(1):213–214. [PubMed] [Google Scholar]
  183. Vernon S. K., Lawrence W. C., Cohen G. H., Durso M., Rubin B. A. Morphological components of herpesvirus. II. Preservation of virus during negative staining procedures. J Gen Virol. 1976 May;31(2):183–191. doi: 10.1099/0022-1317-31-2-183. [DOI] [PubMed] [Google Scholar]
  184. Vernon S. K., Lawrence W. C., Cohen G. H. Morphological components of herpesvirus. I. Intercapsomeric fibrils and the geometry of the capsid. Intervirology. 1974;4(4):237–248. doi: 10.1159/000149968. [DOI] [PubMed] [Google Scholar]
  185. Verwoerd D. W., Rapp F. Biochemical transformation of mouse cells by herpes simplex virus type 2: enhancement by means of low-level photodynamic treatment. J Virol. 1978 Apr;26(1):200–202. doi: 10.1128/jvi.26.1.200-202.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  186. Vázquez J. J., Ortuño G., Cervós-Navarro J. An ultrastructural study of spheroidal nuclear bodies found in gliomas. Virchows Arch B Cell Pathol. 1970;5(4):288–293. doi: 10.1007/BF02893570. [DOI] [PubMed] [Google Scholar]
  187. WATSON M. L. Further observations on the nuclear envelope of the animal cell. J Biophys Biochem Cytol. 1959 Oct;6:147–156. doi: 10.1083/jcb.6.2.147. [DOI] [PMC free article] [PubMed] [Google Scholar]
  188. WATSON M. L. The nuclear envelope; its structure and relation to cytoplasmic membranes. J Biophys Biochem Cytol. 1955 May 25;1(3):257–270. doi: 10.1083/jcb.1.3.257. [DOI] [PMC free article] [PubMed] [Google Scholar]
  189. Walker D. L., Padgett B. L., ZuRhein G. M., Albert A. E., Marsh R. F. Human papovavirus (JC): induction of brain tumors in hamsters. Science. 1973 Aug 17;181(4100):674–676. doi: 10.1126/science.181.4100.674. [DOI] [PubMed] [Google Scholar]
  190. Webber M. M. Cytopathic effects in primary epithelial cultures derived from the human prostate. Invest Urol. 1976 Jan;13(4):259–270. [PubMed] [Google Scholar]
  191. Westphal H., Lai S. P. Quantitative electron microscopy of early adenovirus RNA. J Mol Biol. 1977 Nov 5;116(3):525–548. doi: 10.1016/0022-2836(77)90082-1. [DOI] [PubMed] [Google Scholar]
  192. Wold W. S., Mackey J. K., Brackmann K. H., Takemori N., Rigden P., Green M. Analysis of human tumors and human malignant cell lines for BK virus-specific DNA sequences. Proc Natl Acad Sci U S A. 1978 Jan;75(1):454–458. doi: 10.1073/pnas.75.1.454. [DOI] [PMC free article] [PubMed] [Google Scholar]
  193. Yotsuyanagi Y. Occurrence of mixed forms of intracisternal virus-like particles in somatic hybrid cells. J Ultrastruct Res. 1977 Jul;60(1):71–83. doi: 10.1016/s0022-5320(77)80043-9. [DOI] [PubMed] [Google Scholar]
  194. Ziegler J. L., Magrath I. T., Gerber P., Levine P. H. Epstein-Barr virus and human malignancy. Ann Intern Med. 1977 Mar;86(3):323–336. doi: 10.7326/0003-4819-86-3-323. [DOI] [PubMed] [Google Scholar]
  195. Zimmerman L. E. Changing concepts concerning the pathogenesis of infectious diseases. Am J Ophthalmol. 1970 Jun;69(6):947–964. doi: 10.1016/0002-9394(70)91038-x. [DOI] [PubMed] [Google Scholar]
  196. de Man J. C., Snoep M. P., Huiskens-van der Meij J. W., Warnaar S. O., Schaberg A. A new cell line from a human chondrosarcoma. Br J Cancer. 1977 Apr;35(4):403–414. doi: 10.1038/bjc.1977.61. [DOI] [PMC free article] [PubMed] [Google Scholar]
  197. von Bonsdorff C. H., Pettersson R. Surface structure of Uukuniemi virus. J Virol. 1975 Nov;16(5):1296–1307. doi: 10.1128/jvi.16.5.1296-1307.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]

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