Skip to main content
NCBI home page
Transactions of the American Ophthalmological Society logoLink to Transactions of the American Ophthalmological Society
. 1983;81:549–591.

Acute proliferative retrolental fibroplasia: multivariate risk analysis.

J T Flynn
PMCID: PMC1312463  PMID: 6689564

Abstract

This study has presented a two-way analysis of a data set consisting of demographic, diagnostic, and therapeutic variables against the risk of occurrence of APRLF and its location in the retina in a population of 639 infants in birthweights ranging from 600 to 1500 gm. Univariate and multivariate risk analysis techniques were employed to analyze the data. As established from previous studies, birthweight was a powerful predictor of the outcome variable. Oxygen therapy as defined and quantified in this study was not. Duration of ventilatory assistance did seem associated. The population was not uniform. Infants below 1000 gm birthweight had such a high incidence of APRLF that no other exogenous risk factors seemed of significance. Above 1000 gm birthweight, certain factors, particularly duration of ventilation, seemed of predictive strength and significance.

Full text

PDF
549

Images in this article

559FIGURE 5 A
on p.559
559FIGURE 5 B
on p.559
558FIGURE 4 A
on p.558
558FIGURE 4 B
on p.558

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AVERY M. E. Recent increase in mortality from hyaline membrane disease. J Pediatr. 1960 Oct;57:553–559. doi: 10.1016/s0022-3476(60)80083-2. [DOI] [PubMed] [Google Scholar]
  2. Adamkin D. H., Shott R. J., Cook L. N., Andrews B. F. Nonhyperoxic retrolental fibroplasia. Pediatrics. 1977 Dec;60(6):828–830. [PubMed] [Google Scholar]
  3. Addison D. J., Font R. L., Manschot W. A. Proliferative retinopathy in anencephalic babies. Am J Ophthalmol. 1972 Nov;74(5):967–976. doi: 10.1016/0002-9394(72)91220-2. [DOI] [PubMed] [Google Scholar]
  4. Aranda J. V., Sweet A. Y. Sustained hyperoxemia without cicatricial retrolental fibroplasia. Pediatrics. 1974 Oct;54(4):434–437. [PubMed] [Google Scholar]
  5. Brockhurst R. J., Chishti M. I. Cicatricial retrolental fibroplasia: its occurrence without oxygen administration and in full term infants. Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1975;195(2):113–128. doi: 10.1007/BF00417114. [DOI] [PubMed] [Google Scholar]
  6. CAMPBELL K. Intensive oxygen therapy as a possible cause of retrolental fibroplasia; a clinical approach. Med J Aust. 1951 Jul 14;2(2):48–50. [PubMed] [Google Scholar]
  7. CLASSIFICATION of retrolental fibroplasia. Am J Ophthalmol. 1953 Oct;36(10):1333–1335. [PubMed] [Google Scholar]
  8. Cantolino S. J., O'Grady G. E., Herrera J. A., Israel C., Justice J., Jr, Flynn J. T. Ophthalmoscopic monitoring of oxygen therapy in premature infants. Fluorescein angiography in acute retrolental fibroplasia. Am J Ophthalmol. 1971 Aug;72(2):322–331. doi: 10.1016/0002-9394(71)91301-8. [DOI] [PubMed] [Google Scholar]
  9. Cross K. W. Cost of preventing retrolental fibroplasia? Lancet. 1973 Oct 27;2(7835):954–956. doi: 10.1016/s0140-6736(73)92610-x. [DOI] [PubMed] [Google Scholar]
  10. Ederer F., Hiller R. Clinical trials, diabetic retinopathy and photocoagulation. A reanalysis of five studies. Surv Ophthalmol. 1975 Mar-Apr;19(5):267–286. [PubMed] [Google Scholar]
  11. Finer N. N., Schindler R. F., Grant G., Hill G. B., Peters K. Effect of intramuscular vitamin E on frequency and severity of retrolental fibroplasia. A controlled trial. Lancet. 1982 May 15;1(8281):1087–1091. doi: 10.1016/s0140-6736(82)92276-0. [DOI] [PubMed] [Google Scholar]
