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. 1996;94:299–314.

Multiple changes in oncogenes and tumor suppressor genes in human retinoblastoma.

R O Howard 1
PMCID: PMC1312101  PMID: 8981702

Abstract

PURPOSE: To present data to support the hypothesis that human retinoblastoma tumors form by a multistep process. METHODS: Survey of the karyotype of 90 human retinoblastomas, with emphasis on changes in chromosomal regions known to contain oncogenes and tumor suppressor genes. CONCLUSION: The data support the hypothesis that retinoblastoma occurs after multiple and often varied steps, similar to other human malignancies.

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Selected References

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