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EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) ; Scientific Opinion on the substantiation of health claims related to walnuts and maintenance of normal blood LDL‐cholesterol concentrations (ID 1156, 1158) and improvement of endothelium‐dependent vasodilation (ID 1155, 1157) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA Journal 2011;9(4):2074. [19 pp.]. doi: 10.2903/j.efsa.2011.2074.
Panel members: Carlo Agostoni, Jean‐Louis Bresson, Susan Fairweather‐Tait, Albert Flynn, Ines Golly, Hannu Korhonen, Pagona Lagiou, Martinus Løvik, Rosangela Marchelli, Ambroise Martin, Bevan Moseley, Monika Neuhäuser‐Berthold, Hildegard Przyrembel, Seppo Salminen, Yolanda Sanz, Sean (J.J.) Strain, Stephan Strobel, Inge Tetens, Daniel Tomé, Hendrik van Loveren and Hans Verhagen.
Correspondence: nda@efsa.europa.eu
Acknowledgement: The Panel wishes to thank for the preparatory work on this scientific opinion: The members of the Working Group on Claims: Carlo Agostoni, Jean‐Louis Bresson, Susan Fairweather‐Tait, Albert Flynn, Ines Golly, Marina Heinonen, Hannu Korhonen, Martinus Løvik, Ambroise Martin, Hildegard Przyrembel, Seppo Salminen, Yolanda Sanz, Sean (J.J.) Strain, Inge Tetens, Hendrik van Loveren and Hans Verhagen. The members of the Claims Sub‐Working Group on Cardiovascular Health/Oxidative Stress: Antti Aro, Marianne Geleijnse, Marina Heinonen, Ambroise Martin, Wilhelm Stahl and Henk van den Berg.
Adoption date: 28 January 2011
Published date: 8 April 2011
Question number: EFSA‐Q‐2008‐1894, EFSA‐Q‐2008‐1895, EFSA‐Q‐2008‐1896, EFSA‐Q‐2008‐1897
On request from: European Commission
References
- Abbey M, Noakes M, Belling GB and Nestel PJ, 1994. Partial replacement of saturated fatty acids with almonds or walnuts lowers total plasma cholesterol and low‐density‐lipoprotein cholesterol. American Journal of Clinical Nutrition, 59, 995–999. [DOI] [PubMed] [Google Scholar]
- Almario RU, Vonghavaravat V, Wong R and Kasim‐Karakas SE, 2001. Effects of walnut consumption on plasma fatty acids and lipoproteins in combined hyperlipidemia. American Journal of Clinical Nutrition, 74, 72–79. [DOI] [PubMed] [Google Scholar]
- Chisholm A, Mann J, Skeaff M, Frampton C, Sutherland W, Duncan A and Tiszavari S, 1998. A diet rich in walnuts favourably influences plasma fatty acid profile in moderately hyperlipidaemic subjects. European Journal of Clinical Nutrition, 52, 12–16. [DOI] [PubMed] [Google Scholar]
- Cortes B, Nunez I, Cofan M, Gilabert R, Perez‐Heras A, Casals E, Deulofeu R and Ros E, 2006. Acute effects of high‐fat meals enriched with walnuts or olive oil on postprandial endothelial function. Journal of the American College of Cardiology, 48, 1666–1671. [DOI] [PubMed] [Google Scholar]
- EFSA Panel on Dietetic Products Nutrition and Allergies (NDA) , 2009a. Scientific Opinion on the substantiation of health claims related to linoleic acid and maintenance of normal blood cholesterol concentrations (ID 489) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA Journal, 7(9):1276, 12 pp. [Google Scholar]
- EFSA Panel on Dietetic Products Nutrition and Allergies (NDA) , 2009b. Scientific Opinion on the substantiation of health claims related to alpha‐linolenic acid and maintenance of normal blood cholesterol concentrations (ID 493) and maintenance of normal blood pressure (ID 625) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA Journal, 7(9):1252, 17 pp. [Google Scholar]
- EFSA Panel on Dietetic Products Nutrition and Allergies (NDA) , 2011. Scientific Opinion on the substantiation of health claims related to the replacement of mixtures of saturated fatty acids (SFAs) as present in foods or diets with mixtures of monounsaturated fatty acids (MUFAs) and/or mixtures of polyunsaturated fatty acids (PUFAs), and maintenance of normal blood LDL‐cholesterol concentrations (ID 621, 1190, 1203, 2906, 2910, 3065) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA Journal, 9(4):2069, 18 pp. [Google Scholar]
- Iwamoto M, Imaizumi K, Sato M, Hirooka Y, Sakai K, Takeshita A and Kono M, 2002. Serum lipid profiles in Japanese women and men during consumption of walnuts. European Journal of Clinical Nutrition, 56, 629–637. [DOI] [PubMed] [Google Scholar]
- Lavedrine F, Zmirou D, Ravel A, Balducci F and Alary J, 1999. Blood cholesterol and walnut consumption: a cross‐sectional survey in France. Preventive Medicine, 28, 333–339. [DOI] [PubMed] [Google Scholar]
- Ma Y, Njike VY, Millet J, Dutta S, Doughty K, Treu JA and Katz DL, 2010. Effects of walnut consumption on endothelial function in type 2 diabetic subjects: a randomized controlled crossover trial. Diabetes Care, 33, 227–232. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mensink RP and Katan MB, 1992. Effect of dietary fatty acids on serum lipids and lipoproteins. A meta‐analysis of 27 trials. Arteriosclerosis and Thrombosis, 12, 911–919. [DOI] [PubMed] [Google Scholar]
- Mensink RP, Zock PL, Kester AD and Katan MB, 2003. Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta‐analysis of 60 controlled trials. American Journal of Clinical Nutrition, 77, 1146–1155. [DOI] [PubMed] [Google Scholar]
- Morgan JM, Horton K, Reese D, Carey C, Walker K and Capuzzi DM, 2002. Effects of walnut consumption as part of a low‐fat, low‐cholesterol diet on serum cardiovascular risk factors. International Journal for Vitamin and Nutrition Research, 72, 341–347. [DOI] [PubMed] [Google Scholar]
- Mukuddem‐Petersen J, Oosthuizen W and Jerling JC, 2005. A systematic review of the effects of nuts on blood lipid profiles in humans. Journal of Nutrition, 135, 2082–2089. [DOI] [PubMed] [Google Scholar]
- Munoz S, Merlos M, Zambon D, Rodriguez C, Sabate J, Ros E and Laguna JC, 2001. Walnut‐enriched diet increases the association of LDL from hypercholesterolemic men with human HepG2 cells. Journal of Lipid Research, 42, 2069–2076. [PubMed] [Google Scholar]
- Ros E, Nunez I, Perez‐Heras A, Serra M, Gilabert R, Casals E and Deulofeu R, 2004. A walnut diet improves endothelial function in hypercholesterolemic subjects: a randomized crossover trial. Circulation, 109, 1609–1614. [DOI] [PubMed] [Google Scholar]
- Sabate J, Fraser GE, Burke K, Knutsen SF, Bennett H and Lindsted KD, 1993. Effects of walnuts on serum lipid levels and blood pressure in normal men. New England Journal of Medicine, 328, 603–607. [DOI] [PubMed] [Google Scholar]
- Zambon D, Sabate J, Munoz S, Campero B, Casals E, Merlos M, Laguna JC and Ros E, 2000. Substituting walnuts for monounsaturated fat improves the serum lipid profile of hypercholesterolemic men and women. A randomized crossover trial. Annals of Internal Medicine, 132, 538–546. [DOI] [PubMed] [Google Scholar]