  12. Flower R. W., Blake D. A. Retrolental fibroplasia: evidence for a role of the prostaglandin cascade in the pathogenesis of oxygen-induced retinopathy in the newborn beagle. Pediatr Res. 1981 Sep;15(9):1293–1302. doi: 10.1203/00006450-198109000-00013. [DOI] [PubMed] [Google Scholar]
  13. Flynn J. T., Cassady J., Essner D., Zeskind J., Merritt J., Flynn R., Williams M. J. Fluorescein angiography in retrolental fibroplasia: experience from 1969-1977. Ophthalmology. 1979 Oct;86(10):1700–1723. doi: 10.1016/s0161-6420(79)35329-5. [DOI] [PubMed] [Google Scholar]
  14. Flynn J. T., O'Grady G. E., Herrera J., Kushner B. J., Cantolino S., Milam W. Retrolental fibroplasia: I. Clinical observations. Arch Ophthalmol. 1977 Feb;95(2):217–223. doi: 10.1001/archopht.1977.04450020019002. [DOI] [PubMed] [Google Scholar]
  15. Foos R. Y. Acute retrolental fibroplasia. Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1975;195(2):87–100. doi: 10.1007/BF00417112. [DOI] [PubMed] [Google Scholar]
  16. GUY L. P., DANCIS J., LANMAN J. T. Retrolental fibroplasia. N Y State J Med. 1953 Dec 15;53(24):2999–3002. [PubMed] [Google Scholar]
  17. GUY L. P., LANMAN J. T., DANCIS J. The possibility of total elimination of retrolental fibroplasia by oxygen restriction. Pediatrics. 1956 Feb;17(2):247–249. [PubMed] [Google Scholar]
  18. Gunn T. R., Easdown J., Outerbridge E. W., Aranda J. V. Risk factors in retrolental fibroplasia. Pediatrics. 1980 Jun;65(6):1096–1100. [PubMed] [Google Scholar]
  19. Gunn T. R., Easdown J., Outerbridge E. W., Aranda J. V. Risk factors in retrolental fibroplasia. Pediatrics. 1980 Jun;65(6):1096–1100. [PubMed] [Google Scholar]
  20. Hambleton G., Wigglesworth J. S. Origin of intraventricular haemorrhage in the preterm infant. Arch Dis Child. 1976 Sep;51(9):651–659. doi: 10.1136/adc.51.9.651. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Hittner H. M., Godio L. B., Rudolph A. J., Adams J. M., Garcia-Prats J. A., Friedman Z., Kautz J. A., Monaco W. A. Retrolental fibroplasia: efficacy of vitamin E in a double-blind clinical study of preterm infants. N Engl J Med. 1981 Dec 3;305(23):1365–1371. doi: 10.1056/NEJM198112033052301. [DOI] [PubMed] [Google Scholar]
  22. KINSEY V. E. Retrolental fibroplasia; cooperative study of retrolental fibroplasia and the use of oxygen. AMA Arch Ophthalmol. 1956 Oct;56(4):481–543. [PubMed] [Google Scholar]
  23. Kalina R. E., Hodson W. A., Morgan B. C. Retrolental fibroplasia in a cyanotic infant. Pediatrics. 1972 Nov;50(5):765–768. [PubMed] [Google Scholar]
  24. Kalina R. E., Karr D. J. Retrolental fibroplasia. Experience over two decades in one institution. Ophthalmology. 1982 Feb;89(2):91-5, 103. doi: 10.1016/s0161-6420(82)34829-0. [DOI] [PubMed] [Google Scholar]
  25. Karlsberg R. C., Green W. R., Patz A. Congenital retrolental fibroplasia. Arch Ophthalmol. 1973 Feb;89(2):122–123. doi: 10.1001/archopht.1973.01000040124014. [DOI] [PubMed] [Google Scholar]
  26. Kingham J. D. Acute retrolental fibroplasia. Arch Ophthalmol. 1977 Jan;95(1):39–47. doi: 10.1001/archopht.1977.04450010041003. [DOI] [PubMed] [Google Scholar]
  27. Kinsey V. E., Arnold H. J., Kalina R. E., Stern L., Stahlman M., Odell G., Driscoll J. M., Jr, Elliott J. H., Payne J., Patz A. PaO2 levels and retrolental fibroplasia: a report of the cooperative study. Pediatrics. 1977 Nov;60(5):655–668. [PubMed] [Google Scholar]
  28. Kraushar M. F., Harper R. G., Sia C. G. Rentrolental fibroplasia in a full-term infant. Am J Ophthalmol. 1975 Jul;80(1):106–108. doi: 10.1016/0002-9394(75)90879-x. [DOI] [PubMed] [Google Scholar]
  29. Kushner B. J., Essner D., Cohen I. J., Flynn J. T. Retrolental Fibroplasia. II. Pathologic correlation. Arch Ophthalmol. 1977 Jan;95(1):29–38. doi: 10.1001/archopht.1977.04450010031002. [DOI] [PubMed] [Google Scholar]
  30. LANMAN J. T., GUY L. P., DANCIS J. Retrolental fibroplasia and oxygen therapy. J Am Med Assoc. 1954 May 15;155(3):223–226. doi: 10.1001/jama.1954.03690210001001. [DOI] [PubMed] [Google Scholar]
  31. MANTEL N., HAENSZEL W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959 Apr;22(4):719–748. [PubMed] [Google Scholar]
  32. Mantel N. Synthetic retrospective studies and related topics. Biometrics. 1973 Sep;29(3):479–486. [PubMed] [Google Scholar]
  33. McCormick A. Q. Retinopathy of prematurity. Curr Probl Pediatr. 1977 Sep;7(11):1–28. [PubMed] [Google Scholar]
  34. McDonald A. D. Neurological and Ophthalmic Disorders in Children of Very Low Birth Weight. Br Med J. 1962 Mar 31;1(5282):895–900. doi: 10.1136/bmj.1.5282.895. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. PATZ A., HOECK L. E., DE LA CRUZ E. Studies on the effect of high oxygen administration in retrolental fibroplasia. I. Nursery observations. Am J Ophthalmol. 1952 Sep;35(9):1248–1253. doi: 10.1016/0002-9394(52)91140-9. [DOI] [PubMed] [Google Scholar]
  36. Palmer E. A. Optimal timing of examination for acute retrolental fibroplasia. Ophthalmology. 1981 Jul;88(7):662–668. doi: 10.1016/s0161-6420(81)34980-x. [DOI] [PubMed] [Google Scholar]
  37. Peto R., Pike M. C., Armitage P., Breslow N. E., Cox D. R., Howard S. V., Mantel N., McPherson K., Peto J., Smith P. G. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. I. Introduction and design. Br J Cancer. 1976 Dec;34(6):585–612. doi: 10.1038/bjc.1976.220. [DOI] [PMC free article] [PubMed] [Google Scholar]
  38. Phelps D. L. Retinopathy of prematurity: an estimate of vision loss in the United States--1979. Pediatrics. 1981 Jun;67(6):924–925. [PubMed] [Google Scholar]
  39. Puklin J. E., Simon R. M., Ehrenkranz R. A. Influence on retrolental fibroplasia of intramuscular vitamin E administration during respiratory distress syndrome. Ophthalmology. 1982 Feb;89(2):96–103. doi: 10.1016/s0161-6420(82)34830-7. [DOI] [PubMed] [Google Scholar]
  40. Schrager G. O. PDAs, prostaglandins, and RLF. Pediatrics. 1978 Nov;62(5):860–861. [PubMed] [Google Scholar]
  41. Stefani F. H., Ehalt H. Non-oxygen induced retinitis proliferans and retinal detachment in full-term infants. Br J Ophthalmol. 1974 May;58(5):490–513. doi: 10.1136/bjo.58.5.490. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. Truett J., Cornfield J., Kannel W. A multivariate analysis of the risk of coronary heart disease in Framingham. J Chronic Dis. 1967 Jul;20(7):511–524. doi: 10.1016/0021-9681(67)90082-3. [DOI] [PubMed] [Google Scholar]
  43. Walker S. H., Duncan D. B. Estimation of the probability of an event as a function of several independent variables. Biometrika. 1967 Jun;54(1):167–179. [PubMed] [Google Scholar]
  44. Yu V. Y., Hookham D. M., Nave J. R. Retrolental fibroplasia--controlled study of 4 years' experience in a neonatal intensive care unit. Arch Dis Child. 1982 Apr;57(4):247–252. doi: 10.1136/adc.57.4.247. [DOI] [PMC free article] [PubMed] [Google Scholar]
  45. ZACHARIAS L. Retrolental fibroplasia; a survey. Am J Ophthalmol. 1952 Oct;35(10):1426–1454. doi: 10.1016/0002-9394(52)92162-4. [DOI] [PubMed] [Google Scholar]

Articles from Transactions of the American Ophthalmological Society are provided here courtesy of American Ophthalmological Society

RESOURCES